{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:15:41Z","timestamp":1703204141257},"reference-count":8,"publisher":"ALUNA","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship with inflammatory markers. \nMaterials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out. The control group consisted of 25 healthy children identical in age and examination parameters. \nResults: When analyzing the microflora of the nasopharynx of patients, 29,0% of strains were gram-positive bacteria and 71,0% were gram-negative bacteria (Escherichia coli representing 37,0%). Biochemical examination of the biomaterial revealed the presence of sucrase (n=69), maltase (n=87), lactorepoxidase (n-89) and alcohols - sorbitol (hexahydric alcohol, n=102), mannitol (hexahydric alcohol, n=84), xylitol (pentahydric alcohol, n=86). Regarding the markers of inflammatory response, the following dynamics was noted: increase in the level of IgM (3,91 \u00b1 1,79 g\/l, p&lt;0,01) by 2,2 times, elevation of Ig G level by 10 times (145, 91 \u00b1 53,04 g\/l, p&lt; 0,01), slightly higher than the reference values IgE level. In addition, increased IL-1, IL-4, IL-6, \u03b3-IFN, TNF-\u03b1, Neopterin levels were detected. The level of Thyroid stimulating hormone (TSH) was significantly different compared to the control group (0,62 \u00b1 0,57 vs. 1,98 \u00b1 0,30 mIU\/ ml, p&lt; 0,01), but within the reference values. \nConclusions: Predominance of Gram-negative bacteria in the nasopharyngeal microflora of patients along with elevated inflammatory markers and lactop\u00aceroxydase enzyme predominance was detected in the study.<\/jats:p>","DOI":"10.36740\/wlek202311112","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T13:31:09Z","timestamp":1703165469000},"page":"2413-2419","source":"Crossref","is-referenced-by-count":0,"title":["RESPIRATORY MICROBIOME AND ITS RELATIONSHIP WITH INFLAMMATORY MARKERS"],"prefix":"10.36740","volume":"76","author":[{"given":"Olesya M.","family":"Horlenko","sequence":"first","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna Yu.","family":"Pikina","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyubomyra B.","family":"Prylypko","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella B.","family":"Kossey","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Derbak","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian I.","family":"Tomey","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr Yu.","family":"Mashyka","sequence":"additional","affiliation":[{"name":"UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. Havrylenko AO, Smiian OI, Moshchych OP et al. Klinichni osoblyvosti ta kharakter perebihu hostroho bronkhitu v ditei doshkilnoho viku u poiednanni iz syndromom eutyreoidnoi patolohii ta bez noho 1 Modern pediatrics. [Clinical features and nature of the course of acute bronchitis in preschool children in combination with the syndrome of euthyroid pathology and without it]. Suchasna Pediatriya. Ukrayina. 2021;8(120):47-54. doi: 10.15574\/SP.2021.120.47. (in Ukrainian)","DOI":"10.15574\/SP.2021.120.47"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2. Fesenko MIe, Fastovets MM, Ziuzina LS et al. Hostri respiratorni rekurentni infektsii u ditei. [Acute respiratory recurrent infections in children]. Visnyk Ukrainskoi. Medychnoi stomatolohichnoi akademii. 2019:19,4(68):34-38. http:\/\/repository.pdmu.edu.ua\/ handle\/123456789\/17879 [date access 20.05.2023] (in Ukrainian)","DOI":"10.31718\/2077-1096.19.4.34"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. 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Front Cell Dev Biol. 2021. doi:10.3389\/fcell.2020.614030.","DOI":"10.3389\/fcell.2020.614030"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T14:28:24Z","timestamp":1703168904000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WiadLek2023i11.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202311112","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}