{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:10:11Z","timestamp":1756206611545,"version":"3.44.0"},"reference-count":14,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Bone metastases from liver cancer are rare. We report two cases of bone metastases revealing HBV-induced HCC. A 26-year-old african man presented with 4 months of low back pain in the context of general deterioration. Examination revealed a lumbar spinal syndrome and hepatomegaly. Abdominal ultrasound revealed a multinodular liver, and a CT scan of the spine revealed osteolytic lesions. Biological tests revealed a hepatic cytolysis syndrome, hepatic cholestasis and hepatocellular insufficiency. Alpha foetoprotein levels were elevated and hepatitis B serology was positive. We adopted the diagnosis of HCC of viral B origin with bone metastasis. The second case involved a 44-year-old African man admitted for 10 days with back pain. Examination revealed a spinal syndrome, paraplegia and hepatomegaly. A thoracic-abdominal-pelvic CT scan revealed typical HCC lesions and osteolytic lesions on the ribs, pelvis and vertebrae. The biology revealed a biological inflammatory syndrome, hepatic cytolysis, a hepatocellular insufficiency syndrome and a cholestasis syndrome. Alfa-feto proteins were elevated and HBV serology was positive. The diagnosis of bone metastasis of HCC secondary to HBV infection was accepted.<\/jats:p>","DOI":"10.36740\/wlek202402126","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T14:20:43Z","timestamp":1712586043000},"page":"358-362","source":"Crossref","is-referenced-by-count":0,"title":["Vertebral metastasis of hepatocellular carcinoma secondary to viral hepatitis B: case report of 2 patients"],"prefix":"10.36740","volume":"77","author":[{"given":"Yannick Laurent","family":"Tchenadoyo Bayala","sequence":"first","affiliation":[{"name":"RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael Ayouba","family":"Tinni","sequence":"additional","affiliation":[{"name":"RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulgence","family":"Kabore","sequence":"additional","affiliation":[{"name":"RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelle Wenlassida Stephanie","family":"Zabsonre\/ Tiendrebeogo","sequence":"additional","affiliation":[{"name":"RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieu-Donne","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2024]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"1. Samlali H, Bouchbika Z, Bennani Z et al. Metastase cranienne d\u2019un adenocarcinome rectal: a propos d\u2019un cas avec revue de la literature [Brain metastasis from rectal adenocarcinoma: about a case and review of the literature]. Pan Afr Med J. 2017;26:58. doi:10.11604\/pamj.2017.26.58.9826. (French)","key":"ref0","DOI":"10.11604\/pamj.2017.26.58.9826"},{"doi-asserted-by":"publisher","unstructured":"2. Lebosse F, Zoulim F. Vaccination contre le virus de l\u2019hepatite B et prevention du cancer du foie [Hepatitis B vaccine and liver cancer]. Bull Cancer. 2021;108(1):90-101. doi:10.1016\/j.bulcan.2020.10.014. (French)","key":"ref1","DOI":"10.1016\/j.bulcan.2020.10.014"},{"doi-asserted-by":"publisher","unstructured":"3. Vogel A, Meyer T, Sapisochin G et al. Hepatocellular carcinoma. Lancet. 2022;400(10360):1345-1362. doi:10.1016\/S0140-6736(22)01200-4.","key":"ref2","DOI":"10.1016\/s0140-6736(22)01200-4"},{"doi-asserted-by":"publisher","unstructured":"4. Kim SU, Kim DY, Park JY et al. Hepatocellular carcinoma presenting with bone metastasis: clinical characteristics and prognostic factors. J Cancer Res Clin Oncol. 2008;134(12):1377-1384. doi:10.1007\/s00432-008-0410-6.","key":"ref3","DOI":"10.1007\/s00432-008-0410-6"},{"doi-asserted-by":"publisher","unstructured":"5. Yang JD, Hainaut P, Gores GJ et al. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589-604. doi: 10.1038\/s41575-019-0186-y.","key":"ref4","DOI":"10.1038\/s41575-019-0186-y"},{"doi-asserted-by":"publisher","unstructured":"6. Houzou P, Oniankitan S, Bouglouga O et al. Bone metastases indicative of post viral hepatitis C hepatocarcinoma: about two observations. Open J. Rheumatol. Autoimmune Dis. 2021;11:4. doi: 10.4236\/ojra.2021.114015.","key":"ref5","DOI":"10.4236\/ojra.2021.114015"},{"doi-asserted-by":"publisher","unstructured":"7. Yang JD, Gyedu A, Afihene MY et al. Hepatocellular Carcinoma Occurs at an Earlier Age in Africans, Particularly in Association With Chronic Hepatitis B. Am J Gastroenterol. 2015;110(11):1629-1631. doi: 10.1038\/ajg.2015.289.","key":"ref6","DOI":"10.1038\/ajg.2015.289"},{"doi-asserted-by":"publisher","unstructured":"8. Park JW, Chen M, Colombo M et al. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int. 2015;35(9):2155-2166. doi: 10.1111\/liv.12818. DOI","key":"ref7","DOI":"10.1111\/liv.12818"},{"doi-asserted-by":"publisher","unstructured":"9. Harding JJ, Abu-Zeinah G, Chou JF et al. Frequency, morbidity, and mortality of bone metastases in advanced hepatocellular carcinoma. J Natl Compr Canc Netw. 2018;16(1):50-58. doi: 10.6004\/jnccn.2017.7024.","key":"ref8","DOI":"10.6004\/jnccn.2017.7024"},{"doi-asserted-by":"publisher","unstructured":"10. Sidibe R, Samlani Z, Krati K et al. Metastases osseuses revelatrices de carcinome hepatocellulaire. A propos de 3 cas. 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