{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:41:07Z","timestamp":1785620467321,"version":"3.56.0"},"reference-count":32,"publisher":"ALUNA","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Aim: The aim of this research is to clarify the potential effect of CDDO-EA against experimentally sepsis induced lung injury in mice.\nMaterials and Methods: Mice have divided into four groups: Sham group CLP group, Vehicle-treatment group, CDDO-EA-treated group: mice in this group received CDDO-EA 2mg\/kg intraperitoneally, 1hr before CLP, then the animals were sacrificed 24hr after CLP. After exsAngpuinations, tissue samples of lung were collected, followed by markers measurement including, TNF-\u03b1, IL-1\u03b2, VEGF, MPO, caspase11, Angp-1and Angp-2 by ELISA, gene expression of TIE2 and VE-cadherin by qRT-PCR, in addition to histopathological study.\nResults: A significant elevation (p&lt;0.05) in TNF-\u03b1, IL-1\u03b2, MPO, ANGP-2, VEGF, CASPASE 11 in CLP and vehicle groups when compared with sham group. CDDO-EA group showed significantly lower levels p&lt;0.05, level of ANGP-1 was significantly lower p&lt;0.05 in the CLP and vehicle groups as compared with the sham group. Quantitative real-time PCR demonstrated a significant decrement in mRNA expression of TIE2&amp;ve-cadherin genes p&lt;0.05 in sepsis &amp; vehicle.\nConclusions: CDDO-EA has lung protective effects due to its anti-inflammatory and antiAngpiogenic activity, additionally, CDDO-EA showes a lung protective effect as they affect tissue mRNA expression of TIE2 and cadherin gene. Furthermore, CDDO-EA attenuate the histopathological changes that occur during polymicrobial sepsis thereby lung protection effect.<\/jats:p>","DOI":"10.36740\/wlek202403118","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T17:01:25Z","timestamp":1714582885000},"page":"497-505","source":"Crossref","is-referenced-by-count":1,"title":["Effects of CDDO-EA in sepsis-induced acute lung injury: mouse model of endotoxaemia"],"prefix":"10.36740","volume":"77","author":[{"given":"Mohammed Hamzah","family":"Ibadi","sequence":"first","affiliation":[{"name":"BABYLON HEALTH DIRECTORATE, BABYLON, IRAQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Majeed","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF PHARMACOLOGY AND THERAPEUTIC, FACULTY OF MEDICINE, UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhaa Abdulameer","family":"Ghafil","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF PHARMACOLOGY AND THERAPEUTIC, FACULTY OF MEDICINE, UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najah R.","family":"Hadi","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF PHARMACOLOGY AND THERAPEUTIC, FACULTY OF MEDICINE, UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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Shock. 2016;45(2):157-165. doi:10.1097\/SHK.0000000000000499.","DOI":"10.1097\/shk.0000000000000499"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T17:08:50Z","timestamp":1714583330000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2024\/WiadLek2024i3.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024,3]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202403118","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}