{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:04:22Z","timestamp":1759565062377},"reference-count":13,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Aim: The objective of the research was to conduct a comprehensive longitudinal analysis of the temporal dynamics of glutathione system functionality in individuals diagnosed with paranoid schizophrenia. Specifically, the research was focused on investigating variations in the profiles of glutathione-dependent enzymes, with meticulous consideration given to the duration of the illness.\nMaterials and Methods: The study group comprised 300 individuals officially diagnosed with \u2018Paranoid Schizophrenia,\u2019 subdivided into five subgroups, each consisting of 60 patients. The subgroups were defined as follows: Subgroup I included 60 patients with a disease duration ranging from 3 to 5 years; Subgroup II comprised 60 patients with a duration of 6 to 10 years; Subgroup III consisted of 60 patients with a duration of 11 to 15 years; Subgroup IV included 60 patients with a duration of 16 to 20 years; and Subgroup V encompassed 60 patients with a duration of 21 years and older. The comparison group comprised 20 patients diagnosed with \u201cPrimary psychotic episode\u201d.\nResults: The research demonstrates a consistent and noteworthy reduction in the enzymatic activities of glutathione peroxidase, glutathione reductase, and glutathione-S-transferase in various Subgroups of paranoid schizophrenia patients. The observed declines are particularly prominent within the first 3-5 years of the illness, show casing statistically significant reductions. Patients with prolonged illness durations, especially surpassing 21 years, display substantial reductions in all three enzymes, suggesting a cumulative enzymatic impact associated with prolonged illness.\nConclusions: The identification of critical periods of inhibition in the glutathione protection chain, provides valuable information about potential therapeutic interventions for individuals with paranoid schizophrenia.<\/jats:p>","DOI":"10.36740\/wlek202407102","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:22:43Z","timestamp":1725564163000},"page":"1311-1317","source":"Crossref","is-referenced-by-count":1,"title":["Study of the influence of disease duration on glutatione-dependent ensymes dynamics in patients with paranoid schizophrenia"],"prefix":"10.36740","volume":"77","author":[{"given":"Ivan R.","family":"Romash","sequence":"first","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna B.","family":"Romash","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykhaylo M.","family":"Pustovoyt","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. 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Wiad Lek. 2023;76(12):2625-31. doi:10.36740\/WLek202312111.","DOI":"10.36740\/wlek202312111"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:22:54Z","timestamp":1725564174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-192883-113581?filename=Study%20of%20the%20influence%20of.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202407102","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}