{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:05:44Z","timestamp":1789416344622,"version":"build-2803163510"},"reference-count":11,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Aim: The aim of this study was to determine the effect of application of drug with circadian activity (pioglitazone) for treatment of patients with periodontist.\nMaterials and Methods: Group I \u2013 18 individuals with healthy periodontium. Group II \u2013 12 participants with stage II, grade B periodontitis treated with a standard treatment protocol. Group III \u2013 12 participants with stage II, grade B periodontitis, treated with a regimen that included the standard protocol along with the administration of pioglitazone prescribed at recommended times of intake. Group IV \u2013 12 participants with stage II, grade B periodontitis treated with the standard protocol and pioglitazone against the recommended intake hours.\nResults: The Simplified Oral Hygiene Index in Group I was 0.406\u00b10.034. In Group II, it was 2.5\u00b10.06. In Group III, the hygiene index was 2.633\u00b10.056 and in Group IV it was 2.5\u00b10.059. The Papillary-Marginal-Alveolar Index in Group I was 0.033\u00b10.004. In Group II, it was 0.366\u00b10.011. For Group III, the PMA index was 0.38\u00b10.012 and for Group IV it was 0.378\u00b10.01. The Russell\u2019s Periodontal Index in Group I was 0.111\u00b10.008. In Group II, it was 4.668\u00b10.155. For Group III \u2013 4.708\u00b10.132 and for Group IV it was 4.575\u00b10.089. The Gingival Bleeding Index (GBI) in Group I was 0.031\u00b10.003, while in Group II, it was 0.266\u00b10.009, in Group III, it was 0.273\u00b10.007 and in Group IV it was 0.278\u00b10.006.\nConclusions: The administration of pioglitazone (the drug with circadian activity) according to its circadian stage indeed has a positive effect on the periodontal status changes of patients with stage II, grade B periodontitis.<\/jats:p>","DOI":"10.36740\/wlek202407104","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:22:38Z","timestamp":1725564158000},"page":"1325-1330","source":"Crossref","is-referenced-by-count":2,"title":["Index assessment of periodontal status in patients on the background of administering a drug with circadian activity"],"prefix":"10.36740","volume":"77","author":[{"given":"Maryna Y.","family":"Vasko","sequence":"first","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna M.","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav Y.","family":"Vodoriz","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Dvornyk","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh A.","family":"Pysarenko","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","unstructured":"1. Sculean A et al. Periodontal Regenerative Therapy. London. 2010, p.304."},{"key":"ref1","unstructured":"2. Shyliivskyi IV, Nemesh OM, Honta ZM. Suchasni pohlyady na etiolohiyu ta patohenez zapal'nykh zakhvoryuvan' parodontu, yikh zv\u2019yazok z patolohiyeyu sechovydil'noyi systemy [Modern views on the etiology and pathogenesis of inflammatory periodontal diseases, their relationship with the pathology of the urinary system]. Bukovyns'kyy medychnyy visnyk. 2016;20(1):224\u2013227. (Ukrainian)"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Kapila YL. Oral health\u2019s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontology 2000. 2021;87(1):11\u201316. doi: 10.1111\/prd.12398.","DOI":"10.1111\/prd.12398"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nature Reviews Immunology. 2021;21(7):426\u2013440. doi: 10.1038\/s41577-020-00488-6.","DOI":"10.1038\/s41577-020-00488-6"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Mendiz\u00e1bal Y, Llorens S, Nava E. Effects of pioglitazone and rosiglitazone on vascular function of mesenteric resistance arteries in rat genetic hypertension. Pharmacology. 2011;88(1-2):72\u201381. doi: 10.1159\/000330092.","DOI":"10.1159\/000330092"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Mason IC, Qian J, Adler GK, Scheer FAJL. Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020;63:462\u2013472. doi: 10.1007\/s00125-019-05059-6.","DOI":"10.1007\/s00125-019-05059-6"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Vasko MY, Tkachenko IM, Pavlenkova OV, Pysarenko OA. Interrelation of biological rhythms and circadian hormones producement and their impact on medicine usage. Wiad Lek. 2021;74(8):1970-1974.","DOI":"10.36740\/wlek202108133"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Vasko M, Marchenko I, Shundryk M et al. Influence of age, gender characteristics, chronotype on the expression of core clock genes Per1, Clock, Bmal1 and Cry1 in buccal epithelium. Acta Biochim Pol. 2022;69(4):883-888. doi: 10.18388\/abp.2020_6408.","DOI":"10.18388\/abp.2020_6408"},{"key":"ref8","unstructured":"9. Zupanets IA, Starchenko MH, Dobrova VYe. Metodolohichni ta orhanizatsiyni aspekty provedennya klinichnykh vyprobuvan' za uchastyu zdorovykh dobrovol'tsiv [Methodological and organizational aspects of conducting clinical trials involving healthy volunteers]. Menedzhment, ekonomika ta zabezpechennya yakosti u farmatsiyi. 2010;4:4-10. (Ukrainian)"},{"key":"ref9","unstructured":"10. Konovalova OV. Viddaleni rezul'taty likuvannya khvorykh na heneralizovanyy parodontyt z proyavamy psykhoemotsiynoho stresu [Remote results of treatment of patients with generalized periodontitis with manifestations of psychoemotional stress]. Novyny stomatolohiyi. 2019;2:6\u201310. (Ukrainian)"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"11. Francis G. Equivalent statistics and data interpretation. Behavior Research Methods. 2017;49(4):1524-1538.","DOI":"10.3758\/s13428-016-0812-3"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:22:49Z","timestamp":1725564169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-192884-113583?filename=Index%20assessment%20of.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":11,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202407104","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}