{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:07:00Z","timestamp":1789549620495,"version":"build-2803163510"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>It is uncommon for breast cancer and non-Hodgkin lymphoma to present simultaneously. An increase in the rate of simultaneous malignancy identification has resulted from adopting more sensitive staging imaging techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>\n                      Here, we describe a patient who was diagnosed with axillary diffuse large B cell lymphoma (DLBCL) in a cancer hospital during a staging work-up for suspected breast cancer. Breast cancer was staged as Stage IIA and DLBCL as Stage IE. She was given three cycles of rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone (R-CHOP) protocol. Interim positron emission tomography scan showed a complete metabolic response (Deauville score 2). She was given one more cycle of R-CHOP. Then, she had right breast-conserving surgery with axillary lymph node dissection in August 2023. Histopathology report showed residual disease with ductal carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      . She was recommended weekly paclitaxel for 12 cycles and trastuzumab and pertuzumab for 1 year. She is currently having her adjuvant systemic therapy, after which she will be planned for local radiation. Endocrine treatment will be started once chemotherapy is completed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Implications<\/jats:title>\n                    <jats:p>Complete baseline work-up per standard protocols\/guidelines should be done in each malignancy. Biopsy of metastatic sites should be done wherever possible. All histopathologies should be reviewed thoroughly before treatment initiation, as they may significantly alter patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.37029\/jcas.v10i2.655","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T19:39:02Z","timestamp":1723837142000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Synchronous Invasive Ductal Carcinoma of Breast and Diffuse Large B-cell Lymphoma: A Case Report"],"prefix":"10.2478","volume":"10","author":[{"given":"Tahira","family":"Yasmeen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobia","family":"Umar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah Mairah","family":"Razi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2026091608294857130_j_jcas.v10i2.655_ref_001","doi-asserted-by":"crossref","unstructured":"Khan NH, Duan SF, Wu DD, Ji XY. Better reporting and awareness campaigns needed for breast cancer in Pakistani women. Cancer Manage Res 2021;13:2125-9.","DOI":"10.2147\/CMAR.S270671"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_002","unstructured":"Sohail S, Alam SN. Breast cancer in Pakistan-awareness and early detection. J Coll Physicians Surg Pak 2007;17:711-2."},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_003","doi-asserted-by":"crossref","unstructured":"Thandra KC, Barsouk A, Saginala K, Padala SA, Barsouk A, Rawla P. Epidemiology of non-Hodgkin\u2019s lymphoma. Med Sci (Basel) 2021;9:5.","DOI":"10.3390\/medsci9010005"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_004","doi-asserted-by":"crossref","unstructured":"Dutta Roy S, Stafford JA, Scally J, Selvachandran SN. A rare case of breast carcinoma co-existing with axillary mantle cell lymphoma. World J Surg Oncol 2003;1:27.","DOI":"10.1186\/1477-7819-1-27"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_005","doi-asserted-by":"crossref","unstructured":"Miles EF, Jacimore LL. Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: A case report and review of the literature. Case Rep Oncol Med 2012;2012:685919.","DOI":"10.1155\/2012\/685919"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_006","doi-asserted-by":"crossref","unstructured":"Saleem T, Mi K, Pathak R, Yari K, Lu K. Concurrent breast carcinoma and follicular lymphoma: A case series. Am J Case Rep 2021;22:e931772-1.","DOI":"10.12659\/AJCR.931772"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_007","doi-asserted-by":"crossref","unstructured":"Woo EJ, Baugh AD, Ching K. Synchronous presentation of invasive ductal carcinoma and mantle cell lymphoma: A diagnostic challenge in menopausal patients. J Surg Case Rep 2016;2016:rjv153.","DOI":"10.1093\/jscr\/rjv153"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_008","unstructured":"Zhong J, Di L, Zheng W. Synchronous breast cancer and breast lymphoma: Two case reports and literature review. Chin J Cancer Res 2014;26:355."},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_009","doi-asserted-by":"crossref","unstructured":"Salemis NS. Synchronous occurrence of breast cancer and refractory diffuse large B-cell abdominal lymphoma: Management and review of the literature. Intractable Rare Dis Res 2021;10:131-5.","DOI":"10.5582\/irdr.2021.01017"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_010","doi-asserted-by":"crossref","unstructured":"Papaj\u00edk T, Myslivecek M, \u0160edov\u00e1 Z, Buri\u00e1nkov\u00e1 E, Proch\u00e1zka V, Raida L, et al. Synchronous second primary neoplasms detected by initial staging F-18 FDG PET\/CT examination in patients with non-Hodgkin lymphoma. Clin Nucl Med 2011;36:509-12.","DOI":"10.1097\/RLU.0b013e318217541d"},{"key":"2026091608294857130_j_jcas.v10i2.655_ref_011","unstructured":"National Comprehensive Cancer Network. Bone Cancer (Version 1); 2024. 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