{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:10:56Z","timestamp":1789823456794,"version":"4.0.1"},"reference-count":7,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High grade B-cell lymphoma and diffuse large B cell exhibiting myelocytoma (MYC) translocation with B-cell lymphoma 2 (BCL2) and\/or B-cell lymphoma 6 (BCL6) re-arrangements, also known as double and triple hit lymphomas, are aggressive entities. World Health Organization update 2017 includes this cytogenetically defined category of \u201cHigh grade B cell lymphoma with myelocytoma MYC and BCL2 and\/ or BCL6 rearrangements\u201d as a distinct entity on their own. We present an interesting case of an obese patient presenting with a neck mass, suspected to be an aggressive thyroid carcinoma, which eventually turned out to be a high grade B-cell lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>A 64 years-old male presented with complaints of neck pain for 10 weeks and a huge swelling in front of neck for 4 weeks. Respiratory system evaluation revealed cough, pleuritic pain and expectoration. Rest of the systemic review was unremarkable. Baseline reports showed hypothyroid status. Ultrasonography (USG) thyroid showed right upper pole Thyroid Imaging Reporting and Data Systems - 4 (TIRADS-4) nodule with bilateral cervical lymphadenopathy for which correlation with fine needle aspiration cytology (FNAC) was advised. Magnetic resonance imaging (MRI) films were submitted for review which showed overall features of locally invasive primary thyroid malignancy. Case was discussed in a multi-disciplinary team (MDT) meeting and suspicion arose of non-thyroidal origin of tumor. Patient underwent Positron emission tomography\/computed tomography (PET\/CT) as per MDT recommendations. PET\/CT findings were highly suggestive of lymphomatous disease as opposed to thyroidal malignancy suspicion early on, which was confirmed on histopathology of cervical nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Implications<\/jats:title>\n                    <jats:p>High grade B-cell lymphoma is an aggressive entity and can be very deceptive in its presentation, as evident from this case report. Functional imaging modalities such as Fluorodeoxyglucose (F-18 FDG) PET\/CT can provide crucial assistance in unmasking a deceptive disease entity masquerading as some other, thus changing the management plan completely.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.37029\/jcas.v6i2.363","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T04:58:03Z","timestamp":1594011483000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["High-grade B-cell Non-Hodgkin\u2019s Lymphoma Masquerading as Thyroid Carcinoma; a Case Report"],"prefix":"10.2478","volume":"6","author":[{"given":"Ali","family":"Jamal","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine , Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department of Radiology , Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran Khalid","family":"Niazi","sequence":"additional","affiliation":[{"name":"Department of Radiology , Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humayun","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , Shaukat Khanum Memorial Cancer Hospital and Research Centre , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"2026091912280904732_j_jcas.v6i2.363_ref_001","doi-asserted-by":"crossref","unstructured":"Sha C, Barrans S, Cucco F, Bentley MA, Care MA, Cummin T, et al. Molecular high-grade B-cell lymphoma: Defining a poor-risk group that requires different approaches to therapy. J Clin Oncol 2019;37:202-12.","DOI":"10.1200\/JCO.18.01314"},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_002","doi-asserted-by":"crossref","unstructured":"Landsburg DJ, Falkiewicz MK, Petrich AM, Chu BA, Behdad A, Li S, et al. Sole rearrangement but not amplification of MYC is associated with a poor prognosis in patients with diffuse large B cell lymphoma and B cell lymphoma unclassifiable. Br J Haematol 2016;175:631-40.","DOI":"10.1111\/bjh.14282"},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_003","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO Classification of Tumors of Haematopoetic and Lymphoid Tissues. 4th ed. Lyon: IARC; 2017."},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_004","doi-asserted-by":"crossref","unstructured":"Kwak JY, Han KH, Yoon JH, Moon HJ, Son EJ, Park SH, et al. Thyroid imaging reporting and data system for US features of nodules: A step in establishing better stratification of cancer risk. Radiology 2011;260:892-9.","DOI":"10.1148\/radiol.11110206"},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_005","doi-asserted-by":"crossref","unstructured":"Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002;346:1937-47.","DOI":"10.1056\/NEJMoa012914"},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_006","doi-asserted-by":"crossref","unstructured":"Dang CV, O\u2019Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. The c-Myc target gene network. Semin Cancer Biol 2006;16:253-64.","DOI":"10.1016\/j.semcancer.2006.07.014"},{"key":"2026091912280904732_j_jcas.v6i2.363_ref_007","doi-asserted-by":"crossref","unstructured":"Rosenthal A, Younes A. High grade B-cell lymphoma with rearrangements of MYC and BCL2 and\/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma. Blood Rev 2017;31:37-42.","DOI":"10.1016\/j.blre.2016.09.004"}],"container-title":["Journal of Cancer and Allied Specialties"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sfu.ca\/jcas\/index.php\/jcas\/article\/download\/363\/423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.37029\/jcas.v6i2.363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:32:06Z","timestamp":1789821126000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.37029\/jcas.v6i2.363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,6]]},"published-print":{"date-parts":[[2020,7,1]]}},"alternative-id":["10.37029\/jcas.v6i2.363"],"URL":"https:\/\/doi.org\/10.37029\/jcas.v6i2.363","relation":{},"ISSN":["2411-989X"],"issn-type":[{"value":"2411-989X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}