{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:05:59Z","timestamp":1789074359798,"version":"build-2803163510"},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:p>Introduction. Several factors have been associated with the prognosis of prosthetic joint infection (PJI) treated with surgical debridement, antibiotic therapy, and implant retention (DAIR). There is no evidence about the right empirical antibiotic treatment when the causal microorganism is not still identified. Material and methods. We conducted a retrospective observational study in patients with PJI treated with DAIR between 2009 and 2018 in our center. We analyze the risk factors related with their prognosis and the influence of active empirical antibiotic therapy against causative microorganisms in final outcomes. Results. A total of 80 PJI cases treated with DAIR, from 79 patients (58.7% women, mean age 76.3 years), were included in the study period. Among the cases in which empirical antibiotic therapy were active against the causative microorganisms, the success rate was 46\/65 (69.2%) vs 1\/15 when not (6.7%, OR 31.5, p = 0.001). Factors related to the success or failure of the DAIR were analyzed with multivariate analysis. We found that active empirical antibiotic treatment remained statistically significant as a good prognostic factor (OR 0.04, p &lt;0.01). Conclusions. Empirical antibiotic treatment could be an important factor in the prognosis of PJI treated with DAIR. To identify cases at risk of infection by multidrug resistant microorganisms could be useful to guide empirical antibiotic therapy<\/jats:p>","DOI":"10.37201\/req\/033.2021","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T11:15:06Z","timestamp":1625483706000},"page":"475-482","source":"Crossref","is-referenced-by-count":1,"title":["Relevance of empirical antibiotic treatment in the evolution of prosthetic joint infection treated with implant retention"],"prefix":"10.37201","volume":"34","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"Barbero Allende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Vacas C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Montero Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Barreira Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Servicio de Medicina Interna, Hospital Universitario Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"23328","published-online":{"date-parts":[[2021,7,5]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":["Relevancia del tratamiento antibi\u00f3tico emp\u00edrico en la evoluci\u00f3n de la infecci\u00f3n de pr\u00f3tesis articular tratada con retenci\u00f3n del implante"],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T05:24:11Z","timestamp":1635225851000},"score":1,"resource":{"primary":{"URL":"https:\/\/seq.es\/abstract\/rev-esp-quimioter-2021-july-5-2\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,25]]},"published-print":{"date-parts":[[2021,10,25]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/033.2021","relation":{},"ISSN":["0214-3429","1988-9518"],"issn-type":[{"value":"0214-3429","type":"print"},{"value":"1988-9518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]}}}