{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T05:41:39Z","timestamp":1664343699628},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"published-print":{"date-parts":[[2022,9,27]]},"abstract":"<jats:p>Objectives. Congenital cytomegalovirus infection (cCMV) has been considered more prevalent among HIV-exposed children during pregnancy. Spanish national guidelines recommend the cCMV screening in these newborns. Nowadays, pregnant women have a better control of HIV infection compared to previous decades. We aim to analyze the prevalence and associated risk factors to cCMV in these children. Patients and methods. A retrospective cross-sectorial study was performed. All newborns exposed to HIV were assisted in a third-level hospital (2014-2020). Epidemiological and clinical data of the mother and newborn were recorded. Shell vial urine culture and\/or CRP were performed along the two first weeks of life for the neonatal screening of cCMV. Results. Overall 69 newborns were enrolled. A high proportion (82.4%) of the mothers had been diagnosed with HIV before getting pregnant. All women received ART during the pregnancy. Median T-CD4 lymphocytes before delivery was 641\/mm3 (IQR: 480-865) and the viral load was undetectable in 83.6%. Serological test for CMV along the first trimester of pregnancy was performed in 73.5% (positive IgG in 96%). There were no congenital cases of HIV neither cCMV (CI 95%:0-5.3%). Conclusions. The cCMV prevalence in newborns exposed to HIV was 0%, lower than reported before, probably related to a better and earlier ART during pregnancy, leading to a better immunological status.<\/jats:p>","DOI":"10.37201\/req\/037.2022","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T17:23:21Z","timestamp":1657992201000},"page":"482-491","source":"Crossref","is-referenced-by-count":0,"title":["Congenital cytomegalovirus infection, is more prevalent in our country in newborns exposed to HIV?"],"prefix":"10.37201","volume":"35","author":[{"given":"Jorge","family":"Bustamante-Amador","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Mellado-Sola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"Romero-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Cabrera-Lafuente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"de la Calle-Fern\u00e1ndez-Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal\u00eda","family":"Sainz-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mellado-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Escosa-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"23328","published-online":{"date-parts":[[2022,7,18]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":["La infecci\u00f3n cong\u00e9nita por citomegalovirus, \u00bfes m\u00e1s prevalente en nuestro medio en neonatos expuestos al VIH?"],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T11:24:36Z","timestamp":1664277876000},"score":1,"resource":{"primary":{"URL":"https:\/\/seq.es\/abstract\/rev-esp-quimioter-2022-july-18-2\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,27]]},"published-print":{"date-parts":[[2022,9,27]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/037.2022","relation":{},"ISSN":["0214-3429","1988-9518"],"issn-type":[{"value":"0214-3429","type":"print"},{"value":"1988-9518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}