{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:57:29Z","timestamp":1758351449861,"version":"3.44.0"},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:p>Se describe el caso de una mujer de 46 a\u00f1os con artritis psori\u00e1sica tratada con metotrexato y prednisona, candidata a certolizumab. Previo al biol\u00f3gico se diagnostic\u00f3 infecci\u00f3n tuberculosa latente mediante Mantoux positivo (6 mm) e imagen tor\u00e1cica normal. Se instaur\u00f3 rifampicina 600 mg\/d\u00eda m\u00e1s isoniazida + piridoxina 300\/50 mg\/d\u00eda durante tres meses. Al mes se inici\u00f3 certolizumab y se observ\u00f3 descenso de neutr\u00f3filos de 2,8 a 1,7 \u00d7 109\/L; 15 d\u00edas despu\u00e9s apareci\u00f3 neutropenia grave (0,3 \u00d7 109\/L). Se suspendieron rifampicina e isoniacida, manteniendo certolizumab; el recuento se recuper\u00f3 a 0,8 \u00d7 109\/L en una semana y se normaliz\u00f3 al mes. Posteriormente se reintrodujo isoniazida en monoterapia (nueve meses) sin recurrencia. Seg\u00fan el algoritmo de Karch-Lasagna modificado, la relaci\u00f3n rifampicina-neutropenia se clasific\u00f3 como \u00abprobable\u00bb (puntuaci\u00f3n 6). La neutropenia inducida por f\u00e1rmacos antituberculosos es rara (&lt;1 %), pero potencialmente grave. La cronolog\u00eda, la reversibilidad tras la retirada y la tolerancia a isoniazida sugieren a la rifampicina como agente causal. Este caso destaca la necesidad de monitorizar el hemograma, adem\u00e1s de las transaminasas, al menos durante el primer mes de tratamiento de la infecci\u00f3n tuberculosa latente con rifampicina, especialmente en pacientes con factores de riesgo, a fin de detectar precozmente alteraciones hematol\u00f3gicas y prevenir la progresi\u00f3n a agranulocitosis.<\/jats:p>","DOI":"10.37201\/req\/062.2025","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:47:54Z","timestamp":1757933274000},"page":"444-446","source":"Crossref","is-referenced-by-count":0,"title":["Neutropenia probable secundaria al tratamiento con rifampicina"],"prefix":"10.37201","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3501-7459","authenticated-orcid":false,"given":"Guillermo","family":"Espa\u00f1a-Mar\u00ed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-4263","authenticated-orcid":false,"given":"Laura","family":"\u00c1lvarez-Arroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2285-7433","authenticated-orcid":false,"given":"Anna","family":"Alentado-Mateu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6386-4161","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Lim\u00f3n-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4162-9649","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Monta\u00f1\u00e9s-Pauls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"23328","published-online":{"date-parts":[[2025,9,15]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":[],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:32:05Z","timestamp":1758270725000},"score":1,"resource":{"primary":{"URL":"https:\/\/revespquimioterapia.com\/articulo\/neutropenia-probable-secundaria-al-tratamiento-con-rifampicina"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,15]]},"published-print":{"date-parts":[[2025,9,15]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/062.2025","relation":{},"ISSN":["1988-9518","0214-3429"],"issn-type":[{"type":"electronic","value":"1988-9518"},{"type":"print","value":"0214-3429"}],"subject":[],"published":{"date-parts":[[2025,9,15]]}}}