{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:32:45Z","timestamp":1747222365401,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:p>Objective. To date, no data exist regarding the prevalence of integrase inhibitor (INSTI) resistance-associated mutations (HIVDRM) in HIV-infected pregnant women (HPW) in Latin America. We describe the prevalence and transmissibility of integrase HIVDRM in a historical cohort of INSTI-na\u00efve HPW from Argentina (n=56) with Next Generation Sequencing (NGS). Material and methods. Bioinformatics analysis was performed by HyDRA software for 20%, 10%, 5%, 2%, and 1% sensitivity thresholds. We calculated the mutational viral load for each INSTI-HIVDRM, considering those with &gt;1000 c\/mL as of high risk of transmissibility. Results. The predominant HIV subtype was BF (78.5%). Major HIVDRM were not detected with the population sequencing 20% filter. With a 1% threshold, the prevalence increased to 8.9%; Y143C\/S, E92G, E138K, and T66I mutations were found. The median (range) mutational load (expressed in c\/mL) was: 355 (50.2-11705); with only 1 case &gt;1000 c\/mL Accessory mutations (G163R\/K, T97A) were detected mostly with a 20% sensitivity threshold with an overall prevalence of 23.2%; the median (IQR) mutational load was: 23929 (4009-63158) c\/mL; all of them above 1000 c\/mL. Conclusion. Our results show evidence of the presence of major INSTI-HIVDRM as aleatory mutations and a high frequency of accessory mutations with potential transmissibility in HPW.<\/jats:p>","DOI":"10.37201\/req\/074.2024","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T14:05:21Z","timestamp":1728050721000},"page":"479-485","source":"Crossref","is-referenced-by-count":0,"title":["Integrase strand transfer inhibitors resistance-associated mutations in HIV-infected pregnant women"],"prefix":"10.37201","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8545-6132","authenticated-orcid":false,"given":"Diego","family":"Cecchini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1857-4496","authenticated-orcid":false,"given":"Javier","family":"Sfalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7516-263X","authenticated-orcid":false,"given":"In\u00e9s","family":"Zapiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7273-5677","authenticated-orcid":false,"given":"Alan","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3281-5361","authenticated-orcid":false,"given":"Silvina","family":"Fernandez-Giuliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2387-2971","authenticated-orcid":false,"given":"Claudia","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-3443","authenticated-orcid":false,"given":"Lilia","family":"Mammana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4133-0649","authenticated-orcid":false,"given":"Anal\u00eda","family":"Seravalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-1964","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Fay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4007-1013","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"Torroija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1860-1827","authenticated-orcid":false,"given":"Gabriela","family":"Bugar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1389-8940","authenticated-orcid":false,"given":"Mar\u00eda Bel\u00e9n","family":"Bouzas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"23328","published-online":{"date-parts":[[2024,10,4]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":[],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T13:32:02Z","timestamp":1731677522000},"score":1,"resource":{"primary":{"URL":"https:\/\/seq.es\/abstract\/rev-esp-quimioter-2024-october-4-2\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,11,5]]},"published-print":{"date-parts":[[2024,11,5]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/074.2024","relation":{},"ISSN":["0214-3429","1988-9518"],"issn-type":[{"type":"print","value":"0214-3429"},{"type":"electronic","value":"1988-9518"}],"subject":[],"published":{"date-parts":[[2024,10,4]]}}}