{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:57:40Z","timestamp":1790697460280,"version":"4.1.0"},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"published-print":{"date-parts":[[2024,3,6]]},"abstract":"<jats:p>Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives<\/jats:p>","DOI":"10.37201\/req\/143.2023","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T10:18:51Z","timestamp":1703240331000},"page":"127-133","source":"Crossref","is-referenced-by-count":27,"title":["Safety of fluoroquinolones"],"prefix":"10.37201","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-9813","authenticated-orcid":false,"given":"Jos\u00e9","family":"Barber\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"de la Cuerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Tejeda Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"L\u00f3pez Aparicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-8321","authenticated-orcid":false,"given":"Carlos","family":"Monfort Vinuesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ramos S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Cristina Barber\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"23328","published-online":{"date-parts":[[2023,12,22]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":[],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T15:41:06Z","timestamp":1709739666000},"score":1,"resource":{"primary":{"URL":"https:\/\/seq.es\/abstract\/rev-esp-quimioter-2023-december-22-2\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,3,6]]},"published-print":{"date-parts":[[2024,3,6]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/143.2023","relation":{},"ISSN":["0214-3429","1988-9518"],"issn-type":[{"value":"0214-3429","type":"print"},{"value":"1988-9518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]}}}