{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:17:57Z","timestamp":1787030277723,"version":"build-2736575974"},"reference-count":0,"publisher":"Sociedad Espanola de Quimioterapia","issue":"Suppl1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Esp Quimioter"],"abstract":"<jats:p>The increase in nosocomial infections by beta-lactamase producing Gram-negative bacilli constitutes a therapeutic challenge. The combination of ceftazidime-avibactam offers a very interesting therapeutic option for nosocomial pneumonia caused by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, multidrug-resistant Pseudomonas aeruginosa, and other enterobacteria. Compared to carbapenems, ceftazidime-avibactam has demonstrated non-inferiority in the treatment of nosocomial pneumonia including better clinical and microbiological cure rates and mortality compared to colistin. The limitation of ceftazidime-avibactam in the treatment of infections caused by metallo-beta-lactamase-producing Enterobacteriaceae can be overcome with the addition of aztreonam.<\/jats:p>","DOI":"10.37201\/req\/s01.09.2022","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T03:26:27Z","timestamp":1651289187000},"page":"40-42","source":"Crossref","is-referenced-by-count":20,"title":["Ceftazidime-avibactam"],"prefix":"10.37201","volume":"35","author":[{"given":"Francisco","family":"Sanz Herrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"23328","published-online":{"date-parts":[[2022,4,22]]},"container-title":["Revista Espa\u00f1ola de Quimioterapia"],"original-title":[],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T03:46:46Z","timestamp":1651636006000},"score":1,"resource":{"primary":{"URL":"https:\/\/seq.es\/abstract\/rev-esp-quimioter-2022-april-09\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":0,"journal-issue":{"issue":"Suppl1","published-online":{"date-parts":[[2022,4,22]]},"published-print":{"date-parts":[[2022,4,22]]}},"URL":"https:\/\/doi.org\/10.37201\/req\/s01.09.2022","relation":{},"ISSN":["0214-3429","1988-9518"],"issn-type":[{"value":"0214-3429","type":"print"},{"value":"1988-9518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]}}}