{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:54:34Z","timestamp":1785185674035,"version":"3.55.0"},"reference-count":78,"publisher":"China Science Publishing & Media Ltd.","issue":"5","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2022,5,1]]},"DOI":"10.3724\/abbs.2022042","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T03:57:53Z","timestamp":1654142273000},"page":"625-636","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Osteoblasts induce glucose-derived ATP perturbations in chondrocytes through noncontact communication"],"prefix":"10.3724","volume":"54","author":[{"given":"Jieya","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daimo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.joca.2014.05.023","author":"Yuan XL","year":"2014","unstructured":"Yuan XL, Meng HY, Wang YC, Peng J, Guo QY, Wang AY, Lu SB. Bone\u2013cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies. Osteoarthritis Cartilage, 2014, 1077-1089.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41413-020-0100-9","author":"Ni Z","year":"2020","unstructured":"Ni Z, Zhou S, Li S, Kuang L, Chen H, Luo X, Ouyang J. Exosomes: roles and therapeutic potential in osteoarthritis. Bone Res, 2020,","journal-title":"Bone Res"},{"key":"CITATION3","doi-asserted-by":"crossref","unstructured":"Ansari N, Sims NA. The cells of bone and their interactions. Handb Exp Pharmacol 2020, 262: 1\u201325.","DOI":"10.1007\/164_2019_343"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41413-021-00173-x","author":"Zhou C","year":"2021","unstructured":"Zhou C, Cui Y, Yang Y, Guo D, Zhang D, Fan Y, Li X. Runx1 protects against the pathological progression of osteoarthritis. Bone Res, 2021,","journal-title":"Bone Res"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/annrheumdis-2020-218089","author":"Hu W","year":"2020","unstructured":"Hu W, Chen Y, Dou C, Dong S. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis. Ann Rheum Dis, 2020, 413-422.","journal-title":"Ann Rheum Dis"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11926-017-0660-x","author":"Aaron RK","year":"2017","unstructured":"Aaron RK, Racine J, Dyke JP. Contribution of circulatory disturbances in subchondral bone to the pathophysiology of osteoarthritis. Curr Rheumatol Rep, 2017,","journal-title":"Curr Rheumatol Rep"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11914-019-00506-0","author":"Hollander JM","year":"2019","unstructured":"Hollander JM, Zeng L. The emerging role of glucose metabolism in cartilage development. Curr Osteoporos Rep, 2019, 59-69.","journal-title":"Curr Osteoporos Rep"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1038\/onc.2014.320","author":"Lincet H","year":"2015","unstructured":"Lincet H, Icard P. How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?. Oncogene, 2015, 3751-3759.","journal-title":"Oncogene"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3892\/ijo.2020.5083","author":"Zhang Y","year":"2020","unstructured":"Zhang Y, Cai H, Liao Y, Zhu Y, Wang F, Hou J. Activation of PGK1 under hypoxic conditions promotes glycolysis and increases stem cell\u2011like properties and the epithelial\u2011mesenchymal transition in oral squamous cell carcinoma cells via the AKT signalling pathway. Int J Oncol, 2020, 743-755.","journal-title":"Int J Oncol"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.biochi.2017.02.008","author":"Sajnani K","year":"2017","unstructured":"Sajnani K, Islam F, Smith RA, Gopalan V, Lam AK. Genetic alterations in Krebs cycle and its impact on cancer pathogenesis. Biochimie, 2017, 164-172.","journal-title":"Biochimie"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1080\/15384101.2019.1618125","author":"Ghashghaeinia M","year":"2019","unstructured":"Ghashghaeinia M, K\u00f6berle M, Mrowietz U, Bernhardt I. Proliferating tumor cells mimick glucose metabolism of mature human erythrocytes. Cell Cycle, 2019, 1316-1334.","journal-title":"Cell Cycle"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1042\/bj3210095","author":"Lee RB","year":"1997","unstructured":"Lee RB, Urban JPG. Evidence for a negative Pasteur effect in articular cartilage. Biochem J, 1997, 95-102.","journal-title":"Biochem J"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13075-015-0566-9","author":"Lane RS","year":"2015","unstructured":"Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther, 2015,","journal-title":"Arthritis Res Ther"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/1529-0131(199707)40:7&lt;1282::AID-ART13&gt;3.0.CO;2-E","author":"Westacott CI","year":"1997","unstructured":"Westacott CI, Webb GR, Warnock MG, Sims JV, Elson CJ. Alteration of cartilage metabolism by cells from osteoarthritic bone. Arthritis Rheumatism, 1997, 1282-1291.","journal-title":"Arthritis Rheumatism"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.joca.2005.07.012","author":"Sanchez C","year":"2005","unstructured":"Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthritis Cartilage, 2005, 988-997.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.joca.2005.03.008","author":"Sanchez C","year":"2005","unstructured":"Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1\u03b2 and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage, 2005, 979-987.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/cpr.12239","author":"Zhang T","year":"2016","unstructured":"Zhang T, Xie J, Sun K, Fu N, Deng S, Lin S, Shi S. Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts. Cell Prolif, 2016, 122-133.","journal-title":"Cell Prolif"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1302\/2046-3758.108.BJR-2021-0086","author":"Duan M","year":"2021","unstructured":"Duan M, Wang Q, Liu Y, Xie J. The role of TGF-\u03b22 in cartilage development and diseases. Bone Joint Res, 2021, 474-487.","journal-title":"Bone Joint Res"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1002\/art.27397","author":"Prasadam I","year":"2010","unstructured":"Prasadam I, van Gennip S, Friis T, Shi W, Crawford R, Xiao Y. ERK-1\/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts. Arthritis Rheumatism, 2010, 1349-1360.","journal-title":"Arthritis Rheumatism"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1002\/art.38799","author":"Funck-Brentano T","year":"2014","unstructured":"Funck-Brentano T, Bouaziz W, Marty C, Geoffroy V, Hay E, Cohen-Solal M. Dkk-1-mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis in mice. Arthritis Rheumatol, 2014, 3028-3039.","journal-title":"Arthritis Rheumatol"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/abbs\/gmab021","author":"Yang Y","year":"2021","unstructured":"Yang Y, Wei J, Li J, Cui Y, Zhou X, Xie J. Lipid metabolism in cartilage and its diseases: a concise review of the research progress. Acta Biochim Biophys Sin, 2021, 517-527.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","author":"Rabinowitz JD","year":"2020","unstructured":"Rabinowitz JD, Enerb\u00e4ck S. Lactate: the ugly duckling of energy metabolism. Nat Metab, 2020, 566-571.","journal-title":"Nat Metab"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1158\/1078-0432.CCR-16-0606","author":"Jochmanova I","year":"2016","unstructured":"Jochmanova I, Pacak K. Pheochromocytoma: the first metabolic endocrine cancer. Clin Cancer Res, 2016, 5001-5011.","journal-title":"Clin Cancer Res"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"1102S","DOI":"10.1177\/19476035211063858","author":"Kan S","year":"2021","unstructured":"Kan S, Duan M, Liu Y, Wang C, Xie J. Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis. Cartilage, 2021, 1102S-1121S.","journal-title":"Cartilage"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/s12885-018-4443-1","author":"Zhou X","year":"2018","unstructured":"Zhou X, Curbo S, Li F, Krishnan S, Karlsson A. Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose. BMC Cancer, 2018,","journal-title":"BMC Cancer"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1007\/s00296-018-4103-4","author":"Tchetina EV","year":"2018","unstructured":"Tchetina EV, Markova GA. Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes. Rheumatol Int, 2018, 1963-1974.","journal-title":"Rheumatol Int"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.2106\/00004623-198365050-00012","author":"Brighton CT","year":"1983","unstructured":"Brighton CT, Lackman RD, Cuckler JM. Absence of the glycerol phosphate shuttle in the various zones of the growth plate. J Bone Joint Surg, 1983, 663-666.","journal-title":"J Bone Joint Surg"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1113\/JP273408","author":"Jespersen NR","year":"2017","unstructured":"Jespersen NR, Yokota T, St\u00f8ttrup NB, Bergdahl A, Paelestik KB, Povlsen JA, Dela F. Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Physiol, 2017, 3765-3780.","journal-title":"J Physiol"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"e128568","DOI":"10.1172\/jci.insight.128568","author":"Shen J","year":"2019","unstructured":"Shen J, Wang C, Ying J, Xu T, McAlinden A, O\u2032Keefe RJ. Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. JCI Insight, 2019,","journal-title":"JCI Insight"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1113\/jphysiol.2012.230185","author":"Larsen S","year":"2012","unstructured":"Larsen S, Nielsen J, Hansen CN, Nielsen LB, Wibrand F, Stride N, Schroder HD. Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol, 2012, 3349-3360.","journal-title":"J Physiol"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.brainres.2009.08.080","author":"Zanatta A","year":"2009","unstructured":"Zanatta A, Schuck PF, Viegas CM, Knebel LA, Busanello ENB, Moura AP, Wajner M. In vitro evidence that D-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex. Brain Res, 2009, 186-193.","journal-title":"Brain Res"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S0006-291X(05)81279-3","author":"Pollesello P","year":"1991","unstructured":"Pollesello P, de Bernard B, Grandolfo M, Paoletti S, Vittur F, Kvam BJ. Energy state of chondrocytes assessed by 31P-NMR studies of preosseous cartilage. Biochem Biophys Res Commun, 1991, 216-222.","journal-title":"Biochem Biophys Res Commun"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/jor.1100020304","author":"Stambough JL","year":"1984","unstructured":"Stambough JL, Brighton CT, Iannotti JP, Storey BT. Characterization of growth plate mitochondria. J Orthop Res, 1984, 235-246.","journal-title":"J Orthop Res"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00441-014-2042-2","author":"Gonzales S","year":"2015","unstructured":"Gonzales S, Wang C, Levene H, Cheung HS, Huang CYC. ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. Cell Tissue Res, 2015, 635-642.","journal-title":"Cell Tissue Res"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.cell.2012.12.029","author":"Zala D","year":"2013","unstructured":"Zala D, Hinckelmann MV, Yu H, Lyra da Cunha MM, Liot G, Cordeli\u00e8res FP, Marco S. Vesicular glycolysis provides on-board energy for fast axonal transport. Cell, 2013, 479-491.","journal-title":"Cell"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1086\/689592","author":"Rajendran M","year":"2016","unstructured":"Rajendran M, Dane E, Conley J, Tantama M. Imaging adenosine triphosphate (ATP). Biol Bull, 2016, 73-84.","journal-title":"Biol Bull"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","author":"Lee W","year":"2014","unstructured":"Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A, 2014, E5114-E5122.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.3389\/fphar.2019.01304","author":"Wei L","year":"2019","unstructured":"Wei L, Mousawi F, Li D, Roger S, Li J, Yang X, Jiang LH. Adenosine triphosphate release and P2 receptor signaling in piezo1 channel-dependent mechanoregulation. Front Pharmacol, 2019,","journal-title":"Front Pharmacol"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3109\/03008207.2010.491928","author":"Costello JC","year":"2011","unstructured":"Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM. Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. Connective Tissue Res, 2011, 139-146.","journal-title":"Connective Tissue Res"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"15019","DOI":"10.1038\/ncomms15019","author":"Corciulo C","year":"2017","unstructured":"Corciulo C, Lendhey M, Wilder T, Schoen H, Cornelissen AS, Chang G, Kennedy OD. Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression. Nat Commun, 2017,","journal-title":"Nat Commun"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1196\/annals.1346.011","author":"Guilak F","year":"2006","unstructured":"Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann New York Acad Sci, 2006, 498-512.","journal-title":"Ann New York Acad Sci"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","author":"Frantz C","year":"2010","unstructured":"Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci, 2010, 4195-4200.","journal-title":"J Cell Sci"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.bbrc.2018.01.001","author":"Tominaga A","year":"2018","unstructured":"Tominaga A, Sato M, Takahashi T, Toyoda E, Toyoda K, Suzuki T, Takahashi M. Quality assessment of cellular and tissue-based products using liquid chromatography-tandem mass spectrometry. Biochem Biophys Res Commun, 2018, 429-435.","journal-title":"Biochem Biophys Res Commun"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"17799","DOI":"10.1074\/jbc.RA119.009556","author":"Terabe K","year":"2019","unstructured":"Terabe K, Ohashi Y, Tsuchiya S, Ishizuka S, Knudson CB, Knudson W. Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism. J Biol Chem, 2019, 17799-17817.","journal-title":"J Biol Chem"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41586-019-0874-3","author":"Stegen S","year":"2019","unstructured":"Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R. HIF-1\u03b1 metabolically controls collagen synthesis and modification in chondrocytes. Nature, 2019, 511-515.","journal-title":"Nature"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1002\/jcp.22605","author":"Pattappa G","year":"2011","unstructured":"Pattappa G, Heywood HK, de Bruijn JD, Lee DA. The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol, 2011, 2562-2570.","journal-title":"J Cell Physiol"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.bbadis.2015.12.017","author":"Fang H","year":"2016","unstructured":"Fang H, Zhang F, Li F, Shi H, Ma L, Du M, You Y. Mitochondrial DNA haplogroups modify the risk of osteoarthritis by altering mitochondrial function and intracellular mitochondrial signals. Biochim Biophys Acta (BBA) - Mol Basis Dis, 2016, 829-836.","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bbrc.2008.06.011","author":"Heywood HK","year":"2008","unstructured":"Heywood HK, Lee DA. Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun, 2008, 224-229.","journal-title":"Biochem Biophys Res Commun"},{"key":"CITATION49","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0248-4900(91)90052-O","author":"Mignotte F","year":"1991","unstructured":"Mignotte F, Champagne AM, Froger-Gaillard B, Benel L, Gueride M, Adolphe M, Mounolou JC. Mitochondrial biogenesis in rabbit articular chondrocytes transferred to culture. Biol Cell, 1991, 67-72.","journal-title":"Biol Cell"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/0014-4827(87)90172-8","author":"Champagne AM","year":"1987","unstructured":"Champagne AM, Benel L, Ronot X, Mignotte F, Adolphe M, Mounolou JC. Rhodamine 123 uptake and mitochondrial DNA content in rabbit articular chondrocytes evolve differently upon transfer from cartilage to culture conditions. Exp Cell Res, 1987, 404-410.","journal-title":"Exp Cell Res"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s10856-017-5968-6","author":"Kudva AK","year":"2017","unstructured":"Kudva AK, Luyten FP, Patterson J. Initiating human articular chondrocyte re-differentiation in a 3D system after 2D expansion. J Mater Sci-Mater Med, 2017,","journal-title":"J Mater Sci-Mater Med"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/ijms18112359","author":"Ko KW","year":"2017","unstructured":"Ko KW, Choi B, Park S, Arai Y, Choi WC, Lee JM, Bae H. Down-regulation of transglutaminase 2 stimulates redifferentiation of dedifferentiated chondrocytes through enhancing glucose metabolism. Int J Mol Sci, 2017,","journal-title":"Int J Mol Sci"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.actbio.2020.03.043","author":"Borciani G","year":"2020","unstructured":"Borciani G, Montalbano G, Baldini N, Cerqueni G, Vitale-Brovarone C, Ciapetti G. Co\u2013culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches. Acta Biomater, 2020, 22-45.","journal-title":"Acta Biomater"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"e13156","DOI":"10.1111\/cpr.13156","author":"Yang Y","year":"2021","unstructured":"Yang Y, Zhang D, Guo D, Li J, Xu S, Wei J, Xie J. Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling. Cell Prolif, 2021,","journal-title":"Cell Prolif"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/ijos.2015.39","author":"Xie J","year":"2015","unstructured":"Xie J, Fu N, Cai LY, Gong T, Li G, Peng Q, Cai XX. The effects of interleukin-1\u03b2 in modulating osteoclast-conditioned medium\u2019s influence on gelatinases in chondrocytes through mitogen-activated protein kinases. Int J Oral Sci, 2015, 220-231.","journal-title":"Int J Oral Sci"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1093\/abbs\/gmab136","author":"Liu Y","year":"2021","unstructured":"Liu Y, Duan M, Guo D, Kan S, Zhang L, Aili M, Zhang D. PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K\/Akt signaling pathway. Acta Biochim Biophys Sin, 2021, 1640-1649.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION57","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/term.19","author":"Hendriks J","year":"2007","unstructured":"Hendriks J, Riesle J, van Blitterswijk CA. Co-culture in cartilage tissue engineering. J Tissue Eng Regen Med, 2007, 170-178.","journal-title":"J Tissue Eng Regen Med"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1101\/gad.889901","author":"Gottlob K","year":"2001","unstructured":"Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt\/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev, 2001, 1406-1418.","journal-title":"Genes Dev"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"32081","DOI":"10.1074\/jbc.M502876200","author":"Hahn-Windgassen A","year":"2005","unstructured":"Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem, 2005, 32081-32089.","journal-title":"J Biol Chem"},{"key":"CITATION60","doi-asserted-by":"publisher","first-page":"17269","DOI":"10.1074\/jbc.272.28.17269","author":"Deprez J","year":"1997","unstructured":"Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem, 1997, 17269-17275.","journal-title":"J Biol Chem"},{"key":"CITATION61","doi-asserted-by":"publisher","first-page":"68749","DOI":"10.18632\/oncotarget.11899","author":"Moench R","year":"2016","unstructured":"Moench R, Grimmig T, Kannen V, Tripathi S, Faber M, Moll EM, Chandraker A. Exclusive inhibition of PI3K\/Akt\/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. Oncotarget, 2016, 68749-68767.","journal-title":"Oncotarget"},{"key":"CITATION62","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1210\/me.2008-0111","author":"St\u00f6ckli J","year":"2008","unstructured":"St\u00f6ckli J, Davey JR, Hohnen-Behrens C, Xu A, James DE, Ramm G. Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160\/TBC1D4: role of phosphorylation and membrane association. Mol Endocrinol, 2008, 2703-2715.","journal-title":"Mol Endocrinol"},{"key":"CITATION63","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ijbiomac.2017.05.119","author":"Woo JR","year":"2017","unstructured":"Woo JR, Kim SJ, Kim KY, Jang H, Shoelson SE, Park SY. The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization. Int J Biol Macromolecules, 2017, 965-971.","journal-title":"Int J Biol Macromolecules"},{"key":"CITATION64","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1016\/j.celrep.2017.05.041","author":"Waldhart AN","year":"2017","unstructured":"Waldhart AN, Dykstra H, Peck AS, Boguslawski EA, Madaj ZB, Wen J, Veldkamp K. Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin. Cell Rep, 2017, 2005-2013.","journal-title":"Cell Rep"},{"key":"CITATION65","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.copbio.2014.12.007","author":"Gomes AP","year":"2015","unstructured":"Gomes AP, Blenis J. A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Curr Opin Biotechnol, 2015, 110-117.","journal-title":"Curr Opin Biotechnol"},{"key":"CITATION66","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.molcel.2004.11.014","author":"Majewski N","year":"2004","unstructured":"Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell, 2004, 819-830.","journal-title":"Mol Cell"},{"key":"CITATION67","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/S1043-2760(02)00662-8","author":"Whiteman EL","year":"2002","unstructured":"Whiteman EL, Cho H, Birnbaum MJ. Role of Akt\/protein kinase B in metabolism. Trends Endocrinol Metab, 2002, 444-451.","journal-title":"Trends Endocrinol Metab"},{"key":"CITATION68","doi-asserted-by":"publisher","first-page":"10105","DOI":"10.1074\/jbc.M600272200","author":"Zhang W","year":"2006","unstructured":"Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A. FoxO1 regulates multiple metabolic pathways in the liver. J Biol Chem, 2006, 10105-10117.","journal-title":"J Biol Chem"},{"key":"CITATION69","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1535-6108(03)00187-9","author":"Brugarolas JB","year":"2003","unstructured":"Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin Jr. WG. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell, 2003, 147-158.","journal-title":"Cancer Cell"},{"key":"CITATION70","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.semcancer.2008.11.010","author":"Robey RB","year":"2009","unstructured":"Robey RB, Hay N. Is Akt the \u201cWarburg kinase\u201d?\u2014Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol, 2009, 25-31.","journal-title":"Semin Cancer Biol"},{"key":"CITATION71","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fendo.2014.00145","author":"J\u00f3\u017awiak P","year":"2014","unstructured":"J\u00f3\u017awiak P, Forma E, Bry\u015b M, Krze\u015blak A. O-GlcNAcylation and metabolic reprograming in cancer. Front Endocrinol, 2014,","journal-title":"Front Endocrinol"},{"key":"CITATION72","doi-asserted-by":"publisher","first-page":"41029","DOI":"10.1074\/jbc.M102824200","author":"Xi X","year":"2001","unstructured":"Xi X, Han J, Zhang JZ. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J Biol Chem, 2001, 41029-41034.","journal-title":"J Biol Chem"},{"key":"CITATION73","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/JPER.20-0869","author":"Zhang L","year":"2021","unstructured":"Zhang L, Cheng L, Cui Y, Wu Z, Cai L, Yang L, Duan M. The virulence factor GroEL directs the osteogenic and adipogenic differentiation of human periodontal ligament stem cells through the involvement of JNK\/MAPK and NF\u2010\u03baB signaling. J Periodontol, 2021,","journal-title":"J Periodontol"},{"key":"CITATION74","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1158\/1078-0432.CCR-05-0149","author":"Bando H","year":"2005","unstructured":"Bando H, Atsumi T, Nishio T, Niwa H, Mishima S, Shimizu C, Yoshioka N. Phosphorylation of the 6-phosphofructo-2-kinase\/fructose 2,6-bisphosphatase\/PFKFB3 family of glycolytic regulators in human cancer. Clin Cancer Res, 2005, 5784-5792.","journal-title":"Clin Cancer Res"},{"key":"CITATION75","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1042\/BJ20121886","author":"Novellasdemunt L","year":"2013","unstructured":"Novellasdemunt L, Bultot L, Manzano A, Ventura F, Rosa JL, Vertommen D, Rider MH. PFKFB3 activation in cancer cells by the p38\/MK2 pathway in response to stress stimuli. Biochem J, 2013, 531-543.","journal-title":"Biochem J"},{"key":"CITATION76","doi-asserted-by":"publisher","first-page":"15439","DOI":"10.1074\/jbc.M611214200","author":"Crunkhorn S","year":"2007","unstructured":"Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R. Peroxisome proliferator activator receptor \u03b3 coactivator-1 expression is reduced in obesity. J Biol Chem, 2007, 15439-15450.","journal-title":"J Biol Chem"},{"key":"CITATION77","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.1128\/MCB.25.12.4853-4862.2005","author":"Emerling BM","year":"2005","unstructured":"Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol, 2005, 4853-4862.","journal-title":"Mol Cell Biol"},{"key":"CITATION78","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","author":"Kim J","year":"2006","unstructured":"Kim J, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab, 2006, 177-185.","journal-title":"Cell Metab"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/7EADBB0779B14C569F9432A8E9707E69","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2022042","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/7EADBB0779B14C569F9432A8E9707E69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T14:33:32Z","timestamp":1658414012000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2022042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":78,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,5]]},"published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2022042","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,1]]}}}