{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:53:20Z","timestamp":1783140800749,"version":"3.54.6"},"reference-count":39,"publisher":"China Science Publishing & Media Ltd.","issue":"11","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2022,11,1]]},"DOI":"10.3724\/abbs.2022173","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:53:33Z","timestamp":1667973213000},"page":"1731-1739","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["KRAS G12D mutation eliminates reactive oxygen species through the Nrf2\/CSE\/H                     &amp;lt;sub&amp;gt;2&amp;lt;\/sub&amp;gt;S axis and contributes to pancreatic cancer growth"],"prefix":"10.3724","volume":"54","author":[{"given":"Kun","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houbao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.canlet.2018.01.017","volume":"418","author":"Fan K","year":"2018","unstructured":"Fan K, Yang C, Fan Z, Huang Q, Zhang Y, Cheng H, Jin K. MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. Cancer Lett, 2018, 418: 167-175.","journal-title":"Cancer Lett"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"Siegel RL","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin, 2020, 70: 7-30.","journal-title":"CA Cancer J Clin"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature14169","volume":"518","author":"Waddell N","year":"2015","unstructured":"Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature, 2015, 518: 495-501.","journal-title":"Nature"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.canlet.2019.01.013","volume":"446","author":"Cheng H","year":"2019","unstructured":"Cheng H, Fan K, Luo G, Fan Z, Yang C, Huang Q, Jin K. KrasG12D mutation contributes to regulatory T cell conversion through activation of the MEK\/ERK pathway in pancreatic cancer. Cancer Lett, 2019, 446: 103-111.","journal-title":"Cancer Lett"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.cell.2015.10.041","volume":"163","author":"Wang MT","year":"2015","unstructured":"Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. K-Ras promotes tumorigenicity through suppression of non-canonical wnt signaling. Cell, 2015, 163: 1237-1251.","journal-title":"Cell"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.cell.2016.03.029","volume":"165","author":"Tape CJ","year":"2016","unstructured":"Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC. Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 2016, 165: 910-920.","journal-title":"Cell"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1158\/2159-8290.CD-19-1006","volume":"10","author":"Hobbs GA","year":"2020","unstructured":"Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO. Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer. Cancer Discovery, 2020, 10: 104-123.","journal-title":"Cancer Discovery"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.lungcan.2018.07.013","volume":"124","author":"Ferrer I","year":"2018","unstructured":"Ferrer I, Zugazagoitia J, Herbertz S, John W, Paz-Ares L, Schmid-Bindert G. KRAS-mutant non-small cell lung cancer: from biology to therapy. Lung Cancer, 2018, 124: 53-64.","journal-title":"Lung Cancer"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/cancers9050042","volume":"9","author":"Cicenas J","year":"2017","unstructured":"Cicenas J, Kvederaviciute K, Meskinyte I, Meskinyte-Kausiliene E, Skeberdyte A, Cicenas J. KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 mutations in pancreatic cancer. Cancers, 2017, 9:","journal-title":"Cancers"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1158\/1078-0432.CCR-19-3523","volume":"26","author":"Ryan MB","year":"2020","unstructured":"Ryan MB, Fece DLCF, Phat S, Myers DT, Wong E, Shahzade HA, Hong CB. Vertical pathway inhibition overcomes adaptive feedback resistance to KRASG12C inhibition. Clin Cancer Res, 2020, 26: 1633-1643.","journal-title":"Clin Cancer Res"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/sj.bjc.6601894","volume":"91","author":"Bamford S","year":"2004","unstructured":"Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 2004, 91: 355-358.","journal-title":"Br J Cancer"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"a031435","DOI":"10.1101\/cshperspect.a031435","volume":"8","author":"Waters AM","year":"2018","unstructured":"Waters AM, Der CJ. KRAS: the critical driver and therapeutic target for pancreatic cancer. Cold Spring Harb Perspect Med, 2018, 8:","journal-title":"Cold Spring Harb Perspect Med"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1242\/dmm.021055","volume":"8","author":"Gopinathan A","year":"2015","unstructured":"Gopinathan A, Morton JP, Jodrell DI, Sansom OJ. GEMMs as preclinical models for testing pancreatic cancer therapies. Dis Model Mech, 2015, 8: 1185-1200.","journal-title":"Dis Model Mech"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1101\/gad.1158703","volume":"17","author":"Aguirre AJ","year":"2003","unstructured":"Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS. Activated Kras and                         Ink4a\/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev, 2003, 17: 3112-3126.","journal-title":"Genes Dev"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","volume":"7","author":"Hingorani SR","year":"2005","unstructured":"Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell, 2005, 7: 469-483.","journal-title":"Cancer Cell"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","volume":"4","author":"Hingorani SR","year":"2003","unstructured":"Hingorani SR, Petricoin Iii EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell, 2003, 4: 437-450.","journal-title":"Cancer Cell"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","volume":"12","author":"Sosa V","year":"2013","unstructured":"Sosa V, Molin\u00e9 T, Somoza R, Paciucci R, Kondoh H, LLeonart ME. Oxidative stress and cancer: an overview. Ageing Res Rev, 2013, 12: 376-390.","journal-title":"Ageing Res Rev"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","volume":"1859","author":"Cadenas S","year":"2018","unstructured":"Cadenas S. Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta Bioenerg, 2018, 1859: 940-950.","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.canlet.2016.03.042","volume":"387","author":"Prasad S","year":"2017","unstructured":"Prasad S, Gupta SC, Tyagi AK. Reactive oxygen species (ROS) and cancer: role of antioxidative nutraceuticals. Cancer Lett, 2017, 387: 95-105.","journal-title":"Cancer Lett"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"11601","DOI":"10.1074\/jbc.M808026200","volume":"284","author":"Chiku T","year":"2009","unstructured":"Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R. H2S biogenesis by human cystathionine \u03b3-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem, 2009, 284: 11601-11612.","journal-title":"J Biol Chem"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1016\/j.cellsig.2014.08.023","volume":"26","author":"Fan K","year":"2014","unstructured":"Fan K, Li N, Qi J, Yin P, Zhao C, Wang L, Li Z. Wnt\/\u03b2-catenin signaling induces the transcription of cystathionine-\u03b3-lyase, a stimulator of tumor in colon cancer. Cell Signal, 2014, 26: 2801-2808.","journal-title":"Cell Signal"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2008.2282","volume":"12","author":"Kimura Y","year":"2010","unstructured":"Kimura Y, Goto YI, Kimura H. Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid Redox Signal, 2010, 12: 1-13.","journal-title":"Antioxid Redox Signal"},{"key":"CITATION23","doi-asserted-by":"crossref","unstructured":"Hellmich MR, Szabo C. Hydrogen sulfide and cancer.                                                      Handb Exp Pharmacol                          2015, 230: 233\u2013241.","DOI":"10.1007\/978-3-319-18144-8_12"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1042\/CBI20090368","volume":"34","author":"Cai WJ","year":"2010","unstructured":"Cai WJ, Wang MJ, Ju LH, Wang C, Zhu YC. Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21. Cell Biol Int, 2010, 34: 565-572.","journal-title":"Cell Biol Int"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cellsig.2012.02.003","volume":"24","author":"Yin P","year":"2012","unstructured":"Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N. Sp1 is involved in regulation of cystathionine \u03b3-lyase gene expression and biological function by PI3K\/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal, 2012, 24: 1229-1240.","journal-title":"Cell Signal"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"112118","DOI":"10.1016\/j.yexcr.2020.112118","volume":"394","author":"Fan K","year":"2020","unstructured":"Fan K, Wang J, Sun W, Shen S, Ni X, Gong Z, Zheng B. MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth. Exp Cell Res, 2020, 394:","journal-title":"Exp Cell Res"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"847","DOI":"10.14348\/molcells.2016.0310","volume":"39","author":"Lee N","year":"2016","unstructured":"Lee N, Kim D. Cancer metabolism: fueling more than just growth. Molecules Cells, 2016, 39: 847-854.","journal-title":"Molecules Cells"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/ijc.31069","volume":"142","author":"Rodic S","year":"2018","unstructured":"Rodic S, Vincent MD. Reactive oxygen species (ROS) are a key determinant of cancer\u2019s metabolic phenotype. Int J Cancer, 2018, 142: 440-448.","journal-title":"Int J Cancer"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan D","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell, 2011, 144: 646-674.","journal-title":"Cell"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","volume":"34","author":"Rojo DLVM","year":"2018","unstructured":"Rojo DLVM, Chapman E, Zhang DD. NRF2 and the hallmarks of cancer. Cancer Cell, 2018, 34: 21-43.","journal-title":"Cancer Cell"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","volume":"1865","author":"Bellezza I","year":"2018","unstructured":"Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res, 2018, 1865: 721-733.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1089\/ars.2017.7342","volume":"29","author":"Tonelli C","year":"2018","unstructured":"Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2. Antioxid Redox Signal, 2018, 29: 1727-1745.","journal-title":"Antioxid Redox Signal"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13578-019-0309-8","volume":"9","author":"Cai SJ","year":"2019","unstructured":"Cai SJ, Liu Y, Han S, Yang C. Brusatol, an NRF2 inhibitor for future cancer therapeutic. Cell Biosci, 2019, 9:","journal-title":"Cell Biosci"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jare.2020.07.006","volume":"27","author":"Youness RA","year":"2021","unstructured":"Youness RA, Gad AZ, Sanber K, Ahn YJ, Lee GJ, Khallaf E, Hafez HM. Targeting hydrogen sulphide signaling in breast cancer. J Adv Res, 2021, 27: 177-190.","journal-title":"J Adv Res"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mrfmmm.2014.03.002","volume":"763-764","author":"Pan Y","year":"2014","unstructured":"Pan Y, Ye S, Yuan D, Zhang J, Bai Y, Shao C. Hydrogen sulfide (H2S)\/cystathionine \u03b3-lyase (CSE) pathway contributes to the proliferation of hepatoma cells. Mutat Res, 2014, 763-764: 10-18.","journal-title":"Mutat Res"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ccell.2020.03.013","volume":"37","author":"Drosten M","year":"2020","unstructured":"Drosten M, Barbacid M. Targeting the MAPK pathway in KRAS-driven tumors. Cancer Cell, 2020, 37: 543-550.","journal-title":"Cancer Cell"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/cvr\/cvx245","volume":"114","author":"Yuan F","year":"2018","unstructured":"Yuan F, Woollard JR, Jordan KL, Lerman A, Lerman LO, Eirin A. Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome. Cardiovasc Res, 2018, 114: 431-442.","journal-title":"Cardiovasc Res"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3390\/ijms20020313","volume":"20","author":"Cao X","year":"2019","unstructured":"Cao X, Zhang W, Moore PK, Bian J. Protective smell of hydrogen sulfide and polysulfide in cisplatin-induced nephrotoxicity. Int J Mol Sci, 2019, 20:","journal-title":"Int J Mol Sci"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3892\/ijo.2019.4823","volume":"55","author":"Wang L","year":"2019","unstructured":"Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, Shi X. Cystathionine\u2011\u03b3\u2011lyase promotes the metastasis of breast cancer via the VEGF signaling pathway. Int J Oncol, 2019, 55:","journal-title":"Int J Oncol"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/A914929BAEDB429DB95CB563A1801117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2022173","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/A914929BAEDB429DB95CB563A1801117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T06:32:44Z","timestamp":1672122764000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2022173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,24]]},"published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2022173","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}