{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:01:21Z","timestamp":1781071281726,"version":"3.54.1"},"reference-count":47,"publisher":"China Science Publishing & Media Ltd.","issue":"3","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2023,3,1]]},"DOI":"10.3724\/abbs.2023018","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T02:32:03Z","timestamp":1676514723000},"page":"426-437","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Cyclic di-adenosine monophosphate regulates the osteogenic and adipogenic differentiation of hPDLSCs via MAPK and NF-&amp;kappa;B signaling"],"prefix":"10.3724","volume":"55","author":[{"given":"Sirui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ismej.2011.191","volume":"6","author":"Griffen AL","year":"2012","unstructured":"Griffen AL, Beall CJ, Campbell JH, Firestone ND, Kumar PS, Yang ZK, Podar M. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J, 2012, 6: 1176-1185.","journal-title":"ISME J"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fcimb.2019.00262","volume":"9","author":"Jia L","year":"2019","unstructured":"Jia L, Han N, Du J, Guo L, Luo Z, Liu Y. Pathogenesis of important virulence factors of porphyromonas gingivalis via Toll-like receptors. Front Cell Infect Microbiol, 2019, 9:","journal-title":"Front Cell Infect Microbiol"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fcimb.2014.00092","volume":"4","author":"Rosier BT","year":"2014","unstructured":"Rosier BT, De Jager M, Zaura E, Krom BP. Historical and contemporary hypotheses on the development of oral diseases: are we there yet?. Front Cell Infect Microbiol, 2014, 4:","journal-title":"Front Cell Infect Microbiol"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mib.2017.11.007","volume":"41","author":"Devaux L","year":"2018","unstructured":"Devaux L, Kaminski PA, Trieu-Cuot P, Firon A. Cyclic di-AMP in host\u2013pathogen interactions. Curr Opin Microbiol, 2018, 41: 21-28.","journal-title":"Curr Opin Microbiol"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"9327","DOI":"10.1039\/C6CC03439J","volume":"52","author":"Opoku-Temeng C","year":"2016","unstructured":"Opoku-Temeng C, Zhou J, Zheng Y, Su J, Sintim HO. Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. Chem Commun, 2016, 52: 9327-9342.","journal-title":"Chem Commun"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/mmi.13026","volume":"97","author":"Commichau FM","year":"2015","unstructured":"Commichau FM, Dickmanns A, Gundlach J, Ficner R, St\u00fclke J. A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP. Mol Microbiol, 2015, 97: 189-204.","journal-title":"Mol Microbiol"},{"key":"CITATION7","doi-asserted-by":"crossref","unstructured":"Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection.                                                      mBio                          2013, 4: e00282-13.","DOI":"10.1128\/mBio.00282-13"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.jmb.2019.01.014","volume":"431","author":"Hengge R","year":"2019","unstructured":"Hengge R, H\u00e4ussler S, Pruteanu M, St\u00fclke J, Tschowri N, Turgay K. Recent advances and current trends in nucleotide second messenger signaling in bacteria. J Mol Biol, 2019, 431: 908-927.","journal-title":"J Mol Biol"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1126\/science.1189801","volume":"328","author":"Woodward JJ","year":"2010","unstructured":"Woodward JJ, Iavarone AT, Portnoy DA. c-di-AMP secreted by intracellular                         Listeria monocytogenes activates a host type I interferon response. Science, 2010, 328: 1703-1705.","journal-title":"Science"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1084\/jem.20082874","volume":"206","author":"McWhirter SM","year":"2009","unstructured":"McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med, 2009, 206: 1899-1911.","journal-title":"J Exp Med"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/ni.2460","volume":"13","author":"Parvatiyar K","year":"2012","unstructured":"Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol, 2012, 13: 1155-1161.","journal-title":"Nat Immunol"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"34756","DOI":"10.1038\/srep34756","volume":"6","author":"Omura H","year":"2016","unstructured":"Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F. Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci Rep, 2016, 6:","journal-title":"Sci Rep"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/embor.2013.132","volume":"14","author":"Abdul\u2010Sater AA","year":"2013","unstructured":"Abdul\u2010Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC. Cyclic\u2010di\u2010GMP and cyclic\u2010di\u2010AMP activate the NLRP3 inflammasome. EMBO Rep, 2013, 14: 900-906.","journal-title":"EMBO Rep"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","volume":"364","author":"Seo BM","year":"2004","unstructured":"Seo BM, Miura M, Gronthos S, Mark Bartold P, Batouli S, Brahim J, Young M. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet, 2004, 364: 149-155.","journal-title":"Lancet"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3727\/096368910X519292","volume":"20","author":"Park JY","year":"2011","unstructured":"Park JY, Jeon SH, Choung PH. Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis. Cell TransPlant, 2011, 20: 271-286.","journal-title":"Cell TransPlant"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1634\/stemcells.2007-0734","volume":"26","author":"Liu Y","year":"2008","unstructured":"Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, Gronthos S. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells, 2008, 26: 1065-1073.","journal-title":"Stem Cells"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/972313","volume":"2015","author":"Zhu W","year":"2015","unstructured":"Zhu W, Liang M. Periodontal ligament stem cells: current status, concerns, and future prospects. Stem Cells Int, 2015, 2015: 1-11.","journal-title":"Stem Cells Int"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2217\/rme.09.55","volume":"4","author":"Huang CYC","year":"2009","unstructured":"Huang CYC, Pelaez D, Bendala JD, Garcia-Godoy F, Cheung HS. Plasticity of stem cells derived from adult periodontal ligament. Regenerative Med, 2009, 4: 809-821.","journal-title":"Regenerative Med"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/prd.12024","volume":"63","author":"Wada N","year":"2013","unstructured":"Wada N, Gronthos S, Bartold PM. Immunomodulatory effects of stem cells. Periodontol 2000, 2013, 63: 198-216.","journal-title":"Periodontol 2000"},{"key":"CITATION20","doi-asserted-by":"crossref","unstructured":"Elmanfi S, Sintim HO, Zhou J, Gursoy M, Kononen E, Gursoy UK. Activation of gingival fibroblasts by bacterial cyclic dinucleotides and lipopolysaccharide.                                                      Pathogens                          2020, 9: 792.","DOI":"10.3390\/pathogens9100792"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"2003617","DOI":"10.1080\/20002297.2021.2003617","volume":"14","author":"Onyedibe KI","year":"2022","unstructured":"Onyedibe KI, Elmanfi S, Aryal UK, K\u00f6n\u00f6nen E, G\u00fcrsoy UK, Sintim HO. Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP. J Oral Microbiol, 2022, 14:","journal-title":"J Oral Microbiol"},{"key":"CITATION22","doi-asserted-by":"crossref","unstructured":"Armitage GC. Development of a classification system for periodontal diseases and conditions.                                                      Ann Periodontol                          1999, 4: 1\u20136.","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2334\/josnusd.19-0159","volume":"62","author":"Takai H","year":"2020","unstructured":"Takai H, Furuse N, Ogata Y. Anti-heat shock protein 70 levels in gingival crevicular fluid of Japanese patients with chronic periodontitis. J Oral Sci, 2020, 62: 281-284.","journal-title":"J Oral Sci"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"104991","DOI":"10.1016\/j.archoralbio.2020.104991","volume":"122","author":"Zhang L","year":"2021","unstructured":"Zhang L, Cui Y, Yang Y, Wei J, Liu W, Cai L, Wang L. The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells. Arch Oral Biol, 2021, 122:","journal-title":"Arch Oral Biol"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"105801","DOI":"10.1016\/j.intimp.2019.105801","volume":"75","author":"Liu H","year":"2019","unstructured":"Liu H, Zheng J, Zheng T, Wang P. Exendin-4 regulates Wnt and NF-\u03baB signaling in lipopolysaccharide-induced human periodontal ligament stem cells to promote osteogenic differentiation. Int Immunopharmacol, 2019, 75:","journal-title":"Int Immunopharmacol"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"E60","DOI":"10.1002\/JPER.21-0339","volume":"93","author":"Wu Z","year":"2022","unstructured":"Wu Z, Chen S, He Y, Zhang D, Zou S, Xie J, Zhou C. Connective tissue growth factor promotes cell\u2010to\u2010cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway. J Periodontol, 2022, 93: E60-E72.","journal-title":"J Periodontol"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41413-021-00173-x","volume":"9","author":"Zhou C","year":"2021","unstructured":"Zhou C, Cui Y, Yang Y, Guo D, Zhang D, Fan Y, Li X. Runx1 protects against the pathological progression of osteoarthritis. Bone Res, 2021, 9:","journal-title":"Bone Res"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"e12544","DOI":"10.1111\/cpr.12544","volume":"52","author":"Wang Q","year":"2019","unstructured":"Wang Q, Zhou C, Li X, Cai L, Zou J, Zhang D, Xie J. TGF\u2010\u03b21 promotes gap junctions formation in chondrocytes via Smad3\/Smad4 signalling. Cell Prolif, 2019, 52:","journal-title":"Cell Prolif"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/abbs\/gmaa025","volume":"52","author":"Zhang D","year":"2020","unstructured":"Zhang D, Li X, Pi C, Cai L, Liu Y, Du W, Yang W. Osteoporosis-decreased extracellular matrix stiffness impairs connexin 43-mediated gap junction intercellular communication in osteocytes. Acta Biochim Biophys Sin, 2020, 52: 517-526.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41368-019-0052-3","volume":"11","author":"Zhou C","year":"2019","unstructured":"Zhou C, Wang Q, Zhang D, Cai L, Du W, Xie J. Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells. Int J Oral Sci, 2019, 11:","journal-title":"Int J Oral Sci"},{"key":"CITATION31","doi-asserted-by":"crossref","unstructured":"Meunier P, Aaron J, Edouard C, Vignon GJCo, research r. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies.                                                      Clin Orthop Relat Res                          1971, 80: 147-54.","DOI":"10.1097\/00003086-197110000-00021"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"e0199603","DOI":"10.1371\/journal.pone.0199603","volume":"13","author":"Deng C","year":"2018","unstructured":"Deng C, Sun Y, Liu H, Wang W, Wang J, Zhang F. Selective adipogenic differentiation of human periodontal ligament stem cells stimulated with high doses of glucose. PLoS ONE, 2018, 13:","journal-title":"PLoS ONE"},{"key":"CITATION33","doi-asserted-by":"crossref","unstructured":"Kawasaki T, Kawai T. Discrimination between self and non-self-nucleic acids by the innate immune system.                                                      Int Rev Cell Mol Biol                          2019, 344: 1\u201330.","DOI":"10.1016\/bs.ircmb.2018.08.004"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fcimb.2017.00273","volume":"7","author":"G\u00fcrsoy UK","year":"2017","unstructured":"G\u00fcrsoy UK, G\u00fcrsoy M, K\u00f6n\u00f6nen E, Sintim HO. Cyclic dinucleotides in Oral bacteria and in Oral biofilms. Front Cell Infect Microbiol, 2017, 7:","journal-title":"Front Cell Infect Microbiol"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"1538927","DOI":"10.1080\/20002297.2018.1538927","volume":"11","author":"Elmanfi S","year":"2019","unstructured":"Elmanfi S, Zhou J, Sintim HO, K\u00f6n\u00f6nen E, G\u00fcrsoy M, G\u00fcrsoy UK. Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides. J Oral Microbiol, 2019, 11:","journal-title":"J Oral Microbiol"},{"key":"CITATION36","doi-asserted-by":"crossref","unstructured":"Elmanfi S, Yilmaz M, Ong WWS, Yeboah KS, Sintim HO, Gursoy M, Kononen E,                         et al. Bacterial cyclic dinucleotides and the cGAS-cGAMP-STING pathway: a role in periodontitis?                                                      Pathogens                          2021, 10: 12.","DOI":"10.3390\/pathogens10060675"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/jbmr.440","volume":"26","author":"Liu N","year":"2011","unstructured":"Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B. High levels of \u03b2-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J Bone Miner Res, 2011, 26: 2082-2095.","journal-title":"J Bone Miner Res"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/stem.1567","volume":"32","author":"Chen Q","year":"2014","unstructured":"Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W. An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells, 2014, 32: 327-337.","journal-title":"Stem Cells"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/JPER.20-0869","volume":"92","author":"Zhang L","year":"2021","unstructured":"Zhang L, Cheng L, Cui Y, Wu Z, Cai L, Yang L, Duan M. The virulence factor GroEL directs the osteogenic and adipogenic differentiation of human periodontal ligament stem cells through the involvement of JNK\/MAPK and NF\u2010\u03baB signaling. J Periodontol, 2021, 92: 103-115.","journal-title":"J Periodontol"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/nri3713","volume":"14","author":"Gay NJ","year":"2014","unstructured":"Gay NJ, Symmons MF, Gangloff M, Bryant CE. Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol, 2014, 14: 546-558.","journal-title":"Nat Rev Immunol"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"36840","DOI":"10.1039\/C8RA04603D","volume":"8","author":"Sooreshjani MA","year":"2018","unstructured":"Sooreshjani MA, Gursoy UK, Aryal UK, Sintim HO. Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways. RSC Adv, 2018, 8: 36840-36851.","journal-title":"RSC Adv"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"1900109","DOI":"10.1002\/prca.201900109","volume":"14","author":"Aryal UK","year":"2020","unstructured":"Aryal UK, Hedrick V, Onyedibe KI, Sobreira TJP, Sooreshjani MA, Wang M, G\u00fcrsoy UK. Global proteomic analyses of STING\u2010positive and \u2010negative macrophages reveal STING and on\u2010STING differentially regulated cellular and molecular pathways. Prot Clin Appl, 2020, 14:","journal-title":"Prot Clin Appl"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nri2918","volume":"11","author":"Hajishengallis G","year":"2011","unstructured":"Hajishengallis G, Lambris JD. Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol, 2011, 11: 187-200.","journal-title":"Nat Rev Immunol"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/ni1297","volume":"7","author":"Tabeta K","year":"2006","unstructured":"Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, Mudd S. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol, 2006, 7: 156-164.","journal-title":"Nat Immunol"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"27502","DOI":"10.1073\/pnas.2015919117","volume":"117","author":"Chang D","year":"2020","unstructured":"Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci USA, 2020, 117: 27502-27508.","journal-title":"Proc Natl Acad Sci USA"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"54","DOI":"10.31083\/j.fbl2702054","volume":"27","author":"Yong J","year":"2022","unstructured":"Yong J, Groeger S, Meyle J, Ruf S. MAPK and \u03b2-Catenin signaling: implication and interplay in orthodontic tooth movement. Front Biosci (Landmark Ed), 2022, 27:","journal-title":"Front Biosci (Landmark Ed)"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"645005","DOI":"10.3389\/fcell.2021.645005","volume":"9","author":"Yong J","year":"2021","unstructured":"Yong J, von Bremen J, Ruiz-Heiland G, Ruf S. Adiponectin as well as compressive forces regulate in vitro \u03b2-catenin expression on cementoblasts via mitogen-activated protein kinase signaling activation. Front Cell Dev Biol, 2021, 9:","journal-title":"Front Cell Dev Biol"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/84C957D7DCAD4A77BA5E928424D2E374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023018","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/84C957D7DCAD4A77BA5E928424D2E374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T01:03:11Z","timestamp":1682557391000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2,24]]},"published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2023018","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,24]]}}}