{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:07:37Z","timestamp":1762254457102},"reference-count":59,"publisher":"China Science Publishing & Media Ltd.","issue":"4","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2023,4,1]]},"DOI":"10.3724\/abbs.2023042","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T04:00:32Z","timestamp":1678420832000},"page":"548-560","update-policy":"http:\/\/dx.doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6\/IGFBP5 axis in the early stages of mouse thymic involution"],"prefix":"10.3724","volume":"55","author":[{"given":"Bingxin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqiong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longsheng","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingru","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.3389\/fimmu.2018.02063","volume":"9","author":"Xu M","year":"2018","unstructured":"Xu M, Gan T, Ning H, Wang L. MicroRNA functions in thymic biology: thymic development and involution. Front Immunol, 2018, 9:","journal-title":"Front Immunol"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12979-020-0173-8","volume":"17","author":"Thomas R","year":"2020","unstructured":"Thomas R, Wang W, Su DM. Contributions of age-related thymic involution to immunosenescence and inflammaging. Immun Ageing, 2020, 17:","journal-title":"Immun Ageing"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.it.2009.05.001","volume":"30","author":"Shanley DP","year":"2009","unstructured":"Shanley DP, Aw D, Manley NR, Palmer DB. An evolutionary perspective on the mechanisms of immunosenescence. Trends Immunol, 2009, 30: 374-381.","journal-title":"Trends Immunol"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/abbs\/gmx029","volume":"49","author":"Guo D","year":"2017","unstructured":"Guo D, Ye Y, Qi J, Tan X, Zhang Y, Ma Y, Li Y. Age and sex differences in microRNAs expression during the process of thymus aging. Acta Biochim Biophys Sin, 2017, 49: 409-419.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/intimm\/dxr073","volume":"23","author":"Gui J","year":"2011","unstructured":"Gui J, Morales AJ, Maxey SE, Bessette KA, Ratcliffe NR, Kelly JA, Craig RW. MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthood. Int Immunol, 2011, 23: 647-659.","journal-title":"Int Immunol"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7986071","volume":"2020","author":"Barbouti A","year":"2020","unstructured":"Barbouti A, Vasileiou PVS, Evangelou K, Vlasis KG, Papoudou-Bai A, Gorgoulis VG, Kanavaros P. Implications of oxidative stress and cellular senescence in age-related thymus involution. Oxid Med Cell Longev, 2020, 2020: 1-14.","journal-title":"Oxid Med Cell Longev"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.coi.2013.06.002","volume":"25","author":"Ventevogel MS","year":"2013","unstructured":"Ventevogel MS, Sempowski GD. Thymic rejuvenation and aging. Curr Opin Immunol, 2013, 25: 516-522.","journal-title":"Curr Opin Immunol"},{"key":"CITATION8","unstructured":"Gui J, Mustachio LM, Su DM, Craig RW. Thymus size and age-related thymic involution: early programming, sexual dimorphism, progenitors and stroma.                                                      Aging Dis                          2012, 3:280\u2013290."},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/jcsm.12374","volume":"10","author":"Li Z","year":"2019","unstructured":"Li Z, Cai B, Abdalla BA, Zhu X, Zheng M, Han P, Nie Q. LncIRS1 controls muscle atrophy via sponging miR\u201015 family to activate IGF1\u2010PI3K\/AKT pathway. J Cachexia Sarcopenia Muscle, 2019, 10: 391-410.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"8957","DOI":"10.1038\/srep08957","volume":"5","author":"Zhao W","year":"2015","unstructured":"Zhao W, Mu Y, Ma L, Wang C, Tang Z, Yang S, Zhou R. Systematic identification and characterization of long intergenic non-coding RNAs in fetal porcine skeletal muscle development. Sci Rep, 2015, 5:","journal-title":"Sci Rep"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"12470","DOI":"10.7554\/eLife.12470","volume":"5","author":"Phelps M","year":"2016","unstructured":"Phelps M, Coss C, Wang H, Cook M. Registered report: coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. eLife, 2016, 5:","journal-title":"eLife"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","volume":"146","author":"Salmena L","year":"2011","unstructured":"Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the rosetta stone of a hidden RNA language?. Cell, 2011, 146: 353-358.","journal-title":"Cell"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nature09144","volume":"465","author":"Poliseno L","year":"2010","unstructured":"Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature, 2010, 465: 1033-1038.","journal-title":"Nature"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fgene.2019.00091","volume":"10","author":"Yue B","year":"2019","unstructured":"Yue B, Li H, Liu M, Wu J, Li M, Lei C, Huang B. Characterization of lncRNA\u2013miRNA\u2013mRNA Network to Reveal Potential Functional ceRNAs in Bovine Skeletal Muscle. Front Genet, 2019, 10:","journal-title":"Front Genet"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3390\/genes11020147","volume":"11","author":"Li B","year":"2020","unstructured":"Li B, Zhang K, Ye Y, Xing J, Wu Y, Ma Y, Li Y. Effects of castration on miRNA, lncRNA, and mRNA profiles in mice thymus. Genes, 2020, 11:","journal-title":"Genes"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3390\/ijms20051107","volume":"20","author":"Wang J","year":"2019","unstructured":"Wang J, Ren Q, Hua L, Chen J, Zhang J, Bai H, Li H. Comprehensive analysis of differentially expressed mRNA, lncRNA and circRNA and their ceRNA networks in the longissimus dorsi muscle of two different pig breeds. Int J Mol Sci, 2019, 20:","journal-title":"Int J Mol Sci"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1186\/s12864-017-4145-0","volume":"18","author":"Wang S","year":"2017","unstructured":"Wang S, Ge W, Luo Z, Guo Y, Jiao B, Qu L, Zhang Z. Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus). BMC Genomics, 2017, 18:","journal-title":"BMC Genomics"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7501851","volume":"2018","author":"Qu X","year":"2018","unstructured":"Qu X, Dang X, Wang W, Li Y, Xu D, Shang D, Chang Y. Long noncoding RNAs and mRNA regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease. Mediators Inflamm, 2018, 2018: 1-14.","journal-title":"Mediators Inflamm"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/ni.f.213","volume":"9","author":"Bromley SK","year":"2008","unstructured":"Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol, 2008, 9: 970-980.","journal-title":"Nat Immunol"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S1388-1981(00)00053-6","volume":"1486","author":"Borst P","year":"2000","unstructured":"Borst P, Zelcer N, van Helvoort A. ABC transporters in lipid transport. Biochim Biophys Acta, 2000, 1486: 128-144.","journal-title":"Biochim Biophys Acta"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cr.2009.139","volume":"20","author":"Dunkelberger JR","year":"2010","unstructured":"Dunkelberger JR, Song WC. Complement and its role in innate and adaptive immune responses. Cell Res, 2010, 20: 34-50.","journal-title":"Cell Res"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"23533","DOI":"10.1038\/srep23533","volume":"6","author":"Hsu FC","year":"2016","unstructured":"Hsu FC, Shapiro MJ, Dash B, Chen CC, Constans MM, Chung JY, Romero Arocha SR. An essential role for the transcription factor runx1 in t cell maturation. Sci Rep, 2016, 6:","journal-title":"Sci Rep"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/imr.12418","volume":"271","author":"Chaudhry MS","year":"2016","unstructured":"Chaudhry MS, Velardi E, Dudakov JA, van den Brink MRM. Thymus: the next (re)generation. Immunol Rev, 2016, 271: 56-71.","journal-title":"Immunol Rev"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"117997","DOI":"10.1016\/j.lfs.2020.117997","volume":"256","author":"Xiao Z","year":"2020","unstructured":"Xiao Z, Chu Y, Qin W. IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. Life Sci, 2020, 256:","journal-title":"Life Sci"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/hep.26126","volume":"57","author":"Jo H","year":"2013","unstructured":"Jo H, Choe SS, Shin KC, Jang H, Lee JH, Seong JK, Back SH. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low\u2010density lipoprotein receptor. Hepatology, 2013, 57: 1366-1377.","journal-title":"Hepatology"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.1016\/j.jmb.2020.05.017","volume":"432","author":"Shen J","year":"2020","unstructured":"Shen J, Wu G, Tsai AL, Zhou M. Structure and mechanism of a unique diiron center in mammalian stearoyl-CoA desaturase. J Mol Biol, 2020, 432: 5152-5161.","journal-title":"J Mol Biol"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1556\/030.63.2016.2.1","volume":"63","author":"Csaba G","year":"2016","unstructured":"Csaba G. The immunoendocrine thymus as a pacemaker of lifespan. Acta Microbiol Immunol Hung, 2016, 63: 139-158.","journal-title":"Acta Microbiol Immunol Hung"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.exger.2017.12.022","volume":"105","author":"Cepeda S","year":"2018","unstructured":"Cepeda S, Griffith AV. Thymic stromal cells: roles in atrophy and age-associated dysfunction of the thymus. Exp Gerontol, 2018, 105: 113-117.","journal-title":"Exp Gerontol"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1152\/physiolgenomics.00098.2017","volume":"50","author":"Wei C","year":"2018","unstructured":"Wei C, Guo D, Li Y, Zhang K, Liang G, Li Y, Ma Y. Profiling analysis of 17\u03b2-estradiol-regulated lncRNAs in mouse thymic epithelial cells. Physiol Genomics, 2018, 50: 553-562.","journal-title":"Physiol Genomics"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0165-2478(02)00233-X","volume":"85","author":"Moser B","year":"2003","unstructured":"Moser B, Ebert L. Lymphocyte traffic control by chemokines: follicular B helper T cells. Immunol Lett, 2003, 85: 105-112.","journal-title":"Immunol Lett"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.11.054","volume":"118","author":"Hun M","year":"2017","unstructured":"Hun M, Barsanti M, Wong K, Ramshaw J, Werkmeister J, Chidgey AP. Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation. Biomaterials, 2017, 118: 1-15.","journal-title":"Biomaterials"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1152\/physrev.00008.2006","volume":"86","author":"Page MJ","year":"2006","unstructured":"Page MJ, Di Cera E. Role of Na                         + and K                         + in Enzyme Function. Physiol Rev, 2006, 86: 1049-1092.","journal-title":"Physiol Rev"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.4049\/jimmunol.1401174","volume":"193","author":"Nikolich-\u017dugich J","year":"2014","unstructured":"Nikolich-\u017dugich J. Aging of the T cell compartment in mice and humans: From no naive expectations to foggy memories. J Immunol, 2014, 193: 2622-2629.","journal-title":"J Immunol"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.smim.2012.04.002","volume":"24","author":"Dixit VD","year":"2012","unstructured":"Dixit VD. Impact of immune-metabolic interactions on age-related thymic demise and T cell senescence. Semin Immunol, 2012, 24: 321-330.","journal-title":"Semin Immunol"},{"key":"CITATION35","unstructured":"Salam N, Rane S, Das R, Faulkner M, Gund R, Kandpal U, Lewis V,                         et al. T cell ageing: effects of age on development, survival & function.                                                      Indian J Med Res                          2013, 138: 595\u2013608."},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1046\/j.1365-2567.2002.01381.x","volume":"105","author":"Cumberbatch M","year":"2002","unstructured":"Cumberbatch M, Dearman RJ, Kimber I. Influence of ageing on langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology, 2002, 105: 466-477.","journal-title":"Immunology"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1474-9728.2004.00102.x","volume":"3","author":"Plowden J","year":"2004","unstructured":"Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S. Innate immunity in aging: Impact on macrophage function. Aging Cell, 2004, 3: 161-167.","journal-title":"Aging Cell"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s10875-010-9501-7","volume":"31","author":"Frasca D","year":"2011","unstructured":"Frasca D, Blomberg BB. Aging affects human B cell responses. J Clin Immunol, 2011, 31: 430-435.","journal-title":"J Clin Immunol"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.4049\/jimmunol.1401871","volume":"193","author":"Hsu FC","year":"2014","unstructured":"Hsu FC, Shapiro MJ, Chen MW, McWilliams DC, Seaburg LM, Tangen SN, Shapiro VS. Immature recent thymic emigrants are eliminated by complement. J Immunol, 2014, 193: 6005-6015.","journal-title":"J Immunol"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1134\/S0006297916050060","volume":"81","author":"Kisseleva EP","year":"2016","unstructured":"Kisseleva EP, Krylov AV, Lyamina IV, Kudryavtsev IV, Lioudyno VI. Role of vascular Endothelial growth factor (VEGF) in thymus of mice under normal conditions and with tumor growth. Biochem Moscow, 2016, 81: 491-501.","journal-title":"Biochem Moscow"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"111177","DOI":"10.1016\/j.mad.2019.111177","volume":"185","author":"Marttila S","year":"2020","unstructured":"Marttila S, Chatsirisupachai K, Palmer D, de Magalh\u00e3es JP. Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways. Mech Ageing Dev, 2020, 185:","journal-title":"Mech Ageing Dev"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1016\/j.bbrc.2016.08.133","volume":"478","author":"Ming G","year":"2016","unstructured":"Ming G, Wu K, Hu K, Chen Y, Xiao J. NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 as lncRNA\/miR-22\/SIRT1 pathway. Biochem Biophys Res Commun, 2016, 478: 1382-1388.","journal-title":"Biochem Biophys Res Commun"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/eji.201142305","volume":"42","author":"Dooley J","year":"2012","unstructured":"Dooley J, Liston A. Molecular control over thymic involution: from cytokines and micro RNA to aging and adipose tissue. Eur J Immunol, 2012, 42: 1073-1079.","journal-title":"Eur J Immunol"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.4049\/jimmunol.164.4.2180","volume":"164","author":"Sempowski GD","year":"2000","unstructured":"Sempowski GD, Hale LP, Sundy JS, Massey JM, Koup RA, Douek DC, Patel DD. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol, 2000, 164: 2180-2187.","journal-title":"J Immunol"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7826874","volume":"2020","author":"Li L","year":"2020","unstructured":"Li L, Zheng W, Wang C, Qi J, Li H. Mogroside V protects against hepatic steatosis in mice on a high-fat diet and LO2 cells treated with free fatty acids via AMPK activation. Evid Based Complement Alternat Med, 2020, 2020: 1-11.","journal-title":"Evid Based Complement Alternat Med"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.3389\/fphar.2019.01134","volume":"10","author":"Wu X","year":"2019","unstructured":"Wu X, Xu N, Li M, Huang Q, Wu J, Gan Y, Chen L. Protective effect of patchouli alcohol against high-fat diet induced hepatic steatosis by alleviating endoplasmic reticulum stress and regulating VLDL metabolism in rats. Front Pharmacol, 2019, 10:","journal-title":"Front Pharmacol"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.molmet.2017.12.008","volume":"8","author":"Zarei M","year":"2018","unstructured":"Zarei M, Barroso E, Palomer X, Dai J, Rada P, Quesada-L\u00f3pez T, Escol\u00e0-Gil JC. Hepatic regulation of VLDL receptor by PPAR\u03b2\/\u03b4 and FGF21 modulates non-alcoholic fatty liver disease. Mol Metab, 2018, 8: 117-131.","journal-title":"Mol Metab"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.canlet.2013.05.002","volume":"336","author":"Luther GA","year":"2013","unstructured":"Luther GA, Lamplot J, Chen X, Rames R, Wagner ER, Liu X, Parekh A. IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma. Cancer Lett, 2013, 336: 222-230.","journal-title":"Cancer Lett"},{"key":"CITATION49","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13008-020-00061-6","volume":"15","author":"Dong C","year":"2020","unstructured":"Dong C, Zhang J, Fang S, Liu F. IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in glioblastoma multiforme cells. Cell Div, 2020, 15:","journal-title":"Cell Div"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.toxlet.2014.08.010","volume":"230","author":"Qiao D","year":"2014","unstructured":"Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z. Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Lett, 2014, 230: 444-453.","journal-title":"Toxicol Lett"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"18782","DOI":"10.1002\/jcb.29191","volume":"120","author":"Wang T","year":"2019","unstructured":"Wang T, Wang C, Tian S, Song H. Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK\/MAPK axis. J Cell Biochem, 2019, 120: 18782-18792.","journal-title":"J Cell Biochem"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/abbs\/gmv136","volume":"48","author":"Guo D","year":"2016","unstructured":"Guo D, Ye Y, Qi J, Xu L, Zhang L, Tan X, Tan Z. MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7. Acta Biochim Biophys Sin, 2016, 48: 290-297.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1093\/abbs\/gmw068","volume":"48","author":"Guo D","year":"2016","unstructured":"Guo D, Ye Y, Qi J, Zhang L, Xu L, Tan X, Yu X. MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-\u03b2 signaling. Acta Biochim Biophys Sin, 2016, 48: 840-849.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/iub.1864","volume":"70","author":"Jia HL","year":"2018","unstructured":"Jia HL, Zeng XQ, Huang F, Liu YM, Gong BS, Zhang KZ, Zeng JH. Integrated microRNA and mRNA sequencing analysis of age-related changes to mouse thymic epithelial cells. IUBMB Life, 2018, 70: 678-690.","journal-title":"IUBMB Life"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"113223","DOI":"10.1016\/j.expneurol.2020.113223","volume":"327","author":"Chen Z","year":"2020","unstructured":"Chen Z, Yang J, Zhong J, Luo Y, Du W, Hu C, Xia H. MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression. Exp Neurol, 2020, 327:","journal-title":"Exp Neurol"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.7150\/thno.23547","volume":"8","author":"Meng F","year":"2018","unstructured":"Meng F, Li Z, Zhang Z, Yang Z, Kang Y, Zhao X, Long D. MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3. Theranostics, 2018, 8: 2862-2883.","journal-title":"Theranostics"},{"key":"CITATION57","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jinorgbio.2018.06.013","volume":"186","author":"Liu T","year":"2018","unstructured":"Liu T, Yang T, Xu Z, Tan S, Pan T, Wan N, Li S. MicroRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1. J Inorg Biochem, 2018, 186: 235-245.","journal-title":"J Inorg Biochem"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.3390\/ijms20112615","volume":"20","author":"Puvvula PK","year":"2019","unstructured":"Puvvula PK. LncRNAs regulatory networks in cellular senescence. Int J Mol Sci, 2019, 20:","journal-title":"Int J Mol Sci"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"14518","DOI":"10.1002\/jcb.28713","volume":"120","author":"Yao J","year":"2019","unstructured":"Yao J, Shi Z, Ma X, Xu D, Ming G. lncRNA GAS5\/miR\u2010223\/NAMPT axis modulates the cell proliferation and senescence of endothelial progenitor cells through PI3K\/AKT signaling. J Cell Biochem, 2019, 120: 14518-14530.","journal-title":"J Cell Biochem"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/44B1DB42869C47C28E466E02722A1025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023042","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/44B1DB42869C47C28E466E02722A1025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:04:08Z","timestamp":1684217048000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":59,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4,19]]},"published-print":{"date-parts":[[2023,4,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2023042","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}