{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:55:04Z","timestamp":1782996904018,"version":"3.54.5"},"reference-count":61,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2023,11,1]]},"DOI":"10.3724\/abbs.2023223","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T01:44:27Z","timestamp":1693187067000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["&amp;kappa;-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-&amp;kappa;B pathway"],"prefix":"10.3724","author":[{"given":"Yi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.reth.2020.07.007","volume":"15","author":"Di Nicola V","year":"2020","unstructured":"Di Nicola V. Degenerative osteoarthritis a reversible chronic disease. Regenerative Ther, 2020, 15: 149-160.","journal-title":"Regenerative Ther"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"106504","DOI":"10.1016\/j.phrs.2022.106504","volume":"185","author":"Yamaura K","year":"2022","unstructured":"Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ. The effects of fisetin on bone and cartilage: a systematic review. Pharmacol Res, 2022, 185:","journal-title":"Pharmacol Res"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"20190338","DOI":"10.1515\/jbcpp-2019-0338","volume":"30","author":"Khotib J","year":"2019","unstructured":"Khotib J, Setiawan HU, Nurhan AD, Rahadiansyah E, Ardianto C, Rahmadi M. Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: weighing clinical risk and benefit. J Basic Clin Physiol Pharmacol, 2019, 30:","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s40265-023-01863-y","volume":"83","author":"Assi R","year":"2023","unstructured":"Assi R, Quintiens J, Monteagudo S, Lories RJ. Innovation in targeted intra-articular therapies for osteoarthritis. Drugs, 2023, 83: 649-663.","journal-title":"Drugs"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"eade4645","DOI":"10.1126\/sciadv.ade4645","volume":"9","author":"Bolander J","year":"2023","unstructured":"Bolander J, Moviglia Brandolina MT, Poehling G, Jochl O, Parsons E, Vaughan W, Moviglia G. The synovial environment steers cartilage deterioration and regeneration. Sci Adv, 2023, 9:","journal-title":"Sci Adv"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","volume":"18","author":"Sanchez-Lopez E","year":"2022","unstructured":"Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol, 2022, 18: 258-275.","journal-title":"Nat Rev Rheumatol"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/jor.24457","volume":"38","author":"Woodell-May JE","year":"2020","unstructured":"Woodell-May JE, Sommerfeld SD. Role of inflammation and the immune system in the progression of osteoarthritis. J Orthopaedic Res, 2020, 38: 253-257.","journal-title":"J Orthopaedic Res"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","volume":"64","author":"Motta F","year":"2023","unstructured":"Motta F, Barone E, Sica A, Selmi C. Inflammaging and osteoarthritis. Clinic Rev Allerg Immunol, 2023, 64: 222-238.","journal-title":"Clinic Rev Allerg Immunol"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrrheum.2016.162","volume":"12","author":"Nefla M","year":"2016","unstructured":"Nefla M, Holzinger D, Berenbaum F, Jacques C. The danger from within: alarmins in arthritis. Nat Rev Rheumatol, 2016, 12: 669-683.","journal-title":"Nat Rev Rheumatol"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13075-021-02512-z","volume":"23","author":"Lu J","year":"2021","unstructured":"Lu J, Zhang H, Pan J, Hu Z, Liu L, Liu Y, Yu X. Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-\u03baB pathways. Arthritis Res Ther, 2021, 23:","journal-title":"Arthritis Res Ther"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","volume":"24","author":"Kraus VB","year":"2016","unstructured":"Kraus VB, McDaniel G, Huebner JL, Stabler TV, Pieper CF, Shipes SW, Petry NA. Direct                          in vivo evidence of activated macrophages in human osteoarthritis. Osteoarthritis Cartilage, 2016, 24: 1613-1621.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1172\/JCI121561","volume":"129","author":"Zhu S","year":"2019","unstructured":"Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest, 2019, 129: 1076-1093.","journal-title":"J Clin Invest"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1080\/15548627.2019.1664705","volume":"16","author":"Zhang B","year":"2020","unstructured":"Zhang B, Chen H, Ouyang J, Xie Y, Chen L, Tan Q, Du X. SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B\/IL-1\u03b2 and contributes to LIPUS-mediated anti-inflammatory effect. Autophagy, 2020, 16: 1262-1278.","journal-title":"Autophagy"},{"key":"CITATION14","unstructured":"Griffin TM, Scanzello CR. Innate inflammation and synovial macrophages in osteoarthritis pathophysiology.                                                       Clin Exp Rheumatol                          2019, 37(Suppl 120): 57\u201363."},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"114935","DOI":"10.1016\/j.bcp.2022.114935","volume":"198","author":"Ni L","year":"2022","unstructured":"Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y. Itaconate attenuates osteoarthritis by inhibiting STING\/NF-\u03baB axis in chondrocytes and promoting M2 polarization in macrophages. Biochem Pharmacol, 2022, 198:","journal-title":"Biochem Pharmacol"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/00002508-200207001-00002","volume":"18","author":"Inturrisi CE","year":"2002","unstructured":"Inturrisi CE. Clinical pharmacology of opioids for pain. Clin J Pain, 2002, 18: S3-S13.","journal-title":"Clin J Pain"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.36076\/ppj.2008\/11\/S133","volume":"11","author":"Trescot AM","year":"2008","unstructured":"Trescot AM. Opioid pharmacology. Pain Phys, 2008, 11: S133-S153.","journal-title":"Pain Phys"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jaad.2021.07.078","volume":"86","author":"Sutaria N","year":"2022","unstructured":"Sutaria N, Adawi W, Goldberg R, Roh YS, Choi J, Kwatra SG. Itch: Pathogenesis and treatment. J Am Acad Dermatol, 2022, 86: 17-34.","journal-title":"J Am Acad Dermatol"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"741503","DOI":"10.3389\/fnins.2021.741503","volume":"15","author":"Dworsky-Fried Z","year":"2021","unstructured":"Dworsky-Fried Z, Chadwick CI, Kerr BJ, Taylor AMW. Multiple sclerosis and the endogenous opioid system. Front Neurosci, 2021, 15:","journal-title":"Front Neurosci"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"837671","DOI":"10.3389\/fphar.2022.837671","volume":"13","author":"Dalefield ML","year":"2022","unstructured":"Dalefield ML, Scouller B, Bibi R, Kivell BM. The kappa opioid receptor: a promising therapeutic target for multiple pathologies. Front Pharmacol, 2022, 13:","journal-title":"Front Pharmacol"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/rheumatology\/kei156","volume":"45","author":"Bileviciute-Ljungar I","year":"2006","unstructured":"Bileviciute-Ljungar I, Saxne T, Spetea M. Anti-inflammatory effects of contralateral administration of the \u03ba-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis. Rheumatology, 2006, 45: 295-302.","journal-title":"Rheumatology"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"e88553","DOI":"10.1172\/jci.insight.88553","volume":"2","author":"Wu L","year":"2017","unstructured":"Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight, 2017, 2:","journal-title":"JCI Insight"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1002\/art.41250","volume":"72","author":"Weber AE","year":"2020","unstructured":"Weber AE, Jalali O, Limfat S, Shkhyan R, Van Der Horst R, Lee S, Lin Y. Modulation of hedgehog signaling by kappa opioids to attenuate osteoarthritis. Arthritis Rheumatology, 2020, 72: 1278-1288.","journal-title":"Arthritis Rheumatology"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"Lawrence T","year":"2009","unstructured":"Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect  Biol, 2009, 1:","journal-title":"Cold Spring Harb Perspect  Biol"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/ni.2065","volume":"12","author":"Oeckinghaus A","year":"2011","unstructured":"Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-\u03baB signaling pathways. Nat Immunol, 2011, 12: 695-708.","journal-title":"Nat Immunol"},{"key":"CITATION26","doi-asserted-by":"crossref","unstructured":"Choi MC, Jo J, Park J, Kang HK, Park Y. NF-\u03baB Signaling Pathways in Osteoarthritic Cartilage Destruction.                          Cells 2019, 8: 734.","DOI":"10.3390\/cells8070734"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41419-020-2710-y","volume":"11","author":"Chen Z","year":"2020","unstructured":"Chen Z, Lin CX, Song B, Li CC, Qiu JX, Li SX, Lin SP. Spermidine activates RIP1 deubiquitination to inhibit TNF-\u03b1-induced NF-\u03baB\/p65 signaling pathway in osteoarthritis. Cell Death Dis, 2020, 11:","journal-title":"Cell Death Dis"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.cyto.2013.01.002","volume":"61","author":"Lin JJ","year":"2013","unstructured":"Lin JJ, Wang HY, Li J, Wang QM, Zhang SM, Feng N, Fan R. \u03ba-Opioid receptor stimulation modulates TLR4\/NF-\u03baB signaling in the rat heart subjected to ischemia\u2013reperfusion. Cytokine, 2013, 61: 842-848.","journal-title":"Cytokine"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12902-015-0004-7","volume":"15","author":"Zhou X","year":"2015","unstructured":"Zhou X, Wang D, Zhang Y, Zhang J, Xiang D, Wang H. Activation of \u03ba-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats. BMC Endocr Disord, 2015, 15:","journal-title":"BMC Endocr Disord"},{"key":"CITATION30","doi-asserted-by":"crossref","unstructured":"Zhang L, Li X, Zhang H, Huang Z, Zhang N, Zhang L, Xing R,                          et al. Agnuside alleviates synovitis and fibrosis in knee osteoarthritis through the inhibition of HIF-1\u03b1 and NLRP3 inflammasome.                                                       Mediators Inflamm                          2021, 2021: 5534614.","DOI":"10.1155\/2021\/5534614"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1021\/acs.molpharmaceut.2c00979","volume":"20","author":"Teng H","year":"2023","unstructured":"Teng H, Chen S, Fan K, Wang Q, Xu B, Chen D, Zhao F. Dexamethasone liposomes alleviate osteoarthritis in miR-204\/-211-deficient mice by repolarizing synovial macrophages to M2 phenotypes. Mol Pharm, 2023, 20: 3843-3853.","journal-title":"Mol Pharm"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jep.2010.07.025","volume":"131","author":"Kang M","year":"2010","unstructured":"Kang M, Jung I, Hur J, Kim SH, Lee JH, Kang JY, Jung KC. The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of                          Lonicera japonica Thunb and                          Anemarrhena asphodeloides BUNGE                          in vivo. J Ethnopharmacol, 2010, 131: 485-496.","journal-title":"J Ethnopharmacol"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"105692","DOI":"10.1016\/j.phrs.2021.105692","volume":"170","author":"Ohayon L","year":"2021","unstructured":"Ohayon L, Zhang X, Dutta P. The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease. Pharmacol Res, 2021, 170:","journal-title":"Pharmacol Res"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","volume":"44","author":"Ginhoux F","year":"2016","unstructured":"Ginhoux F, Guilliams M. Tissue-resident macrophage ontogeny and homeostasis. Immunity, 2016, 44: 439-449.","journal-title":"Immunity"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"Shapouri-Moghaddam A","year":"2018","unstructured":"Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol, 2018, 233: 6425-6440.","journal-title":"J Cell Physiol"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/1878-0261.12644","volume":"14","author":"Dan H","year":"2020","unstructured":"Dan H, Liu S, Liu J, Liu D, Yin F, Wei Z, Wang J. RACK1 promotes cancer progression by increasing the M2\/M1 macrophage ratio via the NF\u2010\u03baB pathway in oral squamous cell carcinoma. Mol Oncol, 2020, 14: 795-807.","journal-title":"Mol Oncol"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"106473","DOI":"10.1016\/j.phrs.2022.106473","volume":"185","author":"Chen XS","year":"2022","unstructured":"Chen XS, Wang SH, Liu CY, Gao YL, Meng XL, Wei W, Shou ST. Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-\u03baB and MAPK signaling. Pharmacol Res, 2022, 185:","journal-title":"Pharmacol Res"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","volume":"104","author":"Abramoff B","year":"2020","unstructured":"Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin N Am, 2020, 104: 293-311.","journal-title":"Med Clin N Am"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/ddr.21741","volume":"82","author":"Kumar A","year":"2021","unstructured":"Kumar A, Palit P, Thomas S, Gupta G, Ghosh P, Goswami RP, Kumar Maity T. Osteoarthritis: prognosis and emerging therapeutic approach for disease management. Drug Dev Res, 2021, 82: 49-58.","journal-title":"Drug Dev Res"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.berh.2008.07.002","volume":"22","author":"Das SK","year":"2008","unstructured":"Das SK, Farooqi A. Osteoarthritis. Best Pract Res Clin Rheumatology, 2008, 22: 657-675.","journal-title":"Best Pract Res Clin Rheumatology"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3724\/abbs.2023086","volume":"55","author":"Liu Y","year":"2023","unstructured":"Liu Y, Duan M, Zhang D, Xie J. The role of mechano growth factor in chondrocytes and cartilage defects: a concise review. Acta Biochim Biophys Sin, 2023, 55: 701-712.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3724\/abbs.2023078","volume":"55","author":"Li W","year":"2023","unstructured":"Li W, Tao C, Mao M, Zhu K. The Nrf2\/HMGB1\/NF-\u03baB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis. Acta Biochim Biophys Sin, 2023, 55: 818-830.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.joca.2021.11.009","volume":"30","author":"Jiang Y","year":"2022","unstructured":"Jiang Y. Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage, 2022, 30: 207-215.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/jcm8091343","volume":"8","author":"Nees TA","year":"2019","unstructured":"Nees TA, Rosshirt N, Zhang JA, Reiner T, Sorbi R, Tripel E, Walker T. Synovial cytokines significantly correlate with osteoarthritis-related knee pain and disability: inflammatory mediators of potential clinical relevance. J Clin Med, 2019, 8:","journal-title":"J Clin Med"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.joca.2019.12.007","volume":"28","author":"Wu CL","year":"2020","unstructured":"Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. The role of macrophages in osteoarthritis and cartilage repair. Osteoarthritis Cartilage, 2020, 28: 544-554.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","volume":"77","author":"Zhang H","year":"2018","unstructured":"Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis, 2018, 77: 1524-1534.","journal-title":"Ann Rheum Dis"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"25138","DOI":"10.18632\/aging.104110","volume":"12","author":"Zhang J","year":"2020","unstructured":"Zhang J, Rong Y, Luo C, Cui W. Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization. Aging, 2020, 12: 25138-25152.","journal-title":"Aging"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13075-019-1923-x","volume":"21","author":"Haraden CA","year":"2019","unstructured":"Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB. Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. Arthritis Res Ther, 2019, 21:","journal-title":"Arthritis Res Ther"},{"key":"CITATION49","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.apsb.2019.01.015","volume":"9","author":"Zhou F","year":"2019","unstructured":"Zhou F, Mei J, Han X, Li H, Yang S, Wang M, Chu L. Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-\u03baB\/MAPK signaling and protecting chondrocytes. Acta Pharmaceutica Sin B, 2019, 9: 973-985.","journal-title":"Acta Pharmaceutica Sin B"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"669213","DOI":"10.3389\/fphar.2021.669213","volume":"12","author":"Tian Z","year":"2021","unstructured":"Tian Z, Zeng F, Zhao C, Dong S. Angelicin alleviates post-trauma osteoarthritis progression by regulating macrophage polarization via STAT3 signaling pathway. Front Pharmacol, 2021, 12:","journal-title":"Front Pharmacol"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","volume":"28","author":"Zhang H","year":"2020","unstructured":"Zhang H, Cai D, Bai X. Macrophages regulate the progression of osteoarthritis. Osteoarthritis Cartilage, 2020, 28: 555-561.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.imbio.2017.11.001","volume":"223","author":"Arora S","year":"2018","unstructured":"Arora S, Dev K, Agarwal B, Das P, Syed MA. Macrophages: their role, activation and polarization in pulmonary diseases. Immunobiology, 2018, 223: 383-396.","journal-title":"Immunobiology"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/imcb.12236","volume":"97","author":"Kim SY","year":"2019","unstructured":"Kim SY, Nair MG. Macrophages in wound healing: activation and plasticity. Immunol Cell Biol, 2019, 97: 258-267.","journal-title":"Immunol Cell Biol"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.3892\/etm.2018.6852","volume":"16","author":"Liu B","year":"2018","unstructured":"Liu B, Zhang M, Zhao J, Zheng M, Yang H. Imbalance of M1\/M2 macrophages is linked to severity level of knee osteoarthritis. Exp Ther Med, 2018, 16: 5009-5014.","journal-title":"Exp Ther Med"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.3390\/antiox11122315","volume":"11","author":"Sun H","year":"2022","unstructured":"Sun H, Sun Z, Xu X, Lv Z, Li J, Wu R, Fei Y. Blocking TRPV4 ameliorates osteoarthritis by inhibiting M1 macrophage polarization via the ROS\/NLRP3 signaling pathway. Antioxidants, 2022, 11:","journal-title":"Antioxidants"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"106091","DOI":"10.1016\/j.phrs.2022.106091","volume":"177","author":"French AR","year":"2022","unstructured":"French AR, van Rijn RM. An updated assessment of the translational promise of G-protein-biased kappa opioid receptor agonists to treat pain and other indications without debilitating adverse effects. Pharmacol Res, 2022, 177:","journal-title":"Pharmacol Res"},{"key":"CITATION57","doi-asserted-by":"crossref","unstructured":"Gao GJ, Song DD, Li L, Zhao F, Sun YJ. \u03ba-opioid receptor agonist U50448H protects against acute lung injury in rats with cardiopulmonary bypass via the CAP-NLRP3 signaling pathway.                                                       Evid Based Complement Alternat Med                          2022, 2022: 2868135.","DOI":"10.1155\/2022\/2868135"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1021\/acschemneuro.9b00195","volume":"10","author":"Dunn AD","year":"2019","unstructured":"Dunn AD, Reed B, Erazo J, Ben-Ezra A, Kreek MJ. Signaling properties of structurally diverse kappa opioid receptor ligands: toward in vitro models of                          in vivo responses. ACS Chem Neurosci, 2019, 10: 3590-3600.","journal-title":"ACS Chem Neurosci"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","volume":"132","author":"Lepetsos P","year":"2019","unstructured":"Lepetsos P, Papavassiliou KA, Papavassiliou AG. Redox and NF-\u03baB signaling in osteoarthritis. Free Radical Biol Med, 2019, 132: 90-100.","journal-title":"Free Radical Biol Med"},{"key":"CITATION60","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","volume":"8","author":"Yao Q","year":"2023","unstructured":"Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Sig Transduct Target Ther, 2023, 8:","journal-title":"Sig Transduct Target Ther"},{"key":"CITATION61","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10753-017-0558-9","volume":"40","author":"Zheng W","year":"2017","unstructured":"Zheng W, Tao Z, Cai L, Chen C, Zhang C, Wang Q, Ying X. Chrysin attenuates IL-1\u03b2-induced expression of inflammatory mediators by suppressing NF-\u03baB in human osteoarthritis chondrocytes. Inflammation, 2017, 40: 1143-1154.","journal-title":"Inflammation"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/A4F9ECF6CF43461EBA841C15B5AB6946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023223","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/A4F9ECF6CF43461EBA841C15B5AB6946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T05:55:16Z","timestamp":1701150916000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":61,"URL":"https:\/\/doi.org\/10.3724\/abbs.2023223","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}