{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:20:20Z","timestamp":1773307220588,"version":"3.50.1"},"reference-count":64,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2024,1,1]]},"DOI":"10.3724\/abbs.2023275","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:03:24Z","timestamp":1701151404000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Human umbilical cord mesenchymal stem cells protect                     against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis                     and inhibiting iron loading"],"prefix":"10.3724","author":[{"given":"Haiqin","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1242\/dmm.015537","volume":"7","author":"Gonz\u00e1lez-Rodr\u00edguez \u00c1","year":"2014","unstructured":"Gonz\u00e1lez-Rodr\u00edguez \u00c1, Reibert B, Amann T, Constien R, Rondinone CM, Valverde \u00c1M. In vivo siRNA delivery of Keap1 modulates death                         and survival signaling pathways and attenuates Concanavalin A-induced acute                         liver injury in mice. Dis Model Mech, 2014, 7: 1093-1100.","journal-title":"Dis Model Mech"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jhep.2013.04.001","volume":"59","author":"Saliba F","year":"2013","unstructured":"Saliba F, Samuel D. Acute liver failure: Current trends. J Hepatol, 2013, 59: 6-8.","journal-title":"J Hepatol"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","volume":"394","author":"Stravitz RT","year":"2019","unstructured":"Stravitz RT, Lee WM. Acute liver failure. Lancet, 2019, 394: 869-881.","journal-title":"Lancet"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1055\/s-2008-1073113","volume":"28","author":"Riordan S","year":"2008","unstructured":"Riordan S, Williams R. Perspectives on liver failure: past and future. Semin Liver Dis, 2008, 28: 137-141.","journal-title":"Semin Liver Dis"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jhep.2016.12.003","volume":"66","author":"Wendon J","year":"2017","unstructured":"Wendon J, Cordoba J, Dhawan A, Larsen FS, Manns M, Nevens F, Samuel D. EASL Clinical Practical Guidelines on the management of acute                         (fulminant) liver failure. J Hepatol, 2017, 66: 1047-1081.","journal-title":"J Hepatol"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"Dixon SJ","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 2012, 149: 1060-1072.","journal-title":"Cell"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"Chen J","year":"2022","unstructured":"Chen J, Li X, Ge C, Min J, Wang F. The multifaceted role of ferroptosis in liver disease. Cell Death                             Differ, 2022, 29: 467-480.","journal-title":"Cell Death                             Differ"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"Stockwell BR","year":"2022","unstructured":"Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological                         functions, and therapeutic applications. Cell, 2022, 185: 2401-2421.","journal-title":"Cell"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/tra.12905","volume":"24","author":"Liao Z","year":"2023","unstructured":"Liao Z, Tong B, Ou Z, Wei J, Lei M, Yang C. The role of extracellular vesicles in iron homeostasis and                         ferroptosis: focus on musculoskeletal diseases. Traffic, 2023, 24: 384-396.","journal-title":"Traffic"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"Gao M","year":"2015","unstructured":"Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell, 2015, 59: 298-308.","journal-title":"Mol Cell"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Xie Y","year":"2016","unstructured":"Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R. Ferroptosis: process and function. Cell Death Differ, 2016, 23: 369-379.","journal-title":"Cell Death Differ"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"7811","DOI":"10.1074\/jbc.M008923200","volume":"276","author":"Pigeon C","year":"2001","unstructured":"Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Lor\u00e9al O. A new mouse liver-specific gene, encoding a protein homologous to                         human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem, 2001, 276: 7811-7819.","journal-title":"J Biol Chem"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1182\/blood-2017-05-786590","volume":"131","author":"Aschemeyer S","year":"2018","unstructured":"Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR. Structure-function analysis of ferroportin defines the binding                         site and an alternative mechanism of action of hepcidin. Blood, 2018, 131: 899-910.","journal-title":"Blood"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s12011-011-8967-3","volume":"143","author":"Li L","year":"2011","unstructured":"Li L, Holscher C, Chen BB, Zhang ZF, Liu YZ. Hepcidin treatment modulates the expression of divalent metal                         transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex                         and hippocampus. Biol Trace Elem                             Res, 2011, 143: 1581-1593.","journal-title":"Biol Trace Elem                             Res"},{"key":"CITATION15","doi-asserted-by":"crossref","unstructured":"Zhang H, Ostrowski R, Jiang D, Zhao Q, Liang Y, Che X, Zhao J, et                         al. Hepcidin promoted ferroptosis through iron metabolism which is                         associated with DMT1 signaling activation in early brain injury following                         subarachnoid hemorrhage.                              Oxid Med Cell                         Longev                          2021, 2021: 9800794.","DOI":"10.1155\/2021\/9800794"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","volume":"102","author":"Ganz T","year":"2003","unstructured":"Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of                         anemia of inflammation. Blood, 2003, 102: 783-788.","journal-title":"Blood"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1073\/pnas.072632499","volume":"99","author":"Nicolas G","year":"2002","unstructured":"Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M. Severe iron deficiency anemia in transgenic mice expressing liver                         hepcidin. Proc Natl Acad Sci                             USA, 2002, 99: 4596-4601.","journal-title":"Proc Natl Acad Sci                             USA"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"8955","DOI":"10.1073\/pnas.0503804102","volume":"102","author":"De Domenico I","year":"2005","unstructured":"De Domenico I, Ward DMV, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci                             USA, 2005, 102: 8955-8960.","journal-title":"Proc Natl Acad Sci                             USA"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41419-023-05688-1","volume":"14","author":"Zheng H","year":"2023","unstructured":"Zheng H, Guo X, Kang S, Li Z, Tian T, Li J, Wang F. Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during                         the acute phase and inhibitory effects during the recovery phase of ischemic                         stroke. Cell Death Dis, 2023, 14:","journal-title":"Cell Death Dis"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12192-022-01257-1","volume":"27","author":"Tian H","year":"2021","unstructured":"Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z. Activation of NRF2\/FPN1 pathway attenuates myocardial                         ischemia\u2013reperfusion injury in diabetic rats by regulating iron homeostasis                         and ferroptosis. Cell Stress                             Chaperones, 2021, 27: 149-164.","journal-title":"Cell Stress                             Chaperones"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4252\/wjsc.v15.i1.1","volume":"15","author":"Ma JF","year":"2023","unstructured":"Ma JF, Gao JP, Shao ZW. Acute liver failure: a systematic review and network                         meta-analysis of optimal type of stem cells in animal models. World J Stem Cells, 2023, 15: 1-14.","journal-title":"World J Stem Cells"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"674","DOI":"10.5009\/gnl220417","volume":"17","author":"Wang YH","year":"2023","unstructured":"Wang YH, Chen EQ. Mesenchymal stem cell therapy in acute liver failure. Gut Liver, 2023, 17: 674-683.","journal-title":"Gut Liver"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bioactmat.2023.05.001","volume":"28","author":"Jin Y","year":"2023","unstructured":"Jin Y, Zhang J, Xu Y, Yi K, Li F, Zhou H, Wang H. Stem cell-derived hepatocyte therapy using versatile biomimetic                         nanozyme incorporated nanofiber-reinforced decellularized extracellular                         matrix hydrogels for the treatment of acute liver failure. Bioactive                             Mater, 2023, 28: 112-131.","journal-title":"Bioactive                             Mater"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bioactmat.2023.04.024","volume":"28","author":"Wei H","year":"2023","unstructured":"Wei H, Li F, Xue T, Wang H, Ju E, Li M, Tao Y. MicroRNA-122-functionalized DNA tetrahedron stimulate hepatic                         differentiation of human mesenchymal stem cells for acute liver failure                         therapy. Bioactive                             Mater, 2023, 28: 50-60.","journal-title":"Bioactive                             Mater"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41419-022-04708-w","volume":"13","author":"Lin F","year":"2022","unstructured":"Lin F, Chen W, Zhou J, Zhu J, Yao Q, Feng B, Feng X. Mesenchymal stem cells protect against ferroptosis via                         exosome-mediated stabilization of SLC7A11 in acute liver injury. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"110793","DOI":"10.1016\/j.cellsig.2023.110793","volume":"109","author":"Zuo H","year":"2023","unstructured":"Zuo H, Wang Y, Yuan M, Zheng W, Tian X, Pi Y, Zhang X. Small extracellular vesicles from HO-1-modified bone                         marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury                         after steatotic liver transplantation by suppressing ferroptosis via                         miR-214-3p. Cell Signal, 2023, 109:","journal-title":"Cell Signal"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2022.10.268","volume":"193","author":"Yu Y","year":"2022","unstructured":"Yu Y, Wu T, Lu Y, Zhao W, Zhang J, Chen Q, Ge G. Exosomal thioredoxin-1 from hypoxic human umbilical cord                         mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced                         cardiotoxicity via mTORC1 signaling. Free                             Radical Biol Med, 2022, 193: 108-121.","journal-title":"Free                             Radical Biol Med"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"12204","DOI":"10.7150\/thno.47683","volume":"10","author":"Xu J","year":"2020","unstructured":"Xu J, Wang X, Chen J, Chen S, Li Z, Liu H, Bai Y. Embryonic stem cell-derived mesenchymal stem cells promote colon                         epithelial integrity and regeneration by elevating circulating IGF-1 in                         colitis mice. Theranostics, 2020, 10: 12204-12222.","journal-title":"Theranostics"},{"key":"CITATION29","doi-asserted-by":"crossref","unstructured":"Wang H, Ba T, Wang Q, Yang L, Li C, Hao X, Yin Y, et al.                         Human umbilical cord mesenchymal stem cells attenuate severe burn-induced                         multiple organ injury via potentiating IGF-1 and BCL-2\/BAX Pathway.                              Stem Cells Int                                                  2022, 2022: 5474289.","DOI":"10.1155\/2022\/5474289"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.3892\/ijo.2012.1666","volume":"41","author":"Kasprzak A","year":"2012","unstructured":"Kasprzak A, Adamek A. The insulin-like growth factor (IGF) signaling axis and hepatitis                         C virus-associated carcinogenesis (Review). Int J Oncol, 2012, 41: 1919-1931.","journal-title":"Int J Oncol"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/j.1478-3231.2010.02428.x","volume":"31","author":"Bonefeld K","year":"2011","unstructured":"Bonefeld K, M\u00f8ller S. Insulin-like growth factor-I and the liver. Liver Int, 2011, 31: 911-919.","journal-title":"Liver Int"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-017-1198-4","volume":"15","author":"Morales-Garza LA","year":"2017","unstructured":"Morales-Garza LA, Puche JE, Aguirre GA, Mu\u00f1oz \u00da, Garc\u00eda-Magari\u00f1o M, De la Garza RG, Castilla-Cortazar I. Experimental approach to IGF-1 therapy in CCl4-induced acute                         liver damage in healthy controls and mice with partial IGF-1 deficiency. J Transl Med, 2017, 15:","journal-title":"J Transl Med"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1634\/stemcells.2005-0053","volume":"24","author":"Fu YS","year":"2006","unstructured":"Fu YS, Cheng YC, Lin MYA, Cheng H, Chu PM, Chou SC, Shih YH. Conversion of human umbilical cord mesenchymal stem cells in                         wharton\u2019s jelly to dopaminergic neurons in vitro: potential therapeutic                         application for parkinsonism. Stem Cells, 2006, 24: 115-124.","journal-title":"Stem Cells"},{"key":"CITATION34","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2023.9598\/2023","volume":"116","author":"Fernandes DA","year":"2023","unstructured":"Fernandes DA, Assis-Mendoca GR, Costa LBE, Freitas LLL, Boin IFFS, Reis F. Amyloidosis: a rare cause of severe acute liver failure. Rev Esp                             Enferm Dig, 2023, 116:","journal-title":"Rev Esp                             Enferm Dig"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"e00479","DOI":"10.14309\/crj.0000000000000479","volume":"7","author":"Kim HJ","year":"2020","unstructured":"Kim HJ, Tomaszewski M, Lam EC, Xiong W, Moosavi S. Amyloidosis: a rare cause of severe cholestasis and acute liver                         failure. ACG Case Rep                             J, 2020, 7:","journal-title":"ACG Case Rep                             J"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.7150\/thno.71400","volume":"12","author":"Guo R","year":"2022","unstructured":"Guo R, Jia X, Ding Z, Wang G, Jiang M, Li B, Chen S. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte                         necroptosis and hepatic stellate cell activation. Theranostics, 2022, 12: 5220-5236.","journal-title":"Theranostics"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"110612","DOI":"10.1016\/j.cellsig.2023.110612","volume":"105","author":"Zhang Y","year":"2023","unstructured":"Zhang Y, Wang Y, Zhang K, Liang X, Guan J, Jin J, Zhang Y. Profile of 5-HT2A receptor involved in signaling cascades                         associated to intracellular inflammation and apoptosis in hepatocytes and                         its role in carbon tetrachloride-induced hepatotoxicity. Cell Signal, 2023, 105:","journal-title":"Cell Signal"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1080\/15384101.2022.2108128","volume":"21","author":"Tong H","year":"2022","unstructured":"Tong H, Wang L, Shi J, Jin H, Zhang K, Bao Y, Wu Y. Upregulated miR-322-5p regulates cell cycle and promotes cell                         proliferation and apoptosis by directly targeting Wee1 in mice liver injury. Cell Cycle, 2022, 21: 2635-2650.","journal-title":"Cell Cycle"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"922885","DOI":"10.3389\/fphar.2022.922885","volume":"13","author":"Liu Z","year":"2022","unstructured":"Liu Z, Wu X, Wang Q, Li Z, Liu X, Sheng X, Zhu H. CD73-adenosine A1R axis regulates the activation and apoptosis of                         hepatic stellate cells through the PLC-IP3-Ca2+\/DAG-PKC signaling                         pathway. Front Pharmacol, 2022, 13:","journal-title":"Front Pharmacol"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/liv.15558","volume":"43","author":"Shi B","year":"2023","unstructured":"Shi B, Wang W, Ye M, Liang M, Yu Z, Zhang Y, Liu Z. Spermidine suppresses the activation of hepatic stellate cells to                         cure liver fibrosis through autophagy activator MAP1S. Liver Int, 2023, 43: 1307-1319.","journal-title":"Liver Int"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"Sun S","year":"2023","unstructured":"Sun S, Shen J, Jiang J, Wang F, Min J. Targeting ferroptosis opens new avenues for the development of                         novel therapeutics. Sig Transduct                             Target Ther, 2023, 8:","journal-title":"Sig Transduct                             Target Ther"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"2192438","DOI":"10.1080\/15592294.2023.2192438","volume":"18","author":"Zhai H","year":"2023","unstructured":"Zhai H, Zhong S, Wu R, Mo Z, Zheng S, Xue J, Meng H. Suppressing circIDE\/miR-19b-3p\/RBMS1 axis exhibits                         promoting-tumour activity through upregulating GPX4 to diminish ferroptosis                         in hepatocellular carcinoma. Epigenetics, 2023, 18:","journal-title":"Epigenetics"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.2147\/IJN.S399318","volume":"18","author":"Meng H","year":"2023","unstructured":"Meng H, Li R, Xie Y, Mo Z, Zhai H, Zhang G, Liang G. Nanoparticles mediated circROBO1 silencing to inhibit                         hepatocellular carcinoma progression by modulating miR-130a-5p\/CCNT2 axis. Int J Nanomedicine, 2023, 18: 1677-1693.","journal-title":"Int J Nanomedicine"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40104-023-00845-0","volume":"14","author":"Wei Y","year":"2023","unstructured":"Wei Y, Gao C, Wang H, Zhang Y, Gu J, Zhang X, Gong X. Mori fructus aqueous extracts attenuates liver injury by                         inhibiting ferroptosis via the Nrf2 pathway. J Anim Sci                             Biotechnol, 2023, 14:","journal-title":"J Anim Sci                             Biotechnol"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1053\/j.gastro.2008.09.027","volume":"136","author":"Tsuchiya H","year":"2009","unstructured":"Tsuchiya H, Akechi Y, Ikeda R, Nishio R, Sakabe T, Terabayashi K, Matsumi Y. Suppressive effects of retinoids on iron-induced oxidative stress                         in the liver. Gastroenterology, 2009, 136: 341-350.e8.","journal-title":"Gastroenterology"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2023.06.003","volume":"205","author":"Lai X","year":"2023","unstructured":"Lai X, Wu A, Bing Y, Liu Y, Luo J, Yan H, Zheng P. Retinoic acid protects against lipopolysaccharide-induced                         ferroptotic liver injury and iron disorders by regulating Nrf2\/HO-1 and RAR\u03b2                         signaling. Free                             Radical Biol Med, 2023, 205: 202-213.","journal-title":"Free                             Radical Biol Med"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"961892","DOI":"10.3389\/fnut.2022.961892","volume":"9","author":"Zhang L","year":"2022","unstructured":"Zhang L, Dai X, Wang L, Cai J, Shen J, Shen Y, Li X. Iron overload accelerated lipid metabolism disorder and liver                         injury in rats with non-alcoholic fatty liver disease. Front Nutr, 2022, 9:","journal-title":"Front Nutr"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"6493","DOI":"10.3390\/ijms22126493","volume":"22","author":"Nemeth E","year":"2021","unstructured":"Nemeth E, Ganz T. Hepcidin-ferroportin interaction controls systemic iron                         homeostasis. Int J Mol Sci, 2021, 22:","journal-title":"Int J Mol Sci"},{"key":"CITATION49","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.ajpath.2021.04.005","volume":"191","author":"Bloomer SA","year":"2021","unstructured":"Bloomer SA, Brown KE. Hepcidin and iron metabolism in experimental liver injury. Am J Pathol, 2021, 191: 1165-1179.","journal-title":"Am J Pathol"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jhep.2016.03.007","volume":"65","author":"Bao WD","year":"2016","unstructured":"Bao WD, Fan Y, Deng YZ, Long LY, Wang J, Guan DX, Qian ZY. Iron overload in hereditary tyrosinemia type 1 induces liver                         injury through the Sp1\/Tfr2\/hepcidin axis. J Hepatol, 2016, 65: 137-145.","journal-title":"J Hepatol"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"4977","DOI":"10.1182\/blood-2011-03-345066","volume":"118","author":"Theurl I","year":"2011","unstructured":"Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K. Pharmacologic inhibition of hepcidin expression reverses anemia                         of chronic inflammation in rats. Blood, 2011, 118: 4977-4984.","journal-title":"Blood"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1182\/blood-2010-06-289082","volume":"117","author":"Poli M","year":"2011","unstructured":"Poli M, Girelli D, Campostrini N, Maccarinelli F, Finazzi D, Luscieti S, Nai A. Heparin: a potent inhibitor of hepcidin expression in                         vitro and in vivo. Blood, 2011, 117: 997-1004.","journal-title":"Blood"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1474-9726.2011.00683.x","volume":"10","author":"Elis S","year":"2011","unstructured":"Elis S, Wu YJ, Courtland HW, Sun H, Rosen CJ, Adamo ML, Yakar S. Increased serum IGF-1 levels protect the musculoskeletal system                         but are associated with elevated oxidative stress markers and increased                         mortality independent of tissue igf1 gene expression. Aging                             Cell, 2011, 10: 547-550.","journal-title":"Aging                             Cell"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/biof.1255","volume":"42","author":"Puche JE","year":"2016","unstructured":"Puche JE, Mu\u00f1oz \u00da, Garc\u00eda\u2010Magari\u00f1o M, S\u00e1daba MC, Castilla\u2010Cort\u00e1zar I. PartialIGF \u20101 deficiency induces brain oxidative damage and                         edema, which are ameliorated by replacement therapy. Biofactors, 2016, 42: 60-79.","journal-title":"Biofactors"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.etp.2008.04.012","volume":"60","author":"Kokoszko A","year":"2008","unstructured":"Kokoszko A, D\u0105browski J, Lewi\u0144ski A, Karbownik-Lewi\u0144ska M. Protective effects of GH and IGF-I against iron-induced lipid                         peroxidation in vivo. Exp Toxicologic                             Pathol, 2008, 60: 453-458.","journal-title":"Exp Toxicologic                             Pathol"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/febs.15844","volume":"289","author":"Di Tullio F","year":"2022","unstructured":"Di Tullio F, Schwarz M, Zorgati H, Mzoughi S, Guccione E. The duality of PRDM proteins: epigenetic and structural                         perspectives. FEBS J, 2022, 289: 1256-1275.","journal-title":"FEBS J"},{"key":"CITATION57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/292574","volume":"2015","author":"Maggio M","year":"2015","unstructured":"Maggio M, De Vita F, Fisichella A, Lauretani F, Ticinesi A, Ceresini G, Cappola A. The Role of the Multiple Hormonal Dysregulation in the Onset of                         \u201cAnemia of Aging\u201d: focus on Testosterone, IGF-1, and Thyroid Hormones. Int J Endocrinol, 2015, 2015: 1-22.","journal-title":"Int J Endocrinol"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"F488","DOI":"10.1152\/ajprenal.00044.2008","volume":"295","author":"Kucic T","year":"2008","unstructured":"Kucic T, Copland IB, Cuerquis J, Coutu DL, Chalifour LE, Gagnon RF, Galipeau J. Mesenchymal stromal cells genetically engineered to overexpress                         IGF-I enhance cell-based gene therapy of renal failure-induced anemia. Am J Physiol                             Renal Physiol, 2008, 295: F488-F496.","journal-title":"Am J Physiol                             Renal Physiol"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3324\/haematol.2019.232124","volume":"105","author":"Camaschella C","year":"2020","unstructured":"Camaschella C, Nai A, Silvestri L. Iron metabolism and iron disorders revisited in the hepcidin era. Haematologica, 2020, 105: 260-272.","journal-title":"Haematologica"},{"key":"CITATION60","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1146\/annurev-med-050109-142444","volume":"62","author":"Ganz T","year":"2011","unstructured":"Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev                             Med, 2011, 62: 347-360.","journal-title":"Annu Rev                             Med"},{"key":"CITATION61","doi-asserted-by":"publisher","first-page":"788247","DOI":"10.3389\/fendo.2021.788247","volume":"12","author":"Krygier A","year":"2021","unstructured":"Krygier A, Szczepanek-Parulska E, Cie\u015blewicz M, Wrotkowska E, Chanaj-Kaczmarek J, Rucha\u0142a M. Iron homeostasis and hepcidin concentration in patients with                         acromegaly. Front Endocrinol, 2021, 12:","journal-title":"Front Endocrinol"},{"key":"CITATION62","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/hep.25615","volume":"56","author":"Goodnough JB","year":"2012","unstructured":"Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology, 2012, 56: 291-299.","journal-title":"Hepatology"},{"key":"CITATION63","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.freeradbiomed.2021.03.019","volume":"168","author":"Banerjee S","year":"2021","unstructured":"Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, Sircar D. Black pepper prevents anemia of inflammation by inhibiting                         hepcidin over-expression through BMP6-SMAD1\/ IL6-STAT3 signaling pathway. Free                             Radical Biol Med, 2021, 168: 189-202.","journal-title":"Free                             Radical Biol Med"},{"key":"CITATION64","doi-asserted-by":"publisher","first-page":"649640","DOI":"10.3389\/fnut.2021.649640","volume":"8","author":"Zhang F","year":"2021","unstructured":"Zhang F, Zhao P, Qian Z, Zhong M. Central nervous system inflammation induced by lipopolysaccharide                         up-regulates hepatic hepcidin expression by activating the IL-6\/JAK2\/STAT3                         pathway in mice. Front Nutr, 2021, 8:","journal-title":"Front Nutr"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/01702924DE584195AB2D05E60E7C3557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023275","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/01702924DE584195AB2D05E60E7C3557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T05:34:59Z","timestamp":1706247299000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2023275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":64,"URL":"https:\/\/doi.org\/10.3724\/abbs.2023275","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,1]]}}}