{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:33:54Z","timestamp":1787240034465,"version":"build-2736575974"},"reference-count":42,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2024,3,1]]},"DOI":"10.3724\/abbs.2024029","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:59:28Z","timestamp":1709870368000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Baicalin ameliorates the gut barrier function and                     intestinal microbiota of broiler chickens"],"prefix":"10.3724","author":[{"given":"Shuangxiu","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuohai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansen","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s13238-020-00784-w","volume":"12","author":"Lin TL","year":"2021","unstructured":"Lin TL, Lu CC, Lai WF, Wu TS, Lu JJ, Chen YM, Tzeng CM. Role of gut microbiota in identification of novel TCM-derived                         active metabolites. Protein Cell, 2021, 12: 394-410.","journal-title":"Protein Cell"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"E5896","DOI":"10.1073\/pnas.1801745115","volume":"115","author":"Dai J","year":"2018","unstructured":"Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J. Chemoproteomics reveals baicalin activates hepatic CPT1 to                         ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci                             USA, 2018, 115: E5896-E5905.","journal-title":"Proc Natl Acad Sci                             USA"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.ijbiomac.2020.10.259","volume":"166","author":"Cui L","year":"2021","unstructured":"Cui L, Guan X, Ding W, Luo Y, Wang W, Bu W, Song J. Scutellaria baicalensis Georgi polysaccharide ameliorates                         DSS-induced ulcerative colitis by improving intestinal barrier function and                         modulating gut microbiota. Int J Biol                             Macromolecules, 2021, 166: 1035-1045.","journal-title":"Int J Biol                             Macromolecules"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"32225","DOI":"10.1038\/srep32225","volume":"6","author":"Bae MJ","year":"2016","unstructured":"Bae MJ, Shin HS, See HJ, Jung SY, Kwon DA, Shon DH. Baicalein induces CD4+Foxp3+ T cells and enhances intestinal                         barrier function in a mouse model of food allergy. Sci Rep, 2016, 6:","journal-title":"Sci Rep"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1021\/acschemneuro.8b00074","volume":"9","author":"Gao L","year":"2018","unstructured":"Gao L, Li J, Zhou Y, Huang X, Qin X, Du G. Effects of baicalein on cortical proinflammatory cytokines and                         the intestinal microbiome in senescence accelerated mouse prone 8. ACS Chem                             Neurosci, 2018, 9: 1714-1724.","journal-title":"ACS Chem                             Neurosci"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"48863","DOI":"10.18632\/oncotarget.16458","volume":"8","author":"Yang Y","year":"2017","unstructured":"Yang Y, Chen G, Yang Q, Ye J, Cai X, Tsering P, Cheng X. Gut microbiota drives the attenuation of dextran sulphate                         sodium-induced colitis by Huangqin decoction. Oncotarget, 2017, 8: 48863-48874.","journal-title":"Oncotarget"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"eaba5435","DOI":"10.1126\/science.aba5435","volume":"368","author":"Wang H","year":"2020","unstructured":"Wang H, Sun S, Ge W, Zhao L, Hou B, Wang K, Lyu Z. Horizontal gene transfer of Fhb7 from fungus                         underlies Fusarium head blight resistance in wheat. Science, 2020, 368:","journal-title":"Science"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/10937404.2017.1326071","volume":"20","author":"Robert H","year":"2017","unstructured":"Robert H, Payros D, Pinton P, Th\u00e9odorou V, Mercier-Bonin M, Oswald IP. Impact of mycotoxins on the intestine: are mucus and microbiota                         new targets?. J Toxicol                             Environ Health Part B, 2017, 20: 249-275.","journal-title":"J Toxicol                             Environ Health Part B"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s00204-018-2228-6","volume":"92","author":"Vignal C","year":"2018","unstructured":"Vignal C, Djouina M, Pichavant M, Caboche S, Waxin C, Beury D, Hot D. Chronic ingestion of deoxynivalenol at human dietary levels                         impairs intestinal homeostasis and gut microbiota in mice. Arch Toxicol, 2018, 92: 2327-2338.","journal-title":"Arch Toxicol"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.psj.2019.10.034","volume":"99","author":"Yang X","year":"2020","unstructured":"Yang X, Liang S, Guo F, Ren Z, Yang X, Long F. Gut microbiota mediates the protective role of                         Lactobacillus plantarum in ameliorating deoxynivalenol-induced                         apoptosis and intestinal inflammation of broiler chickens. Poultry Sci, 2020, 99: 2395-2406.","journal-title":"Poultry Sci"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"e00007","DOI":"10.1128\/mBio.00007-17","volume":"8","author":"Payros D","year":"2017","unstructured":"Payros D, Dobrindt U, Martin P, Secher T, Bracarense APFL, Boury M, Laffitte J. The food contaminant deoxynivalenol exacerbates the genotoxicity                         of gut microbiota. mBio, 2017, 8: e00007-17.","journal-title":"mBio"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s42003-021-02827-2","volume":"4","author":"Feng Y","year":"2021","unstructured":"Feng Y, Wang Y, Zhu B, Gao GF, Guo Y, Hu Y. Metagenome-assembled genomes and gene catalog from the chicken                         gut microbiome aid in deciphering antibiotic resistomes. Commun Biol, 2021, 4:","journal-title":"Commun Biol"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13059-020-1947-1","volume":"21","author":"Glendinning L","year":"2020","unstructured":"Glendinning L, Stewart RD, Pallen MJ, Watson KA, Watson M. Assembly of hundreds of novel bacterial genomes from the chicken                         caecum. Genome Biol, 2020, 21:","journal-title":"Genome Biol"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.3389\/fmicb.2017.01967","volume":"8","author":"Ding J","year":"2017","unstructured":"Ding J, Dai R, Yang L, He C, Xu K, Liu S, Zhao W. Inheritance and establishment of gut microbiota in chickens. Front Microbiol, 2017, 8:","journal-title":"Front Microbiol"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.3389\/fmicb.2017.01089","volume":"8","author":"Wilkinson TJ","year":"2017","unstructured":"Wilkinson TJ, Cowan AA, Vallin HE, Onime LA, Oyama LB, Cameron SJ, Gonot C. Characterization of the microbiome along the gastrointestinal                         tract of growing turkeys. Front Microbiol, 2017, 8:","journal-title":"Front Microbiol"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3382\/ps\/pew372","volume":"96","author":"Xiao Y","year":"2017","unstructured":"Xiao Y, Xiang Y, Zhou W, Chen J, Li K, Yang H. Microbial community mapping in intestinal tract of broiler                         chicken. Poultry Sci, 2017, 96: 1387-1393.","journal-title":"Poultry Sci"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3389\/fmicb.2017.01310","volume":"8","author":"Cui Y","year":"2017","unstructured":"Cui Y, Wang Q, Liu S, Sun R, Zhou Y, Li Y. Age-related variations in intestinal microflora of free-range and                         caged hens. Front Microbiol, 2017, 8:","journal-title":"Front Microbiol"},{"key":"CITATION18","doi-asserted-by":"crossref","unstructured":"Wang L, Lilburn M, Yu Z. Intestinal microbiota of broiler                         chickens as affected by litter management regimens.                              Front                         Microbiol                          2016, 7: 593.","DOI":"10.3389\/fmicb.2016.00593"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s40168-020-00908-8","volume":"8","author":"McKenna A","year":"2020","unstructured":"McKenna A, Ijaz UZ, Kelly C, Linton M, Sloan WT, Green BD, Lavery U. Impact of industrial production system parameters on chicken                         microbiomes: mechanisms to improve performance and reduce Campylobacter. Microbiome, 2020, 8:","journal-title":"Microbiome"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"e01300","DOI":"10.1128\/mSystems.01300-20","volume":"6","author":"Zenner C","year":"2021","unstructured":"Zenner C, Hitch TCA, Riedel T, Wortmann E, Tiede S, Buhl EM, Abt B. Early-Life immune system maturation in chickens using a synthetic                         community of cultured gut bacteria. mSystems, 2021, 6: e01300-20.","journal-title":"mSystems"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.3389\/fimmu.2017.01592","volume":"8","author":"Wang H","year":"2017","unstructured":"Wang H, Ni X, Qing X, Liu L, Lai J, Khalique A, Li G. Probiotic enhanced intestinal immunity in broilers against                         subclinical necrotic enteritis. Front Immunol, 2017, 8:","journal-title":"Front Immunol"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"45308","DOI":"10.1038\/srep45308","volume":"7","author":"Yan W","year":"2017","unstructured":"Yan W, Sun C, Yuan J, Yang N. Gut metagenomic analysis reveals prominent roles of                          Lactobacillus and cecal microbiota in chicken feed efficiency. Sci Rep, 2017, 7:","journal-title":"Sci Rep"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12917-022-03392-4","volume":"18","author":"Wan S","year":"2022","unstructured":"Wan S, Sun N, Li H, Khan A, Zheng X, Sun Y, Fan R. Deoxynivalenol damages the intestinal barrier and biota of the                         broiler chickens. BMC Vet Res, 2022, 18:","journal-title":"BMC Vet Res"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s13568-017-0439-5","volume":"7","author":"Qing X","year":"2017","unstructured":"Qing X, Zeng D, Wang H, Ni X, Liu L, Lai J, Khalique A. Preventing subclinical necrotic enteritis through Lactobacillus                         johnsonii BS15 by ameliorating lipid metabolism and intestinal                         microflora in broiler chickens. AMB Expr, 2017, 7:","journal-title":"AMB Expr"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s40168-017-0315-1","volume":"5","author":"Gao P","year":"2017","unstructured":"Gao P, Ma C, Sun Z, Wang L, Huang S, Su X, Xu J. Feed-additive probiotics accelerate yet antibiotics delay                         intestinal microbiota maturation in broiler chicken. Microbiome, 2017, 5:","journal-title":"Microbiome"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1039\/D0FO03080E","volume":"12","author":"Xu B","year":"2021","unstructured":"Xu B, Yan Y, Yin B, Zhang L, Qin W, Niu Y, Tang Y. Dietary glycyl-glutamine supplementation ameliorates intestinal                         integrity, inflammatory response, and oxidative status in association with                         the gut microbiota in LPS-challenged piglets. Food Funct, 2021, 12: 3539-3551.","journal-title":"Food Funct"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3390\/ijms20102390","volume":"20","author":"Fu S","year":"2019","unstructured":"Fu S, Zhuang F, Guo L, Qiu Y, Xiong J, Ye C, Liu Y. Effect of baicalin-aluminum complexes on fecal microbiome in                         piglets. Int J Mol Sci, 2019, 20:","journal-title":"Int J Mol Sci"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1039\/D1FO00055A","volume":"12","author":"Wang J","year":"2021","unstructured":"Wang J, Ishfaq M, Li J. Baicalin ameliorates Mycoplasma gallisepticum-induced                         inflammatory injury in the chicken lung through regulating the intestinal                         microbiota and phenylalanine metabolism. Food Funct, 2021, 12: 4092-4104.","journal-title":"Food Funct"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.molmed.2017.02.008","volume":"23","author":"Kaakoush NO","year":"2017","unstructured":"Kaakoush NO, Morris MJ. More flavor for flavonoid-based interventions?. Trends Mol                             Med, 2017, 23: 293-295.","journal-title":"Trends Mol                             Med"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1089\/dna.2021.0080","volume":"40","author":"Guo L","year":"2021","unstructured":"Guo L, He J, Zhang J, Zhang X, Zhang D, Zhou L, Yuan Y. Baicalin-aluminum modulates the broiler gut microbiome. DNA Cell Biol, 2021, 40: 881-894.","journal-title":"DNA Cell Biol"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"100807","DOI":"10.1016\/j.psj.2020.10.061","volume":"100","author":"Guo F","year":"2021","unstructured":"Guo F, Wang F, Ma H, Ren Z, Yang X, Yang X. Study on the interactive effect of deoxynivalenol and Clostridium                         perfringens on the jejunal health of broiler chickens. Poultry Sci, 2021, 100:","journal-title":"Poultry Sci"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2133.2006.07642.x","volume":"156","author":"Peltonen S","year":"2007","unstructured":"Peltonen S, Riehokainen J, Pummi K, Peltonen J. Tight junction components occludin, ZO-1, and claudin-1, -4 and                         -5 in active and healing psoriasis. Br J                             Dermatol, 2007, 156: 466-472.","journal-title":"Br J                             Dermatol"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3390\/toxins14100682","volume":"14","author":"Zhai X","year":"2022","unstructured":"Zhai X, Qiu Z, Wang L, Luo Y, He W, Yang J. Possible toxic mechanisms of deoxynivalenol (DON) exposure to                         intestinal barrier damage and dysbiosis of the gut microbiota in laying hens. Toxins, 2022, 14:","journal-title":"Toxins"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3390\/toxins8090264","volume":"8","author":"Springler A","year":"2016","unstructured":"Springler A, Hessenberger S, Schatzmayr G, Mayer E. Early activation of MAPK p44\/42 is partially involved in                         DON-induced disruption of the intestinal barrier function and tight junction                         network. Toxins, 2016, 8:","journal-title":"Toxins"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"114660","DOI":"10.1016\/j.biopha.2023.114660","volume":"162","author":"Li L","year":"2023","unstructured":"Li L, Cui H, Zhang Y, Xie W, Lin Y, Guo Y, Huang T. Baicalin ameliorates multidrug-resistant Pseudomonas                         aeruginosa induced pulmonary inflammation in rat via arginine                         biosynthesis. Biomed                             Pharmacother, 2023, 162:","journal-title":"Biomed                             Pharmacother"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s40104-018-0286-5","volume":"9","author":"Wu S","year":"2018","unstructured":"Wu S, Liu Y, Duan Y, Wang F, Guo F, Yan F, Yang X. Intestinal toxicity of deoxynivalenol is limited by                         supplementation with Lactobacillus plantarum JM113 and                         consequentially altered gut microbiota in broiler chickens. J Anim Sci                             Biotechnol, 2018, 9:","journal-title":"J Anim Sci                             Biotechnol"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.intimp.2015.07.024","volume":"29","author":"Wang L","year":"2015","unstructured":"Wang L, Liu C, Chen M, Ya T, Huang W, Gao P, Zhang H. A novel Lactobacillus plantarum strain P-8                         activates beneficial immune response of broiler chickens. Int                             Immunopharmacol, 2015, 29: 901-907.","journal-title":"Int                             Immunopharmacol"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3389\/fimmu.2017.00704","volume":"8","author":"Chen Q","year":"2017","unstructured":"Chen Q, Tong C, Ma S, Zhou L, Zhao L, Zhao X. Involvement of microRNAs in probiotics-induced reduction of the                         cecal inflammation by Salmonella Typhimurium. Front Immunol, 2017, 8:","journal-title":"Front Immunol"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bcp.2017.04.033","volume":"139","author":"Esp\u00edn JC","year":"2017","unstructured":"Esp\u00edn JC, Gonz\u00e1lez-Sarr\u00edas A, Tom\u00e1s-Barber\u00e1n FA. The gut microbiota: a key factor in the therapeutic effects of                         (poly) phenols. Biochem                             Pharmacol, 2017, 139: 82-93.","journal-title":"Biochem                             Pharmacol"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1080\/10408398.2021.1965536","volume":"63","author":"Li Q","year":"2023","unstructured":"Li Q, Van de Wiele T. Gut microbiota as a driver of the interindividual variability of                         cardiometabolic effects from tea polyphenols. Crit Rev                             Food Sci Nutr, 2023, 63: 1500-1526.","journal-title":"Crit Rev                             Food Sci Nutr"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s40168-021-01115-9","volume":"9","author":"Wu Z","year":"2021","unstructured":"Wu Z, Huang S, Li T, Li N, Han D, Zhang B, Xu ZZ. Gut microbiota from green tea polyphenol-dosed mice improves                         intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome, 2021, 9:","journal-title":"Microbiome"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40104-022-00737-9","volume":"13","author":"Bai Y","year":"2022","unstructured":"Bai Y, Ma K, Li J, Ren Z, Zhang J, Shan A. Lactobacillus rhamnosus GG ameliorates                         DON-induced intestinal damage depending on the enrichment of beneficial                         bacteria in weaned piglets. J Anim Sci                             Biotechnol, 2022, 13:","journal-title":"J Anim Sci                             Biotechnol"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/8387BDDA79A346F2AD77325ED2837881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2024029","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/8387BDDA79A346F2AD77325ED2837881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T22:49:21Z","timestamp":1710974961000},"score":1,"resource":{"primary":{"URL":"https:\/\/engine.scichina.com\/doi\/10.3724\/abbs.2024029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":42,"URL":"https:\/\/doi.org\/10.3724\/abbs.2024029","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}