{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:44:57Z","timestamp":1790999097496,"version":"4.1.0"},"reference-count":27,"publisher":"China Science Publishing & Media Ltd.","issue":"10","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2024,10,1]]},"DOI":"10.3724\/abbs.2024098","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:10:10Z","timestamp":1717708210000},"page":"1509-1520","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["FTO-mediated m                     <sup>6<\/sup>A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis"],"prefix":"10.3724","volume":"56","author":[{"given":"Tingjuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/hep.31418","volume":"73","author":"Zhang J","year":"2021","unstructured":"Zhang J, Li Y, Liu Q, Huang Y, Li R, Wu T, Zhang Z. Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on smad2 in hepatic stellate cells. Hepatology, 2021, 73: 1140-1157.","journal-title":"Hepatology"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mcna.2013.09.002","volume":"98","author":"Gossard AA","year":"2014","unstructured":"Gossard AA, Talwalkar JA. Cholestatic liver disease. Med Clin N Am, 2014, 98: 73-85.","journal-title":"Med Clin N Am"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrm2245","volume":"8","author":"Klionsky DJ","year":"2007","unstructured":"Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol, 2007, 8: 931-937.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.jhep.2022.03.031","volume":"77","author":"Baselli GA","year":"2022","unstructured":"Baselli GA, Jamialahmadi O, Pelusi S, Ciociola E, Malvestiti F, Saracino M, Santoro L. Rare ATG7 genetic variants predispose patients to severe fatty liver disease. J Hepatol, 2022, 77: 596-606.","journal-title":"J Hepatol"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","volume":"73","author":"Gao J","year":"2020","unstructured":"Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, Cooper SA. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. J Hepatol, 2020, 73: 1144-1154.","journal-title":"J Hepatol"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrg3724","volume":"15","author":"Fu Y","year":"2014","unstructured":"Fu Y, Dominissini D, Rechavi G, He C. Gene expression regulation mediated through reversible m                         6A RNA methylation. Nat Rev Genet, 2014, 15: 293-306.","journal-title":"Nat Rev Genet"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s12033-016-9947-9","volume":"58","author":"Wu R","year":"2016","unstructured":"Wu R, Jiang D, Wang Y, Wang X. N                         6-methyladenosine (m                         6A) methylation in mRNA with a dynamic and reversible epigenetic modification. Mol Biotechnol, 2016, 58: 450-459.","journal-title":"Mol Biotechnol"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"Zhao X","year":"2014","unstructured":"Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res, 2014, 24: 1403-1419.","journal-title":"Cell Res"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41422-018-0034-6","volume":"28","author":"Deng X","year":"2018","unstructured":"Deng X, Su R, Weng H, Huang H, Li Z, Chen J. RNA N6-methyladenosine modification in cancers: current status and perspectives. Cell Res, 2018, 28: 507-517.","journal-title":"Cell Res"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41422-018-0069-8","volume":"28","author":"Jin S","year":"2018","unstructured":"Jin S, Zhang X, Miao Y, Liang P, Zhu K, She Y, Wu Y. m                         6A RNA modification controls autophagy through upregulating ULK1 protein abundance. Cell Res, 2018, 28: 955-957.","journal-title":"Cell Res"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","volume":"16","author":"Wang X","year":"2020","unstructured":"Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q. m                         6A mRNA methylation controls autophagy and adipogenesis by targeting                          Atg5 and                          Atg7. Autophagy, 2020, 16: 1221-1235.","journal-title":"Autophagy"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"109034","DOI":"10.1016\/j.biopha.2019.109034","volume":"116","author":"Huang TJ","year":"2019","unstructured":"Huang TJ, Ren JJ, Zhang QQ, Kong YY, Zhang HY, Guo XH, Fan HQ. IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K\/AKT\/mTOR pathway. Biomed Pharmacother, 2019, 116:","journal-title":"Biomed Pharmacother"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"116902","DOI":"10.1016\/j.lfs.2019.116902","volume":"237","author":"Kong Y","year":"2019","unstructured":"Kong Y, Huang T, Zhang H, Zhang Q, Ren J, Guo X, Fan H. The lncRNA NEAT1\/miR-29b\/Atg9a axis regulates IGFBPrP1-induced autophagy and activation of mouse hepatic stellate cells. Life Sci, 2019, 237:","journal-title":"Life Sci"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1080\/15548627.2022.2151190","volume":"19","author":"Duckney P","year":"2023","unstructured":"Duckney P, Li C, Hussey PJ, Wang P. TraB, a novel plant ER-mitochondrial contact site protein functions as a mitophagy receptor in plants. Autophagy, 2023, 19: 2148-2150.","journal-title":"Autophagy"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/s41419-022-05381-9","volume":"13","author":"Gonz\u00e1lez-Rodr\u00edguez P","year":"2022","unstructured":"Gonz\u00e1lez-Rodr\u00edguez P, Delorme-Axford E, Bernard A, Keane L, Stratoulias V, Grabert K, Engskog-Vlachos P. SETD2 transcriptional control of ATG14L\/S isoforms regulates autophagosome\u2013lysosome fusion. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s13046-019-1328-3","volume":"38","author":"Chai W","year":"2019","unstructured":"Chai W, Ye F, Zeng L, Li Y, Yang L. HMGB1-mediated autophagy regulates sodium\/iodide symporter protein degradation in thyroid cancer cells. J Exp Clin Cancer Res, 2019, 38:","journal-title":"J Exp Clin Cancer Res"},{"key":"CITATION17","unstructured":"Liu S, Li G, Li Q, Zhang Q, Zhuo L, Chen X, Zhai B,                          et al. The roles and mechanisms of YTH domain-containing proteins in cancer development and progression.                                                       Am J Cancer Res                          2020, 10: 1068\u20131084."},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.1016\/j.ymthe.2022.07.020","volume":"30","author":"Li Y","year":"2022","unstructured":"Li Y, Kang X, Zhou Z, Pan L, Chen H, Liang X, Chu J. The m                         6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis. Mol Ther, 2022, 30: 3714-3728.","journal-title":"Mol Ther"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"102378","DOI":"10.1016\/j.redox.2022.102378","volume":"54","author":"Sun R","year":"2022","unstructured":"Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L. The m                         6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis. Redox Biol, 2022, 54:","journal-title":"Redox Biol"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"e7299","DOI":"10.1590\/1414-431x20187299","volume":"51","author":"Li S","year":"2018","unstructured":"Li S, Wang X, Zhang J, Li J, Liu X, Ma Y, Han C. Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. Braz J Med Biol Res, 2018, 51:","journal-title":"Braz J Med Biol Res"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"174900","DOI":"10.1016\/j.ejphar.2022.174900","volume":"922","author":"Yang JJ","year":"2022","unstructured":"Yang JJ, Wang J, Yang Y, Yang Y, Li J, Lu D, Lu C. ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m                         6A dependent manner. Eur J Pharmacol, 2022, 922:","journal-title":"Eur J Pharmacol"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"102151","DOI":"10.1016\/j.redox.2021.102151","volume":"47","author":"Shen M","year":"2021","unstructured":"Shen M, Li Y, Wang Y, Shao J, Zhang F, Yin G, Chen A. N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells. Redox Biol, 2021, 47:","journal-title":"Redox Biol"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2022.02.028","volume":"182","author":"Shen M","year":"2022","unstructured":"Shen M, Guo M, Li Y, Wang Y, Qiu Y, Shao J, Zhang F. m                         6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells. Free Radical Biol Med, 2022, 182: 246-259.","journal-title":"Free Radical Biol Med"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.cell.2014.08.005","volume":"158","author":"Lee M","year":"2014","unstructured":"Lee M, Kim B, Kim VN. Emerging roles of RNA modification: m                         6A and U-Tail. Cell, 2014, 158: 980-987.","journal-title":"Cell"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12943-019-1119-7","volume":"18","author":"Liu L","year":"2019","unstructured":"Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N. m                         6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma. Mol Cancer, 2019, 18:","journal-title":"Mol Cancer"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/stcltm\/szac049","volume":"11","author":"He M","year":"2022","unstructured":"He M, Lei H, He X, Liu Y, Wang A, Ren Z, Liu X. METTL14 regulates osteogenesis of bone marrow mesenchymal stem cells via inducing autophagy through m                         6A\/IGF2BPs\/Beclin-1 signal axis. Stem Cells Transl Med, 2022, 11: 987-1001.","journal-title":"Stem Cells Transl Med"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"116182","DOI":"10.1016\/j.bone.2021.116182","volume":"154","author":"He Y","year":"2022","unstructured":"He Y, Wang W, Xu X, Yang B, Yu X, Wu Y, Wang J. Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m                         6A modification. Bone, 2022, 154:","journal-title":"Bone"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/D82A4886958F40D0B284E2AA098DF411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024098","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/D82A4886958F40D0B284E2AA098DF411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T02:49:30Z","timestamp":1732157370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,8,22]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2024098","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,22]]}}}