{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:37:38Z","timestamp":1772941058631,"version":"3.50.1"},"reference-count":60,"publisher":"China Science Publishing & Media Ltd.","issue":"10","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2024,10,1]]},"DOI":"10.3724\/abbs.2024155","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:43:14Z","timestamp":1725612194000},"page":"1537-1548","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the cytotoxicity of a new gold(I) complex towards hepatocellular carcinoma by inhibiting TrxR activity"],"prefix":"10.3724","volume":"56","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haokun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-019-0987-8","volume":"567","author":"Jiang Y","year":"2019","unstructured":"Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature, 2019, 567: 257-261.","journal-title":"Nature"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1055\/a-2242-7543","volume":"44","author":"Liu H","year":"2024","unstructured":"Liu H, Sethi V, Li X, Xiao Y, Humar A. Liver transplantation for hepatocellular carcinoma: a narrative review and a glimpse into the future. Semin Liver Dis, 2024, 44: 79-98.","journal-title":"Semin Liver Dis"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"e190024","DOI":"10.1148\/rycan.2020190024","volume":"2","author":"Mendiratta-Lala M","year":"2020","unstructured":"Mendiratta-Lala M, Masch WR, Shampain K, Zhang A, Jo AS, Moorman S, Aslam A. MRI assessment of hepatocellular carcinoma after Local-Regional therapy: a comprehensive review. Radiol-Imag Cancer, 2020, 2:","journal-title":"Radiol-Imag Cancer"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1002\/hep.30633","volume":"70","author":"Brown ZJ","year":"2019","unstructured":"Brown ZJ, Greten TF, Heinrich B. Adjuvant treatment of hepatocellular carcinoma: prospect of immunotherapy. Hepatology, 2019, 70: 1437-1442.","journal-title":"Hepatology"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.freeradbiomed.2018.01.028","volume":"127","author":"Benhar M","year":"2018","unstructured":"Benhar M. Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress. Free Radical Biol Med, 2018, 127: 160-164.","journal-title":"Free Radical Biol Med"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.1021\/acs.jmedchem.8b01595","volume":"62","author":"Bian M","year":"2019","unstructured":"Bian M, Fan R, Zhao S, Liu W. Targeting the thioredoxin system as a strategy for cancer therapy. J Med Chem, 2019, 62: 7309-7321.","journal-title":"J Med Chem"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.tips.2017.06.001","volume":"38","author":"Zhang J","year":"2017","unstructured":"Zhang J, Li X, Han X, Liu R, Fang J. Targeting the thioredoxin system for cancer therapy. Trends Pharmacol Sci, 2017, 38: 794-808.","journal-title":"Trends Pharmacol Sci"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","volume":"66","author":"Lu J","year":"2014","unstructured":"Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radical Biol Med, 2014, 66: 75-87.","journal-title":"Free Radical Biol Med"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/13543776.2017.1272576","volume":"27","author":"Zhang B","year":"2017","unstructured":"Zhang B, Zhang J, Peng S, Liu R, Li X, Hou Y, Han X. Thioredoxin reductase inhibitors: a patent review. Expert Opin Ther Patents, 2017, 27: 547-556.","journal-title":"Expert Opin Ther Patents"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"102351","DOI":"10.1016\/j.redox.2022.102351","volume":"54","author":"Xu Z","year":"2022","unstructured":"Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F. Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma. Redox Biol, 2022, 54:","journal-title":"Redox Biol"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"111721","DOI":"10.1016\/j.ejmech.2019.111721","volume":"183","author":"Fan R","year":"2019","unstructured":"Fan R, Bian M, Hu L, Liu W. A new rhodium(I) NHC complex inhibits TrxR: in vitro cytotoxicity and in vivo hepatocellular carcinoma suppression. Eur J Med Chem, 2019, 183:","journal-title":"Eur J Med Chem"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.bbrc.2011.12.091","volume":"417","author":"Skogastierna C","year":"2012","unstructured":"Skogastierna C, Johansson M, Parini P, Eriksson M, Eriksson LC, Ekstr\u00f6m L, Bj\u00f6rkhem-Bergman L. Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development. Biochem Biophys Res Commun, 2012, 417: 1046-1051.","journal-title":"Biochem Biophys Res Commun"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"13005","DOI":"10.1074\/jbc.C600012200","volume":"281","author":"Yoo MH","year":"2006","unstructured":"Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem, 2006, 281: 13005-13008.","journal-title":"J Biol Chem"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/med.21507","volume":"39","author":"Zhang J","year":"2019","unstructured":"Zhang J, Zhang B, Li X, Han X, Liu R, Fang J. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: an update. Med Res Rev, 2019, 39: 5-39.","journal-title":"Med Res Rev"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ejmech.2017.12.048","volume":"145","author":"Reddy TS","year":"2018","unstructured":"Reddy TS, Priv\u00e9r SH, Mirzadeh N, Bhargava SK. Synthesis of gold(I) phosphine complexes containing the 2-BrC6F4PPh2 ligand: evaluation of anticancer activity in 2D and 3D spheroidal models of HeLa cancer cells. Eur J Med Chem, 2018, 145: 291-301.","journal-title":"Eur J Med Chem"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"14237","DOI":"10.1021\/acs.inorgchem.7b02345","volume":"56","author":"Karaca \u00d6","year":"2017","unstructured":"Karaca \u00d6, Scalcon V, Meier-Menches SM, Bonsignore R, Brouwer JMJL, Tonolo F, Folda A. Characterization of hydrophilic gold(I) N-heterocyclic carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches. Inorg Chem, 2017, 56: 14237-14250.","journal-title":"Inorg Chem"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"5518","DOI":"10.1039\/D1CS00933H","volume":"51","author":"Lu Y","year":"2022","unstructured":"Lu Y, Ma X, Chang X, Liang Z, Lv L, Shan M, Lu Q. Recent development of gold(I) and gold(III) complexes as therapeutic agents for cancer diseases. Chem Soc Rev, 2022, 51: 5518-5556.","journal-title":"Chem Soc Rev"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"e1449","DOI":"10.1002\/wnan.1449","volume":"9","author":"Riley RS","year":"2017","unstructured":"Riley RS, Day ES. Gold nanoparticle\u2010mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2017, 9:","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"3934","DOI":"10.1021\/acs.jmedchem.2c01798","volume":"66","author":"Yang Z","year":"2023","unstructured":"Yang Z, Bian M, Lv L, Chang X, Wen Z, Li F, Lu Y. Tumor-targeting NHC\u2013Au(I) complex induces immunogenic cell death in hepatocellular carcinoma. J Med Chem, 2023, 66: 3934-3952.","journal-title":"J Med Chem"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.1021\/acs.jmedchem.3c00063","volume":"66","author":"Xu Z","year":"2023","unstructured":"Xu Z, Lu Q, Shan M, Jiang G, Liu Y, Yang Z, Lu Y. NSAID\u2013Au(I) complexes induce ros-driven DAMPs and interpose inflammation to stimulate the immune response against ovarian cancer. J Med Chem, 2023, 66: 7813-7833.","journal-title":"J Med Chem"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"106731","DOI":"10.1016\/j.phrs.2023.106731","volume":"190","author":"Lu Y","year":"2023","unstructured":"Lu Y, Sheng X, Liu C, Liang Z, Wang X, Liu L, Wen Z. SERD-NHC-Au(I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer. Pharmacol Res, 2023, 190:","journal-title":"Pharmacol Res"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1021\/acs.jmedchem.2c01458","volume":"66","author":"Liang Z","year":"2023","unstructured":"Liang Z, Liu L, Zhou Y, Liu W, Lu Y. Research progress on bioactive metal complexes against ER-Positive advanced breast cancer. J Med Chem, 2023, 66: 2235-2256.","journal-title":"J Med Chem"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/acs.jmedchem.3c01785","volume":"67","author":"Li F","year":"2024","unstructured":"Li F, Wen Z, Wu C, Yang Z, Wang Z, Diao W, Chen D. Simultaneous activation of immunogenic cell death and cGAS-STING pathway by liver- and mitochondria-targeted Gold(I) complexes for chemoimmunotherapy of hepatocellular carcinoma. J Med Chem, 2024, 67: 1982-2003.","journal-title":"J Med Chem"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"9197","DOI":"10.1021\/acs.jmedchem.0c00257","volume":"63","author":"Bian M","year":"2020","unstructured":"Bian M, Fan R, Jiang G, Wang Y, Lu Y, Liu W. Halo and pseudohalo gold(I)\u2013NHC complexes derived from 4,5-Diarylimidazoles with excellent in vitro and in vivo anticancer activities against HCC. J Med Chem, 2020, 63: 9197-9211.","journal-title":"J Med Chem"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"112234","DOI":"10.1016\/j.ejmech.2020.112234","volume":"193","author":"Bian M","year":"2020","unstructured":"Bian M, Wang X, Sun Y, Liu W. Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity. Eur J Med Chem, 2020, 193:","journal-title":"Eur J Med Chem"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1248\/yakushi.20-00179-2","volume":"141","author":"Momose I","year":"2021","unstructured":"Momose I, Onodera T, Kawada M. Potential anticancer activity of auranofin. Yakugaku Zasshi, 2021, 141: 315-321.","journal-title":"Yakugaku Zasshi"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"101652","DOI":"10.1016\/j.redox.2020.101652","volume":"36","author":"Liu X","year":"2020","unstructured":"Liu X, Zhang Y, Lu W, Han Y, Yang J, Jiang W, You X. Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo. Redox Biol, 2020, 36:","journal-title":"Redox Biol"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"18121","DOI":"10.1074\/jbc.M000690200","volume":"275","author":"Zhong L","year":"2000","unstructured":"Zhong L, Holmgren A. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. J Biol Chem, 2000, 275: 18121-18128.","journal-title":"J Biol Chem"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"14749","DOI":"10.1039\/c3dt51565f","volume":"42","author":"Kaiser M","year":"2013","unstructured":"Kaiser M, Leitner SP, Hirtenlehner C, List M, Gerisch A, Monkowius U. Azobenzene-functionalized N-heterocyclic carbenes as photochromic ligands in silver(i) and gold(i) complexes. Dalton Trans, 2013, 42:","journal-title":"Dalton Trans"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1039\/b602560a","volume":"30","author":"Baker MV","year":"2006","unstructured":"Baker MV, Barnard PJ, Berners-Price SJ, Brayshaw SK, Hickey JL, Skelton BW, White AH. Cationic, linear Au(i) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity. Dalton Trans, 2006, 30: 3708-3715.","journal-title":"Dalton Trans"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3390\/pharmaceutics13040461","volume":"13","author":"Babgi BA","year":"2021","unstructured":"Babgi BA, Alsayari J, Alenezi HM, Abdellatif MH, Eltayeb NE, Emwas AHM, Jaremko M. Alteration of anticancer and protein-binding properties of gold(I) alkynyl by phenolic schiff bases moieties. Pharmaceutics, 2021, 13:","journal-title":"Pharmaceutics"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1107\/S2056989018002955","volume":"74","author":"MathivathananL L","year":"2018","unstructured":"MathivathananL L, Yang G, Leng F, Raptis RG. Crystal structure and conformational analysis of doxorubicin nitrate. Acta Crystallogr E Crystallogr Commun, 2018, 74: 400-405.","journal-title":"Acta Crystallogr E Crystallogr Commun"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"15127","DOI":"10.1039\/c9dt03044a","volume":"48","author":"Stein T","year":"2019","unstructured":"Stein T, Hoffmann F, Fr\u00f6ba M. A new set of metal-organic frameworks synthesised from diisophthalate-based, 2'-phosphorus-substituted m-terphenyl linker molecules. Acta Crystallogr E Crystallogr Commun, 2019, 48: 15127-15135.","journal-title":"Acta Crystallogr E Crystallogr Commun"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053273314026370","volume":"71","author":"Sheldrick GM","year":"2015","unstructured":"Sheldrick GM. SHELXT\u2013Integrated space-group and crystal-structure determination. Acta Crystlogr A Found Adv, 2015, 71: 3-8.","journal-title":"Acta Crystlogr A Found Adv"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick GM","year":"2015","unstructured":"Sheldrick GM. Crystal structure refinement with SHELXL. Acta Crystlogr C Struct Chem, 2015, 71: 3-8.","journal-title":"Acta Crystlogr C Struct Chem"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ejmech.2017.09.027","volume":"140","author":"Zhang J","year":"2017","unstructured":"Zhang J, Liu Y, Shi D, Hu G, Zhang B, Li X, Liu R. Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. Eur J Med Chem, 2017, 140: 435-447.","journal-title":"Eur J Med Chem"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris GM","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem, 2009, 30: 2785-2791.","journal-title":"J Comput Chem"},{"key":"CITATION38","unstructured":"Schrodinger L. The AxPyMOL Molecular Graphics Plugin for Microsoft Powerpoint, Version 1.8. 2015."},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"119323","DOI":"10.1016\/j.bbamcr.2022.119323","volume":"1869","author":"Xu Q","year":"2022","unstructured":"Xu Q, Zhang J, Zhao Z, Chu Y, Fang J. Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote cancer cell apoptosis. Biochim Biophys Acta Mol Cell Res, 2022, 1869:","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"13173","DOI":"10.1039\/C9NJ02502B","volume":"43","author":"Fereidoonnezhad M","year":"2019","unstructured":"Fereidoonnezhad M, Ahmadi Mirsadeghi H, Abedanzadeh S, Yazdani A, Alamdarlou A, Babaghasabha M, Almansaf Z. Synthesis and biological evaluation of thiolate gold(I) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors. New J Chem, 2019, 43: 13173-13182.","journal-title":"New J Chem"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1074\/jbc.M807068200","volume":"284","author":"Cheng Q","year":"2009","unstructured":"Cheng Q, Sandalova T, Lindqvist Y, Arn\u00e9r ESJ. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. J Biol Chem, 2009, 284: 3998-4008.","journal-title":"J Biol Chem"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"105854","DOI":"10.1016\/j.phrs.2021.105854","volume":"174","author":"Bj\u00f8rklund G","year":"2021","unstructured":"Bj\u00f8rklund G, Zou L, Wang J, Chasapis CT, Peana M. Thioredoxin reductase as a pharmacological target. Pharmacol Res, 2021, 174:","journal-title":"Pharmacol Res"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1550-2783-2-2-38","volume":"2","author":"Kerksick C","year":"2005","unstructured":"Kerksick C, Willoughby D. The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J Int Soc Sports Nutr, 2005, 2: 38-44.","journal-title":"J Int Soc Sports Nutr"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-022-02626-4","volume":"19","author":"Liu M","year":"2022","unstructured":"Liu M, Li H, Yang R, Ji D, Xia X. GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J Neuroinflamm, 2022, 19:","journal-title":"J Neuroinflamm"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1515\/hsz-2016-0102","volume":"397","author":"Fulda S","year":"2016","unstructured":"Fulda S. Regulation of necroptosis signaling and cell death by reactive oxygen species. Biol Chem, 2016, 397: 657-660.","journal-title":"Biol Chem"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.3390\/molecules28041959","volume":"28","author":"Todorov L","year":"2023","unstructured":"Todorov L, Kostova I. Recent trends in the development of novel metal-based antineoplastic drugs. Molecules, 2023, 28:","journal-title":"Molecules"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/molecules23061410","volume":"23","author":"Yeo CI","year":"2018","unstructured":"Yeo CI, Ooi KK, Tiekink ERT. Gold-based medicine: a paradigm shift in anti-cancer therapy?. Molecules, 2018, 23:","journal-title":"Molecules"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/15384047.2016.1210732","volume":"17","author":"Hanson B","year":"2016","unstructured":"Hanson B. Necroptosis: a new way of dying?. Cancer Biol Ther, 2016, 17: 899-910.","journal-title":"Cancer Biol Ther"},{"key":"CITATION49","doi-asserted-by":"crossref","unstructured":"Chan, FK, Moriwaki K, De Rosa MJ. Detection of necrosis by release of lactate dehydrogenase activity. Methods Mol Biol 2013, 979: 65\u201370.","DOI":"10.1007\/978-1-62703-290-2_7"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s00018-016-2192-3","volume":"73","author":"He S","year":"2016","unstructured":"He S, Huang S, Shen Z. Biomarkers for the detection of necroptosis. Cell Mol Life Sci, 2016, 73: 2177-2181.","journal-title":"Cell Mol Life Sci"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","volume":"18","author":"Gong Y","year":"2019","unstructured":"Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H. The role of necroptosis in cancer biology and therapy. Mol Cancer, 2019, 18:","journal-title":"Mol Cancer"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s00018-016-2190-5","volume":"73","author":"Zhang J","year":"2016","unstructured":"Zhang J, Yang Y, He W, Sun L. Necrosome core machinery: MLKL. Cell Mol Life Sci, 2016, 73: 2153-2163.","journal-title":"Cell Mol Life Sci"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"7199","DOI":"10.1007\/s00018-021-03947-y","volume":"78","author":"Liu S","year":"2021","unstructured":"Liu S, Joshi K, Denning MF, Zhang J. RIPK3 signaling and its role in the pathogenesis of cancers. Cell Mol Life Sci, 2021, 78: 7199-7217.","journal-title":"Cell Mol Life Sci"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/cdd.2016.8","volume":"23","author":"Su Z","year":"2016","unstructured":"Su Z, Yang Z, Xie L, DeWitt JP, Chen Y. Cancer therapy in the necroptosis era. Cell Death Differ, 2016, 23: 748-756.","journal-title":"Cell Death Differ"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.canlet.2016.05.036","volume":"380","author":"Hannes S","year":"2016","unstructured":"Hannes S, Abhari BA, Fulda S. Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. Cancer Lett, 2016, 380: 31-38.","journal-title":"Cancer Lett"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1038\/aps.2017.112","volume":"38","author":"Lu B","year":"2017","unstructured":"Lu B, Gong X, Wang Z, Ding Y, Wang C, Luo T, Piao M. Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1\/RIP3 necrosome formation. Acta Pharmacol Sin, 2017, 38: 1543-1553.","journal-title":"Acta Pharmacol Sin"},{"key":"CITATION57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms18010023","volume":"18","author":"Dasgupta A","year":"2017","unstructured":"Dasgupta A, Nomura M, Shuck R, Yustein J. Cancer\u2019s achilles\u2019 heel: apoptosis and necroptosis to the rescue. Int J Mol Sci, 2017, 18:","journal-title":"Int J Mol Sci"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms22094642","volume":"22","author":"Juan CA","year":"2021","unstructured":"Juan CA, P\u00e9rez de la Lastra JM, Plou FJ, P\u00e9rez-Lebe\u00f1a E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci, 2021, 22:","journal-title":"Int J Mol Sci"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.molcel.2007.04.021","volume":"26","author":"Kim YS","year":"2007","unstructured":"Kim YS, Morgan MJ, Choksi S, Liu Z. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell, 2007, 26: 675-687.","journal-title":"Mol Cell"},{"key":"CITATION60","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.1172308","volume":"325","author":"Zhang DW","year":"2009","unstructured":"Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 2009, 325: 332-336.","journal-title":"Science"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/1AA0B14B0EC84328A395E4BE77730347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/engine.scichina.com\/doi\/pdf\/1AA0B14B0EC84328A395E4BE77730347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:49:11Z","timestamp":1732175351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,9,20]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2024155","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,20]]}}}