{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:18:30Z","timestamp":1793333910077,"version":"4.5.0"},"reference-count":27,"publisher":"China Science Publishing & Media Ltd.","issue":"4","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2025,4,1]]},"DOI":"10.3724\/abbs.2024162","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:04:46Z","timestamp":1725599086000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["YTHDF2 influences hepatic fibrosis by regulating                     ferroptosis in hepatic stellate cells by mediating the expression of ACSL4 in an                     m&amp;lt;sup&amp;gt;6&amp;lt;\/sup&amp;gt;A-dependent manner"],"prefix":"10.3724","volume":"57","author":[{"given":"Wentao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41419-018-1272-8","volume":"10","author":"George J","year":"2019","unstructured":"George J, Tsuchishima M, Tsutsumi M. Molecular mechanisms in the pathogenesis of                         N-nitrosodimethylamine induced hepatic fibrosis. Cell Death Dis, 2019, 10:","journal-title":"Cell Death Dis"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"Yang WS","year":"2016","unstructured":"Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol, 2016, 26: 165-176.","journal-title":"Trends Cell Biol"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"914977","DOI":"10.3389\/fimmu.2022.914977","volume":"13","author":"Xie H","year":"2022","unstructured":"Xie H, Shi M, Liu Y, Cheng C, Song L, Ding Z, Jin H. Identification of m6A- and ferroptosis-related lncRNA signature                         for predicting immune efficacy in hepatocellular carcinoma. Front Immunol, 2022, 13:","journal-title":"Front Immunol"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.freeradbiomed.2022.11.011","volume":"193","author":"Cho SS","year":"2022","unstructured":"Cho SS, Yang JH, Lee JH, Baek JS, Ku SK, Cho IJ, Kim KM. Ferroptosis contribute to hepatic stellate cell activation and                         liver fibrogenesis. Free                             Radical Biol Med, 2022, 193: 620-637.","journal-title":"Free                             Radical Biol Med"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","volume":"40","author":"Liao P","year":"2022","unstructured":"Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A. CD8+ T cells and fatty acids orchestrate tumor ferroptosis and                         immunity via ACSL4. Cancer Cell, 2022, 40: 365-378.e6.","journal-title":"Cancer Cell"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41419-022-05137-5","volume":"13","author":"Grube J","year":"2022","unstructured":"Grube J, Woitok MM, Mohs A, Erschfeld S, Lynen C, Trautwein C, Otto T. ACSL4-dependent ferroptosis does not represent a                         tumor-suppressive mechanism but ACSL4 rather promotes liver cancer                         progression. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12943-019-1119-7","volume":"18","author":"Liu L","year":"2019","unstructured":"Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N. m6A mRNA methylation regulates CTNNB1 to promote the                         proliferation of hepatoblastoma. Mol Cancer, 2019, 18:","journal-title":"Mol Cancer"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","volume":"139","author":"Mathiyalagan P","year":"2019","unstructured":"Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D. FTO-dependent N6-methyladenosine regulates cardiac                         function during remodeling and repair. Circulation, 2019, 139: 518-532.","journal-title":"Circulation"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1093\/nar\/gkz157","volume":"47","author":"Zhuang M","year":"2019","unstructured":"Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M. The m6A reader YTHDF1 regulates axon guidance through                         translational control of Robo3.1 expression. Nucleic Acids Res, 2019, 47: 4765-4777.","journal-title":"Nucleic Acids Res"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"102378","DOI":"10.1016\/j.redox.2022.102378","volume":"54","author":"Sun R","year":"2022","unstructured":"Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L. The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver                         fibrosis. Redox Biol, 2022, 54:","journal-title":"Redox Biol"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jare.2021.10.001","volume":"37","author":"Yang H","year":"2022","unstructured":"Yang H, Hu Y, Weng M, Liu X, Wan P, Hu Y, Ma M. Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through                         m6A-YTHDF2-dependent modulation of CBS in gastric cancer. J Adv Res, 2022, 37: 91-106.","journal-title":"J Adv Res"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"918140","DOI":"10.3389\/fimmu.2022.918140","volume":"13","author":"Li D","year":"2022","unstructured":"Li D, Li K, Zhang W, Yang KW, Mu DA, Jiang GJ, Shi RS. The m6A\/m5C\/m1A regulated gene signature predicts the prognosis                         and correlates with the immune status of hepatocellular carcinoma. Front Immunol, 2022, 13:","journal-title":"Front Immunol"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.31491\/APT.2024.03.132","volume":"6","author":"Chaplygina AV","year":"2024","unstructured":"Chaplygina AV, Zhdanova DY. Effects of mitochondrial fusion and fission regulation on mouse                         hippocampal primary cultures: relevance to Alzheimer\u2019s disease. Aging Pathobiol                             Ther, 2024, 6: 8-17.","journal-title":"Aging Pathobiol                             Ther"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.31491\/apt.2023.12.124","volume":"5","author":"Xu Z","year":"2023","unstructured":"Xu Z, Wang Z, Ma W, Huang Z. Carvacrol induces osteogenic differentiation of BMSCs and                         alleviates osteolysis in aged mice by upregulating lncRNA NEAT1 to promote                         SIRT1 expression. Aging Pathobiol                             Ther, 2023, 5: 125-139.","journal-title":"Aging Pathobiol                             Ther"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"101037","DOI":"10.1016\/j.xpro.2021.101037","volume":"3","author":"Han C","year":"2022","unstructured":"Han C, Sun L, Pan Q, Sun Y, Wang W, Chen Y. Polysome profiling followed by quantitative PCR for identifying                         potential micropeptide encoding long non-coding RNAs in suspension cell                         lines. STAR Protocols, 2022, 3:","journal-title":"STAR Protocols"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","volume":"6","author":"Liu RM","year":"2015","unstructured":"Liu RM, Desai LP. Reciprocal regulation of TGF-\u03b2 and reactive oxygen species: A                         perverse cycle for fibrosis. Redox Biol, 2015, 6: 565-577.","journal-title":"Redox Biol"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.7150\/ijms.62903","volume":"18","author":"Pan Q","year":"2021","unstructured":"Pan Q, Luo Y, Xia Q, He K. Ferroptosis and liver fibrosis. Int J Med Sci, 2021, 18: 3361-3366.","journal-title":"Int J Med Sci"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/lipd.12023","volume":"53","author":"Lu N","year":"2018","unstructured":"Lu N, Li X, Yu J, Li Y, Wang C, Zhang L, Wang T. Curcumin attenuates lipopolysaccharide-induced hepatic lipid                         metabolism disorder by modification of m6A RNA methylation in                         piglets. Lipids, 2018, 53: 53-63.","journal-title":"Lipids"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.2217\/epi-2019-0365","volume":"12","author":"Cui Z","year":"2020","unstructured":"Cui Z, Huang N, Liu L, Li X, Li G, Chen Y, Wu Q. Dynamic analysis of m6A methylation spectroscopy during                         progression and reversal of hepatic fibrosis. Epigenomics, 2020, 12: 1707-1723.","journal-title":"Epigenomics"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1074\/jbc.M116.749689","volume":"292","author":"Yang Z","year":"2017","unstructured":"Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y. MicroRNA-145 modulates N6-methyladenosine levels by targeting the                         3\u2032-untranslated mRNA region of the N6-methyladenosine binding YTH domain                         family 2 protein. J Biol Chem, 2017, 292: 3614-3623.","journal-title":"J Biol Chem"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"Li J","year":"2020","unstructured":"Li J, Cao F, Yin H, Huang Z, Lin Z, Mao N, Sun B. Ferroptosis: past, present and future. Cell Death Dis, 2020, 11:","journal-title":"Cell Death Dis"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/s41422-020-00434-0","volume":"30","author":"Aldrovandi M","year":"2020","unstructured":"Aldrovandi M, Conrad M. Ferroptosis: the good, the bad and the ugly. Cell Res, 2020, 30: 1061-1062.","journal-title":"Cell Res"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.2019002907","volume":"136","author":"Yu Y","year":"2020","unstructured":"Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, Wang J. Hepatic transferrin plays a role in systemic iron homeostasis and                         liver ferroptosis. Blood, 2020, 136: 726-739.","journal-title":"Blood"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1080\/15548627.2018.1503146","volume":"14","author":"Zhang Z","year":"2018","unstructured":"Zhang Z, Yao Z, Wang L, Ding H, Shao J, Chen A, Zhang F. Activation of ferritinophagy is required for the RNA-binding                         protein ELAVL1\/HuR to regulate ferroptosis in hepatic stellate cells. Autophagy, 2018, 14: 2083-2103.","journal-title":"Autophagy"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"102262","DOI":"10.1016\/j.redox.2022.102262","volume":"51","author":"Wang Y","year":"2022","unstructured":"Wang Y, Zhang M, Bi R, Su Y, Quan F, Lin Y, Yue C. ACSL4 deficiency confers protection against ferroptosis-mediated                         acute kidney injury. Redox Biol, 2022, 51:","journal-title":"Redox Biol"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41556-021-00818-3","volume":"24","author":"Zhang HL","year":"2022","unstructured":"Zhang HL, Hu BX, Li ZL, Du T, Shan JL, Ye ZP, Peng XD. PKC\u03b2II phosphorylates ACSL4 to amplify lipid peroxidation to                         induce ferroptosis. Nat Cell Biol, 2022, 24: 88-98.","journal-title":"Nat Cell Biol"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41392-022-00917-z","volume":"7","author":"Tuo Q","year":"2022","unstructured":"Tuo Q, Liu Y, Xiang Z, Yan HF, Zou T, Shu Y, Ding X. Thrombin induces ACSL4-dependent ferroptosis during cerebral                         ischemia\/reperfusion. Sig Transduct                             Target Ther, 2022, 7:","journal-title":"Sig Transduct                             Target Ther"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/6E2597BE38FA4023A110EC439CA164C2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024162","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/6E2597BE38FA4023A110EC439CA164C2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T03:01:25Z","timestamp":1757646085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,24]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2024162","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,24]]}}}