{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:10:34Z","timestamp":1792188634362,"version":"4.4.0"},"reference-count":39,"publisher":"China Science Publishing & Media Ltd.","issue":"5","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2025,5,1]]},"DOI":"10.3724\/abbs.2024183","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T05:04:23Z","timestamp":1728536663000},"page":"758-769","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Cannabidiol alleviates the inflammatory response in rats with traumatic brain injury through the PGE&amp;lt;sub&amp;gt;2&amp;lt;\/sub&amp;gt;-EP2-cAMP-PKA signaling pathway"],"prefix":"10.3724","volume":"57","author":[{"given":"Yan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenghan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"e392","DOI":"10.1016\/j.wneu.2021.06.117","volume":"153","author":"Kuru Bekta\u015fo\u011flu P","year":"2021","unstructured":"Kuru Bekta\u015fo\u011flu P, Koyuncuo\u011flu T, Demir D, Sucu G, Akak\u0131n D, Peker Ey\u00fcbo\u011flu \u0130, Y\u00fcksel M. Neuroprotective effect of cinnamaldehyde on secondary brain injury after traumatic brain injury in a rat model. World Neurosurg, 2021, 153: e392-e402.","journal-title":"World Neurosurg"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3171\/2017.10.JNS17352","volume":"130","author":"Dewan MC","year":"2018","unstructured":"Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung YC, Punchak M, Agrawal A. Estimating the global incidence of traumatic brain injury. J Neurosurg, 2018, 130: 1080-1097.","journal-title":"J Neurosurg"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000495467","volume":"26","author":"Liu J","year":"2019","unstructured":"Liu J, Xiong X, Sui Y. Isoliquiritigenin attenuates neuroinflammation in traumatic brain injury in young rats. Neuroimmunomodulation, 2019, 26: 102-110.","journal-title":"Neuroimmunomodulation"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1177\/0271678X20923551","volume":"40","author":"Ren H","year":"2020","unstructured":"Ren H, Han R, Chen X, Liu X, Wan J, Wang L, Yang X. Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update. J Cereb Blood Flow Metab, 2020, 40: 1752-1768.","journal-title":"J Cereb Blood Flow Metab"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"Liddelow SA","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML. Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 2017, 541: 481-487.","journal-title":"Nature"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.tips.2009.01.002","volume":"30","author":"Choi SH","year":"2009","unstructured":"Choi SH, Aid S, Bosetti F. The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. Trends Pharmacol Sci, 2009, 30: 174-181.","journal-title":"Trends Pharmacol Sci"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.brainres.2018.05.030","volume":"1698","author":"Li P","year":"2018","unstructured":"Li P, Jiang H, Wu H, Wu D, Li H, Yu J, Lai J. AH6809 decreases production of inflammatory mediators by PGE2-EP2-cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. Brain Res, 2018, 1698: 11-28.","journal-title":"Brain Res"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1742-2094-8-22","volume":"8","author":"Wu T","year":"2011","unstructured":"Wu T, Wu H, Wang J, Wang J. Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. J Neuroinflamm, 2011, 8:","journal-title":"J Neuroinflamm"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1523\/JNEUROSCI.4485-03.2004","volume":"24","author":"McCullough L","year":"2004","unstructured":"McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci, 2004, 24: 257-268.","journal-title":"J Neurosci"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.pharmthera.2017.02.041","volume":"175","author":"Pisanti S","year":"2017","unstructured":"Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M. Cannabidiol: state of the art and new challenges for therapeutic applications. Pharmacol Ther, 2017, 175: 133-150.","journal-title":"Pharmacol Ther"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"108819","DOI":"10.1016\/j.cbi.2019.108819","volume":"312","author":"Zorzenon MRT","year":"2019","unstructured":"Zorzenon MRT, Santiago AN, Mori MA, Piovan S, Jansen CA, Perina Padilha ME, Ciotta SR. Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion. Chem Biol Interact, 2019, 312:","journal-title":"Chem Biol Interact"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"147586","DOI":"10.1016\/j.brainres.2021.147586","volume":"1768","author":"Jiang H","year":"2021","unstructured":"Jiang H, Li H, Cao Y, Zhang R, Zhou L, Zhou Y, Zeng X. Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats. Brain Res, 2021, 1768:","journal-title":"Brain Res"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuropharm.2019.02.011","volume":"149","author":"Jiang J","year":"2019","unstructured":"Jiang J, Yu Y, Kinjo ER, Du Y, Nguyen HP, Dingledine R. Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury. Neuropharmacology, 2019, 149: 149-160.","journal-title":"Neuropharmacology"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/epi4.12409","volume":"5","author":"Yu Y","year":"2020","unstructured":"Yu Y, Jiang J. COX\u20102\/PGE2 axis regulates hippocampal BDNF\/TrkB signaling via EP2 receptor after prolonged seizures. Epilepsia Open, 2020, 5: 418-431.","journal-title":"Epilepsia Open"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.4103\/1673-5374.257534","volume":"14","author":"Song YM","year":"2019","unstructured":"Song YM, Qian Y, Su WQ, Liu XH, Huang JH, Gong ZT, Luo HL. Differences in pathological changes between two rat models of severe traumatic brain injury. Neural Regen Res, 2019, 14: 1796-1804.","journal-title":"Neural Regen Res"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1002\/cpim.83","volume":"126","author":"Goldim MPS","year":"2019","unstructured":"Goldim MPS, Della Giustina A, Petronilho F. Using evans blue dye to determine blood-brain barrier integrity in rodents. Curr Protoc Immunol, 2019, 126:","journal-title":"Curr Protoc Immunol"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"114202","DOI":"10.1016\/j.expneurol.2022.114202","volume":"357","author":"Radpour M","year":"2022","unstructured":"Radpour M, Choopani S, Pourbadie HG, Sayyah M. Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. Exp Neurol, 2022, 357:","journal-title":"Exp Neurol"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/MCC.0b013e3280895d5c","volume":"13","author":"Schouten JW","year":"2007","unstructured":"Schouten JW. Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature. Curr Opin Crit Care, 2007, 13: 134-142.","journal-title":"Curr Opin Crit Care"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0006-8993(02)02586-6","volume":"940","author":"Kapural M","year":"2002","unstructured":"Kapural M, Krizanac-Bengez L, Barnett G, Perl J, Masaryk T, Apollo D, Rasmussen P. Serum S-100\u03b2 as a possible marker of blood\u2013brain barrier disruption. Brain Res, 2002, 940: 102-104.","journal-title":"Brain Res"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"342","DOI":"10.25259\/SNI_294_2021","volume":"12","author":"Wijanarko F","year":"2021","unstructured":"Wijanarko F, Alifianto U, Setyono H, Arsika Ramadhana G, Sungkar AA, Saadhi I, Setiawati DA. S100\u03b2 protein levels as a parameter to assess the clinical development of adult patients with mild traumatic brain injury in Dr. Moewardi Public Hospital, Surakarta. Surg Neurol Int, 2021, 12:","journal-title":"Surg Neurol Int"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.046","volume":"27","author":"Branco JP","year":"2018","unstructured":"Branco JP, Oliveira S, Sargento-Freitas J, Santos Costa J, Cordeiro G, Cunha L, Freire Gon\u00e7alves A. S100\u03b2 protein as a predictor of poststroke functional outcome: a prospective study. J Stroke Cerebrovasc Dis, 2018, 27: 1890-1896.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3340\/jkns.2017.0200","volume":"61","author":"Choi JI","year":"2018","unstructured":"Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH. S100\u00df, matrix metalloproteinase-9, D-dimer, and heat shock protein 70 are serologic biomarkers of acute cerebral infarction in a mouse model of transient MCA occlusion. J Korean Neurosurg Soc, 2018, 61: 548-558.","journal-title":"J Korean Neurosurg Soc"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.3892\/ol.2020.11751","volume":"20","author":"Yu D","year":"2020","unstructured":"Yu D, Liu B, Jiang G, Pei S, Pan H. Correlation of changes in serum S100\u03b2, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment. Oncol Lett, 2020, 20: 1968-1972.","journal-title":"Oncol Lett"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000094158","volume":"28","author":"Pardes Berger R","year":"2006","unstructured":"Pardes Berger R, Adelson PD, Richichi R, Kochanek PM. Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury. Dev Neurosci, 2006, 28: 327-335.","journal-title":"Dev Neurosci"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nm.3407","volume":"19","author":"Obermeier B","year":"2013","unstructured":"Obermeier B, Daneman R, Ransohoff RM. Development, maintenance and disruption of the blood-brain barrier. Nat Med, 2013, 19: 1584-1596.","journal-title":"Nat Med"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1203\/PDR.0b013e3182276b11","volume":"70","author":"Lafuente H","year":"2011","unstructured":"Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X. Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs. Pediatr Res, 2011, 70: 272-277.","journal-title":"Pediatr Res"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.3390\/pharmaceutics14081609","volume":"14","author":"Santiago-Casta\u00f1eda C","year":"2022","unstructured":"Santiago-Casta\u00f1eda C, Huerta de la Cruz S, Mart\u00ednez-Aguirre C, Orozco-Su\u00e1rez SA, Rocha L. Cannabidiol reduces short- and long-term high glutamate release after severe traumatic brain injury and improves functional recovery. Pharmaceutics, 2022, 14:","journal-title":"Pharmaceutics"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"113844","DOI":"10.1016\/j.expneurol.2021.113844","volume":"346","author":"Friedman LK","year":"2021","unstructured":"Friedman LK, Peng H, Zeman RJ. Cannabidiol reduces lesion volume and restores vestibulomotor and cognitive function following moderately severe traumatic brain injury. Exp Neurol, 2021, 346:","journal-title":"Exp Neurol"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fphar.2019.00352","volume":"10","author":"Belardo C","year":"2019","unstructured":"Belardo C, Iannotta M, Boccella S, Rubino RC, Ricciardi F, Infantino R, Pieretti G. Oral cannabidiol prevents allodynia and neurological dysfunctions in a mouse model of mild traumatic brain injury. Front Pharmacol, 2019, 10:","journal-title":"Front Pharmacol"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.expneurol.2015.05.004","volume":"275","author":"Kulbe JR","year":"2016","unstructured":"Kulbe JR, Geddes JW. Current status of fluid biomarkers in mild traumatic brain injury. Exp Neurol, 2016, 275: 334-352.","journal-title":"Exp Neurol"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/4170156","volume":"2020","author":"Huang Y","year":"2020","unstructured":"Huang Y, Long X, Tang J, Li X, Zhang X, Luo C, Zhou Y. The attenuation of traumatic brain injury via inhibition of oxidative stress and apoptosis by tanshinone IIA. Oxid Med Cell Longev, 2020, 2020: 1-12.","journal-title":"Oxid Med Cell Longev"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neuropharm.2016.12.017","volume":"116","author":"Cepri\u00e1n M","year":"2017","unstructured":"Cepri\u00e1n M, Jim\u00e9nez-S\u00e1nchez L, Vargas C, Barata L, Hind W, Mart\u00ednez-Orgado J. Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke. Neuropharmacology, 2017, 116: 151-159.","journal-title":"Neuropharmacology"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s12035-020-02171-2","volume":"58","author":"Wang J","year":"2021","unstructured":"Wang J, Hou Y, Zhang L, Liu M, Zhao J, Zhang Z, Ma Y. Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and astrocyte-mediated neuroinflammatory responses. Mol Neurobiol, 2021, 58: 1052-1061.","journal-title":"Mol Neurobiol"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3892\/etm.2016.2975","volume":"11","author":"Ren S","year":"2016","unstructured":"Ren S, Xu Y, Lv D, Zhang L. Rosiglitazone ameliorates astrocyte over-activation and inflammatory cytokine release induced by global cerebral ischemia\/reperfusion. Exp Ther Med, 2016, 11: 1071-1076.","journal-title":"Exp Ther Med"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1002\/jnr.22319","volume":"88","author":"Li P","year":"2010","unstructured":"Li P, Kaur C, Lu J, Sivakumar V, Dheen ST, Ling E. Expression of cyclooxygenase-2 and microsomal prostaglandin\u2010E synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells. J Neurosci Res, 2010, 88: 1577-1594.","journal-title":"J Neurosci Res"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.neuroscience.2009.08.044","volume":"164","author":"Li P","year":"2009","unstructured":"Li P, Lu J, Kaur C, Sivakumar V, Tan KL, Ling EA. Expression of cyclooxygenase-1\/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE2 in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells. Neuroscience, 2009, 164: 948-962.","journal-title":"Neuroscience"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"110079","DOI":"10.1016\/j.cbi.2022.110079","volume":"365","author":"Zhang J","year":"2022","unstructured":"Zhang J, Luo Z, Zhang Z, Zhao M, Tong C, Cong P, Mao S. Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice. Chem Biol Interact, 2022, 365:","journal-title":"Chem Biol Interact"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.3390\/ijms23105427","volume":"23","author":"Genovese T","year":"2022","unstructured":"Genovese T, Cordaro M, Siracusa R, Impellizzeri D, Caudullo S, Raffone E, Macr\u00ed F. Molecular and biochemical mechanism of cannabidiol in the management of the inflammatory and oxidative processes associated with endometriosis. Int J Mol Sci, 2022, 23:","journal-title":"Int J Mol Sci"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"BSR20190141","DOI":"10.1042\/BSR20190141","volume":"39","author":"Ruan J","year":"2019","unstructured":"Ruan J, Liu L, Shan X, Xia B, Fu Q. Anti-depressant effects of oil from fructus gardeniae via PKA-CREB-BDNF signaling. Biosci Rep, 2019, 39:","journal-title":"Biosci Rep"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/53EA32C4E73F4D3BBAB252C43B2EE8E9","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024183","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/53EA32C4E73F4D3BBAB252C43B2EE8E9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T03:04:20Z","timestamp":1757646260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,8]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,2,8]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2024183","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,8]]}}}