{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:17:54Z","timestamp":1787030274318,"version":"build-2736575974"},"reference-count":114,"publisher":"China Science Publishing & Media Ltd.","issue":"2","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2025,2,1]]},"DOI":"10.3724\/abbs.2024189","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T05:22:45Z","timestamp":1729228965000},"page":"169-181","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Battling pain from osteoarthritis: causing novel cell death"],"prefix":"10.3724","volume":"57","author":[{"given":"Yuheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"CITATION1","doi-asserted-by":"crossref","unstructured":"Yu H, Huang T, Lu WW, Tong L, Chen D. Osteoarthritis pain. International Journal of Molecular Sciences 2022, 23: 4642.","DOI":"10.3390\/ijms23094642"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s11914-018-0477-1","volume":"16","author":"O\u2019Neill TW","year":"2018","unstructured":"O\u2019Neill TW, Felson DT. Mechanisms of osteoarthritis (OA) pain. Curr Osteoporos Rep, 2018, 16: 611-616.","journal-title":"Curr Osteoporos Rep"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s11914-018-0473-5","volume":"16","author":"Zhang A","year":"2018","unstructured":"Zhang A, Lee YC. Mechanisms for joint pain in rheumatoid arthritis (RA): from cytokines to central sensitization. Curr Osteoporos Rep, 2018, 16: 603-610.","journal-title":"Curr Osteoporos Rep"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"115272","DOI":"10.1016\/j.bone.2020.115272","volume":"134","author":"Oostinga D","year":"2020","unstructured":"Oostinga D, Steverink JG, van Wijck AJM, Verlaan JJ. An understanding of bone pain: a narrative review. Bone, 2020, 134:","journal-title":"Bone"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.semarthrit.2014.05.011","volume":"44","author":"Dimitroulas T","year":"2014","unstructured":"Dimitroulas T, Duarte RV, Behura A, Kitas GD, Raphael JH. Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment. Semin Arthritis Rheumatism, 2014, 44: 145-154.","journal-title":"Semin Arthritis Rheumatism"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bjpt.2020.08.004","volume":"25","author":"Dantas LO","year":"2021","unstructured":"Dantas LO, Salvini TF, McAlindon TE. Knee osteoarthritis: key treatments and implications for physical therapy. Braz J Phys Ther, 2021, 25: 135-146.","journal-title":"Braz J Phys Ther"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s40674-023-00205-z","volume":"9","author":"Young JJ","year":"2023","unstructured":"Young JJ, Pedersen JR, Bricca A. Exercise therapy for knee and hip osteoarthritis: is there an ideal prescription?. Curr Treat Options Rheum, 2023, 9: 82-98.","journal-title":"Curr Treat Options Rheum"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","volume":"397","author":"Cohen SP","year":"2021","unstructured":"Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet, 2021, 397: 2082-2097.","journal-title":"Lancet"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"15292","DOI":"10.3390\/ijms242015292","volume":"24","author":"Khaleque MA","year":"2023","unstructured":"Khaleque MA, Kim JH, Hwang BJ, Kang JK, Quan M, Kim YY. Role of necroptosis in intervertebral disc degeneration. Int J Mol Sci, 2023, 24:","journal-title":"Int J Mol Sci"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.3390\/cells11192979","volume":"11","author":"Gao L","year":"2022","unstructured":"Gao L, Hua W, Tian L, Zhou X, Wang D, Yang Y, Ni G. Molecular mechanism of ferroptosis in orthopedic diseases. Cells, 2022, 11:","journal-title":"Cells"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"789948","DOI":"10.3389\/fcell.2021.789948","volume":"9","author":"Yang J","year":"2022","unstructured":"Yang J, Hu S, Bian Y, Yao J, Wang D, Liu X, Guo Z. Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis. Front Cell Dev Biol, 2022, 9:","journal-title":"Front Cell Dev Biol"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/cells11030394","volume":"11","author":"Ohnishi T","year":"2022","unstructured":"Ohnishi T, Iwasaki N, Sudo H. Causes of and molecular targets for the treatment of intervertebral disc degeneration: a review. Cells, 2022, 11:","journal-title":"Cells"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"809806","DOI":"10.3389\/fimmu.2021.809806","volume":"12","author":"Zhao J","year":"2021","unstructured":"Zhao J, Jiang P, Guo S, Schrodi SJ, He D. Apoptosis, autophagy, netosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis. Front Immunol, 2021, 12:","journal-title":"Front Immunol"},{"key":"CITATION14","unstructured":"Wang SH, Liu Y, Xue X, Pan SA, Yuan HY, Li J, Yue ZH. Effects of electroacupuncture on NLRP3 inflammasome and pyroptosis protein GSDMD in uterine tissue in rats with primary dysmenorrhea. Zhongguo Zhen Jiu 2023, 43: 309\u2013316."},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"912933","DOI":"10.3389\/fimmu.2022.912933","volume":"13","author":"Li W","year":"2022","unstructured":"Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q. A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4\/NF-\u03baB\/NLRP3 activation-induced pyroptosis. Front Immunol, 2022, 13:","journal-title":"Front Immunol"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"599022","DOI":"10.3389\/fphar.2020.599022","volume":"11","author":"Ma Z","year":"2021","unstructured":"Ma Z, Huang Z, Zhang L, Li X, Xu B, Xiao Y, Shi X. Vanillic acid reduces pain-related behavior in knee osteoarthritis rats through the inhibition of NLRP3 inflammasome-related synovitis. Front Pharmacol, 2021, 11:","journal-title":"Front Pharmacol"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6833867","volume":"2022","author":"Lin D","year":"2022","unstructured":"Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z, Hautz T. Targeting ferroptosis attenuates inflammation, fibrosis, and mast cell activation in chronic prostatitis. J Immunol Res, 2022, 2022: 1-12.","journal-title":"J Immunol Res"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"102700","DOI":"10.1016\/j.redox.2023.102700","volume":"62","author":"Ding Z","year":"2023","unstructured":"Ding Z, Liang X, Wang J, Song Z, Guo Q, Sch\u00e4fer MKE, Huang C. Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain. Redox Biol, 2023, 62:","journal-title":"Redox Biol"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"103143","DOI":"10.1016\/j.redox.2024.103143","volume":"73","author":"Hu Z","year":"2024","unstructured":"Hu Z, Chen L, Zhao J, Zhang W, Jin Z, Sun Y, Li Z. Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2\/LPAR3\/Nrf2 axis in synovial fibroblast-like synoviocytes. Redox Biol, 2024, 73:","journal-title":"Redox Biol"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.yjmcc.2018.10.018","volume":"125","author":"Yang Z","year":"2018","unstructured":"Yang Z, Li C, Wang Y, Yang J, Yin Y, Liu M, Shi Z. Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL\/CaMKII dependent necroptosis. J Mol Cell Cardiol, 2018, 125: 185-194.","journal-title":"J Mol Cell Cardiol"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"638382","DOI":"10.3389\/fcell.2021.638382","volume":"9","author":"Cheng J","year":"2021","unstructured":"Cheng J, Duan X, Fu X, Jiang Y, Yang P, Cao C, Li Q. RIP1 perturbation induces chondrocyte necroptosis and promotes osteoarthritis pathogenesis via targeting BMP7. Front Cell Dev Biol, 2021, 9:","journal-title":"Front Cell Dev Biol"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"e0259130","DOI":"10.1371\/journal.pone.0259130","volume":"16","author":"Jhun JY","year":"2021","unstructured":"Jhun JY, Na HS, Cho KH, Kim J, Moon YM, Lee SY, Lee JS. A green-lipped mussel reduces pain behavior and chondrocyte inflammation and attenuated experimental osteoarthritis progression. PLoS One, 2021, 16:","journal-title":"PLoS One"},{"key":"CITATION23","doi-asserted-by":"crossref","unstructured":"Ji X, Zhang H. Current strategies for the treatment of early stage osteoarthritis. Frontiers in Mechanical Engineering 2019, 5: 57.","DOI":"10.3389\/fmech.2019.00057"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","volume":"27","author":"Bannuru RR","year":"2019","unstructured":"Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, Kraus VB. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage, 2019, 27: 1578-1589.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1007\/s00167-020-05908-7","volume":"28","author":"Ahmed GO","year":"2020","unstructured":"Ahmed GO, ELSweify K, Ahmed AF. Usability of the AAOS Appropriate Use Criteria (AUC) for the surgical management of knee osteoarthritis in clinical practice. Knee Surg Sports Traumatol Arthrosc, 2020, 28: 2077-2081.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1186\/s12891-022-05954-x","volume":"23","author":"Fukui N","year":"2022","unstructured":"Fukui N, Conaghan PG, Togo K, Ebata N, Abraham L, Jackson J, Berry M. Physician and patient perceptions of surgical procedures for osteoarthritis of the knee in the United States, Europe, and Japan: Results of a real-world study. BMC Musculoskelet Disord, 2022, 23:","journal-title":"BMC Musculoskelet Disord"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","volume":"161","author":"Raja SN","year":"2020","unstructured":"Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ. The revised International Association for the Study of Pain Definition of Pain: concepts, challenges, and compromises. Pain, 2020, 161: 1976-1982.","journal-title":"Pain"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"12076","DOI":"10.3390\/ijms232012076","volume":"23","author":"O-Sullivan IS","year":"2022","unstructured":"O-Sullivan IS, Kc R, Singh G, Das V, Ma K, Li X, Mwale F. Sensory neuron-specific deletion of tropomyosin receptor kinase a (TrkA) in mice abolishes osteoarthritis (OA) pain via NGF\/TrkA intervention of peripheral sensitization. Int J Mol Sci, 2022, 23:","journal-title":"Int J Mol Sci"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.expneurol.2014.09.019","volume":"263","author":"Guan XH","year":"2015","unstructured":"Guan XH, Fu QC, Shi D, Bu HL, Song ZP, Xiong BR, Shu B. Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats. Exp Neurol, 2015, 263: 39-49.","journal-title":"Exp Neurol"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/19476035231154514","volume":"14","author":"Kato Y","year":"2023","unstructured":"Kato Y, Nakasa T, Sumii J, Kanemitsu M, Ishikawa M, Miyaki S, Adachi N. Changes in the subchondral bone affect pain in the natural course of traumatic articular cartilage defects. Cartilage, 2023, 14: 247-255.","journal-title":"Cartilage"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"S138","DOI":"10.1097\/j.pain.0000000000001923","volume":"161","author":"Vincent TL","year":"2020","unstructured":"Vincent TL. Peripheral pain mechanisms in osteoarthritis. Pain, 2020, 161: S138-S146.","journal-title":"Pain"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1016\/j.pain.2013.07.044","volume":"154","author":"Mantyh P","year":"2013","unstructured":"Mantyh P. Bone cancer pain: causes, consequences, and therapeutic opportunities. Pain, 2013, 154: S54-S62.","journal-title":"Pain"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.semarthrit.2020.10.008","volume":"51","author":"Simon LS","year":"2021","unstructured":"Simon LS, Taylor PC, Choy EH, Sebba A, Quebe A, Knopp KL, Porreca F. The Jak\/STAT pathway: a focus on pain in rheumatoid arthritis. Semin Arthritis Rheumatism, 2021, 51: 278-284.","journal-title":"Semin Arthritis Rheumatism"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2147\/JPR.S124326","volume":"10","author":"Liu M","year":"2017","unstructured":"Liu M, Yao M, Wang H, Xu L, Zheng Y, Huang B, Ni H. P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain. J Pain Res, 2017, 10: 417-426.","journal-title":"J Pain Res"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbi.2016.10.009","volume":"60","author":"Song Z","year":"2017","unstructured":"Song Z, Xiong B, Zheng H, Manyande A, Guan X, Cao F, Ren L. STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia. Brain Behav Immun, 2017, 60: 161-173.","journal-title":"Brain Behav Immun"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.berh.2015.04.017","volume":"29","author":"Perrot S","year":"2015","unstructured":"Perrot S. Osteoarthritis pain. Best Pract Res Clin Rheumatology, 2015, 29: 90-97.","journal-title":"Best Pract Res Clin Rheumatology"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","volume":"6","author":"Sellam J","year":"2010","unstructured":"Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol, 2010, 6: 625-635.","journal-title":"Nat Rev Rheumatol"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/annrheumdis-2020-218089","volume":"80","author":"Hu W","year":"2021","unstructured":"Hu W, Chen Y, Dou C, Dong S. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis. Ann Rheum Dis, 2021, 80: 413-422.","journal-title":"Ann Rheum Dis"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1172\/JCI121561","volume":"129","author":"Zhu S","year":"2019","unstructured":"Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest, 2019, 129: 1076-1093.","journal-title":"J Clin Invest"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"e66532","DOI":"10.7554\/eLife.66532","volume":"10","author":"Sun Q","year":"2021","unstructured":"Sun Q, Zhen G, Li TP, Guo Q, Li Y, Su W, Xue P. Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice. eLife, 2021, 10:","journal-title":"eLife"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.bioactmat.2023.03.010","volume":"26","author":"Lu K","year":"2023","unstructured":"Lu K, Wang Q, Hao L, Wei G, Wang T, Lu WW, Xiao G. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction. Bioactive Mater, 2023, 26: 425-436.","journal-title":"Bioactive Mater"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","volume":"18","author":"Sanchez-Lopez E","year":"2022","unstructured":"Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol, 2022, 18: 258-275.","journal-title":"Nat Rev Rheumatol"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"e13662","DOI":"10.1111\/acel.13662","volume":"21","author":"D\u2032Amico D","year":"2022","unstructured":"D\u2032Amico D, Olmer M, Fouassier AM, Vald\u00e9s P, Andreux PA, Rinsch C, Lotz M. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell, 2022, 21:","journal-title":"Aging Cell"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"He L","year":"2020","unstructured":"He L, He T, Xing J, Zhou Q, Fan L, Liu C, Chen Y. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther, 2020, 11:","journal-title":"Stem Cell Res Ther"},{"key":"CITATION45","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.joca.2022.09.007","volume":"31","author":"Walsh DA","year":"2023","unstructured":"Walsh DA, Sofat N, Guermazi A, Hunter DJ. Osteoarthritis bone marrow lesions. Osteoarthritis Cartilage, 2023, 31: 11-17.","journal-title":"Osteoarthritis Cartilage"},{"key":"CITATION46","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3724\/abbs.2024017","volume":"56","author":"Chen W","year":"2024","unstructured":"Chen W, Wang Q, Tao H, Lu L, Zhou J, Wang Q, Huang W. Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues. Acta Biochim Biophys Sin, 2024, 56: 499-512.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION47","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nm.3143","volume":"19","author":"Zhen G","year":"2013","unstructured":"Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB. Inhibition of TGF-\u03b2 signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med, 2013, 19: 704-712.","journal-title":"Nat Med"},{"key":"CITATION48","doi-asserted-by":"publisher","first-page":"886604","DOI":"10.3389\/fcell.2022.886604","volume":"10","author":"Emmi A","year":"2022","unstructured":"Emmi A, Stocco E, Boscolo-Berto R, Contran M, Belluzzi E, Favero M, Ramonda R. Infrapatellar fat pad-synovial membrane anatomo-fuctional unit: microscopic basis for piezo1\/2 mechanosensors involvement in osteoarthritis pain. Front Cell Dev Biol, 2022, 10:","journal-title":"Front Cell Dev Biol"},{"key":"CITATION49","doi-asserted-by":"publisher","first-page":"2300897","DOI":"10.1002\/advs.202300897","volume":"10","author":"Dai B","year":"2023","unstructured":"Dai B, Zhu Y, Li X, Liang Z, Xu S, Zhang S, Zhang Z. Blockage of osteopontin\u2010integrin \u03b23 signaling in infrapatellar fat pad attenuates osteoarthritis in mice. Adv Sci, 2023, 10:","journal-title":"Adv Sci"},{"key":"CITATION50","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3724\/abbs.2023086","volume":"55","author":"Liu Y","year":"2023","unstructured":"Liu Y, Duan M, Zhang D, Xie J. The role of mechano growth factor in chondrocytes and cartilage defects: a concise review. Acta Biochim Biophys Sin, 2023, 55: 701-712.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION51","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1136\/ard.2010.137844","volume":"70","author":"Ashraf S","year":"2011","unstructured":"Ashraf S, Wibberley H, Mapp PI, Hill R, Wilson D, Walsh DA. Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis. Ann Rheum Dis, 2011, 70: 523-529.","journal-title":"Ann Rheum Dis"},{"key":"CITATION52","doi-asserted-by":"publisher","first-page":"416.1","DOI":"10.1136\/annrheumdis-2021-eular.20","volume":"80","author":"Loef M","year":"2021","unstructured":"Loef M, von Hegedus J, Ghorasaini M, Kroon F, Giera M, Ioan-Facsinay A, Kloppenburg M. Pos0371\u2005biological reproducibility of targeted lipidome analyses in plasma and erythrocytes over a 6-week period. Ann Rheum Dis, 2021, 80: 416.1-416.","journal-title":"Ann Rheum Dis"},{"key":"CITATION53","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.3390\/cells10092241","volume":"10","author":"Krut Z","year":"2021","unstructured":"Krut Z, Pelled G, Gazit D, Gazit Z. Stem cells and exosomes: new therapies for intervertebral disc degeneration. Cells, 2021, 10:","journal-title":"Cells"},{"key":"CITATION54","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.3390\/ijms24065364","volume":"24","author":"Liu S","year":"2023","unstructured":"Liu S, Pan Y, Li T, Zou M, Liu W, Li Q, Wan H. The role of regulated programmed cell death in osteoarthritis: from pathogenesis to therapy. Int J Mol Sci, 2023, 24:","journal-title":"Int J Mol Sci"},{"key":"CITATION55","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3724\/abbs.2023223","volume":"56","author":"Shi Y","year":"2024","unstructured":"Shi Y, Tao H, Li X, Zhang L, Li C, Sun W, Chu M. \u03ba-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-\u03baB pathway. Acta Biochim Biophys Sin, 2024, 56: 82-95.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION56","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/abbs\/gmu135","volume":"47","author":"Ma C","year":"2015","unstructured":"Ma C, Wang Y, Dong L, Li M, Cai W. Anti-inflammatory effect of resveratrol through the suppression of NF-\u03baB and JAK\/STAT signaling pathways. Acta Biochim Biophys Sin, 2015, 47: 207-213.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION57","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1172\/JCI42843","volume":"120","author":"Dubin AE","year":"2010","unstructured":"Dubin AE, Patapoutian A. Nociceptors: The sensors of the pain pathway. J Clin Invest, 2010, 120: 3760-3772.","journal-title":"J Clin Invest"},{"key":"CITATION58","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neulet.2008.03.017","volume":"437","author":"Gao YJ","year":"2008","unstructured":"Gao YJ, Ji RR. Activation of JNK pathway in persistent pain. Neurosci Lett, 2008, 437: 180-183.","journal-title":"Neurosci Lett"},{"key":"CITATION59","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1159\/000525690","volume":"29","author":"Lin Y","year":"2022","unstructured":"Lin Y, Chen Y, Zeng J, Li S. Nodakenetin alleviates inflammatory pain hypersensitivity by suppressing NF-\u03baB signal pathway. Neuroimmunomodulation, 2022, 29: 486-492.","journal-title":"Neuroimmunomodulation"},{"key":"CITATION60","doi-asserted-by":"publisher","first-page":"156381","DOI":"10.1016\/j.cyto.2023.156381","volume":"172","author":"Huang Y","year":"2023","unstructured":"Huang Y, Xue Q, Chang J, Wang X, Miao C. Wnt5a: a promising therapeutic target for inflammation, especially rheumatoid arthritis. Cytokine, 2023, 172:","journal-title":"Cytokine"},{"key":"CITATION61","doi-asserted-by":"publisher","first-page":"1069057","DOI":"10.3389\/fendo.2022.1069057","volume":"13","author":"Zhou Q","year":"2022","unstructured":"Zhou Q, Ren Q, Jiao L, Huang J, Yi J, Chen J, Lai J. The potential roles of JAK\/STAT signaling in the progression of osteoarthritis. Front Endocrinol, 2022, 13:","journal-title":"Front Endocrinol"},{"key":"CITATION62","doi-asserted-by":"publisher","first-page":"186","DOI":"10.14336\/AD.2023.0515","volume":"15","author":"Dai XY","year":"2024","unstructured":"Dai XY, Liu L, Song FH, Gao SJ, Wu JY, Li DY, Zhang LQ. Targeting the JAK2\/STAT3 signaling pathway for chronic pain. Aging Dis, 2024, 15:","journal-title":"Aging Dis"},{"key":"CITATION63","doi-asserted-by":"publisher","first-page":"1744806918793232","DOI":"10.1177\/1744806918793232","volume":"14","author":"Chen SP","year":"2018","unstructured":"Chen SP, Sun J, Zhou YQ, Cao F, Braun C, Luo F, Ye DW. Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2\/STAT3 and neuronal CAMKII\/CREB cascades in rat models. Mol Pain, 2018, 14:","journal-title":"Mol Pain"},{"key":"CITATION64","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00011-017-1087-6","volume":"66","author":"Dai T","year":"2017","unstructured":"Dai T, Shi K, Chen G, Shen Y, Pan T. Malvidin attenuates pain and inflammation in rats with osteoarthritis by suppressing NF-\u03baB signaling pathway. Inflamm Res, 2017, 66: 1075-1084.","journal-title":"Inflamm Res"},{"key":"CITATION65","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1096\/fj.08-109355","volume":"22","author":"Niederberger E","year":"2008","unstructured":"Niederberger E, Geisslinger G. The IKK\u2010NF\u2010\u03baB pathway: a source for novel molecular drug targets in pain therapy?. FASEB J, 2008, 22: 3432-3442.","journal-title":"FASEB J"},{"key":"CITATION66","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1177\/1535370220952342","volume":"245","author":"Li B","year":"2020","unstructured":"Li B, Jing L, Jia L, Qian T, Jianyi C, Zhongsheng H, Xiaohong Z. Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2\/CCR2 signaling pathway. Exp Biol Med (Maywood), 2020, 245: 1722-1731.","journal-title":"Exp Biol Med (Maywood)"},{"key":"CITATION67","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","volume":"29","author":"Pezet S","year":"2006","unstructured":"Pezet S, McMahon SB. Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci, 2006, 29: 507-538.","journal-title":"Annu Rev Neurosci"},{"key":"CITATION68","doi-asserted-by":"crossref","unstructured":"Mei W, Zhou YQ, Li DY, Gao SJ, Sun J, Zhang LQ. Targeting the nitric oxide\/cGMP signalling pathway to treat chronic pain. Neural Regen Res 2023, 18: 996\u20131003.","DOI":"10.4103\/1673-5374.355748"},{"key":"CITATION69","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.niox.2019.04.011","volume":"89","author":"Spiller F","year":"2019","unstructured":"Spiller F, Oliveira Formiga R, Fernandes da Silva Coimbra J, Alves-Filho JC, Cunha TM, Cunha FQ. Targeting nitric oxide as a key modulator of sepsis, arthritis and pain. Nitric Oxide, 2019, 89: 32-40.","journal-title":"Nitric Oxide"},{"key":"CITATION70","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev-neuro-072116-031121","volume":"40","author":"Denk F","year":"2017","unstructured":"Denk F, Bennett DL, McMahon SB. Nerve growth factor and pain mechanisms. Annu Rev Neurosci, 2017, 40: 307-325.","journal-title":"Annu Rev Neurosci"},{"key":"CITATION71","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13075-018-1560-9","volume":"20","author":"Lee MC","year":"2018","unstructured":"Lee MC, Saleh R, Achuthan A, Fleetwood AJ, F\u00f6rster I, Hamilton JA, Cook AD. CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Res Ther, 2018, 20:","journal-title":"Arthritis Res Ther"},{"key":"CITATION72","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1038\/s41467-018-07022-2","volume":"9","author":"Deng Y","year":"2018","unstructured":"Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, Ho KK. Reciprocal inhibition of YAP\/TAZ and NF-\u03baB regulates osteoarthritic cartilage degradation. Nat Commun, 2018, 9:","journal-title":"Nat Commun"},{"key":"CITATION73","doi-asserted-by":"publisher","first-page":"10128","DOI":"10.1523\/JNEUROSCI.0800-16.2016","volume":"36","author":"Xu N","year":"2016","unstructured":"Xu N, Wu MZ, Deng XT, Ma PC, Li ZH, Liang L, Xia MF. Inhibition of YAP\/TAZ activity in spinal cord suppresses neuropathic pain. J Neurosci, 2016, 36: 10128-10140.","journal-title":"J Neurosci"},{"key":"CITATION74","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/abbs\/gmu109","volume":"47","author":"Mao B","year":"2015","unstructured":"Mao B, Gao Y, Bai Y, Yuan Z. Hippo signaling in stress response and homeostasis maintenance. Acta Biochim Biophys Sin, 2015, 47: 2-9.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION75","doi-asserted-by":"publisher","first-page":"213413","DOI":"10.1016\/j.bioadv.2023.213413","volume":"149","author":"Gui T","year":"2023","unstructured":"Gui T, Huan S, Zhuang T, Zhang H, Yang J, Li B, Chen T. Hippo\/YAP1 inhibition by verteporfin attenuates osteophyte formation in a mouse surgical osteoarthritis model. BioMater Adv, 2023, 149:","journal-title":"BioMater Adv"},{"key":"CITATION76","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.7150\/ijbs.84353","volume":"19","author":"Ma L","year":"2023","unstructured":"Ma L, Zhao W, Huang S, Xu F, Wang Y, Deng D, Zhang T. IGF\/IGF-1R signal pathway in pain: a promising therapeutic target. Int J Biol Sci, 2023, 19: 3472-3482.","journal-title":"Int J Biol Sci"},{"key":"CITATION77","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ijbiomac.2018.05.124","volume":"117","author":"Sun Y","year":"2018","unstructured":"Sun Y, Zhang G, Liu Q, Liu X, Wang L, Wang J, Liang L. Chondroitin sulfate from sturgeon bone ameliorates pain of osteoarthritis induced by monosodium iodoacetate in rats. Int J Biol Macromol, 2018, 117: 95-101.","journal-title":"Int J Biol Macromol"},{"key":"CITATION78","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jep.2018.12.004","volume":"231","author":"Wang C","year":"2019","unstructured":"Wang C, Yan L, Yan B, Zhou L, Sun W, Yu L, Liu F. Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis. J EthnoPharmacol, 2019, 231: 545-554.","journal-title":"J EthnoPharmacol"},{"key":"CITATION79","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2147\/JIR.S297622","volume":"14","author":"Lu H","year":"2021","unstructured":"Lu H, Wang W, Kang X, Lin Z, Pan J, Cheng S, Zhang J. Hydrogen (H2) alleviates osteoarthritis by inhibiting apoptosis and inflammation via the JNK signaling pathway. J Inflamm Res, 2021, 14: 1387-1402.","journal-title":"J Inflamm Res"},{"key":"CITATION80","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","volume":"25","author":"Yuan J","year":"2024","unstructured":"Yuan J, Ofengeim D. A guide to cell death pathways. Nat Rev Mol Cell Biol, 2024, 25: 379-395.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"CITATION81","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3390\/biology12111426","volume":"12","author":"Hajibabaie F","year":"2023","unstructured":"Hajibabaie F, Abedpoor N, Mohamadynejad P. Types of cell death from a molecular perspective. Biology, 2023, 12:","journal-title":"Biology"},{"key":"CITATION82","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/15384047.2016.1210732","volume":"17","author":"Hanson B","year":"2016","unstructured":"Hanson B. Necroptosis: A new way of dying?. Cancer Biol Ther, 2016, 17: 899-910.","journal-title":"Cancer Biol Ther"},{"key":"CITATION83","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"Tang D","year":"2019","unstructured":"Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. Cell Res, 2019, 29: 347-364.","journal-title":"Cell Res"},{"key":"CITATION84","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/abbs\/gmv086","volume":"47","author":"Wu D","year":"2022","unstructured":"Wu D, Chen L. Ferroptosis: a novel cell death form will be a promising therapy target for diseases. Acta Biochim Biophys Sin, 2022, 47: 857-859.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION85","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/os.13718","volume":"15","author":"Xiang W","year":"2023","unstructured":"Xiang W, Zheng Q, Liu A, Huang S, Chen R, Qiu J, Su Q. Recent therapeutic strategies for excessive chondrocyte death in osteoarthritis: a review. Orthopaedic Surg, 2023, 15: 1437-1453.","journal-title":"Orthopaedic Surg"},{"key":"CITATION86","doi-asserted-by":"publisher","first-page":"903475","DOI":"10.3389\/fimmu.2022.903475","volume":"13","author":"Jiang P","year":"2022","unstructured":"Jiang P, Wei K, Chang C, Zhao J, Zhang R, Xu L, Jin Y. SFRP1 negatively modulates pyroptosis of fibroblast\u2010like synoviocytes in rheumatoid arthritis: a review. Front Immunol, 2022, 13:","journal-title":"Front Immunol"},{"key":"CITATION87","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41419-022-05065-4","volume":"13","author":"Cheng Q","year":"2022","unstructured":"Cheng Q, Chen M, Liu M, Chen X, Zhu L, Xu J, Xue J. Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION88","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3892\/etm.2020.9504","volume":"21","author":"Luo H","year":"2020","unstructured":"Luo H, Zhang R. Icariin enhances cell survival in lipopolysaccharide\u2011induced synoviocytes by suppressing ferroptosis via the Xc\u2011\/GPX4 axis. Exp Ther Med, 2020, 21:","journal-title":"Exp Ther Med"},{"key":"CITATION89","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neulet.2018.11.002","volume":"692","author":"Zhang X","year":"2019","unstructured":"Zhang X, Zhao W, Liu X, Huang Z, Shan R, Huang C. Celastrol ameliorates inflammatory pain and modulates HMGB1\/NF-\u03baB signaling pathway in dorsal root ganglion. Neurosci Lett, 2019, 692: 83-89.","journal-title":"Neurosci Lett"},{"key":"CITATION90","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.2147\/JIR.S368501","volume":"Volume 15","author":"Chang X","year":"2022","unstructured":"Chang X, Kang Y, Yang Y, Chen Y, Shen Y, Jiang C, Shen Y. Pyroptosis: a novel intervention target in the progression of osteoarthritis. J Inflamm Res, 2022, Volume 15: 3859-3871.","journal-title":"J Inflamm Res"},{"key":"CITATION91","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/art.41963","volume":"74","author":"Zhai Z","year":"2022","unstructured":"Zhai Z, Yang F, Xu W, Han J, Luo G, Li Y, Zhuang J. Attenuation of rheumatoid arthritis through the inhibition of tumor necrosis factor\u2013induced caspase 3\/gasdermine\u2013mediated pyroptosis. Arthritis Rheumatology, 2022, 74: 427-440.","journal-title":"Arthritis Rheumatology"},{"key":"CITATION92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2165918","volume":"2019","author":"Zhang L","year":"2019","unstructured":"Zhang L, Xing R, Huang Z, Zhang N, Zhang L, Li X, Wang P. Inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in knee osteoarthritis. Mediators Inflamm, 2019, 2019: 1-11.","journal-title":"Mediators Inflamm"},{"key":"CITATION93","doi-asserted-by":"publisher","first-page":"743086","DOI":"10.3389\/fphar.2021.743086","volume":"12","author":"Li W","year":"2021","unstructured":"Li W, Mao X, Wang X, Liu Y, Wang K, Li C, Li T. Disease-modifying anti-rheumatic drug prescription Baihu-Guizhi decoction attenuates rheumatoid arthritis via suppressing Toll-like receptor 4-mediated NLRP3 inflammasome activation. Front Pharmacol, 2021, 12:","journal-title":"Front Pharmacol"},{"key":"CITATION94","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41419-022-05047-6","volume":"13","author":"Gu L","year":"2022","unstructured":"Gu L, Sun Y, Wu T, Chen G, Tang X, Zhao L, He L. A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol \u03b2 deficiency. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION95","doi-asserted-by":"publisher","first-page":"112261","DOI":"10.1016\/j.jep.2019.112261","volume":"247","author":"Hu J","year":"2020","unstructured":"Hu J, Zhou J, Wu J, Chen Q, Du W, Fu F, Yu H. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-\u03baB activity and pyroptosis in chondrocytes. J EthnoPharmacol, 2020, 247:","journal-title":"J EthnoPharmacol"},{"key":"CITATION96","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/art.42505","volume":"75","author":"Ebata T","year":"2023","unstructured":"Ebata T, Terkawi MA, Kitahara K, Yokota S, Shiota J, Nishida Y, Matsumae G. Noncanonical pyroptosis triggered bymacrophage-derived extracellular vesicles in chondrocytes leading to cartilage catabolism in osteoarthritis. Arthritis Rheumatology, 2023, 75: 1358-1369.","journal-title":"Arthritis Rheumatology"},{"key":"CITATION97","doi-asserted-by":"crossref","unstructured":"Liu G, Liu Q, Yan B, Zhu Z, Xu Y. USP7 inhibition alleviates H2O2-induced injury in chondrocytes via inhibiting NOX4\/NLRP3 pathway. Frontiers in Pharmacology 2020, 11: 617270.","DOI":"10.3389\/fphar.2020.617270"},{"key":"CITATION98","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00232-023-00282-0","volume":"256","author":"Al-Hetty HRAK","year":"2023","unstructured":"Al-Hetty HRAK, Abdulameer SJ, Alghazali MW, Sheri FS, Saleh MM, Jalil AT. The role of ferroptosis in the pathogenesis of osteoarthritis. J Membrane Biol, 2023, 256: 223-228.","journal-title":"J Membrane Biol"},{"key":"CITATION99","doi-asserted-by":"publisher","first-page":"110835","DOI":"10.1016\/j.cbi.2023.110835","volume":"388","author":"Ruan Q","year":"2024","unstructured":"Ruan Q, Wang C, Zhang Y, Sun J. Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2\/SLC7A11\/GPX4 signaling pathway. Chem-Biol Interact, 2024, 388:","journal-title":"Chem-Biol Interact"},{"key":"CITATION100","doi-asserted-by":"publisher","first-page":"122117","DOI":"10.1016\/j.lfs.2023.122117","volume":"332","author":"Sun J","year":"2023","unstructured":"Sun J, Zhang Y, Wang C, Ruan Q. Kukoamine A protects mice against osteoarthritis by inhibiting chondrocyte inflammation and ferroptosis via SIRT1\/GPX4 signaling pathway. Life Sci, 2023, 332:","journal-title":"Life Sci"},{"key":"CITATION101","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/cns.13838","volume":"28","author":"Song FH","year":"2022","unstructured":"Song FH, Liu DQ, Zhou YQ, Mei W. SIRT1: a promising therapeutic target for chronic pain. CNS Neurosci Ther, 2022, 28: 818-828.","journal-title":"CNS Neurosci Ther"},{"key":"CITATION102","doi-asserted-by":"publisher","first-page":"110924","DOI":"10.1016\/j.intimp.2023.110924","volume":"124","author":"Ruan Q","year":"2023","unstructured":"Ruan Q, Wang C, Zhang Y, Sun J. Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1\/Nrf2\/GPX4 signaling pathway. Int Immunopharmacol, 2023, 124:","journal-title":"Int Immunopharmacol"},{"key":"CITATION103","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1002\/tox.24131","volume":"39","author":"Li S","year":"2024","unstructured":"Li S, Han J, Cao J, Han H, Lu B, Wen T, Bian W. ADORA2B, transcriptionally suppressing byMYC , promotes ferroptosis of chondrocytes via inhibition of thePI3K\/Akt pathway in mice with osteoarthritis. Environ Toxicol, 2024, 39: 2487-2501.","journal-title":"Environ Toxicol"},{"key":"CITATION104","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1159\/000495828","volume":"51","author":"Li C","year":"2018","unstructured":"Li C, Deng T, Shang Z, Wang D, Xiao Y. Blocking TRPA1 and TNF-\u03b1 signal improves bortezomib-induced neuropathic pain. Cell Physiol Biochem, 2018, 51: 2098-2110.","journal-title":"Cell Physiol Biochem"},{"key":"CITATION105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/4736670","volume":"2021","author":"Li M","year":"2021","unstructured":"Li M, Zhang L, Liu Z, Zhang L, Xing R, Yin S, Li X. Sanse powder essential oil nanoemulsion negatively regulates TRPA1 by AMPK\/mTOR signaling in synovitis: knee osteoarthritis rat model and fibroblast-like synoviocyte isolates. Mediators Inflamm, 2021, 2021: 1-15.","journal-title":"Mediators Inflamm"},{"key":"CITATION106","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2023.01.006","volume":"196","author":"Wan Y","year":"2023","unstructured":"Wan Y, shen K, Yu H, Fan W. Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. Free Radical Biol Med, 2023, 196: 108-120.","journal-title":"Free Radical Biol Med"},{"key":"CITATION107","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.3390\/cells11213430","volume":"11","author":"Liu H","year":"2022","unstructured":"Liu H, Deng Z, Yu B, Liu H, Yang Z, Zeng A, Fu M. Identification of SLC3A2 as a potential therapeutic target of osteoarthritis involved in ferroptosis by integrating bioinformatics, clinical factors and experiments. Cells, 2022, 11:","journal-title":"Cells"},{"key":"CITATION108","doi-asserted-by":"publisher","first-page":"4230","DOI":"10.1111\/jcmm.17438","volume":"26","author":"Bai H","year":"2022","unstructured":"Bai H, Zhang Z, Liu L, Wang X, Song X, Gao L. Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3\/caspase\u20101\/GSDMD induced signalling. J Cell Mol Medi, 2022, 26: 4230-4243.","journal-title":"J Cell Mol Medi"},{"key":"CITATION109","doi-asserted-by":"publisher","first-page":"109085","DOI":"10.1016\/j.intimp.2022.109085","volume":"111","author":"Gong Y","year":"2022","unstructured":"Gong Y, Qiu J, Ye J, Jiang T, Zhang W, Zheng X, Zhu Z. AZ-628 delays osteoarthritis progression via inhibiting the TNF-\u03b1-induced chondrocyte necroptosis and regulating osteoclast formation. Int Immunopharmacol, 2022, 111:","journal-title":"Int Immunopharmacol"},{"key":"CITATION110","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s13018-019-1307-6","volume":"14","author":"Zu Y","year":"2019","unstructured":"Zu Y, Mu Y, Li Q, Zhang ST, Yan HJ. Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res, 2019, 14:","journal-title":"J Orthop Surg Res"},{"key":"CITATION111","doi-asserted-by":"publisher","first-page":"795058","DOI":"10.3389\/fphar.2021.795058","volume":"12","author":"Tian Z","year":"2021","unstructured":"Tian Z, Zhang X, Sun M. Phytochemicals mediate autophagy against osteoarthritis by maintaining cartilage homeostasis. Front Pharmacol, 2021, 12:","journal-title":"Front Pharmacol"},{"key":"CITATION112","doi-asserted-by":"publisher","first-page":"155075","DOI":"10.1016\/j.phymed.2023.155075","volume":"121","author":"Wu D","year":"2023","unstructured":"Wu D, Wang P, Zhao C, Su J, Zhang J, Ma W, Zhang Y. Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK\/NF-\u03baB-NLRP3 inflammasome axis. Phytomedicine, 2023, 121:","journal-title":"Phytomedicine"},{"key":"CITATION113","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3389\/fnins.2020.00831","volume":"14","author":"Wang Y","year":"2020","unstructured":"Wang Y, Li Y, Wang J, Zhao Q, Jin J, Wen S, Wang S. Maresin 1 attenuates radicular pain through the inhibition of NLRP3 inflammasome-induced pyroptosis via NF-\u03baB signaling. Front Neurosci, 2020, 14:","journal-title":"Front Neurosci"},{"key":"CITATION114","doi-asserted-by":"publisher","first-page":"17448069221147792","DOI":"10.1177\/17448069221147792","volume":"19","author":"Zhang W","year":"2023","unstructured":"Zhang W, Zhang L, Yang S, Wen B, Chen J, Chang J. Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis. Mol Pain, 2023, 19:","journal-title":"Mol Pain"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/FC276EF392694B7CAC1527B992CFB4A0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024189","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/FC276EF392694B7CAC1527B992CFB4A0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T01:43:40Z","timestamp":1757641420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2024189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":114,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,10,28]]},"published-print":{"date-parts":[[2025,2,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2024189","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,28]]}}}