{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T18:08:54Z","timestamp":1792951734123,"version":"4.5.0"},"reference-count":44,"publisher":"China Science Publishing & Media Ltd.","issue":"9","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.3724\/abbs.2025051","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T02:08:33Z","timestamp":1743473313000},"page":"1433-1445","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Vesicle-mediated transport-related gene SEC23A promotes cell proliferation by regulating cell cycle leading to gastric cancer progression"],"prefix":"10.3724","volume":"57","author":[{"given":"Kang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41568-021-00412-7","volume":"22","author":"Yeoh KG","year":"2022","unstructured":"Yeoh KG, Tan P. Mapping the genomic diaspora of gastric cancer. Nat Rev Cancer, 2022, 22: 71-84.","journal-title":"Nat Rev Cancer"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.omto.2020.03.012","volume":"17","author":"Cheng J","year":"2020","unstructured":"Cheng J, Zhuo H, Wang L, Zheng W, Chen X, Hou J, Zhao J. Identification of the combinatorial effect of miRNA family regulatory network in different growth patterns of GC. Mol Ther Oncolytics, 2020, 17: 531-546.","journal-title":"Mol Ther Oncolytics"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12967-018-1582-8","volume":"16","author":"Cheng J","year":"2018","unstructured":"Cheng J, Zhuo H, Xu M, Wang L, Xu H, Peng J, Hou J. Regulatory network of circRNA\u2013miRNA\u2013mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med, 2018, 16:","journal-title":"J Transl Med"},{"key":"CITATION4-1","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1007\/s00268-005-7795-z","volume":"29","author":"Luebke T","year":"2005","unstructured":"Luebke T, Baldus SE, Grass G, Bollschweiler E, Thiele J, Dienes HP, Hoelscher AH. Histological grading in gastric cancer by ming classification: correlation with histopathological subtypes, metastasis, and prognosis. World J Surg, 2005, 29: 1422-1427.","journal-title":"World J Surg"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1002\/1097-0142(197706)39:6<2475::AID-CNCR2820390626>3.0.CO;2-L","volume":"39","author":"Ming SC","year":"1977","unstructured":"Ming SC. Gastric carcinoma: a pathobiological classification. Cancer, 1977, 39: 2475-2485.","journal-title":"Cancer"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1016\/j.cell.2021.03.035","volume":"184","author":"Weigel AV","year":"2021","unstructured":"Weigel AV, Chang CL, Shtengel G, Xu CS, Hoffman DP, Freeman M, Iyer N. ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER. Cell, 2021, 184: 2412-2429.e16.","journal-title":"Cell"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"1034992","DOI":"10.3389\/fimmu.2022.1034992","volume":"13","author":"Qian C","year":"2022","unstructured":"Qian C, Jiang Z, Zhou T, Wu T, Zhang Y, Huang J, Ouyang J. Vesicle-mediated transport-related genes are prognostic predictors and are associated with tumor immunity in lung adenocarcinoma. Front Immunol, 2022, 13:","journal-title":"Front Immunol"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/0968768031000122548","volume":"20","author":"Duden R","year":"2003","unstructured":"Duden R. ER-to-Golgi transport: COP I and COP II function (Review). Mol Membrane Biol, 2003, 20: 197-207.","journal-title":"Mol Membrane Biol"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/s41419-021-04086-9","volume":"12","author":"Xie A","year":"2021","unstructured":"Xie A, Xu X, Kuang P, Zhang L, Yu F. TMED3 promotes the progression and development of lung squamous cell carcinoma by regulating EZR. Cell Death Dis, 2021, 12:","journal-title":"Cell Death Dis"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"895281","DOI":"10.3389\/fgene.2022.895281","volume":"13","author":"Gao W","year":"2022","unstructured":"Gao W, Zhang ZW, Wang HY, Li XD, Peng WT, Guan HY, Liao YX. TMED2\/9\/10 serve as biomarkers for poor prognosis in head and neck squamous carcinoma. Front Genet, 2022, 13:","journal-title":"Front Genet"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1096899","DOI":"10.3389\/fcell.2022.1096899","volume":"10","author":"Roberts BS","year":"2022","unstructured":"Roberts BS, Satpute-Krishnan P. The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis. Front Cell Dev Biol, 2022, 10:","journal-title":"Front Cell Dev Biol"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.7150\/ijbs.37008","volume":"15","author":"Jing J","year":"2019","unstructured":"Jing J, Wang B, Liu P. The functional role of SEC23 in vesicle transportation, autophagy and cancer. Int J Biol Sci, 2019, 15: 2419-2426.","journal-title":"Int J Biol Sci"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nm.2401","volume":"17","author":"Korpal M","year":"2011","unstructured":"Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celi\u00e0-Terrassa T, Mercatali L. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med, 2011, 17: 1101-1108.","journal-title":"Nat Med"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"672832","DOI":"10.3389\/fgene.2021.672832","volume":"12","author":"Zeng B","year":"2021","unstructured":"Zeng B, Zhao Q, Sun Z, Liu D, Chen H, Li X, Wang J. SEC23A is an independent prognostic biomarker in bladder cancer correlated with MAPK signaling. Front Genet, 2021, 12:","journal-title":"Front Genet"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12964-022-00827-1","volume":"20","author":"Sun Z","year":"2022","unstructured":"Sun Z, Liu D, Zeng B, Zhao Q, Li X, Chen H, Wang J. Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy. Cell Commun Signal, 2022, 20:","journal-title":"Cell Commun Signal"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.3390\/cancers15072065","volume":"15","author":"Zhaoran S","year":"2023","unstructured":"Zhaoran S, Linnebacher CS, Linnebacher M. Increased SEC23A expression correlates with poor prognosis and immune infiltration in stomach adenocarcinoma. Cancers, 2023, 15:","journal-title":"Cancers"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ebiom.2018.10.002","volume":"37","author":"Sun Z","year":"2018","unstructured":"Sun Z, Zhou S, Tang J, Ye T, Li J, Liu D, Zhou J. Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression. EBioMedicine, 2018, 37: 47-55.","journal-title":"EBioMedicine"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.7150\/ijbs.60866","volume":"17","author":"Zeng B","year":"2021","unstructured":"Zeng B, Sun Z, Zhao Q, Liu D, chen H, Li X, Xing HR. SEC23A inhibit melanoma metastatic through secretory PF4 cooperation with SPARC to inhibit MAPK signaling pathway. Int J Biol Sci, 2021, 17: 3000-3012.","journal-title":"Int J Biol Sci"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41419-020-02835-w","volume":"11","author":"Sun Z","year":"2020","unstructured":"Sun Z, Zeng B, Liu D, Zhao Q, Wang J, Rosie Xing H. S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy. Cell Death Dis, 2020, 11:","journal-title":"Cell Death Dis"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13046-023-02807-w","volume":"42","author":"Cheng Q","year":"2023","unstructured":"Cheng Q, Liu K, Xiao J, Shen K, Wang Y, Zhou X, Wang J. SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop. J Exp Clin Cancer Res, 2023, 42:","journal-title":"J Exp Clin Cancer Res"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.3390\/cancers15153965","volume":"15","author":"Hong Z","year":"2023","unstructured":"Hong Z, Xie W, Zhuo H, Wei X, Wang K, Cheng J, Lin L. Crosstalk between cancer cells and cancer-associated fibroblasts mediated by TGF-\u03b21\u2013IGFBP7 signaling promotes the progression of infiltrative gastric cancer. Cancers, 2023, 15:","journal-title":"Cancers"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/bioinformatics\/bty750","volume":"35","author":"Wang H","year":"2019","unstructured":"Wang H, Lengerich BJ, Aragam B, Xing EP, Stegle O. Precision lasso: accounting for correlations and linear dependencies in high-dimensional genomic data. Bioinformatics, 2019, 35: 1181-1187.","journal-title":"Bioinformatics"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"12890","DOI":"10.3390\/ijms241612890","volume":"24","author":"Su C","year":"2023","unstructured":"Su C, Yu R, Hong X, Zhang P, Guo Y, Cai JC, Hou J. CXCR4 expressed by tumor-infiltrating B cells in gastric cancer related to survival in the tumor microenvironment: an analysis combining single-cell RNA sequencing with bulk RNA sequencing. Int J Mol Sci, 2023, 24:","journal-title":"Int J Mol Sci"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/s12935-020-01536-w","volume":"20","author":"Peng J","year":"2020","unstructured":"Peng J, Xu H, Cai J. Establishment and characterization of a new gastric cancer cell line, XGC-1. Cancer Cell Int, 2020, 20:","journal-title":"Cancer Cell Int"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.3892\/or.2016.5090","volume":"36","author":"Xu H","year":"2016","unstructured":"Xu H, Peng JG, Zhuang YF, Chen JJ, Luo QC, Huang WF, Lin CD. Establishment and characterization of an expanding-type gastric cancer cell line by Ming\u2019s classification. Oncol Rep, 2016, 36: 3030-3036.","journal-title":"Oncol Rep"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"1455890","DOI":"10.3389\/fmolb.2024.1455890","volume":"11","author":"Su C","year":"2024","unstructured":"Su C, Lin Z, Ye Z, Liang J, Yu R, Wan Z, Hou J. Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape. Front Mol Biosci, 2024, 11:","journal-title":"Front Mol Biosci"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12885-024-11878-7","volume":"24","author":"Hong Z","year":"2024","unstructured":"Hong Z, Wen P, Wang K, Wei X, Xie W, Rao S, Chen X. The macrophage-associated prognostic gene ANXA5 promotes immunotherapy resistance in gastric cancer through angiogenesis. BMC Cancer, 2024, 24:","journal-title":"BMC Cancer"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.semcancer.2019.08.018","volume":"60","author":"Marx S","year":"2020","unstructured":"Marx S, Dal Maso T, Chen JW, Bury M, Wouters J, Michiels C, Le Calv\u00e9 B. Transmembrane (TMEM) protein family members: poorly characterized even if essential for the metastatic process. Semin Cancer Biol, 2020, 60: 96-106.","journal-title":"Semin Cancer Biol"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12929-016-0287-7","volume":"23","author":"Tzeng HT","year":"2016","unstructured":"Tzeng HT, Wang YC. Rab-mediated vesicle trafficking in cancer. J Biomed Sci, 2016, 23:","journal-title":"J Biomed Sci"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41419-023-05596-4","volume":"14","author":"Chen K","year":"2023","unstructured":"Chen K, Xu J, Tong Y, Yan JF, Pan Y, Wang W, Zheng L. Rab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT. Cell Death Dis, 2023, 14:","journal-title":"Cell Death Dis"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13578-023-01006-6","volume":"13","author":"Guo X","year":"2023","unstructured":"Guo X, Yin X, Xu Y, Li L, Yuan M, Zhao H, Jiang Y. TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K\/Akt pathway. Cell Biosci, 2023, 13:","journal-title":"Cell Biosci"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"598532","DOI":"10.3389\/fimmu.2020.598532","volume":"11","author":"Hussain S","year":"2020","unstructured":"Hussain S, Peng B, Cherian M, Song JW, Ahirwar DK, Ganju RK. The roles of stroma-derived chemokine in different stages of cancer metastases. Front Immunol, 2020, 11:","journal-title":"Front Immunol"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.7150\/ijbs.76425","volume":"18","author":"Zhang P","year":"2022","unstructured":"Zhang P, Cao X, Guan M, Li D, Xiang H, Peng Q, Zhou Y. CPNE8 promotes gastric cancer metastasis by modulating focal adhesion pathway and tumor microenvironment. Int J Biol Sci, 2022, 18: 4932-4949.","journal-title":"Int J Biol Sci"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3389\/fimmu.2020.01731","volume":"11","author":"Wu K","year":"2020","unstructured":"Wu K, Lin K, Li X, Yuan X, Xu P, Ni P, Xu D. Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment. Front Immunol, 2020, 11:","journal-title":"Front Immunol"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","volume":"18","author":"Myers JA","year":"2021","unstructured":"Myers JA, Miller JS. Exploring the NK cell platform for cancer immunotherapy. Nat Rev Clin Oncol, 2021, 18: 85-100.","journal-title":"Nat Rev Clin Oncol"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41423-018-0027-x","volume":"16","author":"Wang S","year":"2019","unstructured":"Wang S, Liu W, Ly D, Xu H, Qu L, Zhang L. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer. Cell Mol Immunol, 2019, 16: 6-18.","journal-title":"Cell Mol Immunol"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jcmm.12403","volume":"19","author":"Chua CEL","year":"2015","unstructured":"Chua CEL, Tang BL. The role of the small GTPase Rab31 in cancer. J Cell Mol Med, 2015, 19: 1-10.","journal-title":"J Cell Mol Med"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.3389\/fonc.2020.01747","volume":"10","author":"Yang T","year":"2020","unstructured":"Yang T, Zhiheng H, Zhanhuai W, Qian X, Yue L, Xiaoxu G, Jingsun W. Increased RAB31 expression in cancer-associated fibroblasts promotes colon cancer progression through HGF-MET signaling. Front Oncol, 2020, 10:","journal-title":"Front Oncol"},{"key":"CITATION39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.7150\/ijbs.63388","volume":"18","author":"Huang Y","year":"2022","unstructured":"Huang Y, Liu R, Han X, Hou X, Tian Y, Zhang W. Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation. Int J Biol Sci, 2022, 18: 112-123.","journal-title":"Int J Biol Sci"},{"key":"CITATION40","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.7150\/jca.32072","volume":"10","author":"Li H","year":"2019","unstructured":"Li H, Zhang SR, Xu HX, Wang WQ, Li S, Li TJ, Ni QX. SRPX2 and RAB31 are effective prognostic biomarkers in pancreatic cancer. J Cancer, 2019, 10: 2670-2678.","journal-title":"J Cancer"},{"key":"CITATION41","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1096\/fj.201600698R","volume":"30","author":"Schaaf MBE","year":"2016","unstructured":"Schaaf MBE, Keulers TG, Vooijs MA, Rouschop KMA. LC3\/GABARAP family proteins: autophagy-(un)related functions. FASEB J, 2016, 30: 3961-3978.","journal-title":"FASEB J"},{"key":"CITATION42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1080\/15548627.2020.1749367","volume":"17","author":"Jacquet M","year":"2021","unstructured":"Jacquet M, Guittaut M, Fraichard A, Despouy G. The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?. Autophagy, 2021, 17: 599-611.","journal-title":"Autophagy"},{"key":"CITATION43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12935-020-01267-y","volume":"20","author":"Qiu J","year":"2020","unstructured":"Qiu J, Sun M, Wang Y, Chen B. Identification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients. Cancer Cell Int, 2020, 20:","journal-title":"Cancer Cell Int"},{"key":"CITATION44","doi-asserted-by":"publisher","first-page":"107227","DOI":"10.1016\/j.compbiomed.2023.107227","volume":"163","author":"Wang Z","year":"2023","unstructured":"Wang Z, Chen C, Ai J, Shu J, Ding Y, Wang W, Gao Y. Identifying mitophagy-related genes as prognostic biomarkers and therapeutic targets of gastric carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data. Comput Biol Med, 2023, 163:","journal-title":"Comput Biol Med"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/E521931D1BA0467289695CABB037EB33","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025051","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/E521931D1BA0467289695CABB037EB33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:57:25Z","timestamp":1759139845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5,22]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2025051","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}