{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:07:24Z","timestamp":1759190844122,"version":"3.44.0"},"reference-count":38,"publisher":"China Science Publishing & Media Ltd.","issue":"9","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.3724\/abbs.2025067","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T13:33:21Z","timestamp":1745156001000},"page":"1406-1419","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Integrated multi-omics and experimental approaches identify fascin actin-bundling protein 1 as an unfavorable prognostic biomarker in adrenocortical carcinoma"],"prefix":"10.3724","volume":"57","author":[{"given":"Pingkaiqi","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanfan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weide","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"CITATION1","unstructured":"Favia G, Lumachi F, Carraro P, D\u2032Amico DF. Adrenocortical carcinoma. our experience. Minerva Endocrinol 1995, 20: 95\u201399."},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"e756s","DOI":"10.6061\/clinics\/2018\/e756s","volume":"73","author":"Almeida MQ","year":"2018","unstructured":"Almeida MQ, Bezerra-Neto JE, Mendon\u00e7a BB, Latronico AC, Fragoso MCBV. Primary malignant tumors of the adrenal glands. Clinics, 2018, 73:","journal-title":"Clinics"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.canlet.2020.10.022","volume":"497","author":"Catalano R","year":"2021","unstructured":"Catalano R, Giardino E, Treppiedi D, Mangili F, Morelli V, Elli FM, Serban AL. The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells. Cancer Lett, 2021, 497: 77-88.","journal-title":"Cancer Lett"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"Barrett T","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA. NCBI GEO: archive for functional genomics data sets\u2014update. Nucleic Acids Res, 2013, 41: D991-D995.","journal-title":"Nucleic Acids Res"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.5114\/wo.2014.47136","volume":"1A","author":"Tomczak K","year":"2015","unstructured":"Tomczak K, Czerwi\u0144ska P, Wiznerowicz M. Review the cancer genome atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn), 2015, 1A: 68-77.","journal-title":"Contemp Oncol (Pozn)"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.7150\/jca.67977","volume":"13","author":"Li Z","year":"2022","unstructured":"Li Z, Shi J, Zhang N, Zheng X, Jin Y, Wen S, Hu W. FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance. J Cancer, 2022, 13: 2528-2539.","journal-title":"J Cancer"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1186\/s12885-019-6389-3","volume":"19","author":"Liang J","year":"2019","unstructured":"Liang J, Liu Z, Wei X, Zhou L, Tang Y, Zhou C, Wu K. Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients. BMC Cancer, 2019, 19:","journal-title":"BMC Cancer"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1210\/jc.2018-01717","volume":"104","author":"Poli G","year":"2019","unstructured":"Poli G, Ruggiero C, Cantini G, Canu L, Baroni G, Armignacco R, Jouinot A. Fascin-1 is a novel prognostic biomarker associated with tumor invasiveness in adrenocortical carcinoma. J Clin Endocrinol Metab, 2019, 104: 1712-1724.","journal-title":"J Clin Endocrinol Metab"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"698862","DOI":"10.3389\/fendo.2021.698862","volume":"12","author":"Cantini G","year":"2021","unstructured":"Cantini G, Fei L, Canu L, De Filpo G, Ercolino T, Nesi G, Mannelli M. Circulating fascin 1 as a promising prognostic marker in adrenocortical cancer. Front Endocrinol, 2021, 12:","journal-title":"Front Endocrinol"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"103750","DOI":"10.1016\/j.ebiom.2021.103750","volume":"75","author":"Liu Z","year":"2022","unstructured":"Liu Z, Guo CG, Dang Q, Wang L, Liu L, Weng S, Xu H. Integrative analysis from multi-center studies identities a consensus machine learning-derived lncRNA signature for stage II\/III colorectal cancer. EBioMedicine, 2022, 75:","journal-title":"EBioMedicine"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"Langfelder P","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC BioInf, 2008, 9:","journal-title":"BMC BioInf"},{"key":"CITATION12","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v046.i11","volume":"46: i11","author":"Langfelder P","year":"2012","unstructured":"Langfelder P, Horvath S. Fast R Functions for robust correlations and hierarchical clustering. J Stat Soft, 2012, 46: i11:","journal-title":"J Stat Soft"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1002\/imt2.36","volume":"1","author":"Shen W","year":"2022","unstructured":"Shen W, Song Z, Zhong X, Huang M, Shen D, Gao P, Qian X. Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta, 2022, 1:","journal-title":"iMeta"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"Wu T","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation, 2021, 2:","journal-title":"Innovation"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"Love MI","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol, 2014, 15:","journal-title":"Genome Biol"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.2703","volume":"14","author":"Gajewski TF","year":"2013","unstructured":"Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol, 2013, 14: 1014-1022.","journal-title":"Nat Immunol"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","volume":"31","author":"Yu G","year":"2015","unstructured":"Yu G, Wang LG, He QY. ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics, 2015, 31: 2382-2383.","journal-title":"Bioinformatics"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"eaav1898","DOI":"10.1126\/science.aav1898","volume":"362","author":"Corces MR","year":"2018","unstructured":"Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC. The chromatin accessibility landscape of primary human cancers. Science, 2018, 362:","journal-title":"Science"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1158\/0008-5472.CAN-17-0337","volume":"77","author":"Robinson JT","year":"2017","unstructured":"Robinson JT, Thorvaldsd\u00f3ttir H, Wenger AM, Zehir A, Mesirov JP. Variant review with the integrative genomics viewer. Cancer Res, 2017, 77: e31-e34.","journal-title":"Cancer Res"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","volume":"173","author":"Liu J","year":"2018","unstructured":"Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ. An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell, 2018, 173: 400-416.e11.","journal-title":"Cell"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.7150\/ijbs.77133","volume":"19","author":"Zhong C","year":"2023","unstructured":"Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JYC. M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy. Int J Biol Sci, 2023, 19: 1543-1563.","journal-title":"Int J Biol Sci"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ijbiomac.2018.06.005","volume":"118","author":"Lu J","year":"2018","unstructured":"Lu J, Dong W, He H, Han Z, Zhuo YJ, Mo RJ, Liang Y. Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer. Int J Biol Macromol, 2018, 118: 599-609.","journal-title":"Int J Biol Macromol"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"687975","DOI":"10.3389\/fimmu.2021.687975","volume":"12","author":"Zeng D","year":"2021","unstructured":"Zeng D, Ye Z, Shen R, Yu G, Wu J, Xiong Y, Zhou R. IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures. Front Immunol, 2021, 12:","journal-title":"Front Immunol"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41568-019-0235-4","volume":"20","author":"van der Leun AM","year":"2020","unstructured":"van der Leun AM, Thommen DS, Schumacher TN. CD8+ T cell states in human cancer: insights from single-cell analysis. Nat Rev Cancer, 2020, 20: 218-232.","journal-title":"Nat Rev Cancer"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.canlet.2009.01.006","volume":"278","author":"Ismail A","year":"2009","unstructured":"Ismail A, Bateman A. Expression of TBX2 promotes anchorage-independent growth and survival in the p53-negative SW13 adrenocortical carcinoma. Cancer Lett, 2009, 278: 230-240.","journal-title":"Cancer Lett"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.ecl.2015.03.001","volume":"44","author":"Baudin E","year":"2015","unstructured":"Baudin E. Adrenocortical carcinoma. Endocrinol Metab Clin N Am, 2015, 44: 411-434.","journal-title":"Endocrinol Metab Clin N Am"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/35074122","volume":"410","author":"Shankaran V","year":"2001","unstructured":"Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD. IFN\u03b3 and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature, 2001, 410: 1107-1111.","journal-title":"Nature"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"868296","DOI":"10.3389\/fphar.2022.868296","volume":"13","author":"Cai H","year":"2022","unstructured":"Cai H, Wang R, Tang Z, Lu T, Cui Y. FSCN1 promotes esophageal carcinoma progression through downregulating PTK6 via its RNA-Binding protein effect. Front Pharmacol, 2022, 13:","journal-title":"Front Pharmacol"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.mce.2015.10.021","volume":"419","author":"Liu C","year":"2016","unstructured":"Liu C, Gao H, Cao L, Gui S, Liu Q, Li C, Li D. The role of FSCN1 in migration and invasion of pituitary adenomas. Mol Cell Endocrinol, 2016, 419: 217-224.","journal-title":"Mol Cell Endocrinol"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/ijc.34526","volume":"153","author":"Ruggiero C","year":"2023","unstructured":"Ruggiero C, Tamburello M, Rossini E, Zini S, Durand N, Cantini G, Cioppi F. FSCN1 as a new druggable target in adrenocortical carcinoma. Intl J Cancer, 2023, 153: 210-223.","journal-title":"Intl J Cancer"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s13402-022-00726-0","volume":"45","author":"Huang Y","year":"2022","unstructured":"Huang Y, Shan G, Yi Y, Liang J, Hu Z, Bi G, Chen Z. FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis. Cell Oncol, 2022, 45: 1383-1399.","journal-title":"Cell Oncol"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41419-022-04579-1","volume":"13","author":"Chen C","year":"2022","unstructured":"Chen C, Xie B, Li Z, Chen L, Chen Y, Zhou J, Ju S. Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis. Cell Death Dis, 2022, 13:","journal-title":"Cell Death Dis"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/jcp.20144","volume":"202","author":"Derenzini M","year":"2005","unstructured":"Derenzini M, Montanaro L, Chill\u00e0 A, Tosti E, Vici M, Barbieri S, Govoni M. Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells. J Cell Physiol, 2005, 202: 483-491.","journal-title":"J Cell Physiol"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.acthis.2017.01.009","volume":"119","author":"Derenzini M","year":"2017","unstructured":"Derenzini M, Montanaro L, Trer\u00e8 D. Ribosome biogenesis and cancer. Acta Histochemica, 2017, 119: 190-197.","journal-title":"Acta Histochemica"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"4396","DOI":"10.1038\/onc.2014.1","volume":"33","author":"Brighenti E","year":"2014","unstructured":"Brighenti E, Calabrese C, Liguori G, Giannone FA, Trer\u00e8 D, Montanaro L, Derenzini M. Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer. Oncogene, 2014, 33: 4396-4406.","journal-title":"Oncogene"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.tcb.2020.06.003","volume":"30","author":"St. Paul M","year":"2020","unstructured":"St. Paul M, Ohashi PS. The roles of CD8+ T cell subsets in antitumor immunity. Trends Cell Biol, 2020, 30: 695-704.","journal-title":"Trends Cell Biol"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"215888","DOI":"10.1016\/j.canlet.2022.215888","volume":"548","author":"Frankiw L","year":"2022","unstructured":"Frankiw L, Li G. The tumor microenvironment\u2032s role in malignant progression and treatment response. Cancer Lett, 2022, 548:","journal-title":"Cancer Lett"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature21349","volume":"541","author":"Chen DS","year":"2017","unstructured":"Chen DS, Mellman I. Elements of cancer immunity and the cancer\u2013immune set point. Nature, 2017, 541: 321-330.","journal-title":"Nature"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/ECBA917BD5D343CA9D34E949FB82D96A","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025067","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/ECBA917BD5D343CA9D34E949FB82D96A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:56:17Z","timestamp":1759139777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5,19]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2025067","relation":{},"ISSN":["1672-9145"],"issn-type":[{"type":"print","value":"1672-9145"}],"subject":[],"published":{"date-parts":[[2025,5,19]]}}}