{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:27:21Z","timestamp":1792016841113,"version":"4.4.0"},"reference-count":27,"publisher":"China Science Publishing & Media Ltd.","issue":"3","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,3,1]]},"DOI":"10.3724\/abbs.2025148","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:57:12Z","timestamp":1755237432000},"page":"638-648","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis"],"prefix":"10.3724","volume":"58","author":[{"given":"Lingyu","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/biom14010010","volume":"14","author":"Tsoporis JN","year":"2024","unstructured":"Tsoporis JN, Triantafyllis AS, Kalogeropoulos AS, Izhar S, Rigopoulos AG, Rallidis LS, Sakadakis E. Differential expression of circulating damage-associated molecular patterns in patients with coronary artery ectasia. Biomolecules, 2024, 14: 10.","journal-title":"Biomolecules"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/bjs.8679","volume":"99","author":"Segelman J","year":"2012","unstructured":"Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A. Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. Br J Surg, 2012, 99: 699-705.","journal-title":"Br J Surg"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/SLA.0000000000006492","volume":"280","author":"Dagenborg VJ","year":"2024","unstructured":"Dagenborg VJ, Brudvik KW, Lund-Andersen C, Torgunrud A, Lund-Iversen M, Flatmark K, Larsen SG. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy and liver resection is a treatment option for patients with peritoneal and liver metastases from colorectal cancer. Ann Surg, 2024, 280: 745-752.","journal-title":"Ann Surg"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1158\/1078-0432.CCR-24-1651","volume":"30","author":"Nakamura Y","year":"2024","unstructured":"Nakamura Y, Tsukada Y, Matsuhashi N, Murano T, Shiozawa M, Takahashi Y, Oki E. Colorectal cancer recurrence prediction using a tissue-free epigenomic minimal residual disease assay. Clin Cancer Res, 2024, 30: 4377-4387.","journal-title":"Clin Cancer Res"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1186\/s12967-024-05467-2","volume":"22","author":"Lund-Andersen C","year":"2024","unstructured":"Lund-Andersen C, Torgunrud A, Kanduri C, Dagenborg VJ, Fr\u00f8ysnes IS, Larsen MM, Davidson B. Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer. J Transl Med, 2024, 22: 646.","journal-title":"J Transl Med"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"2402966","DOI":"10.1002\/adhm.202402966","volume":"14","author":"Marwedel B","year":"2025","unstructured":"Marwedel B, De May H, Anderson L, Medina LY, Kennedy E, Flores E, O\u2032Rourke J. TLR agonist nano immune therapy clears peritoneal and systemic ovarian cancer. Adv Healthcare Mater, 2025, 14: 2402966.","journal-title":"Adv Healthcare Mater"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1681\/ASN.2013101079","volume":"25","author":"Chen YT","year":"2014","unstructured":"Chen YT, Chang YT, Pan SY, Chou YH, Chang FC, Yeh PY, Liu YH. Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury. J Am Soc Nephrol, 2014, 25: 2847-2858.","journal-title":"J Am Soc Nephrol"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1756-9966-29-139","volume":"29","author":"Lv ZD","year":"2010","unstructured":"Lv ZD, Na D, Liu FN, Du ZM, Sun Z, Li Z, Ma XY. Induction of gastric cancer cell adhesion through transforming growth factor-beta1-mediated peritoneal fibrosis. J Exp Clin Cancer Res, 2010, 29: 139.","journal-title":"J Exp Clin Cancer Res"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1158\/0008-5472.CAN-16-0964","volume":"77","author":"Tanaka M","year":"2017","unstructured":"Tanaka M, Kuriyama S, Itoh G, Maeda D, Goto A, Tamiya Y, Yanagihara K. Mesothelial cells create a novel tissue niche that facilitates gastric cancer invasion. Cancer Res, 2017, 77: 684-695.","journal-title":"Cancer Res"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","volume":"40","author":"Huang H","year":"2022","unstructured":"Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G. Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell, 2022, 40: 656-673.e7.","journal-title":"Cancer Cell"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1038\/s41467-020-17383-2","volume":"11","author":"Au-Yeung CL","year":"2020","unstructured":"Au-Yeung CL, Yeung TL, Achreja A, Zhao H, Yip KP, Kwan SY, Onstad M. ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Nat Commun, 2020, 11: 3546.","journal-title":"Nat Commun"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.semcancer.2020.12.024","volume":"77","author":"Ghoneum A","year":"2021","unstructured":"Ghoneum A, Almousa S, Warren B, Abdulfattah AY, Shu J, Abouelfadl H, Gonzalez D. Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer. Semin Cancer Biol, 2021, 77: 83-98.","journal-title":"Semin Cancer Biol"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mito.2019.07.009","volume":"49","author":"Pettersen IKN","year":"2019","unstructured":"Pettersen IKN, Tusubira D, Ashrafi H, Dyrstad SE, Hansen L, Liu XZ, Nilsson LIH. Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion, 2019, 49: 97-110.","journal-title":"Mitochondrion"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"101938","DOI":"10.1016\/j.molmet.2024.101938","volume":"84","author":"Desmet SJ","year":"2024","unstructured":"Desmet SJ, Thommis J, Vanderhaeghen T, Vandenboorn EMF, Clarisse D, Li Y, Timmermans S. Crosstalk interactions between transcription factors ERR\u03b1 and PPAR\u03b1 assist PPAR\u03b1-mediated gene expression. Mol Metab, 2024, 84: 101938.","journal-title":"Mol Metab"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"e2408049121","DOI":"10.1073\/pnas.2408049121","volume":"121","author":"Sinha A","year":"2024","unstructured":"Sinha A, Saini KK, Chandramouli A, Tripathi K, Khan MA, Satrusal SR, Verma A. ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis. Proc Natl Acad Sci USA, 2024, 121: e2408049121.","journal-title":"Proc Natl Acad Sci USA"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"109134","DOI":"10.1016\/j.envint.2024.109134","volume":"193","author":"Zhou M","year":"2024","unstructured":"Zhou M, Qian Y, Du M, Wang J, Li J, Wang W. Metabolite identification of emerging disinfection byproduct dibromo-benzoquinone in vivo and in vitro: multi-strategy mass-spectrometry annotation and toxicity characterization. Environ Int, 2024, 193: 109134.","journal-title":"Environ Int"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"2406562","DOI":"10.1002\/advs.202406562","volume":"12","author":"Zhang Z","year":"2025","unstructured":"Zhang Z, Gao Y, Qian Y, Wei B, Jiang K, Sun Z, Zhang F. The Lyn\/RUVBL1 complex promotes colorectal cancer liver metastasis by regulating arachidonic acid metabolism through chromatin remodeling. Adv Sci, 2025, 12: 2406562.","journal-title":"Adv Sci"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"2405758","DOI":"10.1002\/advs.202405758","volume":"12","author":"Xiang Z","year":"2025","unstructured":"Xiang Z, Wang Y, Ma X, Song S, He Y, Zhou J, Feng L. Targeting the NOTCH2\/ADAM10\/TCF7L2 axis-mediated transcriptional regulation of wnt pathway suppresses tumor growth and enhances chemosensitivity in colorectal cancer. Adv Sci, 2025, 12: 2405758.","journal-title":"Adv Sci"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/gutjnl-2024-332752","volume":"74","author":"Schwarzmueller LJ","year":"2025","unstructured":"Schwarzmueller LJ, Adam RS, Moreno LF, Nijman LE, Logiantara A, Eleonora S, Bril O. Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome. Gut, 2025, 74: 571-585.","journal-title":"Gut"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/cac2.12341","volume":"42","author":"Dai W","year":"2022","unstructured":"Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y. PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism. Cancer Commun, 2022, 42: 848-867.","journal-title":"Cancer Commun"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.7150\/ijbs.101051","volume":"20","author":"Chen HH","year":"2024","unstructured":"Chen HH, Luo CW, Chen YL, Chiang JY, Huang CR, Wang YT, Chen CH. Probiotic-facilitated cytokine-induced killer cells suppress peritoneal carcinomatosis and liver metastasis in colorectal cancer cells. Int J Biol Sci, 2024, 20: 6162-6180.","journal-title":"Int J Biol Sci"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1172\/JCI74778","volume":"124","author":"Kenny HA","year":"2014","unstructured":"Kenny HA, Chiang CY, White EA, Schryver EM, Habis M, Romero IL, Ladanyi A. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest, 2014, 124: 4614-4628.","journal-title":"J Clin Invest"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"216901","DOI":"10.1016\/j.canlet.2024.216901","volume":"591","author":"Zhang J","year":"2024","unstructured":"Zhang J, Fu L, Wang H, Yonemura A, Semba T, Yasuda-Yoshihara N, Nishimura A. RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. Cancer Lett, 2024, 591: 216901.","journal-title":"Cancer Lett"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"135733","DOI":"10.1016\/j.jhazmat.2024.135733","volume":"479","author":"Zhang R","year":"2024","unstructured":"Zhang R, Tu L, Lin Y, Liu J, Liang T, Lu W, Chen B. Effective strategies alleviate mitochondrial toxicity of perfluorooctanoic acid: modification of functional head group and inhibition of toxic target. J Hazard Mater, 2024, 479: 135733.","journal-title":"J Hazard Mater"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/abbi.2000.1946","volume":"381","author":"Wu P","year":"2000","unstructured":"Wu P, Blair PV, Sato J, Jaskiewicz J, Popov KM, Harris RA. Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch Biochem Biophys, 2000, 381: 1-7.","journal-title":"Arch Biochem Biophys"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2024.10.015","volume":"37","author":"Zhu R","year":"2025","unstructured":"Zhu R, Ye X, Lu X, Xiao L, Yuan M, Zhao H, Guo D. ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion. Cell Metab, 2025, 37: 361-376.e7.","journal-title":"Cell Metab"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s41418-024-01341-2","volume":"31","author":"Liu YT","year":"2024","unstructured":"Liu YT, Chen L, Li SJ, Wang WY, Wang YY, Yang QC, Song A. Dysregulated Wnt\/\u03b2-catenin signaling confers resistance to cuproptosis in cancer cells. Cell Death Differ, 2024, 31: 1452-1466.","journal-title":"Cell Death Differ"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/1E4E7C38F12944FA8E74B0139531CC99","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025148","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/1E4E7C38F12944FA8E74B0139531CC99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:18:06Z","timestamp":1775204286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,1,28]]},"published-print":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2025148","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,28]]}}}