{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:25:09Z","timestamp":1786933509683,"version":"build-2736575974"},"reference-count":38,"publisher":"China Science Publishing & Media Ltd.","issue":"7","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.3724\/abbs.2025257","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T08:42:27Z","timestamp":1767516147000},"page":"1557-1567","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Glycolysis reprogramming predicts poor prognosis and drives therapy resistance via CLN6 in lethal prostate cancer"],"prefix":"10.3724","volume":"58","author":[{"given":"Zhouda","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jipu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongding","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianheng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weide","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71: 209-249.","journal-title":"CA Cancer J Clin"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-022-01042-7","volume":"7","author":"He Y","year":"2022","unstructured":"He Y, Xu W, Xiao YT, Huang H, Gu D, Ren S. Targeting signaling pathways in prostate cancer: Mechanisms and clinical trials. Sig Transduct Target Ther, 2022, 7:","journal-title":"Sig Transduct Target Ther"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"217808","DOI":"10.1016\/j.canlet.2025.217808","volume":"625","author":"Jiang H","year":"2025","unstructured":"Jiang H, Zeng Y, Ning W, Hong J, Zhu M, Li P, Ye F. Ketogenesis instigates immune suppression in enzalutamide resistant prostate cancer via OTUD7B \u03b2-hydroxybutyrylation. Cancer Lett, 2025, 625:","journal-title":"Cancer Lett"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ajur.2022.11.002","volume":"10","author":"He W","year":"2023","unstructured":"He W, Xiao Y, Yan S, Zhu Y, Ren S. Cell-free DNA in the management of prostate cancer: current status and future prospective. Asian J Urol, 2023, 10: 298-316.","journal-title":"Asian J Urol"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/ijms24020910","volume":"24","author":"Lasorsa F","year":"2023","unstructured":"Lasorsa F, di Meo NA, Rutigliano M, Ferro M, Terracciano D, Tataru OS, Battaglia M. Emerging hallmarks of metabolic reprogramming in prostate cancer. Int J Mol Sci, 2023, 24:","journal-title":"Int J Mol Sci"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"Hanahan D","year":"2022","unstructured":"Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov, 2022, 12: 31-46.","journal-title":"Cancer Discov"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1126\/science.1058079","volume":"292","author":"Pfeiffer T","year":"2001","unstructured":"Pfeiffer T, Schuster S, Bonhoeffer S. Cooperation and competition in the evolution of ATP-Producing pathways. Science, 2001, 292: 504-507.","journal-title":"Science"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2478\/jtim-2022-0051","volume":"12","author":"Liu L","year":"2024","unstructured":"Liu L, Pang W, Liu J, Xu S, Zhang Z, Hao R, Wan J. Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis via pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension. J Transl Internal Med, 2024, 12: 437-451.","journal-title":"J Transl Internal Med"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"217583","DOI":"10.1016\/j.canlet.2025.217583","volume":"621","author":"Cui R","year":"2025","unstructured":"Cui R, Wang G, Liu F, Wang Y, Zhao Z, Mutailipu M, Mu H. Neurturin-induced activation of GFRA2-RET axis potentiates pancreatic cancer glycolysis via phosphorylated hexokinase 2. Cancer Lett, 2025, 621:","journal-title":"Cancer Lett"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.3724\/abbs.2024226","volume":"57","author":"Zhou Z","year":"2025","unstructured":"Zhou Z, Ye S, Chen J, Dai F, Chen L, Ye R, Zhang J. ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5. Acta Biochim Biophys Sin, 2025, 57: 1093-1105.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.canlet.2020.05.007","volume":"485","author":"Wang J","year":"2020","unstructured":"Wang J, Xu W, Wang B, Lin G, Wei Y, Abudurexiti M, Zhu W. GLUT1 is an AR target contributing to tumor growth and glycolysis in castration-resistant and enzalutamide-resistant prostate cancers. Cancer Lett, 2020, 485: 45-55.","journal-title":"Cancer Lett"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1158\/0008-5472.CAN-21-3074","volume":"82","author":"Li R","year":"2022","unstructured":"Li R, Zhu J, Zhong WD, Jia Z. Comprehensive evaluation of machine learning models and gene expression signatures for prostate cancer prognosis using large population cohorts. Cancer Res, 2022, 82: 1832-1843.","journal-title":"Cancer Res"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"andr.70015","DOI":"10.1111\/andr.70015","author":"Lin H","year":"2025","unstructured":"Lin H, Lin X, Huang P, Yu X, Liu J, Huang L, Wei Y. Unveiling SMAD family member 6 as a novel biomarker for prognosis and immunotherapy response in testicular germ cell tumors. Andrology, 2025,","journal-title":"Andrology"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"H\u00e4nzelmann S","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-Seq data. BMC BioInf, 2013, 14:","journal-title":"BMC BioInf"},{"key":"CITATION15","doi-asserted-by":"crossref","unstructured":"Zhang J, Li H, Tao W, Zhou J. GseaVis: an R package for enhanced visualization of gene set enrichment analysis in biomedicine.  Med Research  2025, 1: 131\u2013135 .","DOI":"10.1002\/mdr2.70000"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13148-019-0730-1","volume":"11","author":"Engebretsen S","year":"2019","unstructured":"Engebretsen S, Bohlin J. Statistical predictions with glmnet. Clin Epigenet, 2019, 11:","journal-title":"Clin Epigenet"},{"key":"CITATION17","unstructured":"Fang Y, Kong Y, Rong G, Luo Q, Liao W, Zeng D. Systematic investigation of biomolecular interactions using combined frequency and motional resistance measurements.  Sensors and Actuators B: Chemical . 2025, 1: 136\u2013140 ."},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1101\/gr.239244.118","volume":"28","author":"Mayakonda A","year":"2018","unstructured":"Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res, 2018, 28: 1747-1756.","journal-title":"Genome Res"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1002\/imt2.43","volume":"1","author":"Gu Z","year":"2022","unstructured":"Gu Z. Complex heatmap visualization. iMeta, 2022, 1:","journal-title":"iMeta"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.7150\/ijbs.77133","volume":"19","author":"Zhong C","year":"2023","unstructured":"Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JYC. M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy. Int J Biol Sci, 2023, 19: 1543-1563.","journal-title":"Int J Biol Sci"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12951-020-00735-x","volume":"19","author":"Shu F","year":"2021","unstructured":"Shu F, Yang T, Zhang X, Chen W, Wu K, Luo J, Zhou X. Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy. J Nanobiotechnol, 2021, 19:","journal-title":"J Nanobiotechnol"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1210\/endrev\/bnab002","volume":"42","author":"Desai K","year":"2021","unstructured":"Desai K, McManus JM, Sharifi N. Hormonal therapy for prostate cancer. Endocrine Rev, 2021, 42: 354-373.","journal-title":"Endocrine Rev"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"7740","DOI":"10.1093\/nar\/gkae547","volume":"52","author":"Qian C","year":"2024","unstructured":"Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y. ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer. Nucleic Acids Res, 2024, 52: 7740-7760.","journal-title":"Nucleic Acids Res"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.20517\/cdr.2024.173","volume":"8","author":"Adam K","year":"2025","unstructured":"Adam K, Feng H, Yuanquan Y, Eric AS, Peng W, Mingjia L. Overcoming drug resistance in castrate-resistant prostate cancer: current mechanisms and emerging therapeutic approaches. Cancer Drug Resist, 2025, 8:","journal-title":"Cancer Drug Resist"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ajur.2023.01.007","volume":"11","author":"Franklin A","year":"2024","unstructured":"Franklin A, Gianduzzo T, Kua B, Wong D, McEwan L, Walters J, Esler R. The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography\/computed tomography for non-prostate cancer-related pathology: a single centre retrospective study. Asian J Urol, 2024, 11: 33-41.","journal-title":"Asian J Urol"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000012183","volume":"59","author":"Costello LC","year":"2000","unstructured":"Costello LC, Franklin RB. The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy. Oncology, 2000, 59: 269-282.","journal-title":"Oncology"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/S0022-5347(01)66366-3","volume":"155","author":"Effert PJ","year":"1996","unstructured":"Effert PJ, Bares R, Handt S, Wolff JM, Bull U, Jakse G. Metabolic imaging of untreated prostate cancer by positron emission tomography with sup 18 fluorine-labeled deoxyglucose. J Urol, 1996, 155: 994-998.","journal-title":"J Urol"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"680928","DOI":"10.3389\/fgene.2021.680928","volume":"12","author":"Sun X","year":"2021","unstructured":"Sun X, Huang Q, Peng F, Wang J, Zhao W, Guo G. Expression and clinical significance of hkii and hif-1\u03b1 in grade groups of prostate cancer. Front Genet, 2021, 12:","journal-title":"Front Genet"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"217441","DOI":"10.1016\/j.canlet.2025.217441","volume":"611","author":"Hindes MT","year":"2025","unstructured":"Hindes MT, McElligott AM, Best OG, Ward MP, Selemidis S, Miles MA, Nturubika BD. Metabolic reprogramming, malignant transformation and metastasis: lessons from chronic lymphocytic leukaemia and prostate cancer. Cancer Lett, 2025, 611:","journal-title":"Cancer Lett"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.1038\/s41596-024-01020-z","volume":"1","author":"Wang W","year":"2024","unstructured":"Wang W, Wang Y, Yang X, Zhao R, Sandai D, Song Z, Zhang H. ATPexGen: ATP-induced cell death database. Life Conflux, 2024, 1:","journal-title":"Life Conflux"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1093\/nar\/gkae098","volume":"52","author":"Richl T","year":"2024","unstructured":"Richl T, Kuper J, Kisker C. G-quadruplex-mediated genomic instability drives SNVs in cancer. Nucleic Acids Res, 2024, 52: 2198-2211.","journal-title":"Nucleic Acids Res"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s40265-020-01440-7","volume":"81","author":"Specchio N","year":"2021","unstructured":"Specchio N, Ferretti A, Trivisano M, Pietrafusa N, Pepi C, Calabrese C, Livadiotti S. Neuronal ceroid lipofuscinosis: potential for targeted therapy. Drugs, 2021, 81: 101-123.","journal-title":"Drugs"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.yexcr.2004.04.042","volume":"298","author":"Mole SE","year":"2004","unstructured":"Mole SE, Michaux G, Codlin S, Wheeler RB, Sharp JD, Cutler DF. CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein. Exp Cell Res, 2004, 298: 399-406.","journal-title":"Exp Cell Res"},{"key":"CITATION34","doi-asserted-by":"publisher","first-page":"10.1172\/JCI130955","DOI":"10.1172\/JCI130955","volume":"130","author":"Bajaj L","year":"2020","unstructured":"Bajaj L, Sharma J, di Ronza A, Zhang P, Eblimit A, Pal R, Roman D. A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer. J Clin Invest, 2020, 130:","journal-title":"J Clin Invest"},{"key":"CITATION35","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1159\/000529818","volume":"66","author":"Guo X","year":"2023","unstructured":"Guo X, Yu X, Zhang Y, Luo H, Huang R, Zeng Y, Duan C. A novel glycolysis-related signature for predicting the prognosis and immune infiltration of uveal melanoma. Ophthalmic Res, 2023, 66: 692-705.","journal-title":"Ophthalmic Res"},{"key":"CITATION36","doi-asserted-by":"publisher","first-page":"jcs258469","DOI":"10.1242\/jcs.258469","volume":"134","author":"Fuller GG","year":"2021","unstructured":"Fuller GG, Kim JK. Compartmentalization and metabolic regulation of glycolysis. J Cell Sci, 2021, 134:","journal-title":"J Cell Sci"},{"key":"CITATION37","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1038\/s41467-018-06841-7","volume":"9","author":"Liu Y","year":"2018","unstructured":"Liu Y, Guo JZ, Liu Y, Wang K, Ding W, Wang H, Liu X. Nuclear lactate dehydrogenase A senses ROS to produce \u03b1-hydroxybutyrate for HPV-induced cervical tumor growth. Nat Commun, 2018, 9:","journal-title":"Nat Commun"},{"key":"CITATION38","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.ceca.2015.03.003","volume":"58","author":"Cao X","year":"2015","unstructured":"Cao X, Choi S, Mal\u00e9th JJ, Park S, Ahuja M, Muallem S. The ER\/PM microdomain, PI(4,5)P2 and the regulation of STIM1\u2013Orai1 channel function. Cell Calcium, 2015, 58: 342-348.","journal-title":"Cell Calcium"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/0493D5A317BC41E7B67DABF684689ACA","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025257","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/0493D5A317BC41E7B67DABF684689ACA","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:23:09Z","timestamp":1786933389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2025257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,1,13]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2025257","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,13]]}}}