{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:09:30Z","timestamp":1777630170621,"version":"3.51.4"},"reference-count":31,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,4,1]]},"DOI":"10.3724\/abbs.2026044","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:46:43Z","timestamp":1773208003000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Ubiquitin-dependent degradation of MBD3 by TRIM59                     promotes lung adenocarcinoma"],"prefix":"10.3724","author":[{"given":"Wenhui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianya","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1097\/CM9.0000000000002529","volume":"136","author":"Li C","year":"2023","unstructured":"Li C, Lei S, Ding L, Xu Y, Wu X, Wang H, Zhang Z. Global burden and trends of lung cancer incidence and mortality. Chin Med J, 2023, 136: 1583-1590.","journal-title":"Chin Med J"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.21037\/tcr-2025-1092","volume":"14","author":"Wang Y","year":"2025","unstructured":"Wang Y, Xu M, Wei X, Huang H, Chen Q, Chen B, Bao X. Prospective proteomics for discovering biomarkers in lung                         adenocarcinoma: a literature review. Transl Cancer Res, 2025, 14: 6102-6117.","journal-title":"Transl Cancer Res"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3724\/abbs.2023266","volume":"56","author":"Yu P","year":"2024","unstructured":"Yu P, Zhang L, Tian J, Liu J, Que Z, Li G, Zhou Y. NK cell depletion promotes liver metastasis of lung cancer cells. Acta Biochim Biophys                             Sin, 2024, 56: 323-326.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/cr.2016.39","volume":"26","author":"Swatek KN","year":"2016","unstructured":"Swatek KN, Komander D. Ubiquitin modifications. Cell Res, 2016, 26: 399-422.","journal-title":"Cell Res"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/procel\/pwad045","volume":"15","author":"Sheng X","year":"2024","unstructured":"Sheng X, Xia Z, Yang H, Hu R. The ubiquitin codes in cellular stress responses. Protein Cell, 2024, 15: 157-190.","journal-title":"Protein Cell"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.3724\/abbs.2025062","volume":"57","author":"Qiu X","year":"2025","unstructured":"Qiu X, Ren J, Yang Y, Hu W, Wang C, Hu R, Li C. TRIM25 ubiquitinates and degrades p62\/SQSTM1 to suppress                         autophagy. Acta Biochim Biophys                             Sin, 2025, 57: 2129-2132.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.3724\/abbs.2025048","volume":"57","author":"Chen T","year":"2025","unstructured":"Chen T, Xu Y, Yang K, Du Y, Zhu Z, Xu L, Wang X. Withaferin A combined with ricolinostat: a potent synergistic                         therapy for cervical cancer through regulating p53 ubiquitination and                         acetylation. Acta Biochim Biophys                             Sin, 2025, 57: 2133-2136.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3724\/abbs.2024104","volume":"57","author":"Tao Y","year":"2024","unstructured":"Tao Y, Ding X, Jia C, Wang C, Li C. Using protein turnover assay to explore the drug mechanism of                         Carfilzomib. Acta Biochim Biophys                             Sin, 2024, 57: 209-222.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.3724\/abbs.2025201","volume":"57","author":"Chen J","year":"2025","unstructured":"Chen J, Yang Y, Liu G, Huang L, Zhang Y, Wang Y, Xu X. SUN5 interacts with TRIM28, enhancing I\u03baB\u03b1 ubiquitination to                         promote glycolysis in colorectal cancer cells. Acta Biochim Biophys                             Sin, 2025, 57: 2094-2109.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.jmb.2019.10.007","volume":"432","author":"Leighton G","year":"2020","unstructured":"Leighton G, Williams Jr. DC. The methyl-CpG-binding domain 2 and 3 proteins and formation of                         the nucleosome remodeling and deacetylase complex. J Mol Biol, 2020, 432: 1624-1639.","journal-title":"J Mol Biol"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2217\/epi.15.39","volume":"7","author":"Du Q","year":"2015","unstructured":"Du Q, Luu PL, Stirzaker C, Clark SJ. Methyl-CpG-binding domain proteins: readers of the epigenome. Epigenomics, 2015, 7: 1051-1073.","journal-title":"Epigenomics"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/nsr\/nwaa023","volume":"7","author":"Li C","year":"2020","unstructured":"Li C, Lu W, Yang L, Li Z, Zhou X, Guo R, Wang J. MKRN3 regulates the epigenetic switch of mammalian puberty via                         ubiquitination of MBD3. Natl Sci Rev, 2020, 7: 671-685.","journal-title":"Natl Sci Rev"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3724\/abbs.2024044","volume":"56","author":"Huang K","year":"2024","unstructured":"Huang K, Zhang B, Feng Y, Ma H. Magnolol promotes the autophagy of esophageal carcinoma cells by                         upregulating HACE1 gene expression. Acta Biochim Biophys                             Sin, 2024, 56: 1044-1054.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Tang Z","year":"2019","unstructured":"Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression                         profiling and interactive analysis. Nucleic Acids Res, 2019, 47: W556-W560.","journal-title":"Nucleic Acids Res"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.1093\/nar\/gkab155","volume":"49","author":"Li C","year":"2021","unstructured":"Li C, Han T, Li Q, Zhang M, Guo R, Yang Y, Lu W. MKRN3-mediated ubiquitination of poly(A)-binding proteins                         modulates the stability and translation of GNRH1 mRNA in mammalian puberty. Nucleic Acids Res, 2021, 49: 3796-3813.","journal-title":"Nucleic Acids Res"},{"key":"CITATION16","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2025232","author":"Yang Y","year":"2026","unstructured":"Yang Y, Ren J, Qiu X, Liu Y, Yuan S, Hu R, Xia Z. RNF126 writes a non-canonical ubiquitin code on midnolin to tune                         protein stability. Acta Biochim Biophys                             Sin, 2026.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/cr.2017.132","volume":"28","author":"Xu X","year":"2018","unstructured":"Xu X, Li C, Gao X, Xia K, Guo H, Li Y, Hao Z. Excessive UBE3A dosage impairs retinoic acid signaling and                         synaptic plasticity in autism spectrum disorders. Cell Res, 2018, 28: 48-68.","journal-title":"Cell Res"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"991322","DOI":"10.3389\/fendo.2022.991322","volume":"13","author":"Palumbo S","year":"2022","unstructured":"Palumbo S, Cirillo G, Aiello F, Papparella A, Miraglia del Giudice E, Grandone A. MKRN3 role in regulating pubertal onset: The state of art of                         functional studies. Front Endocrinol, 2022, 13: 991322.","journal-title":"Front Endocrinol"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.3390\/cancers17142367","volume":"17","author":"Yamada Y","year":"2025","unstructured":"Yamada Y, Kimura N, Maki K, Hakozaki Y, Urabe F, Kimura S, Fujimura T. The roles of tripartite motif proteins in urological cancers: a                         systematic review. Cancers, 2025, 17: 2367.","journal-title":"Cancers"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3724\/abbs.2023149","volume":"55","author":"Cen X","year":"2023","unstructured":"Cen X, Li Z, Chen X. Ubiquitination in the regulation of autophagy. Acta Biochim Biophys                             Sin, 2023, 55: 1348-1357.","journal-title":"Acta Biochim Biophys                             Sin"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.7150\/ijbs.28757","volume":"14","author":"Wang Y","year":"2018","unstructured":"Wang Y, Zhou Z, Wang X, Zhang X, Chen Y, Bai J, Di W. TRIM59 is a novel marker of poor prognosis and promotes malignant                         progression of ovarian cancer by inducing annexin A2 expression. Int J Biol Sci, 2018, 14: 2073-2082.","journal-title":"Int J Biol Sci"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1038\/s41467-019-12001-2","volume":"10","author":"Sang Y","year":"2019","unstructured":"Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B. CDK5-dependent phosphorylation and nuclear translocation of                         TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nat Commun, 2019, 10: 4013.","journal-title":"Nat Commun"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13046-020-01688-7","volume":"39","author":"Liang M","year":"2020","unstructured":"Liang M, Chen X, Wang L, Qin L, Wang H, Sun Z, Zhao W. Cancer-derived exosomal TRIM59 regulates macrophage NLRP3                         inflammasome activation to promote lung cancer progression. J Exp Clin                             Cancer Res, 2020, 39: 176.","journal-title":"J Exp Clin                             Cancer Res"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"e3000051","DOI":"10.1371\/journal.pbio.3000051","volume":"16","author":"Tan P","year":"2018","unstructured":"Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H. TRIM59 promotes breast cancer motility by suppressing                         p62-selective autophagic degradation of PDCD10. PLoS Biol, 2018, 16: e3000051.","journal-title":"PLoS Biol"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"e70141","DOI":"10.1002\/ddr.70141","volume":"86","author":"Wu L","year":"2025","unstructured":"Wu L, Feng J, Lin H, Chen P. KNK437 suppresses the growth of non-small cell lung cancer cells                         by targeting heat shock factor 1. Drug Dev Res, 2025, 86: e70141.","journal-title":"Drug Dev Res"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"5106","DOI":"10.3892\/ol.2016.5368","volume":"12","author":"Zhong YH","year":"2016","unstructured":"Zhong YH, Cheng HZ, Peng H, Tang SC, Wang P. Heat shock factor 2 is associated with the occurrence of lung                         cancer by enhancing the expression of heat shock proteins. Oncol Lett, 2016, 12: 5106-5112.","journal-title":"Oncol Lett"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.7150\/ijbs.110447","volume":"21","author":"Zhang B","year":"2025","unstructured":"Zhang B, Fan Y, Tan K. HSF1 activation mechanisms, disease roles, and small molecule                         therapeutics. Int J Biol Sci, 2025, 21: 3351-3378.","journal-title":"Int J Biol Sci"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cell.2012.06.031","volume":"150","author":"Mendillo ML","year":"2012","unstructured":"Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E. HSF1 drives a transcriptional program distinct from heat shock to                         support highly malignant human cancers. Cell, 2012, 150: 549-562.","journal-title":"Cell"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"860320","DOI":"10.3389\/fonc.2022.860320","volume":"12","author":"Cyran AM","year":"2022","unstructured":"Cyran AM, Zhitkovich A. Heat shock proteins and HSF1 in cancer. Front Oncol, 2022, 12: 860320.","journal-title":"Front Oncol"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.1093\/nar\/gkac493","volume":"50","author":"Himanen SV","year":"2022","unstructured":"Himanen SV, Puustinen MC, Da Silva AJ, Vihervaara A, Sistonen L. HSFs drive transcription of distinct genes and enhancers during                         oxidative stress and heat shock. Nucleic Acids Res, 2022, 50: 6102-6115.","journal-title":"Nucleic Acids Res"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"eabj6526","DOI":"10.1126\/sciadv.abj6526","volume":"8","author":"Smith RS","year":"2022","unstructured":"Smith RS, Takagishi SR, Amici DR, Metz K, Gayatri S, Alasady MJ, Wu Y. HSF2 cooperates with HSF1 to drive a transcriptional program                         critical for the malignant state. Sci Adv, 2022, 8: eabj6526.","journal-title":"Sci Adv"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/A914DDFEA5B7447C9BE441EB22FC527C","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026044","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/pdf\/A914DDFEA5B7447C9BE441EB22FC527C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:50:11Z","timestamp":1777431011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3724\/abbs.2026044","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}