{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:34:10Z","timestamp":1788564850753,"version":"build-2803163510"},"reference-count":27,"publisher":"China Science Publishing & Media Ltd.","issue":"8","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,8,1]]},"DOI":"10.3724\/abbs.2026046","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:47:14Z","timestamp":1773294434000},"page":"1772-1782","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Discovery and validation of biomarkers for Epstein-Barr virus associated gastric cancer"],"prefix":"10.3724","volume":"58","author":[{"given":"Pincang","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-E","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1053\/j.gastro.2009.05.001","volume":"137","author":"Murphy G","year":"2009","unstructured":"Murphy G, Pfeiffer R, Camargo MC, Rabkin CS. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology, 2009, 137: 824-833.","journal-title":"Gastroenterology"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.canlet.2020.09.019","volume":"495","author":"Yang J","year":"2020","unstructured":"Yang J, Liu Z, Zeng B, Hu G, Gan R. Epstein-Barr virus-associated gastric cancer: a distinct subtype. Cancer Lett, 2020, 495: 191-199.","journal-title":"Cancer Lett"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/CJI.0000000000000316","volume":"43","author":"Xie T","year":"2020","unstructured":"Xie T, Liu Y, Zhang Z, Zhang X, Gong J, Qi C, Li J. Positive status of Epstein-Barr virus as a biomarker for gastric cancer immunotherapy: a prospective observational study. J ImmunoTher, 2020, 43: 139-144.","journal-title":"J ImmunoTher"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2147\/DDDT.S75152","volume":"16","author":"Qing Y","year":"2015","unstructured":"Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu G, Luo H. Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer. Drug Des Devel Ther, 2015, 16:","journal-title":"Drug Des Devel Ther"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1525-1578(10)60642-3","volume":"3","author":"Gulley ML","year":"2001","unstructured":"Gulley ML. Molecular diagnosis of Epstein-Barr virus-related diseases. J Mol Diagnostics, 2001, 3: 1-10.","journal-title":"J Mol Diagnostics"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.1158\/1078-0432.CCR-04-0057","volume":"10","author":"Zhu L","year":"2004","unstructured":"Zhu L, Chow LWC, Loo WTY, Guan XY, Toi M. Her2\/Neu expression predicts the response to antiaromatase neoadjuvant therapy in primary breast cancer. Clin Cancer Res, 2004, 10: 4639-4644.","journal-title":"Clin Cancer Res"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1055\/s-2006-921508","volume":"128","author":"Rody A","year":"2006","unstructured":"Rody A, Karn T, G\u00e4tje R, Kourtis K, Minckwitz G, Loibl S, Munnes M. Gene expression profiles of breast cancer obtained from core cut biopsies before neoadjuvant docetaxel, adriamycin, and cyclophoshamide chemotherapy correlate with routine prognostic markers and could be used to identify predictive signatures. Zentralbl Gynakol, 2006, 128: 76-81.","journal-title":"Zentralbl Gynakol"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10620-012-2357-3","volume":"58","author":"Pirrelli M","year":"2013","unstructured":"Pirrelli M, Caruso ML, Di Maggio M, Armentano R, Valentini AM. Are biopsy specimens predictive of HER2 status in gastric cancer patients?. Dig Dis Sci,  2013, 58: 397-404.","journal-title":"Dig Dis Sci"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJMoa1113205","volume":"366","author":"Gerlinger M","year":"2012","unstructured":"Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med, 2012, 366: 883-892.","journal-title":"N Engl J Med"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41579-025-01181-y","volume":"23","author":"M\u00fcnz C","year":"2025","unstructured":"M\u00fcnz C. Epstein-Barr virus pathogenesis and emerging control strategies. Nat Rev Microbiol, 2025, 23: 667-679.","journal-title":"Nat Rev Microbiol"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1056\/NEJMoa2301496","volume":"389","author":"Li T","year":"2023","unstructured":"Li T, Li F, Guo X, Hong C, Yu X, Wu B, Lian S. Anti-Epstein-Barr virus BNLF2b for mass screening for nasopharyngeal cancer. N Engl J Med, 2023, 389: 808-819.","journal-title":"N Engl J Med"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.tibtech.2024.12.001","volume":"43","author":"Lin CC","year":"2025","unstructured":"Lin CC, Chen CS. Bacterial proteome microarray technology in biomedical research. Trends Biotechnol, 2025, 43: 1317-1327.","journal-title":"Trends Biotechnol"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/infdis\/jir645","volume":"204","author":"Zheng D","year":"2011","unstructured":"Zheng D, Wan J, Cho YG, Wang L, Chiou CJ, Pai S, Woodard C. Comparison of humoral immune responses to Epstein-Barr virus and Kaposi\u2019s sarcoma-ssociated herpesvirus using a viral proteome microarray. J Infect Dis, 2011, 204: 1683-1691.","journal-title":"J Infect Dis"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1007\/s10120-021-01170-z","volume":"24","author":"Song L","year":"2021","unstructured":"Song L, Song M, Camargo MC, Van Duine J, Williams S, Chung Y, Kim KM. Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma. Gastric Cancer, 2021, 24: 858-867.","journal-title":"Gastric Cancer"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"102674","DOI":"10.1016\/j.ebiom.2020.102674","volume":"53","author":"Li Y","year":"2020","unstructured":"Li Y, Li C, Guo S, Guo W, Jiang H, Li H, Tao S. Longitudinal serum autoantibody repertoire profiling identifies surgery-associated biomarkers in lung adenocarcinoma. EBioMedicine, 2020, 53:","journal-title":"EBioMedicine"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"e1003960","DOI":"10.1371\/journal.ppat.1003960","volume":"10","author":"van Gent M","year":"2014","unstructured":"van Gent M, Braem SGE, de Jong A, Delagic N, Peeters JGC, Boer IGJ, Moynagh PN. Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. PLoS Pathog, 2014, 10:","journal-title":"PLoS Pathog"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41564-017-0080-8","volume":"3","author":"Zhang H","year":"2018","unstructured":"Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD. Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. Nat Microbiol, 2018, 3: 1-8.","journal-title":"Nat Microbiol"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","volume":"405","author":"Sundar R","year":"2025","unstructured":"Sundar R, Nakayama I, Markar SR, Shitara K, van Laarhoven HWM, Janjigian YY, Smyth EC. Gastric cancer. Lancet, 2025, 405: 2087-2102.","journal-title":"Lancet"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"8937","DOI":"10.1073\/pnas.1201380109","volume":"109","author":"Niwa T","year":"2012","unstructured":"Niwa T, Kanamori T, Ueda T, Taguchi H. Global analysis of chaperone effects using a reconstituted cell-free translation system. Proc Natl Acad Sci USA, 2012, 109: 8937-8942.","journal-title":"Proc Natl Acad Sci USA"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.3389\/fonc.2020.01779","volume":"10","author":"Feng Y","year":"2020","unstructured":"Feng Y, Xia W, He G, Ke R, Liu L, Xie M, Tang A. Accuracy evaluation and comparison of 14 diagnostic markers for nasopharyngeal carcinoma: a meta-analysis. Front Oncol, 2020, 10:","journal-title":"Front Oncol"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3748\/wjg.v11.i5.629","volume":"11","author":"Luo B","year":"2005","unstructured":"Luo B. Expression of Epstein-Barr virus genes in EBV-associated gastric carcinomas. World J Gastroenterol, 2005, 11: 629-633.","journal-title":"World J Gastroenterol"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev-immunol-031210-101317","volume":"29","author":"Cerutti A","year":"2011","unstructured":"Cerutti A, Chen K, Chorny A. Immunoglobulin responses at the mucosal interface. Annu Rev Immunol, 2011, 29: 273-293.","journal-title":"Annu Rev Immunol"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1128\/JVI.01099-08","volume":"83","author":"Wang JT","year":"2009","unstructured":"Wang JT, Doong SL, Teng SC, Lee CP, Tsai CH, Chen MR. Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway. J Virol, 2009, 83: 1856-1869.","journal-title":"J Virol"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41571-021-00524-x","volume":"18","author":"Wong KCW","year":"2021","unstructured":"Wong KCW, Hui EP, Lo KW, Lam WKJ, Johnson D, Li L, Tao Q. Nasopharyngeal carcinoma: an evolving paradigm. Nat Rev Clin Oncol, 2021, 18: 679-695.","journal-title":"Nat Rev Clin Oncol"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13073-021-00963-2","volume":"13","author":"Chen ZH","year":"2021","unstructured":"Chen ZH, Yan SM, Chen XX, Zhang Q, Liu SX, Liu Y, Luo YL. The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma. Genome Med, 2021, 13:","journal-title":"Genome Med"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1038\/s41591-018-0101-z","volume":"24","author":"Kim ST","year":"2018","unstructured":"Kim ST, Cristescu R, Bass AJ, Kim KM, Odegaard JI, Kim K, Liu XQ. Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat Med, 2018, 24: 1449-1458.","journal-title":"Nat Med"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"19956","DOI":"10.1038\/srep19956","volume":"6","author":"Xu Z","year":"2016","unstructured":"Xu Z, Huang L, Zhang H, Li Y, Guo S, Wang N, Wang S. PMD: a resource for archiving and analyzing protein microarray data. Sci Rep, 2016, 6:","journal-title":"Sci Rep"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/BF99AC944FAA4C418C70F64E07374BB6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026046","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/BF99AC944FAA4C418C70F64E07374BB6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T02:04:25Z","timestamp":1787277865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,3,24]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.3724\/abbs.2026046","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,24]]}}}