{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:59:07Z","timestamp":1785383947310,"version":"3.55.0"},"reference-count":33,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.3724\/abbs.2026111","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:46:59Z","timestamp":1781160419000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["TRIM31 promotes lenvatinib resistance and stemness in hepatocellular carcinoma through K48\/K63-linked ubiquitination of GLDC"],"prefix":"10.3724","author":[{"given":"Zhipeng","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Housheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray F","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74: 229-263.","journal-title":"CA Cancer J Clin"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1002\/cncr.31373","volume":"124","author":"Kim NG","year":"2018","unstructured":"Kim NG, Nguyen PP, Dang H, Kumari R, Garcia G, Esquivel CO, Nguyen MH. Temporal trends in disease presentation and survival of patients with hepatocellular carcinoma: a real-world experience from 1998 to 2015. Cancer, 2018, 124: 2588-2598.","journal-title":"Cancer"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fcell.2020.00047","volume":"8","author":"Vescovo T","year":"2020","unstructured":"Vescovo T, Pagni B, Piacentini M, Fimia GM, Antonioli M. Regulation of autophagy in cells infected with oncogenic human viruses and its impact on cancer development. Front Cell Dev Biol, 2020, 8:","journal-title":"Front Cell Dev Biol"},{"key":"CITATION4","unstructured":"Fan Z, Zhou P, Jin B, Li G, Feng L, Zhuang C, Wang S. Recent therapeutics in hepatocellular carcinoma.  Am J Cancer Res  2023, 13:261\u2013275. ."},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3389\/fonc.2020.00920","volume":"10","author":"Liang Y","year":"2020","unstructured":"Liang Y, Liang Q, Qiao L, Xiao F. MicroRNAs modulate drug resistance-related mechanisms in hepatocellular carcinoma. Front Oncol, 2020, 10:","journal-title":"Front Oncol"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.semcdb.2021.12.009","volume":"132","author":"Mart\u00ednez-F\u00e9rriz A","year":"2022","unstructured":"Mart\u00ednez-F\u00e9rriz A, Ferrando A, Fathinajafabadi A, Farr\u00e0s R. Ubiquitin-mediated mechanisms of translational control. Semin Cell Dev Biol, 2022, 132: 146-154.","journal-title":"Semin Cell Dev Biol"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-biochem-060815-014922","volume":"86","author":"Zheng N","year":"2017","unstructured":"Zheng N, Shabek N. Ubiquitin ligases: structure, function, and regulation. Annu Rev Biochem, 2017, 86: 129-157.","journal-title":"Annu Rev Biochem"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nrm.2016.91","volume":"17","author":"Buetow L","year":"2016","unstructured":"Buetow L, Huang DT. Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nat Rev Mol Cell Biol, 2016, 17: 626-642.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1074\/jbc.TM117.000117","volume":"293","author":"Grumati P","year":"2018","unstructured":"Grumati P, Dikic I. Ubiquitin signaling and autophagy. J Biol Chem, 2018, 293: 5404-5413.","journal-title":"J Biol Chem"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41392-020-00421-2","volume":"6","author":"Zhou X","year":"2021","unstructured":"Zhou X, Sun SC. Targeting ubiquitin signaling for cancer immunotherapy. Sig Transduct Target Ther, 2021, 6:","journal-title":"Sig Transduct Target Ther"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"116846","DOI":"10.1016\/j.biopha.2024.116846","volume":"176","author":"Deng NH","year":"2024","unstructured":"Deng NH, Tian Z, Zou YJ, Quan SB. E3 ubiquitin ligase TRIM31: a potential therapeutic target. Biomed Pharmacother, 2024, 176:","journal-title":"Biomed Pharmacother"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"1047177","DOI":"10.3389\/fonc.2022.1047177","volume":"12","author":"Guo Y","year":"2022","unstructured":"Guo Y, Lin P, Hua Y, Wang C. TRIM31: a molecule with a dual role in cancer. Front Oncol, 2022, 12:","journal-title":"Front Oncol"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"42781","DOI":"10.1038\/srep42781","volume":"7","author":"Jiang MX","year":"2017","unstructured":"Jiang MX, Hong X, Liao BB, Shi SZ, Lai XF, Zheng HY, Xie L. Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation. Sci Rep, 2017, 7:","journal-title":"Sci Rep"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"102274","DOI":"10.1016\/j.redox.2022.102274","volume":"51","author":"Ge C","year":"2022","unstructured":"Ge C, Tan J, Lou D, Zhu L, Zhong Z, Dai X, Sun Y. Mulberrin confers protection against hepatic fibrosis by Trim31\/Nrf2 signaling. Redox Biol, 2022, 51:","journal-title":"Redox Biol"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5764592","volume":"2022","author":"Chen H","year":"2022","unstructured":"Chen H, Zhang C, Zhou Q, Guo Y, Ren Z, Yu Z, Del Turco S. Integrated bioinformatic analysis identifies TIPIN as a prognostic biomarker in hepatocellular carcinoma. Dis Markers, 2022, 2022: 1-15.","journal-title":"Dis Markers"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/onc.2017.349","volume":"37","author":"Guo P","year":"2018","unstructured":"Guo P, Ma X, Zhao W, Huai W, Li T, Qiu Y, Zhang Y. TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex. Oncogene, 2018, 37: 478-488.","journal-title":"Oncogene"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"8721","DOI":"10.7150\/thno.41648","volume":"10","author":"Huang T","year":"2020","unstructured":"Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, Sastry N. Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics, 2020, 10: 8721-8743.","journal-title":"Theranostics"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.stem.2024.06.003","volume":"31","author":"Saw PE","year":"2024","unstructured":"Saw PE, Liu Q, Wong PP, Song E. Cancer stem cell mimicry for immune evasion and therapeutic resistance. Cell Stem Cell, 2024, 31: 1101-1112.","journal-title":"Cell Stem Cell"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","volume":"85","author":"Yu L","year":"2022","unstructured":"Yu L, Wei J, Liu P. Attacking the PI3K\/Akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer. Semin Cancer Biol, 2022, 85: 69-94.","journal-title":"Semin Cancer Biol"},{"key":"CITATION20","unstructured":"Xia P, Xu XY. PI3K\/Akt\/mTOR signaling pathway in cancer stem cells: from basic research to clinical application.  Am J Cancer Res  2015, 5: 1602\u20131609. ."},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41392-021-00711-3","volume":"6","author":"Wang X","year":"2021","unstructured":"Wang X, Zhang H, Shao Z, Zhuang W, Sui C, Liu F, Chen X. TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity. Sig Transduct Target Ther, 2021, 6:","journal-title":"Sig Transduct Target Ther"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/s41418-024-01334-1","volume":"31","author":"Zhao Z","year":"2024","unstructured":"Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R. E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson\u2019s disease model. Cell Death Differ, 2024, 31: 1410-1421.","journal-title":"Cell Death Differ"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s40265-019-01116-x","volume":"79","author":"Al-Salama ZT","year":"2019","unstructured":"Al-Salama ZT, Syed YY, Scott LJ. Lenvatinib: a review in hepatocellular carcinoma. Drugs, 2019, 79: 665-674.","journal-title":"Drugs"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"188391","DOI":"10.1016\/j.bbcan.2020.188391","volume":"1874","author":"Zhao Y","year":"2020","unstructured":"Zhao Y, Zhang YN, Wang KT, Chen L. Lenvatinib for hepatocellular carcinoma: from preclinical mechanisms to anti-cancer therapy. Biochim Biophys Acta Rev Cancer, 2020, 1874:","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"865","DOI":"10.2174\/1568009622666220428111327","volume":"22","author":"Guo J","year":"2022","unstructured":"Guo J, Zhao J, Xu Q, Huang D. Resistance of lenvatinib in hepatocellular carcinoma. Curr Cancer Drug Targets, 2022, 22: 865-878.","journal-title":"Curr Cancer Drug Targets"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1083\/jcb.201902074","volume":"218","author":"Song L","year":"2019","unstructured":"Song L, Luo ZQ. Post-translational regulation of ubiquitin signaling. J Cell Biol, 2019, 218: 1776-1786.","journal-title":"J Cell Biol"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/cells8050510","volume":"8","author":"Venuto S","year":"2019","unstructured":"Venuto S, Merla G. E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis. Cells, 2019, 8:","journal-title":"Cells"},{"key":"CITATION28","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.7150\/ijbs.85893","volume":"19","author":"Chen M","year":"2023","unstructured":"Chen M, Xiao ZY, Huang ZP, Xue KY, Xia H, Zhou JW, Liao DY. Glycine decarboxylase (GLDC) plays a crucial role in regulating energy metabolism, invasion, metastasis and immune escape for prostate cancer. Int J Biol Sci, 2023, 19: 4726-4743.","journal-title":"Int J Biol Sci"},{"key":"CITATION29","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41598-024-79445-5","volume":"15","author":"Shuang L","year":"2025","unstructured":"Shuang L, Su Y, Zhang Y.  Downregulation of Gldc attenuates myocardial ischemia reperfusion injury in vitro by modulating Akt and NF-\u03baB signalings . Sci Rep, 2025, 15:","journal-title":"Sci Rep"},{"key":"CITATION30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.03.003","volume":"120","author":"Zhuang H","year":"2018","unstructured":"Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X. Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells. Free Radical Biol Med, 2018, 120: 1-12.","journal-title":"Free Radical Biol Med"},{"key":"CITATION31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cell.2009.01.041","volume":"137","author":"Xu P","year":"2009","unstructured":"Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell, 2009, 137: 133-145.","journal-title":"Cell"},{"key":"CITATION32","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cbpa.2004.09.009","volume":"8","author":"Pickart CM","year":"2004","unstructured":"Pickart CM, Fushman D. Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol, 2004, 8: 610-616.","journal-title":"Curr Opin Chem Biol"},{"key":"CITATION33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12943-017-0712-x","volume":"16","author":"Khemlina G","year":"2017","unstructured":"Khemlina G, Ikeda S, Kurzrock R. The biology of hepatocellular carcinoma: implications for genomic and immune therapies. Mol Cancer, 2017, 16:","journal-title":"Mol Cancer"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/1E8EF545DD5543618DC13905C234FA75","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026111","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/1E8EF545DD5543618DC13905C234FA75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:15:47Z","timestamp":1785381347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":33,"URL":"https:\/\/doi.org\/10.3724\/abbs.2026111","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}