{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:06:30Z","timestamp":1789380390309,"version":"build-2803163510"},"reference-count":27,"publisher":"China Science Publishing & Media Ltd.","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.3724\/abbs.2026160","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:47:24Z","timestamp":1787726844000},"update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["piR-45962 exacerbates autophagic apoptosis in aged myocardial ischemia-reperfusion injury through modulation of the HNRNPH1\/GATA5 signaling axis"],"prefix":"10.3724","author":[{"given":"Qianqian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yideng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuee","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankui","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"CITATION1","doi-asserted-by":"publisher","first-page":"103471","DOI":"10.1016\/j.redox.2024.103471","volume":"79","author":"Xu H","year":"2025","unstructured":"Xu H, Chen X, Luo S, Jiang J, Pan X, He Y, Deng B. Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis. Redox Biol, 2025, 79:","journal-title":"Redox Biol"},{"key":"CITATION2","doi-asserted-by":"publisher","first-page":"8578","DOI":"10.1038\/s41467-024-52379-2","volume":"15","author":"Yang X","year":"2024","unstructured":"Yang X, Chen H, Shen W, Chen Y, Lin Z, Zhuo J, Wang S. FGF21 modulates immunometabolic homeostasis via the ALOX15\/15-HETE axis in early liver graft injury. Nat Commun, 2024, 15:","journal-title":"Nat Commun"},{"key":"CITATION3","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1161\/CIRCULATIONAHA.123.068595","volume":"150","author":"Zhang W","year":"2024","unstructured":"Zhang W, Zhang J, Wang Z, Li T, Liu C, Kang X, Cui X. Extracellular RIPK3 acts as a damage-associated molecular pattern to exaggerate cardiac ischemia\/reperfusion injury. Circulation, 2024, 150: 1791-1811.","journal-title":"Circulation"},{"key":"CITATION4","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1080\/15548627.2025.2472586","volume":"21","author":"Fogo GM","year":"2025","unstructured":"Fogo GM, Raghunayakula S, Emaus KJ, Torres Torres FJ, Shangguan G, Wider JM, H\u00fcttemann M. Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion. Autophagy, 2025, 21: 1492-1506.","journal-title":"Autophagy"},{"key":"CITATION5","doi-asserted-by":"publisher","first-page":"216494","DOI":"10.1016\/j.canlet.2023.216494","volume":"581","author":"Chen R","year":"2024","unstructured":"Chen R, Zou J, Zhong X, Li J, Kang R, Tang D. HMGB1 in the interplay between autophagy and apoptosis in cancer. Cancer Lett, 2024, 581:","journal-title":"Cancer Lett"},{"key":"CITATION6","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1080\/15548627.2023.2229656","volume":"19","author":"Coppola V","year":"2023","unstructured":"Coppola V, Marino I, Warnken U, Falchi M, Pasquini L, Biffoni M, De Maria R. The autophagic protein FYCO1 controls TNFRSF10\/TRAIL receptor induced apoptosis and is inactivated by CASP8 (Caspase 8). Autophagy, 2023, 19: 2733-2751.","journal-title":"Autophagy"},{"key":"CITATION7","doi-asserted-by":"publisher","first-page":"111469","DOI":"10.1016\/j.cellsig.2024.111469","volume":"124","author":"Zhang Y","year":"2024","unstructured":"Zhang Y, Li B, Fu Y, Cai H, Zheng Y. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cell Signal, 2024, 124:","journal-title":"Cell Signal"},{"key":"CITATION8","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.3724\/abbs.2022186","volume":"54","author":"Lv Y","year":"2022","unstructured":"Lv Y, Xiao S, Ouyang S, Peng Z, Wu L, Tang Z, Zhang W. ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic \u03b2-cells. Acta Biochim Biophys Sin, 2022, 54: 1822-1831.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION9","doi-asserted-by":"publisher","first-page":"gkae1055","DOI":"10.1093\/nar\/gkae1055","volume":"53","author":"Charmant O","year":"2025","unstructured":"Charmant O, Gruchota J, Arnaiz O, Nowak KP, Moisan N, Zangarelli C, B\u00e9termier M. The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium. Nucleic Acids Res, 2025, 53:","journal-title":"Nucleic Acids Res"},{"key":"CITATION10","doi-asserted-by":"publisher","first-page":"H991","DOI":"10.1152\/ajpheart.00833.2024","volume":"328","author":"Shivam P","year":"2025","unstructured":"Shivam P, Ball D, Cooley A, Osi I, Rayford KJ, Gonzalez SB, Edwards AD. Regulatory roles of PIWI-interacting RNAs in cardiovascular disease. Am J Physiol-Heart Circulatory Physiol, 2025, 328: H991-H1004.","journal-title":"Am J Physiol-Heart Circulatory Physiol"},{"key":"CITATION11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41586-023-06588-2","volume":"622","author":"Podvalnaya N","year":"2023","unstructured":"Podvalnaya N, Bronkhorst AW, Lichtenberger R, Hellmann S, Nischwitz E, Falk T, Karaulanov E. piRNA processing by a trimeric Schlafen-domain nuclease. Nature, 2023, 622: 402-409.","journal-title":"Nature"},{"key":"CITATION12","doi-asserted-by":"publisher","first-page":"e53062","DOI":"10.15252\/embr.202153062","volume":"22","author":"Onishi R","year":"2021","unstructured":"Onishi R, Yamanaka S, Siomi MC.  piRNA- and siRNA-mediated transcriptional repression in Drosophila, mice, and yeast: new insights and biodiversity . EMBO Rep, 2021, 22:","journal-title":"EMBO Rep"},{"key":"CITATION13","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3724\/abbs.2024195","volume":"57","author":"Lv X","year":"2024","unstructured":"Lv X, Zhang H, Wu L. Advances in PIWI-piRNA function in female reproduction in mammals. Acta Biochim Biophys Sin, 2024, 57: 148-156.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION14","doi-asserted-by":"publisher","first-page":"e2106058","DOI":"10.1002\/advs.202106058","volume":"9","author":"Wang K","year":"2022","unstructured":"Wang K, Zhou LY, Liu F, Lin L, Ju J, Tian PC, Liu CY.  PIWI-interacting RNA HAAPIR regulates cardiomyocyte death after myocardial infarction by promoting NAT10-mediated ac4 C acetylation of Tfec mRNA . Adv Sci, 2022, 9:","journal-title":"Adv Sci"},{"key":"CITATION15","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1038\/s41401-025-01534-6","volume":"46","author":"Yan H","year":"2025","unstructured":"Yan H, Li H, Yin DH, Zhang ZZ, Zhang QY, Ren ZY, Hu Y. The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia-reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1. Acta Pharmacol Sin, 2025, 46: 2393-2406.","journal-title":"Acta Pharmacol Sin"},{"key":"CITATION16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2217\/epi-2020-0359","volume":"13","author":"Bai X","year":"2021","unstructured":"Bai X, Niu R, Liu J, Pan X, Wang F, Yang W, Wang L. Roles of noncoding RNAs in the initiation and progression of myocardial ischemia-reperfusion injury. Epigenomics, 2021, 13: 715-743.","journal-title":"Epigenomics"},{"key":"CITATION17","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.3724\/abbs.2024024","volume":"56","author":"Chi H","year":"2024","unstructured":"Chi H, Chai Y, Ma L, Wang Y, Wu Q, Wang L, Zhai J. The mechanism by which piR-000699 targets SLC39A14 regulates ferroptosis in aging myocardial ischemia\/reperfusion injury. Acta Biochim Biophys Sin, 2024, 56: 1352-1364.","journal-title":"Acta Biochim Biophys Sin"},{"key":"CITATION18","doi-asserted-by":"publisher","first-page":"9635674","DOI":"10.1155\/2022\/9635674","volume":"2022","author":"Li G","year":"2022","unstructured":"Li G, Ding N, Xiong J, Ma S, Xie L, Xu L, Zhang H. Ischemic postconditioning protects against aged myocardial ischemia\/reperfusion injury by transcriptional and epigenetic regulation of miR-181a-2-3p. Oxid Med Cell Longev, 2022, 2022:","journal-title":"Oxid Med Cell Longev"},{"key":"CITATION19","doi-asserted-by":"publisher","first-page":"eabg0834","DOI":"10.1126\/sciadv.abg0834","volume":"8","author":"Song M","year":"2022","unstructured":"Song M, Yuan X, Racioppi C, Leslie M, Stutt N, Aleksandrova A, Christiaen L. GATA4\/5\/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Sci Adv, 2022, 8:","journal-title":"Sci Adv"},{"key":"CITATION20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","volume":"10","author":"Wang X","year":"2025","unstructured":"Wang X, Chen T, Chen S, Zhang J, Cai L, Liu C, Zhang Y. STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation. Sig Transduct Target Ther, 2025, 10:","journal-title":"Sig Transduct Target Ther"},{"key":"CITATION21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12872-021-01918-6","volume":"21","author":"Deng X","year":"2021","unstructured":"Deng X, Yang P, Gao T, Liu M, Li X.  Allicin attenuates myocardial apoptosis, inflammation and mitochondrial injury during hypoxia-reoxygenation: an in vitro study . BMC Cardiovasc Disord, 2021, 21:","journal-title":"BMC Cardiovasc Disord"},{"key":"CITATION22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s44161-024-00592-z","volume":"4","author":"Ma W","year":"2025","unstructured":"Ma W, Chen H, Tian Y, Huang W, Ren Z, Li J, Ouyang Q. The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice. Nat Cardiovasc Res, 2025, 4: 102-118.","journal-title":"Nat Cardiovasc Res"},{"key":"CITATION23","doi-asserted-by":"publisher","first-page":"e2304329","DOI":"10.1002\/advs.202304329","volume":"10","author":"Wang K","year":"2023","unstructured":"Wang K, Li FH, Zhou LY, Zhao XM, Gao XQ, Liu CY, Li XM.  HNEAP regulates necroptosis of cardiomyocytes by suppressing the m5C methylation of Atf7 mRNA . Adv Sci, 2023, 10:","journal-title":"Adv Sci"},{"key":"CITATION24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15476286.2025.2470511","volume":"22","author":"Jungfleisch J","year":"2025","unstructured":"Jungfleisch J, Gebauer F. RNA-binding proteins as therapeutic targets in cancer. RNA Biol, 2025, 22: 1-8.","journal-title":"RNA Biol"},{"key":"CITATION25","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.1016\/j.cell.2025.06.021","volume":"188","author":"Hentze MW","year":"2025","unstructured":"Hentze MW, Sommerkamp P, Ravi V, Gebauer F. Rethinking RNA-binding proteins: riboregulation challenges prevailing views. Cell, 2025, 188: 4811-4827.","journal-title":"Cell"},{"key":"CITATION26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s10238-026-02074-x","volume":"26","author":"Hashemi Karoii D","year":"2026","unstructured":"Hashemi Karoii D, Osanloo M, Azizi H, Skutella T. Machine learning, whole-transcriptome and integrative omics analysis reveals key regulatory networks governing human spermatogonial stem cells. Clin Exp Med, 2026, 26:","journal-title":"Clin Exp Med"},{"key":"CITATION27","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1093\/cvr\/cvaf101","volume":"121","author":"Zhang S","year":"2025","unstructured":"Zhang S, Xiang B, Zhao Y, Wang W, Chen L, Zhou X. Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5\/ISL1+ fibroblasts in cardiac repair post-myocardial infarction. Cardiovasc Res, 2025, 121: 1419-1432.","journal-title":"Cardiovasc Res"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/099D92FC81A34D43967E39C14CD45BE4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciengine.com\/sci-open\/api\/v1\/open\/file\/pdf\/099D92FC81A34D43967E39C14CD45BE4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:37:46Z","timestamp":1789378666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciengine.com\/doi\/10.3724\/abbs.2026160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":27,"URL":"https:\/\/doi.org\/10.3724\/abbs.2026160","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}