{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:13:44Z","timestamp":1777371224561,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acupuncture &amp; Electro-Therapeutics Research: International Journal of Integrated Medicine"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>\n                    Using the \u201cBi-Digital O-Ring Test Molecular Indentification and Localization Method,\u201d one can identify and localize minute amounts of bioactive substances (including neurotransmitters), micro-organisms, toxic substances, or drugs, and in addition, one can non-invasively image normal organs as well as screen for and image the distribution of specific type of cancer of specific internal organs without using any expensive instrumentation. One can also use this method to perform a qualitative analysis of neurotransmitters, neuromodulators, and hormones on different parts of the imaged organs. The molecule or substance being investigated is compared with a minute amount of a pure control reference substance, and if the substance identical to the control reference substance exists, then the electro-magnetic waves emitted by the identical substance will produce an electro-magnetic resonance phenomenon with the electro-magnetic waves of identical resonance frequency emitted by the control reference substance, and this resonance phenomenon is hypothesized to be the basis of the \u201cBi-Digital O-Ring Test Molecular Identification and Localization Method.\u201d The following substances have been used as control reference substances to identify and localize identical substances\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    : pure neurotransmitters (e.g. serotonin, \u03b2-endorphin, methionine-enkephalin, norepinephrine, dopamine, L-dopa, substance P, etc.), as well as L-tryptophan and L-tyrosine; cholesterol; steroid hormones (including aldosterone, corticosterone, cortisol, progersterone, testosterone, etc.); peptide hormones; microscopic slides of normal organs; microscopic slides of specific cancer cells of specific organs (e.g. aderoecarcinoma of the head of the pancreas, adenocarcinoma of the descending colon, etc.); microscopic slides of pure micro-organisms; toxic substances (e.g. lead, mercury, KCN); drugs (including non-steroidal anti-inflammatory drugs, antibiotics, \u03b2-blockers, calcium channel blockers, etc.); and antibodies against specific substances or micro-organisms. An intensive network of serotonin and L-tryptophan was discovered, by using the \u201cBi-Digital O-Ring Test Molecular Identification and Localization Method,\u201d in different parts of the body. In general, in painful areas, frequently serotonin is markedly reduced, L-tryptophan is markedly increased, and substance P is markedly increased, while in non-painful areas, serotonin is markedly increased, L-tryptophan is markedly decreased, and substance P is markedly decreased. Various other clinical applications of the \u201cBi-Digital O-Ring Test Molecular Identification and Localization Method\u201d are described, including imaging of the pancreas, gall bladder, duodenum, pancreatic duct, bile duct, colon, uterus, ovaries, fallopian tubes, and kidney, and diagnosis and localization of adenocarcinoma of the stomach and its metastases without knowing any history or chief complaint of the patient.\n                  <\/jats:p>","DOI":"10.3727\/036012986816359201","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:29:30Z","timestamp":1446510570000},"page":"65-100","source":"Crossref","is-referenced-by-count":31,"title":["Editorial: \u201cBi-Digital O-Ring Test Molecular Identification and Localization Method\u201d and its Application in Imaging of Internal Organs and Malignant Tumors as Well as Identification and Localization of Neurotransmitters AMD Micro-Organisms\u2014PART 1"],"prefix":"10.1177","volume":"11","author":[{"given":"Yoshiaki","family":"Omura","sequence":"first","affiliation":[{"name":"Director of Medical Research, Heart Disease Research Foundation, 50 Court Street, Brooklyn, N.Y. 11201"},{"name":"Dept. of Pharmacology, University of Health Sciences\/ The Chicago Medical School, 3333 Green Bay Road, North Chicago, Ill. 60064"},{"name":"Visiting Research Professor of Bio-Medical Electronics, Dept. of Electrical Engineering, Manhattan College, Riverdale, N.Y. 10471"},{"name":"Attending Physician, Neuroscience Dept., long Island College Hospital, 340 Henry Street, Brooklyn, N.Y. 11201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"FcwlerJ.s. Wolf A.P. Guest editorial: Special characteristics and potential for radiotracers for positron emission tomography Acupuncture & Electro-Therapeutics Research the International Journal Vol. 6 pp. 81\u2013108 1981.","DOI":"10.3727\/036012981816952315"},{"key":"e_1_3_2_3_2","first-page":"364","article-title":"Use of the (14 C)-deoxyglucose method in acupuncture analgesia studies","volume":"10","author":"Hand P.J.","year":"1985","unstructured":"HandP.J. HuangY.H. LiuC.N. Use of the (14 C)-deoxyglucose method in acupuncture analgesia studies, Acupuncture & Electro-Therapeu-tics Research, the International Journal. Vol. 10, p. 364 (Abstract), 1985.","journal-title":"Acupuncture & Electro-Therapeu-tics Research"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"OmuraY. Editorial: New simple early diagnostic methods using Omura's \u201cBi-Digital O-Ring Dysfunction localization Method\u201d and acupuncture organ representation points and their applications to the \u201cDrug & Food Compatibility Test\u201d for individual organs and to auricular diagnosis of internal organs \u2014 Part I Acupuncture & Electro-Therapeutics Research the International Journal Vol. 6 pp. 239\u2013254 1981.","DOI":"10.3727\/036012981816952199"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"OmuuraY. Editorial: Effects of an electrical field and its polarity on an abnormal part of the body or organ representation point associated with a diseased internal organ and its influence on the \u201cBi-Digital O-Ring Test\u201d (simple non-invasive dysfunction localization method) & drug compatibility test \u2014 Part I Acupuncture & Electro-Therapeutics Research the International Journal Vol. 7 pp. 209\u2013246 1982.","DOI":"10.3727\/036012982816952026"},{"key":"e_1_3_2_6_2","first-page":"564","article-title":"Iosco","volume":"23","author":"Omura Y.","year":"1982","unstructured":"OmuraY. NisterukC.J. Iosco, Bro. M., Heller, S.I., Omura, A., Cook, A., Williams, G., Non-invasive early diagnosis of cardiovascular diseases by the oombined use of the \u201cBi-Digital 0-RIng Test Dysfunction localization Method,\u201d organ representation points & minute notches & slurrings appearing in QRS complexes of wide frequency bandwidth EOG's & selective high frequency wide bandwidth EOG's,\u201d Japanese Heart Journal, Vol. 23, Supplement, pp. 564\u2013566, 1982.","journal-title":"Bro. M."},{"key":"e_1_3_2_7_2","first-page":"57","article-title":"Factors in the prevention of cardiovascular diseases - Part I: 96 cardiovascular risk factors","volume":"7","author":"Omura Y.","year":"1982","unstructured":"OmuraY. HellerS.I. Factors in the prevention of cardiovascular diseases - Part I: 96 cardiovascular risk factors, with special emphasis on the prevention and treatment of hypertension, controllable dietary risk factors, and recommended U.S. dietary goals, Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 7, pp. 57\u201392, 1982.","journal-title":"with special emphasis on the prevention and treatment of hypertension"},{"key":"e_1_3_2_8_2","first-page":"37","article-title":"The \u201cBi-Digital O-Ring Test\u201d: critical evaluation of its abnormal responses with laboratory tests including \u201cblood pressure & blood flow method,\u201d \u201cblood chemistry,\u201d etc. and \u201cneurological method,\u201d Acupuncture & Electro-Therapeutics Research","volume":"8","author":"Omura Y.","year":"1983","unstructured":"OmuraY. The \u201cBi-Digital O-Ring Test\u201d: critical evaluation of its abnormal responses with laboratory tests including \u201cblood pressure & blood flow method,\u201d \u201cblood chemistry,\u201d etc. and \u201cneurological method,\u201d Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 8, pp. 37\u201343, 1983.","journal-title":"the International Journal"},{"key":"e_1_3_2_9_2","first-page":"177","article-title":"Editorial: Non-invasive circulatory evaluation and electro-acupuncture & TES treatment of diseases difficult to treat in Western medicine: 1) abnormal brain circulation and blood pressure: cephalic hypertension or cephalic hypotension syndromes and their related conditions - headache, insomnia, blindness due to macular degeneration & retinitis pigmentosa, and some psychiatric problems;","volume":"8","author":"Omura Y.","year":"1983","unstructured":"OmuraY. Editorial: Non-invasive circulatory evaluation and electro-acupuncture & TES treatment of diseases difficult to treat in Western medicine: 1) abnormal brain circulation and blood pressure: cephalic hypertension or cephalic hypotension syndromes and their related conditions - headache, insomnia, blindness due to macular degeneration & retinitis pigmentosa, and some psychiatric problems; 2) severe lower extremity circulatory disturbances, with intractable pain, intermittent claudication, ulceration and\/or severe diabetic neuropathy, Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 8, pp. 177\u2013255, 1983.","journal-title":"2) severe lower extremity circulatory disturbances, with intractable pain, intermittent claudication, ulceration and\/or severe diabetic neuropathy, Acupuncture & Electro-Therapeutics Research, the International Journal"},{"key":"e_1_3_2_10_2","article-title":"Electro-Acupuntura v Acupuntura Manual","author":"Omura Y.","year":"1983","unstructured":"OmuraY. Electro-Acupuntura v Acupuntura Manual, EDAD S.A., Apdo 15065, Maracaibo, Venezuela, 1983.","journal-title":"EDAD S.A."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"OmuraY. Editorial: Acupuncture (with possible roles of serotonin & melatonin) and related unorthodox methods of diagnosis and treatment: non-invasive spheno-palatine ganglionic block abrasion of naso-pharyngeal mucosa and applied kinesiology Acupuncture & Electro-Therapeutics Research the International Journal Vol. 4 pp. 69\u201389 1979.","DOI":"10.3727\/036012979817552942"},{"key":"e_1_3_2_12_2","article-title":"Akupunktuuri laaketieteelisena Hoitomuotona","author":"Pontinen P.","year":"1983","unstructured":"PontinenP. Akupunktuuri laaketieteelisena Hoitomuotona, Laaketieteellinen Oppimateriaalikustantamo Oy, Tampere, Finland, 1983.","journal-title":"Laaketieteellinen Oppimateriaalikustantamo Oy"},{"issue":"1","key":"e_1_3_2_13_2","first-page":"1","article-title":"Highlights of the forthcoming 1st International Symposium on Acupuncture & Electro-Therapeutics to celebrate the 10th anniversary of Acupuncture & Electro-Therapeutics Research","volume":"10","author":"Omura Y.","year":"1985","unstructured":"OmuraY. Highlights of the forthcoming 1st International Symposium on Acupuncture & Electro-Therapeutics to celebrate the 10th anniversary of Acupuncture & Electro-Therapeutics Research, the \u2022 International Journal, 1) Stress & Immunity and Effects of Stimulation of Deep Peroneal Nerve at St. 36 on Ventricular Arrhythmia, Heart Disease & Sudden Death. 2) New Simple Accurate and Inexpensive Imaging Technique of Internal Organs and Cancer Tissue by a Clinical Application of \u201cBi-Digital O-Ring Test\u201d and Clinical Significance of Newly Discovered Networks of Thymus Glands in Cancer Treatment. Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 10, No. 1\/2, pp. 1\u201312, 1985.","journal-title":"the \u2022 International Journal"},{"issue":"3","key":"e_1_3_2_14_2","first-page":"216","article-title":"New A simple","volume":"10","author":"Omuura Y.","year":"1985","unstructured":"OmuuraY. New A simple, non-invasive imaging technique of internal organs, blood vessels of the heart, and various cancer cells using extended principles of the \u201cBi-Digital O-Ring Test\u201d without using expensive imaging instruments, Acupuncture & Electro-Therapeutics Research, the International Journal. Vol. 10, No. 3, p. 216 (Abstract), 1985.","journal-title":"non-invasive imaging technique of internal organs"},{"issue":"3","key":"e_1_3_2_15_2","first-page":"139","article-title":"Simple and quick non-invasive evaluation of circulatory condition of cerebral arteries by clinical application of the \u201cBi- mDigital O-Ring Test,\u201d Acupuncture & Electro-Therapeutics Research","volume":"10","author":"Omura Y.","year":"1985","unstructured":"OmuraY. Simple and quick non-invasive evaluation of circulatory condition of cerebral arteries by clinical application of the \u201cBi- mDigital O-Ring Test,\u201d Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 10, No. 3, pp. 139\u2013161, 1985.","journal-title":"the International Journal"},{"issue":"3","key":"e_1_3_2_16_2","first-page":"213","article-title":"Preliminary experiences with Omura's Bi-Digital O-Ring Test","volume":"10","author":"Pontinen P.","year":"1985","unstructured":"PontinenP. Preliminary experiences with Omura's Bi-Digital O-Ring Test, Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 10, No. 3, p. 213 (Abstract), 1985.","journal-title":"Acupuncture & Electro-Therapeutics Research"},{"issue":"3","key":"e_1_3_2_17_2","first-page":"214","article-title":"Simple method of estimating the presence of bacterial infection at different organs of humans & animals: effective antibiotics & their optimal dose; and potential infection from air conditioner filters","volume":"10","author":"Omura Y.","year":"1985","unstructured":"OmuraY. Simple method of estimating the presence of bacterial infection at different organs of humans & animals: effective antibiotics & their optimal dose; and potential infection from air conditioner filters, by the \u201cBi-Digital O-Ring Test,\u201d Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 10, No. 3, pp. 214\u2013215 (Abstract), 1985.","journal-title":"by the \u201cBi-Digital O-Ring Test"},{"key":"e_1_3_2_18_2","first-page":"255","article-title":"New A simple","volume":"10","author":"Omura Y.","year":"1985","unstructured":"OmuraY. New A simple, non-invasive imaging technique of internal organs and various cancer tissues using extended principles of the \u201cBi-Digital O-Ring Test\u201d without using expensive imaging instruments or exposing the patient to any undesirable radiation \u2014 Part I, Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 10, pp. 255\u2013277, 1985.","journal-title":"non-invasive imaging technique of internal organs and various cancer tissues using extended principles of the \u201cBi-Digital O-Ring Test\u201d without using expensive imaging instruments or exposing the patient to any undesirable radiation \u2014 Part I"},{"key":"e_1_3_2_19_2","article-title":"Practice of \u201cBi-Digital O-Rina Test.\u201d (1st book on \u201cBi-Digital O-Ring Test,\u201d in Japanese)","author":"Omura Y.","year":"1986","unstructured":"OmuraY. Practice of \u201cBi-Digital O-Rina Test.\u201d (1st book on \u201cBi-Digital O-Ring Test,\u201d in Japanese), Ido-No-Nihon-Sha, Tokyo, Japan, 1986.","journal-title":"Ido-No-Nihon-Sha"},{"key":"e_1_3_2_20_2","article-title":"Neurotransmitters and Drugs","author":"Kruk Z.L.","year":"1979","unstructured":"KrukZ.L. PycockC.J. Neurotransmitters and Drugs, university Park Press, Baltimore, 1979.","journal-title":"university Park Press"},{"key":"e_1_3_2_21_2","article-title":"The Human central Nervous System","author":"Nieuwenhuys R.","year":"1981","unstructured":"NieuwenhuysR. VoogdJ. van HuijzenC., The Human central Nervous System, Springer-Verlag, New York, 1981.","journal-title":"Springer-Verlag, New York"},{"issue":"2","key":"e_1_3_2_22_2","first-page":"127","article-title":"Electro-magnetic resonance phenomenon as a possible mechanism related to the \u201cBi-Digital O-Ring Test Molecular Identifi-cation and Localization Method,\u201d Acupuncture & Electro-Therapeutics Research","volume":"11","author":"Omura Y.","year":"1986","unstructured":"OmuraY. Electro-magnetic resonance phenomenon as a possible mechanism related to the \u201cBi-Digital O-Ring Test Molecular Identifi-cation and Localization Method,\u201d Acupuncture & Electro-Therapeutics Research, the International Journal, Vol. 11, No. 2, pp. 127\u2013145,. 1986.","journal-title":"the International Journal"},{"key":"e_1_3_2_23_2","first-page":"392","article-title":"Applications of ultra-miniature reflection-type photoelectric plethysmographic sensors with a very short response time to the non-traumatic study of the circulatory system","volume":"17","author":"Omura Y.","year":"1971","unstructured":"OmuraY. LeeK. Applications of ultra-miniature reflection-type photoelectric plethysmographic sensors with a very short response time to the non-traumatic study of the circulatory system, Trans. Artif. Internal Organs, Vol. 17, pp. 392\u2013404, 1971.","journal-title":"Trans. Artif. Internal Organs"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331977302400608"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3727\/036012927500100104","article-title":"Pathophysiology of acupuncture: effects of acupuncture on cardiovascular system and nervous systems","volume":"1","author":"Omura Y.","year":"1975","unstructured":"OmuraY. Pathophysiology of acupuncture: effects of acupuncture on cardiovascular system and nervous systems, Acupuncture & Electro-Therapeutics, the International Journal, Vol. 1, pp. 51\u2013141, 1975.","journal-title":"Acupuncture & Electro-Therapeutics"},{"key":"e_1_3_2_26_2","article-title":"The effects of acupuncture on the circulatory system (especially on high blood pressure and triglyceride lowering effects) and a concept of \u201cvaso-neuromuscular functional unit system,\u201d Abstracts of the 6th International Congress of Pharmacology","author":"Omura Y.","year":"1975","unstructured":"OmuraY. The effects of acupuncture on the circulatory system (especially on high blood pressure and triglyceride lowering effects) and a concept of \u201cvaso-neuromuscular functional unit system,\u201d Abstracts of the 6th International Congress of Pharmacology, Helsinki, Finland, 1975.","journal-title":"Helsinki"},{"key":"e_1_3_2_27_2","first-page":"1","article-title":"Pathophysiology of acupuncture effects","volume":"2","author":"Omura Y.","year":"1977","unstructured":"OmuraY. Pathophysiology of acupuncture effects, ACIH and morphine-like substances, pain, phantom sensations (phantom pain, itch and coldness), brain micro-circulation, and memory, Acupuncture & Electro-Therapeutics, the International Journal, Vol. 2, pp. 1\u201331, 1977.","journal-title":"ACIH and morphine-like substances"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3727\/036012978817553258"},{"key":"e_1_3_2_29_2","first-page":"223","article-title":"The effects of electrical and non-electrical acupuncture on cardio-vascular & nervous sytems","volume":"3","author":"Omura Y.","year":"1978","unstructured":"OmuraY. The effects of electrical and non-electrical acupuncture on cardio-vascular & nervous sytems, and pre- and post-acupuncture evaluation of patients, including valuable visible diagnostic signs, such as the \u201cabnormal cardiovascular sign of the ear lobules,\u201d Acupuncture & Electro-Therapeutics, the International Journal, Vol. 3, pp. 223\u2013250, 1978.","journal-title":"and pre- and post-acupuncture evaluation of patients"},{"key":"e_1_3_2_30_2","first-page":"154","article-title":"Minute notches appearing in the QRS complex of EOG's of humans and animals (following experimentally induced minute myocardial injuries)","author":"Omura Y.","year":"1979","unstructured":"OmuraY. NisterukC.J. LoseM. DreschnackP. Minute notches appearing in the QRS complex of EOG's of humans and animals (following experimentally induced minute myocardial injuries), and their clinical significance and application for early diagnosis of myocardial abnormailities, Progress in Electrocardiology, ed. by P.W. Macfarlane, Pitman Medical Pub. Co., Kent, England, pp. 154\u2013160, 1979.","journal-title":"and their clinical significance and application for early diagnosis of myocardial abnormailities"},{"key":"e_1_3_2_31_2","first-page":"449","article-title":"Simple non-invasive methods of evaluating brain circulation and the hypotensive and serum lipid lowering effects of acupuncture","author":"Omura Y.","year":"1979","unstructured":"OmuraY. Simple non-invasive methods of evaluating brain circulation and the hypotensive and serum lipid lowering effects of acupuncture, Prophylactic Approach to Hypertensive Diseases, ed. by Y. Yamori et. al., Raven Press, New York, pp. 449\u2013457, 1979.","journal-title":"Prophylactic Approach to Hypertensive Diseases"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(78)90027-0"},{"key":"e_1_3_2_33_2","first-page":"15","article-title":"Minute notches and slurrings in QRS complexes of EOG's of intrinsic myocardial origins as early diagnostic signs of myocardial diseases and their relationship to lower extremity hypertension syndrome (LEHS)","author":"Omura Y.","year":"1980","unstructured":"OmuraY. NisterukC., IoscoBR. M., HellerS., HorowitzS., Minute notches and slurrings in QRS complexes of EOG's of intrinsic myocardial origins as early diagnostic signs of myocardial diseases and their relationship to lower extremity hypertension syndrome (LEHS), Abstract Book of the 7th International Congress on Electrocardiology, held at Lisbon, Portugal, during June 15\u201319, p. 50, 1980.","journal-title":"Abstract Book of the 7th International Congress on Electrocardiology, held at Lisbon, Portugal, during"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3727\/036012980816952488"}],"container-title":["Acupuncture &amp; Electro-Therapeutics Research: International Journal of Integrated Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/036012986816359201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/036012986816359201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/036012986816359201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:50:01Z","timestamp":1777366201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3727\/036012986816359201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.3727\/036012986816359201"],"URL":"https:\/\/doi.org\/10.3727\/036012986816359201","relation":{},"ISSN":["0360-1293","2167-9010"],"issn-type":[{"value":"0360-1293","type":"print"},{"value":"2167-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}