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The main reason why medications known to be effective prove ineffective with intractable medical problems, the authors found, is that even effective medications often cannot reach these affected areas in sufficient therapeutic doses, even though the medications can reach the normal parts of the body and result in side effects when doses are excessive. These conditions are often difficult to treat or may be considered incurable in both Western and Oriental medicine. As solutions to these problems, the authors found some of the following methods can improve circulation and selectively enhance drug uptake: 1) Acupuncture, 2) Low pulse repetition rate electrical stimulation (1-2 pulses\/second), 3) (+) Qi Gong energy, 4) Soft lasers using Ga-As diode laser or He-Ne gas laser, 5) Certain electro-magnetic fields or rapidly changing or moving electric or magnetic fields, 6) Heat or moxibustion, 7) Individually selected Calcium Channel Blockers, 8) Individually selected Oriental herb medicines known to reduce or eliminate circulatory disturbances. Each method has advantages and limitations and therefore the individually optimal method has to be selected. Applications of (+) Qi Gong energy stored paper or cloth every 4 hours, along with effective medications, were often found to be effective, as Qigongnized materials can often be used repeatedly, as long as they are not exposed to rapidly changing electric, magnetic or electro-magnetic fields. Application of (+) Qi Gong energy-stored paper or cloth, soft laser or changing electric field for 30-60 seconds on the area above the medulla oblongata, vertebral arteries or endocrine representation area at the tail of pancreas reduced or eliminated microcirculatory disturbances and enhanced drug uptake. In order to apply only (+) Qi Gong energy and prevent any potential adverse effects of applying (-) Qi Gong, which often induces vaso-constriction, a simple test to evaluate which parts of the right and left hands, right and left feet, and face emit + or (-) Qi Gong, is shown for the first time. In right-handed individuals, each fingertip of the right hand emits (+) Qi Gong energy. From the right palm, several round spots emit (-) Qi Gong energy, including 2 distinctive coin-shaped areas (one of them being Pc. 8). In the left hand, each fingertip emits (-) Qi Gong energy. In the palm of the left hand, several round spots corresponding to the right hand emit (+) Qi Gong energy. The soles of the feet emit the same patterns as the corresponding hands. On the face, the right eye and the areas between the eyebrows (known as \u201cYin Tang\u201d) emit (-) Qi Gong energy. The left eye and the nose and lips emit (+) Qi Gong energy. Using the Bi-Digital O-Ring Test, determination and localization of pathogenesis and applications of some methods of effective treatment including inducing or enhancing drug uptake of effective medication into diseased areas which are considered to be difficult or impossible to treat will be presented, with examples of successful treatments.<\/jats:p>","DOI":"10.3727\/036012992816357774","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:29:30Z","timestamp":1446510570000},"page":"107-148","source":"Crossref","is-referenced-by-count":19,"title":["COMMON FACTORS CONTRIBUTING TO INTRACTABLE PAIN AND MEDICAL PROBLEMS WITH INSUFFICIENT DRUG UPTAKE IN AREAS TO BE TREATED, AND THEIR PATHOGENESIS AND TREATMENT: PART I. COMBINED USE OF MEDICATION WITH ACUPUNCTURE, (+) QI GONG ENERGY-STORED MATERIAL, SOFT LASER OR ELECTRICAL STIMULATION"],"prefix":"10.1177","volume":"17","author":[{"given":"Yoshiaki","family":"Omura","sequence":"first","affiliation":[{"name":"Director of Medical Research, Heart Disease Research Foundation, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bro. 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shimotsuura","sequence":"additional","affiliation":[{"name":"St. Maria Hospital, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Bi-Digital O-Ring Test Clinic, Chikamori Hospital, Kouchi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoe","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Chairman of Dept. of Internal Medicine, and President of Nara Medical College, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takesuke","family":"Muteki","sequence":"additional","affiliation":[{"name":"Dept. of Anesthesiology, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Dept. of Internal Medicine, School 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