{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:18:40Z","timestamp":1777371520586,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acupuncture &amp; Electro-Therapeutics Research: International Journal of Integrated Medicine"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>A pressor blood pressure response was elicited by strong electric shock stimulation of the front paw in rabbits anesthetized with chloralose and urethane, immobilized by gallamine triethiodide and maintained by artificial ventilation. The pressor response showed a gradual decline in 3-4 successive trials. Naloxone or TCTAP, a specific \u03bc receptor antagonist, administered intraventricularly (icv) at that time could facilitate the pressor response (n=8, P&lt;0.02; n=7, P&lt;0.01), suggesting the involvement of \u03bc receptors in the declination of the pressor response. Electroacupuncture could inhibit the pressor response (n=7, P&lt; 0.01), and the inhibition was readily blocked by TCTAP (n=7, P&lt;0.01). No obvious changes were observed in the normal saline control group. The results suggest that acupuncture is able to inhibit the pressor response via the activation of the opioid peptidergic system, of which the \u03bc receptor is an important component.<\/jats:p>","DOI":"10.3727\/036012994816357411","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:29:30Z","timestamp":1446510570000},"page":"3-9","source":"Crossref","is-referenced-by-count":3,"title":["Mu Opiate Receptor Antagonist Blocks Electroacupuncture Inhibition on Noxious Blood Pressure Response in Rabbits"],"prefix":"10.1177","volume":"19","author":[{"given":"Miaozhen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurobiology, State Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, State Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,2]]},"reference":[{"key":"e_1_3_2_2_2","article-title":"Anatomy of CNS opioid receptors","volume":"11","author":"Alfred M","year":"1988","unstructured":"AlfredM HenryK MichaelEL HudaAand StanleyJW. Anatomy of CNS opioid receptors. TINS 1988; 11: 308","journal-title":"TINS"},{"issue":"2","key":"e_1_3_2_3_2","article-title":"Noxious stimulation depresses nociceptive blood pressure response opioid peptides implicated","volume":"4","author":"Gao LZ","year":"1988","unstructured":"GaoLZ HeLF. Noxious stimulation depresses nociceptive blood pressure response opioid peptides implicated. Chinese J Physiol Sci 1988; 4 (2)185","journal-title":"Chinese J Physiol Sci"},{"key":"e_1_3_2_4_2","article-title":"Involvement of endogenous opioid peptides in acupuncture analgesia","volume":"31","author":"He L.","year":"1987","unstructured":"HeL. Involvement of endogenous opioid peptides in acupuncture analgesia. Pain 1987; 31: 99","journal-title":"Pain"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3727\/036012983816714885"},{"key":"e_1_3_2_6_2","article-title":"Analgesic effect of septal stimulation in rabbits and the influence of naloxone microinjection into the periaqueductal grey","volume":"10","author":"Huang XF","year":"1983","unstructured":"HuangXF WangGN YuGHand MoWY. Analgesic effect of septal stimulation in rabbits and the influence of naloxone microinjection into the periaqueductal grey. Acta Acad Med Primae Shanghai 1983; 10: 199","journal-title":"Acta Acad Med Primae Shanghai"},{"key":"e_1_3_2_7_2","article-title":"Kappa-Opioid receptors and analgesia","volume":"11","author":"Mark JM","year":"1990","unstructured":"MarkJM. Kappa-Opioid receptors and analgesia. TIPS 1990; 11: 70","journal-title":"TIPS"},{"issue":"2","key":"e_1_3_2_8_2","article-title":"Novel peptide mu opioid antagonists, pharmacologic characterization in vitro and in vivo","volume":"249","author":"Thomas HK","year":"1989","unstructured":"ThomasHK JenniferES WieslawK . Novel peptide mu opioid antagonists, pharmacologic characterization in vitro and in vivo. J Pharmacol Exp Ther 1989; 249 (2)544","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Acupuncture &amp; Electro-Therapeutics Research: International Journal of Integrated Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/036012994816357411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/036012994816357411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/036012994816357411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:50:44Z","timestamp":1777366244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3727\/036012994816357411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.3727\/036012994816357411"],"URL":"https:\/\/doi.org\/10.3727\/036012994816357411","relation":{},"ISSN":["0360-1293","2167-9010"],"issn-type":[{"value":"0360-1293","type":"print"},{"value":"2167-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}