{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:19:12Z","timestamp":1790356752176,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>We investigated the fate of human cord blood CD133+ hematopoietic stem cells (HSC) transplanted intravenously (IV) into irradiated nodscid mice previously made deaf by ototoxic treatment with kanamycin and\/or intense noise, to verify whether HSC engraft the cochlea and contribute to inner ear restoration, in vivo. We tested the presence of HLA.DQ\u03b11 by PCR, used for traceability of engrafted cells, finding evidence that HSC migrated to various host tissues, including the organ of Corti (OC). By histology, antibody and lectin-staining analysis, we confirmed that HSC IV transplantation in mice previously damaged by ototoxic agents correlated with the repair process and stimulation ex novo of morphological recovery in the inner ear, while the cochlea of control oto-injured, nontransplanted mice remained seriously damaged. Dual color FISH analysis also provided evidence of positive engraftment in the inner ear and in various mouse tissues, also revealing small numbers of heterokaryons, probably derived from fusion of donor with endogenous cells, for up to 2 months following transplantation. These observations offer the first evidence that transplanted human HSC migrating to the inner ear of oto-injured mice may provide conditions for the resumption of deafened cochlea, emerging as a potential strategy for inner ear rehabilitation.<\/jats:p>","DOI":"10.3727\/096368908786092685","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T22:12:10Z","timestamp":1224108730000},"page":"665-678","source":"Crossref","is-referenced-by-count":39,"title":["Cochlear Repair by Transplantation of Human Cord Blood CD133+ Cells to Nod-Scid Mice Made Deaf with Kanamycin and Noise"],"prefix":"10.1177","volume":"17","author":[{"given":"Roberto P.","family":"Revoltella","sequence":"first","affiliation":[{"name":"Foundation onlus \u201cStaminali e Vita\u201d, Institute of Biomedical Technologies, C.N.R., 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Papini","sequence":"additional","affiliation":[{"name":"Foundation onlus \u201cStaminali e Vita\u201d, Institute of Biomedical Technologies, C.N.R., 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rosellini","sequence":"additional","affiliation":[{"name":"Foundation onlus \u201cStaminali e Vita\u201d, Institute of Biomedical Technologies, C.N.R., 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Michelini","sequence":"additional","affiliation":[{"name":"Foundation onlus \u201cStaminali e Vita\u201d, Institute of Biomedical Technologies, C.N.R., 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Department of Evolution and Experimental Biology, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciorba","sequence":"additional","affiliation":[{"name":"Audiology Unit, Bioacoustic Center and National Institute of Neuroscience, University Hospital S. Anna, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Bertolaso","sequence":"additional","affiliation":[{"name":"Audiology Unit, Bioacoustic Center and National Institute of Neuroscience, University Hospital S. Anna, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Magosso","sequence":"additional","affiliation":[{"name":"Audiology Unit, Bioacoustic Center and National Institute of Neuroscience, University Hospital S. Anna, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Hatzopoulos","sequence":"additional","affiliation":[{"name":"Audiology Unit, Bioacoustic Center and National Institute of Neuroscience, University Hospital S. 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Anna, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Ognio","sequence":"additional","affiliation":[{"name":"Animal Model Facility, National Institute for Cancer Research (IST), 16132 Genua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cilli","sequence":"additional","affiliation":[{"name":"Animal Model Facility, National Institute for Cancer Research (IST), 16132 Genua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Saccardi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, Department of Haematology, University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Urbani","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, Department of Haematology, University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Histopathology Unit, Cancer Research UK, London Research Institute, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Poulsom","sequence":"additional","affiliation":[{"name":"Histopathology Unit, Cancer Research UK, London Research Institute, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[{"name":"Histopathology Unit, Cancer Research UK, London Research Institute, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"bibr1-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00967-0"},{"key":"bibr2-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"bibr3-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69928-3_36"},{"key":"bibr4-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2495"},{"key":"bibr5-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.11.016"},{"key":"bibr6-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20310"},{"key":"bibr7-096368908786092685","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(01)00750-0"},{"key":"bibr8-096368908786092685","first-page":"157","volume":"210","author":"Day I. 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