{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:32Z","timestamp":1777509512852,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Rheumatoid arthritis is a chronic inflammatory disease. The generation of reactive oxygen species (ROS) within an inflamed joint has been suggested as playing a significant pathogenic role. Extracellular superoxide dismutase (EC-SOD) is a major scavenger enzyme of ROS, which has received growing attention for its therapeutic potential. To investigate the therapeutic effect of EC-SOD in mice with collagen-induced arthritis (CIA), we used mouse embryonic fibroblast (MEF) of transgenic mice that overexpresses EC-SOD on the skin by using hK14 promoter. DBA\/1 mice that had been treated with bovine type II collagen were administrated subcutaneous injections of EC-SOD transgenic MEF (each at 1.4 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    cells) on days 28, 35, and 42 after primary immunization. To test EC-SOD activity, blood samples were collected in each group on day 49. The EC-SOD activity was nearly 1.5-fold higher in the transgenic MEF-treated group than in the non-transgenic MEF-treated group (p &lt; 0.05). The severity of arthritis in mice was scored in a double-blind manner, with each paw being assigned a separate clinical score. The severity of arthritis in EC-SOD transgenic MEF-treated mice was significantly suppressed in the arthritic clinical score (p &lt; 0.05). To investigate the alteration of cytokine levels, ELISA was used to measure blood samples. Levels of IL-1\u03b2 and TNF-\u03b1 were reduced in the transgenic MEF-treated group (p &lt; 0.05). Abnormalities of the joints were examined by H&amp;E staining. There were no signs of inflammation except for mild hyperplasia of the synovium in the transgenic MEF-treated group. The proliferation of CII-specific T cells was lower in the transgenic MEF-treated mice than in those in the other groups. The transfer of EC-SOD transgenic MEF has shown a therapeutic effect in CIA mice and this approach may be a safer and more effective form of therapy for rheumatoid arthritis.\n                  <\/jats:p>","DOI":"10.3727\/096368908787648029","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T19:19:38Z","timestamp":1236712778000},"page":"1371-1380","source":"Crossref","is-referenced-by-count":8,"title":["The Therapeutic Effect of Extracellular Superoxide Dismutase (EC-SOD) Mouse Embryonic Fibroblast (MEF) on Collagen-Induced Arthritis (CIA) Mice"],"prefix":"10.1177","volume":"17","author":[{"given":"Dong Hoon","family":"Yu","sequence":"first","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Jung","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hei Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ryeul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Immunology and Dermatology, College of Medicine, Catholic University, Seoul, 137-040, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ah","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Catholic University of Korea, Seoul, 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