{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:13:07Z","timestamp":1789737187817,"version":"4.0.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    We aimed to evaluate the feasibility and efficacy of autologous umbilical cord blood mononuclear cell (UCMNC) transplantation on right ventricular (RV) function in a novel model of chronic RV volume overload. Four-month-old sheep ( n = 20) were randomized into cell ( n = 10) and control groups ( n = 10). After assessment of baseline RV function by the conductance catheter method, a transannular patch (TAP) was sutured to the right ventricular outflow tract (RVOT). Following infundibulotomy the ring of the pulmonary valve was transected without cardiopulmonary bypass. UCMNC implantation (8.22 \u00b1 6.28 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    ) in the cell group and medium injection in the control group were performed into the RV myocardium around the TAP. UCMNCs were cultured for 2 weeks after fluorescence-activated cell sorting (FACS) analysis for CD34 antigen. Transthoracic echocardiography (TTE) and computed tomography were performed after 6 weeks and 3 months, respectively. RV function was assessed 3 months postoperatively before the hearts were excised for immunohistological examinations. FACS analysis revealed 1.2 \u00b1 0.22% CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells within the isolated UCMNCs from which AcLDL\n                    <jats:sup>+<\/jats:sup>\n                    endothelial cells were cultured in vitro. All animals survived surgery. TTE revealed grade II\u2013III pulmonary regurgitation in both groups. Pressure-volume loops under dobutamine stress showed significantly improved RV diastolic function in the cell group (dP\/dt\n                    <jats:sub>min<\/jats:sub>\n                    : p = 0.043; E\n                    <jats:sub>ed<\/jats:sub>\n                    : p = 0.009). CD31 staining indicated a significantly enhanced number of microvessels in the region of UCMNC implantation in the cell group ( p &lt; 0.001). No adverse tissue changes were observed. TAP augmentation and pulmonary annulus distortion without cardiopulmonary bypass constitutes a valid large animal model mimicking the surgical repair of tetralogy of Fallot. Our results indicate that the chronically volume-overloaded RV profits from autologous UCMNC implantation by enhanced diastolic properties with a probable underlying mechanism of increased angiogenesis.\n                  <\/jats:p>","DOI":"10.3727\/096368909x471170","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T20:02:50Z","timestamp":1258574570000},"page":"855-868","source":"Crossref","is-referenced-by-count":42,"title":["Autologous Umbilical Cord Blood Mononuclear Cell Transplantation Preserves Right Ventricular Function in a Novel Model of Chronic Right Ventricular Volume Overload"],"prefix":"10.1177","volume":"18","author":[{"given":"Can","family":"Yerebakan","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Sandica","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Prietz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klopsch","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Ugurlucan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefer","family":"Abdija","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ruppiner Clinics, Neuruppin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Lorenzen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Boltze","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Cell Therapy and Immunology, Translational Center of Regenerative Medicine, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nitzsche","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Cell Therapy and Immunology, Translational Center of Regenerative Medicine, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Egger","sequence":"additional","affiliation":[{"name":"Vita 34 AG, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Barten","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Furlani","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Institute for Experimental Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Liebold","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty, University of Rostock, Rostock, 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