{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:39:24Z","timestamp":1792712364072,"version":"4.5.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>\n                    Human mesenchymal stem cells (hMSC) are a promising source for cell therapy after stroke. To deliver these cells, an IV injection appears safer than a local graft. We aimed to assess the whole-body biodistribution of IV-injected\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-HMPAO-labeled hMSC in normal rats ( n = 9) and following a right middle cerebral artery occlusion (MCAo, n = 9). Whole-body nuclear imaging, isolated organ counting (at 2 and 20 h after injection) and histology were performed. A higher activity was observed in the right damaged hemisphere of the MCAo group [6.5 \u00b1 0.9 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    % of injected dose (ID)\/g] than in the control group (3.6 \u00b1 1.2 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    %ID\/g), 20 h after injection. In MCAo rats, right hemisphere activity was higher than that observed in the contralateral hemisphere at 2 h after injection (11.6 \u00b1 2.8 vs. 9.8 \u00b1 1.7 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    %ID\/g). Following an initial hMSC lung accumulation, there was a decrease in pulmonary activity from 2 to 20 h after injection in both groups. The spleen was the only organ in which activity increased between 2 and 20 h. The presence of hMSC was documented in the spleen, liver, lung, and brain following histology. IV-injected hMSC are transiently trapped in the lungs, can be sequestered in the spleen, and are predominantly eliminated by kidneys. After 20 h, more hMSC are found in the ischemic lesion than into the undamaged cerebral tissue. IV delivery of hMSC could be the initial route for a clinical trial of tolerance.\n                  <\/jats:p>","DOI":"10.3727\/096368909x474230","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T21:01:18Z","timestamp":1267045278000},"page":"1369-1379","source":"Crossref","is-referenced-by-count":137,"title":["Intravenous Administration of\n                    <sup>99m<\/sup>\n                    Tc-HMPAO-Labeled Human Mesenchymal Stem Cells after Stroke: In Vivo Imaging and Biodistribution"],"prefix":"10.1177","volume":"18","author":[{"given":"Olivier","family":"Detante","sequence":"first","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Unit\u00e9 Neuro-Vasculaire, Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efck","family":"Moisan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Service de Biophysique et M\u00e9decine Nucl\u00e9aire, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, U877, Facult\u00e9 de M\u00e9decine, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dimastromatteo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, U877, Facult\u00e9 de M\u00e9decine, La Tronche, France"},{"name":"ERAS Labo, Saint Nazaire-les-Eymes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jeanne","family":"Richard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Unit\u00e9 Mixte de Th\u00e9rapie Cellulaire et Tissulaire, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"Unit\u00e9 de Canc\u00e9rologie biologique et bioth\u00e9rapie, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"INSERM, U823, Institut Albert Bonniot, La Tronche Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Riou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, U877, Facult\u00e9 de M\u00e9decine, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Grillon","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Barbier","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Dominique","family":"Desruet","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Service de Biophysique et M\u00e9decine Nucl\u00e9aire, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, U877, Facult\u00e9 de M\u00e9decine, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"De Fraipont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Unit\u00e9 de Canc\u00e9rologie biologique et bioth\u00e9rapie, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"INSERM, U823, Institut Albert Bonniot, La Tronche Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Segebarth","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Jaillard","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Neuroradiologie\/IRM, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hommel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Unit\u00e9 Neuro-Vasculaire, Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble Cedex 9, France"},{"name":"INSERM U003, Centre d'Investigation Clinique, Centre Hospitalier Universitaire, Grenoble Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, U877, Facult\u00e9 de M\u00e9decine, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Remy","sequence":"additional","affiliation":[{"name":"INSERM, U836, Grenoble Cedex 9, France"},{"name":"Universit\u00e9 Joseph Fourier, Grenoble Cedex 9, 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