{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:06:16Z","timestamp":1780085176639,"version":"3.54.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>There is currently no effective treatment method available for liver fibrosis. We therefore evaluated the use of Wharton's jelly stem cells (WJSCs; the major umbilical cord stem cell population) to treat chemically induced liver fibrosis via intraperitoneal injection of thioacetamide. WJSCs were transplanted into liver-damaged rats via the portal vein and the treatment was evaluated by assessing serum biochemistry and histopathology. Transplanted WJSCs were distributed in the fibrotic area and around blood vessels, and hepatic recovery was accelerated. Serum prothrombin time significantly recovered, and serum albumin also improved at 21 days posttransplantation; collagen accumulation also decreased at 14 days. Thus, human WJSCs promoted recovery after chronic liver damage. Using immunohistochemical analyses, we determined that transplanted WJSCs produce albumin, hepatocyte growth factor (HGF), and metalloproteinase (MMP) after transplantation to chemically injured liver, indicating that WJSC may help to decrease liver collagen and thus may be useful for treating liver fibrosis.<\/jats:p>","DOI":"10.3727\/096368910x514198","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T10:33:51Z","timestamp":1291718031000},"page":"1451-1463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Transplantation of Human Wharton's Jelly-Derived Stem Cells Alleviates Chemically Induced Liver Fibrosis in Rats"],"prefix":"10.1177","volume":"19","author":[{"given":"Shinn-Zong","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University and Hospital and Beigang Hospital, Taichung and Yun-Lin, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Wea","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng-Hong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Ping","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Tzu Chi University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Liang","family":"Yang","sequence":"additional","affiliation":[{"name":"Cord Blood Bank, Tzu Chi Stem Cell Center, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Jyh","family":"Harn","sequence":"additional","affiliation":[{"name":"Pathology Department, China Medical University & Hospital, Taichung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzyy-Wen","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"bibr1-096368910X514198","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.04.017"},{"key":"bibr2-096368910X514198","doi-asserted-by":"publisher","DOI":"10.3727\/000000004783983341"},{"key":"bibr3-096368910X514198","doi-asserted-by":"publisher","DOI":"10.3727\/096368908786516837"},{"issue":"2","key":"bibr4-096368910X514198","first-page":"110","volume":"171","author":"Anand B. 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