{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:51:44Z","timestamp":1777510304149,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>To analyze the effect of a splenectomy on pancytopenia after a peripheral blood stem cell transplantation (PBSCT) in chronic myeloid leukemia (CML) patients. Three CML patients diagnosed with splenomegaly in our department from 2002 to 2006 received a splenectomy after PBSCT. Patient 1, a 42-year-old male in chronic phase (CP), received an HLA-identical sibling allo-PBSCT. Patient 2, a 28-year-old female in aggressive phase (AP), received a PBSCT from her twin. Patient 3, a 26-year-old male in chronic phase (CP), received a PBSCT from an unrelated donor. The conditioning regimen included busulfan and cyclophosphamide (BU\/CY2). Patients 1, 2, and 3 received splenectomies on days 168, 51, and 114, respectively. Bcr-abl transcripts were detected using the polymerase chain reaction (PCR). Chimerism was documented by PCR amplification of a variable number of tandem repeat (VNTR) polymorphrisms. Neither metrisone (2 mg\/kg\/day for 7 days), mycophenolic acid (MMF) (0.5 g twice daily for 1 month), high-dose \u03b3-globulin (0.4 g\/kg\/day for 5 days), granulocyte colony-stimulating factor (G-CSF) therapy, nor erythropoietin (EPO) therapy had produced post-PBSCT hematopoiesis recovery. Patients 1 and 2 had 5% Ph-positive chromosomes while patient 3 exhibited graft-versus-host disease (GVHD). After receiving the splenectomy, all three had a rapid hematopoeitic recovery with no evidence of Ph-positive chromosomes, and patients 1 and 3 showed complete donor chimerism (CDC). Patient 1 developed chronic GVHD (cGVHD) on day 210 postsplenectomy that was treated successfully with prednisone. Patient 2 had acute GVHD on day 55 that was treated successfully with dexamethasone (10 mg), administered intravenously once a day for 3 days with good clinical response. To date, patients 1, 2, and 3 have survived postprocedure for 85, 49, and 25 months, respectively. Splenectomy is an effective option for the patients who have pancytopenia after PBSCT and the patients recovered a good graft function after splenectomy without procedure-related complication and with long-time survival. GVHD can develop in both allo-PBSCT and syngeneic PBSCT. A splenectomy after PBSCT may increase the risk of GVHD, enhance the effect of graft versus leukemia (GVL), promote CDC formation.<\/jats:p>","DOI":"10.3727\/096368910x544951","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T10:34:29Z","timestamp":1291718069000},"page":"1109-1115","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Splenectomy on Pancytopenia after a Peripheral Blood Stem Cell Transplantation"],"prefix":"10.1177","volume":"20","author":[{"given":"Jiahua","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhong Da Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"bibr1-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.56"},{"key":"bibr2-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220308"},{"key":"bibr3-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200205270-00027"},{"key":"bibr4-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.3.257"},{"issue":"6","key":"bibr5-096368910X544951","first-page":"379","volume":"5","author":"Devergie A.","year":"1990","journal-title":"Bone Marrow Transplant."},{"key":"bibr6-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400014900"},{"issue":"4","key":"bibr7-096368910X544951","first-page":"537","volume":"17","author":"Enright H.","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"bibr8-096368910X544951","doi-asserted-by":"publisher","DOI":"10.3727\/096368908787648074"},{"issue":"2","key":"bibr9-096368910X544951","first-page":"177","volume":"10","author":"Grigg A. 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H.","year":"1993","journal-title":"Bone Marrow Transplant."},{"issue":"10","key":"bibr16-096368910X544951","first-page":"1615","volume":"10","author":"Richard C.","year":"1996","journal-title":"Leukemia"},{"key":"bibr17-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198507000-00009"},{"key":"bibr18-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704122"},{"key":"bibr19-096368910X544951","doi-asserted-by":"publisher","DOI":"10.1089\/154732804773099254"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368910X544951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368910X544951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368910X544951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:36:54Z","timestamp":1777390614000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.3727\/096368910X544951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.3727\/096368910X544951"],"URL":"https:\/\/doi.org\/10.3727\/096368910x544951","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}