{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:50:52Z","timestamp":1777510252875,"version":"3.51.4"},"reference-count":3,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Pancreatic islet allotransplantation is an option for patients with unstable type 1 diabetes mellitus (T1DM). Major improvements in islet isolation techniques and the implementation of steroid-free immunosuppressive regimens can maintain insulin independence in the majority of T1DM for at least 1 year after transplantation. Recent studies have emphasized the impact of sirolimus on female reproductive tract. In this communication we report on the alterations of the female reproductive tract in 18 chronically immunosuppressed patients with T1DM following allogenic islet transplantation. Previous research has shown development of ovarian cysts in islet transplant patients receiving sirolimus. We extensively reevaluated this and other possible side effects on the female reproductive system. These side effects have been underestimated, although they are significant, requiring surgical or intensive medical treatment. Pre- and posttransplant gynecological evaluation should be performed to address the development of complications secondary to sirolimus in order to intervene sooner with alternative therapies.<\/jats:p>","DOI":"10.3727\/096368910x557209","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T15:31:23Z","timestamp":1323444683000},"page":"1649-1651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Alterations of the Female Reproductive System in Islet Recipient Receiving Immunosuppression"],"prefix":"10.1177","volume":"20","author":[{"given":"Maria Isabel","family":"Del Olmo Garcia","sequence":"first","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"},{"name":"Department of Endocrinology and Nutrition, University Hospital La Fe, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Lauriola","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"},{"name":"Facolt\u00e1 di Scienze Motorie, Universit\u00e1 degli Studi di Milano, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altagracia Gomez","family":"Aracena","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"},{"name":"Instituto Tecnologico de Santo Domingo (INTEC), Santo Domingo, Dominican Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari","family":"Messinger","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Corrales","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Ricordi","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"},{"name":"DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Jackson Memorial Hospital-University of Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Alejandro","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Miami, FL, University of Miami Miller School of Medicine, USA"},{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"issue":"6","key":"bibr1-096368910X557209","first-page":"622","volume":"22","author":"Alfadhli E.","year":"2009","journal-title":"Int."},{"key":"bibr3-096368910X557209","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000147301.41864.C0"},{"key":"bibr4-096368910X557209","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0490"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368910X557209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368910X557209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368910X557209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:36:32Z","timestamp":1777390592000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.3727\/096368910X557209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":3,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.3727\/096368910X557209"],"URL":"https:\/\/doi.org\/10.3727\/096368910x557209","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}