{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:54:27Z","timestamp":1777510467140,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Hippocampal cholinergic neurostimulating peptide (HCNP) is known to promote differentiation of septohippocampal cholinergic neurons. The HCNP precursor protein (HCNP-pp) may play several roles, for example, as an ATP-binding protein, a Raf kinase inhibitor protein, and a phosphatidylethanolamine-binding protein, as well as a precursor for HCNP. This study therefore aimed to elucidate the involvement of HCNP-pp in specific neural lineages after stroke using a hypoxic\u2013ischemic (HI) rat model of brain ischemia. The specific neural lineages in the hippocampus were investigated 14 days after ischemia. Some bromodeoxyuridine (BrdU)\n                    <jats:sup>+<\/jats:sup>\n                    neural progenitor cells in the hippocampus of hypoxic, HI, or sham-operated rats expressed HCNP-pp. Almost half of the BrdU\n                    <jats:sup>+<\/jats:sup>\n                    \/HCNP-pp\n                    <jats:sup>+<\/jats:sup>\n                    cells also expressed the oligodendrocyte lineage marker 2\u2032,3\u2032-cyclic nucleotide 3\u2032-phosphodiesterase, whereas only a few BrdU\n                    <jats:sup>+<\/jats:sup>\n                    \/HCNP-pp\n                    <jats:sup>+<\/jats:sup>\n                    cells in the hippocampus in HI brains expressed the neuronal lineage marker, doublecortin (DCX). Interestingly, no BrdU\n                    <jats:sup>+<\/jats:sup>\n                    \/HCNP-pp\n                    <jats:sup>+<\/jats:sup>\n                    progenitor cells in hypoxic, HI, or sham-operated brains expressed the astrocyte lineage marker, glial fibrillary acidic protein. Together with previous in vitro data, the results of this study suggest that the expression level of HCNP-pp regulates the differentiation of neural progenitor cells into specific neural lineages in the HI hippocampus, indicating that neural stem cell fate can be controlled via the HCNP-pp mediating pathway.\n                  <\/jats:p>","DOI":"10.3727\/096368911x627543","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T21:16:49Z","timestamp":1333401409000},"page":"2159-2169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Suppression of Astrocyte Lineage in Adult Hippocampal Progenitor Cells Expressing Hippocampal Cholinergic Neurostimulating Peptide Precursor in an in Vivo Ischemic Model"],"prefix":"10.1177","volume":"21","author":[{"given":"Takanari","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Sagisaka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuko","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Wake","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesario V.","family":"Borlongan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Ojika","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<729::AID-JNR10>3.0.CO;2-X"},{"key":"bibr2-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/nature04940"},{"key":"bibr3-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"bibr4-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009567"},{"key":"bibr5-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10773"},{"key":"bibr6-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.037"},{"key":"bibr7-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66051986.x"},{"key":"bibr8-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-009-9275-7"},{"key":"bibr9-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/ng1395"},{"key":"bibr10-096368911X627543","doi-asserted-by":"publisher","DOI":"10.3727\/096368909X470883"},{"key":"bibr11-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1183"},{"key":"bibr12-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14895"},{"key":"bibr13-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21080"},{"key":"bibr14-096368911X627543","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X498278"},{"key":"bibr15-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.121"},{"key":"bibr16-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3239-10.2011"},{"key":"bibr17-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.4"},{"key":"bibr18-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00127-9"},{"key":"bibr19-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.08.031"},{"key":"bibr20-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002524200"},{"key":"bibr21-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.5.1201"},{"key":"bibr22-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603512103"},{"key":"bibr23-096368911X627543","doi-asserted-by":"publisher","DOI":"10.3727\/096368909X477273"},{"key":"bibr24-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<754::AID-JNR3>3.0.CO;2-K"},{"key":"bibr25-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903130558"},{"key":"bibr26-096368911X627543","first-page":"1","volume":"36","author":"Levine S.","year":"1960","journal-title":"Am. J. Pathol."},{"key":"bibr27-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90311-E"},{"key":"bibr28-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21033"},{"key":"bibr29-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.2074"},{"key":"bibr30-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/nature02158"},{"key":"bibr31-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4667-06.2006"},{"key":"bibr32-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1159\/000073512"},{"key":"bibr33-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00215-2"},{"key":"bibr34-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20439"},{"key":"bibr35-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01181-1"},{"key":"bibr36-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00862-0"},{"key":"bibr37-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90465-L"},{"key":"bibr38-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)90043-4"},{"key":"bibr39-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00021-0"},{"key":"bibr40-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.043"},{"key":"bibr41-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.04.003"},{"key":"bibr42-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.071"},{"key":"bibr43-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21036"},{"key":"bibr44-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006028"},{"key":"bibr45-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1159\/000279654"},{"key":"bibr46-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-10-04240.2003"},{"key":"bibr47-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200203000-00007"},{"key":"bibr48-096368911X627543","doi-asserted-by":"publisher","DOI":"10.3727\/000000007783464614"},{"key":"bibr49-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0281"},{"key":"bibr50-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1038\/43686"},{"key":"bibr51-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00199.x"},{"key":"bibr52-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00097-9"},{"key":"bibr53-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.10.1275"},{"key":"bibr54-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.07.012"},{"key":"bibr55-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200404000-00009"},{"key":"bibr56-096368911X627543","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.07.007"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368911X627543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368911X627543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368911X627543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:37:09Z","timestamp":1777390629000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.3727\/096368911X627543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.3727\/096368911X627543"],"URL":"https:\/\/doi.org\/10.3727\/096368911x627543","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}