{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:00:52Z","timestamp":1777510852341,"version":"3.51.4"},"reference-count":144,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Acute ischemic stroke causes a disturbance of neuronal circuitry and disruption of the blood\u2013brain barrier that can lead to functional disabilities. At present, thrombolytic therapy inducing recanalization of the occluded vessels in the cerebral infarcted area is a commonly used therapeutic strategy. However, only a minority of patients have timely access to this kind of therapy. Recently, neural stem cells (NSCs) as therapy for stroke have been developed in preclinical studies. NSCs are harbored in the subventricular zone (SVZ) as well as the subgranular zone of the brain. The microenvironment in the SVZ, including intercellular interactions, extracellular matrix proteins, and soluble factors, can promote NSC proliferation, self-renewal, and multipotency. Endogenous neurogenesis responds to insults of ischemic stroke supporting the existence of remarkable plasticity in the mammalian brain. Homing and integration of NSCs to the sites of damaged brain tissue are complex morphological and physiological processes. This review provides an update on current preclinical cell therapies for stroke, focusing on neurogenesis in the SVZ and dentate gyrus and on recruitment cues that promote NSC homing and integration to the site of the damaged brain.<\/jats:p>","DOI":"10.3727\/096368912x655091","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T11:03:29Z","timestamp":1365505409000},"page":"619-630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Neural Stem Cells and Stroke"],"prefix":"10.1177","volume":"22","author":[{"given":"Dah-Ching","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Huan","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei-Cherng","family":"Shyu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan, ROC"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan, ROC"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, ROC"},{"name":"Department of Neurosurgery, China Medical University Beigang Hospital, Yunlin, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"bibr1-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0318"},{"key":"bibr2-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4721-09.2010"},{"key":"bibr3-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05915.x"},{"key":"bibr4-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002"},{"key":"bibr5-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00111-4"},{"key":"bibr6-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.12.003"},{"key":"bibr7-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"bibr8-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00067.x"},{"key":"bibr9-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.012"},{"key":"bibr10-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp174"},{"key":"bibr11-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20501"},{"key":"bibr12-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.15.407"},{"key":"bibr13-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2054"},{"key":"bibr14-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3047-06.2006"},{"key":"bibr15-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01792.2003"},{"key":"bibr16-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1089\/15258160360732687"},{"key":"bibr17-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.415"},{"key":"bibr18-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2268"},{"key":"bibr19-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1529"},{"key":"bibr20-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600034"},{"key":"bibr21-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000245698.62511.3d"},{"key":"bibr22-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4170fje"},{"key":"bibr23-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.06.015"},{"key":"bibr24-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000173151.36031.be"},{"key":"bibr25-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05702.x"},{"key":"bibr26-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.06.010"},{"key":"bibr27-096368912X655091","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X"},{"key":"bibr28-096368912X655091","doi-asserted-by":"publisher","DOI":"10.2174\/092986706779026237"},{"key":"bibr29-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2003.08.012"},{"key":"bibr30-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80783-7"},{"key":"bibr31-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997"},{"key":"bibr32-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.01.018"},{"key":"bibr33-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.04.001"},{"key":"bibr34-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3798-08.2008"},{"key":"bibr35-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.052"},{"key":"bibr36-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0543"},{"key":"bibr37-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"bibr38-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0068"},{"key":"bibr39-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11879"},{"key":"bibr40-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.13.2485"},{"key":"bibr41-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.12.003"},{"key":"bibr42-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-09-03287.1999"},{"key":"bibr43-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.500470"},{"key":"bibr44-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200502000-00012"},{"key":"bibr45-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030407"},{"key":"bibr46-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.1.84"},{"key":"bibr47-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000190020.30282.cc"},{"key":"bibr48-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00971-6"},{"key":"bibr49-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408258102"},{"key":"bibr50-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X332995"},{"key":"bibr51-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.063"},{"key":"bibr52-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081011098"},{"key":"bibr53-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.10.010"},{"key":"bibr54-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603512103"},{"key":"bibr55-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.05.013"},{"key":"bibr56-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.024802"},{"key":"bibr57-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17902"},{"key":"bibr58-096368912X655091","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.1.0038"},{"key":"bibr59-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.565"},{"key":"bibr60-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X383312"},{"key":"bibr61-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996"},{"key":"bibr62-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3812-07.2007"},{"key":"bibr63-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.09.006"},{"key":"bibr64-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00060"},{"key":"bibr65-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2006.10.003"},{"key":"bibr66-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000156"},{"key":"bibr67-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005586"},{"key":"bibr68-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22474"},{"key":"bibr69-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm306"},{"key":"bibr70-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0762"},{"key":"bibr71-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-1-21"},{"key":"bibr72-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804764200"},{"key":"bibr73-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00148-3"},{"key":"bibr74-096368912X655091","first-page":"549","volume-title":"Adult neurogenesis.","author":"Lindvall O.","year":"2008"},{"key":"bibr75-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40543"},{"key":"bibr76-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.1"},{"key":"bibr77-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251791.64910.cd"},{"key":"bibr78-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8346-1"},{"key":"bibr79-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000176"},{"key":"bibr80-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7888"},{"key":"bibr81-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4667-06.2006"},{"key":"bibr82-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.3.465"},{"key":"bibr83-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1159\/000093098"},{"key":"bibr84-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10342"},{"key":"bibr85-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-63"},{"key":"bibr86-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.051804.101459"},{"key":"bibr87-096368912X655091","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.2.1.69"},{"key":"bibr88-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.004"},{"key":"bibr89-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/382635a0"},{"key":"bibr90-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62546-1"},{"key":"bibr91-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0226"},{"key":"bibr92-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4323-06.2006"},{"key":"bibr93-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600527"},{"key":"bibr94-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7427"},{"key":"bibr95-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-4-295"},{"key":"bibr96-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-19-08487.1999"},{"key":"bibr97-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1995.1035"},{"key":"bibr98-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1996.0595"},{"key":"bibr99-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10393"},{"key":"bibr100-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997"},{"key":"bibr101-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.041"},{"key":"bibr102-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002754"},{"key":"bibr103-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03657.x"},{"key":"bibr104-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nature03889"},{"key":"bibr105-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.12.011"},{"key":"bibr106-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1037"},{"key":"bibr107-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nn0306-299"},{"key":"bibr108-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.03.016"},{"key":"bibr109-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2006.10.013"},{"key":"bibr110-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20798"},{"key":"bibr111-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0229-y"},{"key":"bibr112-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nn1657"},{"key":"bibr113-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1126\/science.1553558"},{"key":"bibr114-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600172"},{"key":"bibr115-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.402"},{"key":"bibr116-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/nature02301"},{"key":"bibr117-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1159\/000086518"},{"key":"bibr118-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01784.2002"},{"key":"bibr119-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.026"},{"key":"bibr120-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001"},{"key":"bibr121-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0585"},{"key":"bibr122-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5165-05.2006"},{"key":"bibr123-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142616.07367.66"},{"key":"bibr124-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.127746"},{"key":"bibr125-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34363"},{"key":"bibr126-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00189.x"},{"key":"bibr127-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-77"},{"key":"bibr128-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200004000-00003"},{"key":"bibr129-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.086"},{"key":"bibr130-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/35102174"},{"key":"bibr131-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0281"},{"key":"bibr132-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20810"},{"key":"bibr133-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0901-778"},{"key":"bibr134-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00486.2002"},{"key":"bibr135-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1999.16.689"},{"key":"bibr136-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000075556.74231.A5"},{"key":"bibr137-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.8.1890"},{"key":"bibr138-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09814.2001"},{"key":"bibr139-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.10.006"},{"key":"bibr140-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00993.x"},{"key":"bibr141-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01182.x"},{"key":"bibr142-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70061-4"},{"key":"bibr143-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10467"},{"key":"bibr144-096368912X655091","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.033"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368912X655091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368912X655091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368912X655091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:38:22Z","timestamp":1777390702000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.3727\/096368912X655091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":144,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.3727\/096368912X655091"],"URL":"https:\/\/doi.org\/10.3727\/096368912x655091","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}