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However, the optimal donor age for OEC associated remyelination is unclear. This project directly compared the remyelinating potential of p75 purified OEC transplants from three donor ages. OECs were sourced from the olfactory bulbs of embryonic, neonatal, and adult rats and purified by immunopanning, and their remyelinating potential was directly compared by transplantation into the same adult rat toxin-induced model of spinal cord demyelination. Remyelination efficiency 3 weeks after transplantation was assessed morphologically and by immunostaining. Our results indicate that all donor ages remyelinate; however, this process is most efficiently achieved by embryonic-derived OECs.<\/jats:p>","DOI":"10.3727\/096368912x656153","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T12:58:38Z","timestamp":1365166718000},"page":"1249-1261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Embryonic-Derived Olfactory Ensheathing Cells Remyelinate Focal Areas of Spinal Cord Demyelination more Efficiently than Neonatal or Adult-Derived Cells"],"prefix":"10.1177","volume":"22","author":[{"given":"David J. 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