{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:47:49Z","timestamp":1790747269411,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>\n                    Diabetes mellitus (DM) is one of the most common and serious chronic diseases in the world. Here, we investigated the effects of mouse dental pulp stem cell (mDPSC) transplantation in a streptozotocin (STZ)-induced diabetes type 1 model. C57BL\/6 mice were treated intraperitoneally with 80 mg\/kg of STZ and transplanted with 1 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    mDPSCs or injected with saline, by an endovenous route, after diabetes onset. Blood and urine glucose levels were reduced in hyperglycemic mice treated with mDPSCs when compared to saline-treated controls. This correlated with an increase in pancreatic islets and insulin production 30 days after mDPSC therapy. Moreover, urea and proteinuria levels normalized after mDPSC transplantation in diabetic mice, indicating an improvement of renal function. This was confirmed by a histopathological analysis of kidney sections. We observed the loss of the epithelial brush border and proximal tubule dilatation only in saline-treated diabetic mice, which is indicative of acute renal lesion. STZ-induced thermal hyperalgesia was also reduced after cell therapy. Three days after transplantation, mDPSC-treated diabetic mice exhibited nociceptive thresholds similar to that of nondiabetic mice, an effect maintained throughout the 90-day evaluation period. Immunofluorescence analyses of the pancreas revealed the presence of GFP\n                    <jats:sup>+<\/jats:sup>\n                    cells in, or surrounding, pancreatic islets. Our results demonstrate that mDPSCs may contribute to pancreatic \u03b2-cell renewal, prevent renal damage in diabetic animals, and produce a powerful and long-lasting antinociceptive effect on behavioral neuropathic pain. Our results suggest stem cell therapy as an option for the control of diabetes complications such as intractable diabetic neuropathic pain.\n                  <\/jats:p>","DOI":"10.3727\/096368912x657972","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T10:18:11Z","timestamp":1365502691000},"page":"2345-2354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Transplantation of Stem Cells Obtained from Murine Dental Pulp Improves Pancreatic Damage, Renal Function, and Painful Diabetic Neuropathy in Diabetic Type 1 Mouse Model"],"prefix":"10.1177","volume":"22","author":[{"given":"Elisalva Teixeira","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"},{"name":"Universidade do Estado da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Da Silva Cruz","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular, Hospital S\u00e3o Rafael, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Farias","family":"De Almeida","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Solano","family":"De Freitas Souza","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia e Terapia Celular, Hospital S\u00e3o Rafael, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Martins","family":"Kaneto","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia e Terapia Celular, Hospital S\u00e3o Rafael, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Fraga","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Washington Luis Conrado Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ribeiro-Dos-Santos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular, Hospital S\u00e3o Rafael, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Flora","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"},{"name":"Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Botelho Pereira","family":"Soares","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz, FIOCRUZ, Bahia, Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular, Hospital S\u00e3o Rafael, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"bibr1-096368912X657972","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2006.00651.x"},{"key":"bibr2-096368912X657972","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(02)00044-3"},{"key":"bibr3-096368912X657972","first-page":"1","volume":"261","author":"Cameron N. 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