{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:54:50Z","timestamp":1789203290155,"version":"build-2803163510"},"reference-count":79,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Interleukin (IL)-20, a member of the IL-10 family of cytokines, was discovered in 2001. IL-20 acts on multiple cell types by activating on a heterodimer receptor complex of either IL-20R1\u2013IL-20R2 or IL-22R1\u2013IL-20R2. Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer. Updated information about IL-20, such as its identification, expression, receptors, signaling, and biological activities, is illustrated in this review based on our research and the data available in the literature. IL-20 is a pleiotropic cytokine, which promotes inflammation, angiogenesis, and chemotaxis. IL-20 also regulates osteoclast differentiation by altering the receptor activator of NF-\u03baB (RANK) and RANK ligand (RANKL) axis. Inflammation, angiogenesis, and osteoclastogenesis are critical for the pathogenesis of RA, osteoporosis, and breast cancer-induced osteolysis. Based on the in vitro and in vivo data and clinical samples, we demonstrated that IL-20 plays pivotal roles in these three diseases. In experimental models, anti-IL-20 monoclonal antibody ameliorates arthritis severity, protects against ovariectomized-induced bone loss, and inhibits breast tumor-induced osteolysis. This review presents the clinical implications of IL-20, which will lead to a better understanding of the biological functions of IL-20 in these diseases and provide new therapeutic options in the future.<\/jats:p>","DOI":"10.3727\/096368914x678319","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T19:00:33Z","timestamp":1399489233000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["The Therapeutic Potential of Anti-Interleukin-20 Monoclonal Antibody"],"prefix":"10.1177","volume":"23","author":[{"given":"Yu-Hsiang","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"bibr1-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21151"},{"key":"bibr2-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79980-0"},{"key":"bibr3-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00187-8"},{"key":"bibr4-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nri2761"},{"key":"bibr5-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060244"},{"key":"bibr6-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803653"},{"key":"bibr7-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2781"},{"key":"bibr8-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200004000-00013"},{"key":"bibr9-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311003"},{"key":"bibr10-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00230-2"},{"key":"bibr11-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.3545"},{"key":"bibr12-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1159\/000060522"},{"key":"bibr13-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363714"},{"key":"bibr14-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.24220"},{"key":"bibr15-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.001"},{"issue":"1","key":"bibr16-096368914X678319","first-page":"23","volume":"130","author":"Hosoi T.","year":"2004","journal-title":"Brain Res."},{"key":"bibr17-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364291"},{"key":"bibr18-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.07.006"},{"key":"bibr19-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.27689"},{"key":"bibr20-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102234"},{"key":"bibr21-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102843"},{"key":"bibr22-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.22039"},{"key":"bibr23-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-12-0276"},{"key":"bibr25-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91107-7"},{"key":"bibr26-096368914X678319","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"bibr27-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7437"},{"key":"bibr28-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0014"},{"key":"bibr29-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199806)41:6<951::AID-ART2>3.0.CO;2-D"},{"key":"bibr30-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.205"},{"issue":"10","key":"bibr31-096368914X678319","first-page":"587","volume":"8","author":"Lampropoulos C. E.","year":"2012","journal-title":"Rev. Rheumatol."},{"key":"bibr32-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00363-4"},{"key":"bibr33-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.410233"},{"key":"bibr34-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.534461"},{"key":"bibr35-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.740006"},{"key":"bibr36-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.130"},{"key":"bibr37-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.540565"},{"key":"bibr38-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.07.006"},{"key":"bibr39-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.28"},{"key":"bibr40-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4288"},{"key":"bibr41-096368914X678319","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0080"},{"key":"bibr42-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1419"},{"key":"bibr43-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.207"},{"key":"bibr44-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.12.004"},{"key":"bibr45-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1186\/ar2167"},{"key":"bibr46-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"bibr47-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nrc867"},{"issue":"3","key":"bibr48-096368914X678319","first-page":"291","volume":"13","author":"Mundy G. R.","year":"1986","journal-title":"Semin. Oncol."},{"key":"bibr49-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.01.007"},{"issue":"6","key":"bibr50-096368914X678319","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"bibr51-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0952"},{"key":"bibr52-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032906"},{"key":"bibr53-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700713"},{"key":"bibr54-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350702"},{"issue":"49","key":"bibr55-096368914X678319","first-page":"47517","volume":"277","author":"Parrish-Novak J.","year":"2002","journal-title":"Differences in receptor-ligand interactions mediate unique biological functions. J. Biol. Chem."},{"key":"bibr56-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104622"},{"key":"bibr57-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.10.6.817"},{"key":"bibr58-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nri846"},{"key":"bibr59-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62349-5"},{"key":"bibr60-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1159\/000218336"},{"key":"bibr61-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.149"},{"key":"bibr62-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00312-8"},{"key":"bibr63-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.11.5.601"},{"key":"bibr64-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13453"},{"key":"bibr65-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/art.22495"},{"key":"bibr66-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken061"},{"key":"bibr67-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"bibr68-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2006"},{"key":"bibr69-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80209-3"},{"key":"bibr70-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1423.039"},{"key":"bibr71-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.06111.x"},{"key":"bibr72-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00048-X"},{"issue":"2","key":"bibr73-096368914X678319","first-page":"427","volume":"170","author":"Teitelbaum S. L.","year":"2007","journal-title":"J. Pathol."},{"key":"bibr74-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707302104"},{"key":"bibr75-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.2.802"},{"key":"bibr76-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.103"},{"key":"bibr77-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.08.001"},{"key":"bibr78-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-006-9087-5"},{"key":"bibr79-096368914X678319","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5397"},{"key":"bibr80-096368914X678319","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939687"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368914X678319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368914X678319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368914X678319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:03Z","timestamp":1777390743000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.3727\/096368914X678319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":79,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.3727\/096368914X678319"],"URL":"https:\/\/doi.org\/10.3727\/096368914x678319","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}