{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:37:18Z","timestamp":1788381438672,"version":"build-2803163510"},"reference-count":79,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure.<\/jats:p>","DOI":"10.3727\/096368914x678409","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T19:00:33Z","timestamp":1399489233000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["The Use of ADSCs as a Treatment for Chronic Stroke"],"prefix":"10.1177","volume":"23","author":[{"given":"Tzu-Min","family":"Chan","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"},{"name":"Everfront Biotech Inc., New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Jyh","family":"Harn","sequence":"additional","affiliation":[{"name":"Department of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Pathology, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Chih","family":"Chiu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"GwoXi Stem Cell Applied Technology, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-I","family":"Wang","sequence":"additional","affiliation":[{"name":"GwoXi Stem Cell Applied Technology, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ing","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Pin","family":"Chuu","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzyy-Wen","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Cheng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yu","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Beigang Hospital, Yunlin, Taiwan"},{"name":"Departmentof Medical Technology, Nursing and Management, Jen-Teh Junior College of Medicine, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"},{"name":"Department of Neurosurgery, China Medical University Beigang Hospital, Yunlin, Taiwan"},{"name":"Department of Neurosurgery, Tainan Municipal An-Nan Hospital, China Medical University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"bibr1-096368914X678409","doi-asserted-by":"publisher","DOI":"10.1159\/000203964"},{"key":"bibr2-096368914X678409","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/812693"},{"key":"bibr3-096368914X678409","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070648"},{"key":"bibr4-096368914X678409","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/0470870834.ch2","volume":"231","author":"Bjorklund A.","year":"2000","journal-title":"Novartis Found. 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