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Ten patients with unilateral MCA stenosis and 24 healthy volunteers underwent limb ischemic preconditioning, consisting of five cycles of 5-min inflations of a blood pressure cuff to 200 mmHg around an upper limb followed by 5 min of reperfusion. Limb ischemic preconditioning has no significant effect on the heart rate, oxygenation index, or mean flow velocity in patients with unilateral MCA stenosis or healthy volunteers. However, healthy volunteers showed a reduction in blood pressure 30 min following reperfusion of the last cycle. Limb ischemic preconditioning was found to be safe and well tolerated in both patients and healthy volunteers. We highlight the potential of limb ischemic preconditioning as an adjunct to neuroprotective treatment.<\/jats:p>","DOI":"10.3727\/096368914x683520","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T21:38:18Z","timestamp":1412977098000},"page":"1901-1911","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients with Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers"],"prefix":"10.1177","volume":"24","author":[{"given":"Sijie","family":"Li","sequence":"first","affiliation":[{"name":"Emergency Department, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema","family":"Esmail","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Wayne State University School of Medicine, Detroit, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hua","sequence":"additional","affiliation":[{"name":"Vascular Ultrasound Division, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Jia","sequence":"additional","affiliation":[{"name":"Vascular Ultrasound Division, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[{"name":"Emergency Department, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Wayne State University School of Medicine, Detroit, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesario V.","family":"Borlongan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"bibr1-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00106.2003"},{"key":"bibr2-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62001-8"},{"key":"bibr3-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317158110"},{"key":"bibr4-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00525-1"},{"key":"bibr5-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.01.070"},{"key":"bibr6-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.05.037"},{"key":"bibr7-096368914X683520","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0377-6"},{"key":"bibr8-096368914X683520","first-page":"CD008472","volume":"7","author":"Desai M.","year":"2011","journal-title":"Cochrane Database Syst. 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